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  1. Proteolysis of matrix components, in particular elastin, is a major contributing factor to the development of lung diseases such as emphysema and chronic obstructive pulmonary disease (COPD). MMP-12 (macrophag...

    Authors: Peter LaPan, Jeff Brady, Christal Grierson, Margaret Fleming, Doug Miller, Joe Sypek and Bin Fu
    Citation: BMC Pulmonary Medicine 2010 10:40
    Content type: Technical advance Published on:

  2. Clinical and experimental data suggest that the inflammatory response is impaired in diabetics and can be modulated by insulin. The present study was undertaken to investigate the role of insulin on the early ...

    Authors: Joilson O Martins, Carlos AL Campos, José WMC Cruz, Simone Manzolli, Venâncio AF Alves, Elcio O Vianna, Sonia Jancar and Paulina Sannomiya
    Citation: BMC Pulmonary Medicine 2010 10:39
    Content type: Research article Published on:

  3. Inadequate glucose control may be simultaneously associated with inflammation and decreased lung function in type 2 diabetes. We evaluated if lung function is worse in patients with inadequate glucose control,...

    Authors: Rodolfo J Dennis, Dario Maldonado, Maria X Rojas, Pablo Aschner, Martin Rondón, Laura Charry and Alejandro Casas
    Citation: BMC Pulmonary Medicine 2010 10:38
    Content type: Research article Published on:

  4. Bronchial Hyperresponsiveness (BHR) is considered a hallmark of asthma. Other methods are helpful in epidemiological respiratory health studies including Fractional Exhaled Nitric Oxide (FENO) and Eosinophils ...

    Authors: Valérie Demange, Pascal Wild, Denis Zmirou-Navier, Paul Tossa, Abraham Bohadana, Annick Barbaud and Christophe Paris
    Citation: BMC Pulmonary Medicine 2010 10:37
    Content type: Research article Published on:

  5. The Eosinophil Cationic Protein (ECP) is a potent multifunctional protein. Three common polymorphisms are present in the ECP gene, which determine the function and production of the protein. The aim was to stu...

    Authors: Ulla-Britt Jönsson, Lena Douhan Håkansson, Rain Jõgi, Christer Janson and Per Venge
    Citation: BMC Pulmonary Medicine 2010 10:36
    Content type: Research article Published on:

  6. Chronic obstructive pulmonary disease (COPD) affects independence and survival in the general population, but it is unknown to which extent this conclusion applies to elderly people with mild disease. The aim ...

    Authors: Claudio Pedone, Simone Scarlata, Claudio Sorino, Francesco Forastiere, Vincenzo Bellia and Raffaele Antonelli Incalzi
    Citation: BMC Pulmonary Medicine 2010 10:35
    Content type: Research article Published on:

  7. Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing. ...

    Authors: Jason Yongha Kim, Jeong Hyun Kim, Tae Joon Park, Joon Seol Bae, Jin Sol Lee, Charisse Flerida Pasaje, Byung Lae Park, Hyun Sub Cheong, Jong-Sook Park, Sung-Woo Park, Soo-Taek Uh, Mi-Kyeong Kim, Inseon S Choi, Sang Heon Cho, Byoung Whui Choi, Choon-Sik Park…
    Citation: BMC Pulmonary Medicine 2010 10:34
    Content type: Research article Published on:

  8. Chronic obstructive pulmonary disease (COPD) and a high body mass index (BMI) can both affect pulmonary volumes as well as exercise tolerance, but their combined effect on these outcomes is not well known. The...

    Authors: Louis Laviolette, Francesco Sava, Denis E O'Donnell, Katherine A Webb, Alan L Hamilton, Steven Kesten and François Maltais
    Citation: BMC Pulmonary Medicine 2010 10:33
    Content type: Research article Published on:

  9. Exertional dyspnea is the most prominent and disabling feature in idiopathic pulmonary fibrosis (IPF). The Medical Research Chronic (MRC) chronic dyspnea score as well as physiological measurements obtained du...

    Authors: Effrosyni D Manali, Panagiotis Lyberopoulos, Christina Triantafillidou, Likourgos F Kolilekas, Christina Sotiropoulou, Joseph Milic-Emili, Charis Roussos and Spyros A Papiris
    Citation: BMC Pulmonary Medicine 2010 10:32
    Content type: Research article Published on:

  10. Both Peak Oxygen Uptake (peak VO2), from cardiopulmonary exercise testing (CPET) and the distance walked during a Six-Minute Walk Test (6 MWD) are used for following the natural history of various diseases, ti...

    Authors: Robert M Ross, Jayasimha N Murthy, Istvan D Wollak and Andrew S Jackson
    Citation: BMC Pulmonary Medicine 2010 10:31
    Content type: Research article Published on:

  11. Airway epithelial cells are critical in host defense against bacteria including Mycoplasma pneumoniae (Mp) in chronic obstructive pulmonary disease (COPD) and asthma. β2-agonists are mainstay of COPD and asthma t...

    Authors: Claire A Gross, Russell P Bowler, Rebecca M Green, Andrew R Weinberger, Christina Schnell and Hong Wei Chu
    Citation: BMC Pulmonary Medicine 2010 10:30
    Content type: Research article Published on:

  12. Asthma management guidelines recommend a stepwise approach to instituting and adjusting anti-inflammatory controller therapy for children with asthma. The objective of this retrospective observational study wa...

    Authors: Mike Thomas, Tarita Murray-Thomas, Tao Fan, Tim Williams and Stephanie Taylor
    Citation: BMC Pulmonary Medicine 2010 10:29
    Content type: Research article Published on:

  13. In chronic obstructive pulmonary disease (COPD), the response of the forced expiratory volume in 1 second (FEV1) after bronchodilator application is weak. Inspiratory parameters like the forced inspiratory vol...

    Authors: Frank J Visser, Sunil Ramlal, Ben Pelzer, PN Richard Dekhuijzen and Yvonne F Heijdra
    Citation: BMC Pulmonary Medicine 2010 10:28
    Content type: Research article Published on:

  14. Injection drug use is associated with an increased risk of human immunodeficiency virus (HIV) infection and with obstructive lung diseases (OLD). Understanding how HIV and OLD may impact respiratory symptoms a...

    Authors: M Bradley Drummond, Gregory D Kirk, Erin P Ricketts, Meredith C McCormack, J Christian Hague, John F McDyer, Shruti H Mehta, Eric A Engels, Robert A Wise and Christian A Merlo
    Citation: BMC Pulmonary Medicine 2010 10:27
    Content type: Research article Published on:

  15. Pulmonary fibrosis (PF) is a group of devastating and largely irreversible diseases. Phosphodiesterase (PDE) 4 is involved in the processes of remodeling and inflammation, which play key role in tissue fibrosi...

    Authors: Sergey Udalov, Rio Dumitrascu, Soni S Pullamsetti, Hamza M Al-tamari, Norbert Weissmann, Hossein A Ghofrani, Andreas Guenther, Robert Voswinckel, Werner Seeger, Friedrich Grimminger and Ralph T Schermuly
    Citation: BMC Pulmonary Medicine 2010 10:26
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Pulmonary Medicine 2022 22:113

  16. Ventilator-induced lung injury (VILI) is a recognized complication of mechanical ventilation. Although the specific mechanism by which mechanical ventilation causes lung injury remains an active area of study,...

    Authors: Scott E Sinclair, Nayak L Polissar and William A Altemeier
    Citation: BMC Pulmonary Medicine 2010 10:25
    Content type: Research article Published on:

  17. The aim is to assess the validity and reliability of transbronchial needle aspiration (TBNA) of mediastinal and hilar adenopathies and to evaluate factors predictive of TBNA outcome.

    Authors: Alberto Fernández-Villar, Maribel Botana, Virginia Leiro, Ana González, Cristina Represas and Alberto Ruano-Raviña
    Citation: BMC Pulmonary Medicine 2010 10:24
    Content type: Research article Published on:

  18. 8-Isoprostane (8-IP) is a marker of lipid peroxidation. Elevated concentrations have been reported in BAL fluid and exhaled breath condensate (EBC) in sarcoidosis (S). To validate the prognostic value of this ...

    Authors: Wojciech J Piotrowski, Zofia Kurmanowska, Adam Antczak, Jerzy Marczak and Paweł Górski
    Citation: BMC Pulmonary Medicine 2010 10:23
    Content type: Research article Published on:

  19. Liver dysfunction reflects the status of heart failure, with congestion and low perfusion of the liver serving as causative mechanisms. Previous studies demonstrated relationship between the results of liver f...

    Authors: Yasuko Takeda, Yutaka Takeda, Shigehiro Tomimoto, Tomomitsu Tani, Hitomi Narita and Genjiro Kimura
    Citation: BMC Pulmonary Medicine 2010 10:22
    Content type: Research article Published on:

  20. A large number of studies have investigated the effects of high tidal volume ventilation in mouse models. In contrast data on very short term effects of low tidal volume ventilation are sparse. Therefore we in...

    Authors: Hans P Hauber, Dörte Karp, Torsten Goldmann, Ekkehard Vollmer and Peter Zabel
    Citation: BMC Pulmonary Medicine 2010 10:21
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Pulmonary Medicine 2012 12:7

  21. While lipopolysaccharide (LPS) from Gram-negative bacteria has been shown to augment inflammation in ventilated lungs information on the effect of Gram-positive bacteria is lacking. Therefore the effect of LPS...

    Authors: Hans P Hauber, Dörte Karp, Torsten Goldmann, Ekkehard Vollmer and Peter Zabel
    Citation: BMC Pulmonary Medicine 2010 10:20
    Content type: Research article Published on:

  22. Few studies have been carried out on acute effects of cement dust exposure. This study is conducted to investigate the associations between current "total" dust exposure and acute respiratory symptoms and resp...

    Authors: Zeyede K Zeleke, Bente E Moen and Magne Bråtveit
    Citation: BMC Pulmonary Medicine 2010 10:19
    Content type: Research article Published on:

  23. Right ventricular dilatation in the setting of acute pulmonary embolism is associated with an adverse prognosis. Treatment with a pulmonary vasodilator has never been studied systematically. We evaluated the e...

    Authors: Albertus J Kooter, Richard G IJzerman, Otto Kamp, Anco B Boonstra and Yvo M Smulders
    Citation: BMC Pulmonary Medicine 2010 10:18
    Content type: Research article Published on:

  24. Pulsus paradoxus estimated by dynamic change in area under the oximeter plethysmograph waveform (PEP) might provide a measure of acute asthma severity. Our primary objective was to determine how well PEP corre...

    Authors: Donald H Arnold, Cathy A Jenkins and Tina V Hartert
    Citation: BMC Pulmonary Medicine 2010 10:17
    Content type: Research article Published on:

  25. Obesity and asthma have reached epidemic proportions in the US. Their concurrent rise over the last 30 years suggests that they may be connected. Numerous observational studies support a temporally-correct, do...

    Authors: Jun Ma, Peg Strub, Carlos A Camargo Jr, Lan Xiao, Estela Ayala, Christopher D Gardner, A Sonia Buist, William L Haskell, Phillip W Lavori and Sandra R Wilson
    Citation: BMC Pulmonary Medicine 2010 10:16
    Content type: Study protocol Published on:

  26. The prevalence of anemia in the intensive care unit is well-described. Less is known, however, of the prevalence of anemia in hospitalized patients with lesser illness severity or without organ dysfunction. Co...

    Authors: Michael C Reade, Lisa Weissfeld, Derek C Angus, John A Kellum and Eric B Milbrandt
    Citation: BMC Pulmonary Medicine 2010 10:15
    Content type: Research article Published on:

  27. There is much interest in the possibility that perinatal factors may influence the risk of disease in later life. We investigated the influence of maternal and perinatal factors on subsequent hospital admissio...

    Authors: Rebekah Davidson, Stephen E Roberts, Clare J Wotton and Michael J Goldacre
    Citation: BMC Pulmonary Medicine 2010 10:14
    Content type: Research article Published on:

  28. Smoking cessation is the best possible way to prevent the progression of smoking related airway diseases. However, the effect and time scale of smoking cessation on airway inflammation/remodelling are largely ...

    Authors: Noora Louhelainen, Harri Stark, Witold Mazur, Paula Rytilä, Ratko Djukanovic and Vuokko L Kinnula
    Citation: BMC Pulmonary Medicine 2010 10:13
    Content type: Research article Published on:

  29. Despite recommendations for outpatient management, low risk patients with lower respiratory tract infections (LRTIs) are often hospitalized. This survey analyzed perceptions of physicians, nurses, patients and...

    Authors: Claudia Baehni, Sabine Meier, Pamela Spreiter, Ursula Schild, Katharina Regez, Rita Bossart, Robert Thomann, Claudine Falconnier, Mirjam Christ-Crain, Sabina De Geest, Beat Müller and Philipp Schuetz
    Citation: BMC Pulmonary Medicine 2010 10:12
    Content type: Research article Published on:

  30. Indacaterol is a novel, once-daily (o.d.) inhaled, long-acting β 2-agonist in development for chronic obstructive pulmonary disease (COPD). This 12-week, double-blind study compared the efficacy, safety, and tole...

    Authors: Gregory Feldman, Thomas Siler, Niyati Prasad, Damon Jack, Simon Piggott, Roger Owen, Mark Higgins and Benjamin Kramer
    Citation: BMC Pulmonary Medicine 2010 10:11
    Content type: Research article Published on:

  31. Health status, dyspnea and psychological status are important clinical outcomes in chronic obstructive pulmonary disease (COPD). However, forced expiratory volume in one second (FEV1) measured by spirometry, the ...

    Authors: Akane Haruna, Toru Oga, Shigeo Muro, Tadashi Ohara, Susumu Sato, Satoshi Marumo, Daisuke Kinose, Kunihiko Terada, Michiyoshi Nishioka, Emiko Ogawa, Yuma Hoshino, Toyohiro Hirai, Kazuo Chin and Michiaki Mishima
    Citation: BMC Pulmonary Medicine 2010 10:10
    Content type: Research article Published on:

  32. Heart failure (HF) and sleep apnoea (SA) association has been recognized but whether it results from confounding factors (hypertension, ischaemia, obesity) remains unclear.

    Authors: Susana Ferreira, Anabela Marinho, Marta Patacho, Elisabete Santa-Clara, Cristina Carrondo, João Winck and Paulo Bettencourt
    Citation: BMC Pulmonary Medicine 2010 10:9
    Content type: Research article Published on:

  33. Pandemic Influenza A (H1N1) 2009 is a novel viral infection that emerged in March 2009. This is the first report addressing the clinical course of patients with cystic fibrosis (CF) and H1N1 infection.

    Authors: Megan W France, Szeanna Tai, Phillip J Masel, Vanessa L Moore, Tracy L McMahon, Alexander J Ritchie and Scott C Bell
    Citation: BMC Pulmonary Medicine 2010 10:8
    Content type: Research article Published on:

  34. Previous health economic studies recommend either a dual screening strategy [tuberculin skin test (TST) followed by interferon-γ-release assay (IGRA)] or a single one [IGRA only] for latent tuberculosis infect...

    Authors: Anil Pooran, Helen Booth, Robert F Miller, Geoff Scott, Motasim Badri, Jim F Huggett, Graham Rook, Alimuddin Zumla and Keertan Dheda
    Citation: BMC Pulmonary Medicine 2010 10:7
    Content type: Research article Published on:

  35. Preventing ventilator-associated lung injury (VALI) has become pivotal in mechanical ventilation of patients with acute lung injury (ALI) or its more severe form, acute respiratory distress syndrome (ARDS). In...

    Authors: Rogier M Determann, Annick ANM Royakkers, Jack J Haitsma, Haibo Zhang, Arthur S Slutsky, V Marco Ranieri and Marcus J Schultz
    Citation: BMC Pulmonary Medicine 2010 10:6
    Content type: Research article Published on:

  36. Non-cystic fibrosis bronchiectasis is characterised by sputum production, exercise limitation and recurrent infections. Although pulmonary rehabilitation is advocated for this patient group, its effects are un...

    Authors: Annemarie L Lee, Nola Cecins, Catherine J Hill, Anne E Holland, Linda Rautela, Robert G Stirling, Phillip J Thompson, Christine F McDonald and Sue Jenkins
    Citation: BMC Pulmonary Medicine 2010 10:5
    Content type: Study protocol Published on:

  37. Nitric oxide (NO) shows differing concentrations in lower and upper airways. Patients after total laryngectomy are the only individuals, in whom a complete separation of upper and lower airways is guaranteed. ...

    Authors: Matthias F Kramer, Bernhard Olzowy, Annette Bihler, Dorothea de la Motte, Dennis Nowak, Rudolf A Jörres and Holger Dressel
    Citation: BMC Pulmonary Medicine 2010 10:4
    Content type: Research article Published on:

  38. IL-13 has been implicated in the development of airway inflammation and hyperresponsiveness. This study investigated the multiple-dose pharmacokinetics and safety profile of human anti-IL-13 antibody (CAT-354)...

    Authors: Dave Singh, Binita Kane, Nestor A Molfino, Raffaella Faggioni, Lorin Roskos and Ashley Woodcock
    Citation: BMC Pulmonary Medicine 2010 10:3
    Content type: Research article Published on:

  39. Urinary incontinence (UI) is a distressing problem for older people. To investigate the relationship between UI and respiratory symptoms among middle-aged and older men, a community-based study was conducted i...

    Authors: Fumi Hirayama, Andy H Lee, Tetsuo Hiramatsu and Yoshimasa Tanikawa
    Citation: BMC Pulmonary Medicine 2010 10:2
    Content type: Research article Published on:

  40. Poor adherence with prescribed asthma medication is a major barrier to positive treatment outcomes. This study was designed to determine the effect of a once-daily administration of mometasone furoate administ...

    Authors: David Price, Anne Robertson, Kevin Bullen, Cynthia Rand, Rob Horne and Heribert Staudinger
    Citation: BMC Pulmonary Medicine 2010 10:1
    Content type: Research article Published on:

  41. Airway inflammation and airway hyperresponsiveness (AHR) are two characteristic features of asthma. Fractional exhaled nitric oxide (FENO) has shown good correlation with AHR in asthmatics. Less information is...

    Authors: Valérie Demange, Abraham Bohadana, Nicole Massin and Pascal Wild
    Citation: BMC Pulmonary Medicine 2009 9:53
    Content type: Research article Published on:

  42. Early detection of exacerbations by COPD patients initiating prompt interventions has shown to be clinically relevant. Until now, research failed to identify the effectiveness of a written individualized Actio...

    Authors: Jaap CA Trappenburg, Lieselotte Koevoets, Gerdien H de Weert-van Oene, Evelyn M Monninkhof, Jean Bourbeau, Thierry Troosters, Theo JM Verheij, Jan-Willem J Lammers and Augustinus JP Schrijvers
    Citation: BMC Pulmonary Medicine 2009 9:52
    Content type: Study protocol Published on:

  43. High levels of exhaled carbon monoxide (eCO) are a marker of airway or lung inflammation. We investigated whether hypo- or hyperventilation can affect measured values.

    Authors: Franco Cavaliere, Carmen Volpe, Riccardo Gargaruti, Andrea Poscia, Michele Di Donato, Giovanni Grieco and Umberto Moscato
    Citation: BMC Pulmonary Medicine 2009 9:51
    Content type: Research article Published on:

  44. Spirometry is a cost-effective diagnostic tool for evaluation of lung function and for case-finding in a resource-limited setting. The acceptance of this test depends on the awareness of its indications and th...

    Authors: Olufemi O Desalu, Olusegun A Busari, Cajetan C Onyedum, Fatai K Salawu, Olusegun A Obateru, Kelechukwu C Nwogu and Alakija K Salami
    Citation: BMC Pulmonary Medicine 2009 9:50
    Content type: Research article Published on:

  45. Despite consensus criteria, diagnosing acute lung injury, or its more severe form acute respiratory distress syndrome (ALI/ARDS) remains challenging. Adding objective measures, such as plasma levels of biologi...

    Authors: Rogier M Determann, Julian L Millo, Sam Waddy, Rene Lutter, Chris S Garrard and Marcus J Schultz
    Citation: BMC Pulmonary Medicine 2009 9:49
    Content type: Research article Published on:

  46. The collection of exhaled breath condensate (EBC) is a suitable and non-invasive method for evaluation of airway inflammation. Several studies indicate that the composition of the condensate and the recovery o...

    Authors: Frank Hoffmeyer, Monika Raulf-Heimsoth, Volker Harth, Jürgen Bünger and Thomas Brüning
    Citation: BMC Pulmonary Medicine 2009 9:48
    Content type: Research article Published on:

  48. Previous studies have shown conflicting results for the association between TLR4 polymorphism (Asp299Gly) and lung function. We investigated the influence of TLR4 Asp299Gly, a polymorphism, on lung function in...

    Authors: Punam Pahwa, Chandima P Karunanayake, Donna C Rennie, Yue Chen, David A Schwartz and James A Dosman
    Citation: BMC Pulmonary Medicine 2009 9:46
    Content type: Research article Published on:

  49. To determine whether oral administration of geranylgeranylacetone (GGA), a nontoxic anti-ulcer drug that is an inducer of heat shock protein (HSP) 70, protects against drug-induced lung injury/fibrosis in vivo.

    Authors: Takayoshi Fujibayashi, Naozumi Hashimoto, Mayumi Jijiwa, Yoshinori Hasegawa, Toshihisa Kojima and Naoki Ishiguro
    Citation: BMC Pulmonary Medicine 2009 9:45
    Content type: Research article Published on:

  50. Tigecycline, an expanded broad-spectrum glycylcycline, exhibits in vitro activity against many common pathogens associated with community-acquired pneumonia (CAP), as well as penetration into lung tissues that...

    Authors: Cristina Tanaseanu, Slobodan Milutinovic, Petre I Calistru, Janos Strausz, Marius Zolubas, Valeriy Chernyak, Nathalie Dartois, Nathalie Castaing, Hassan Gandjini and C Angel Cooper
    Citation: BMC Pulmonary Medicine 2009 9:44
    Content type: Research article Published on:
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BMC Pulmonary Medicine

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