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  1. Ventilatory impairment is known to occur in patients with heart failure (HF). Alveolar volume (VA) is measured by the dilution of an inert gas during a single breath-hold maneuver. Such measurement is sensitive t...

    Authors: Massimo Miniati, Simonetta Monti, Matteo Bottai, Ivana Pavlickova, Claudio Passino, Michele Emdin and Roberta Poletti
    Citation: BMC Pulmonary Medicine 2013 13:69
  2. Bronchodilators are a mainstay of treatment for patients with airflow obstruction. We hypothesized that patients with obesity and no objective documentation of airflow obstruction are inappropriately treated w...

    Authors: Spyridon Fortis, Joseph Kittah, Manuel De Aguirre, Maria Plataki, Armand Wolff, Yaw Amoateng-Adjepong and Constantine A Manthous
    Citation: BMC Pulmonary Medicine 2013 13:68
  3. Mechanical ventilation (MV) is an essential supportive therapy for acute lung injury (ALI); however it can also contribute to systemic inflammation. Since pulmonary surfactant has anti-inflammatory properties,...

    Authors: Valeria Puntorieri, Josh Qua Hiansen, Lynda A McCaig, Li-Juan Yao, Ruud AW Veldhuizen and James F Lewis
    Citation: BMC Pulmonary Medicine 2013 13:67
  4. The fraction of exhaled nitric oxide (FeNO) has been suggested as a non-invasive marker of eosinophilic inflammation in asthma, but lately rather as a biomarker of atopy than of asthma itself. Asthma after bro...

    Authors: Ingvild Bruun Mikalsen, Thomas Halvorsen and Knut Øymar
    Citation: BMC Pulmonary Medicine 2013 13:66
  5. The acute inhalation of endotoxin mimicks several aspects of the inflammation related to chronic obstructive pulmonary disease (COPD). The aim of the current study was to identify and to validate biomarkers of...

    Authors: Olivier Michel, Virginie Doyen, Baptiste Leroy, Benjamin Bopp, Duc Huy Phong Dinh, Francis Corazza and Ruddy Wattiez
    Citation: BMC Pulmonary Medicine 2013 13:65
  6. Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was...

    Authors: Farzian Aminuddin, Tillie-Louise Hackett, Dorota Stefanowicz, Aabida Saferali, Peter D Paré, Amund Gulsvik, Per Bakke, Michael H Cho, Augusto Litonjua, David A Lomas, Wayne H Anderson, Terri H Beaty, Edwin K Silverman and Andrew J Sandford
    Citation: BMC Pulmonary Medicine 2013 13:64
  7. Airway epithelial cells provide a protective barrier against environmental particles including potential pathogens. Epithelial repair in response to tissue damage is abnormal in asthmatic airway epithelium in ...

    Authors: Aleksandra Szczepankiewicz, Peter M Lackie and John W Holloway
    Citation: BMC Pulmonary Medicine 2013 13:63
  8. Anxiety and depression are common co-morbidities in patients with chronic obstructive pulmonary disease (COPD). Serious implications can result from psychological difficulties in COPD including reduced surviva...

    Authors: Karen Heslop, Julia Newton, Christine Baker, Graham Burns, Debbie Carrick-Sen and Anthony De Soyza
    Citation: BMC Pulmonary Medicine 2013 13:62
  9. The relevance of Trichosporon species for cystic fibrosis (CF) patients has not yet been extensively investigated.

    Authors: Carolin Kröner, Matthias Kappler, Ann-Christin Grimmelt, Gudrun Laniado, Benjamin Würstl and Matthias Griese
    Citation: BMC Pulmonary Medicine 2013 13:61
  10. The aim of this case–control study was to analyse the clinical characteristics of children with recurrent community-acquired pneumonia (rCAP) affecting different lung areas (DLAs) and compare them with those o...

    Authors: Francesca Patria, Benedetta Longhi, Claudia Tagliabue, Rossana Tenconi, Patrizia Ballista, Giuseppe Ricciardi, Carlotta Galeone, Nicola Principi and Susanna Esposito
    Citation: BMC Pulmonary Medicine 2013 13:60
  11. It has been suggested that smoking asthmatics benefit less from corticosteroid treatment than never-smoking asthmatics. We investigated differences in blood and sputum inflammatory profiles between ex-, curren...

    Authors: Eef D Telenga, Huib A M Kerstjens, Nick H T ten Hacken, Dirkje S Postma and Maarten van den Berge
    Citation: BMC Pulmonary Medicine 2013 13:58
  12. Pulmonary rehabilitation is widely advocated for people with chronic obstructive pulmonary disease (COPD) to improve exercise capacity, symptoms and quality of life, however only a minority of individuals with...

    Authors: Anne E Holland, Ajay Mahal, Catherine J Hill, Annemarie L Lee, Angela T Burge, Rosemary Moore, Caroline Nicolson, Paul O’Halloran, Narelle S Cox, Aroub Lahham, Rebecca Ndongo, Emily Bell and Christine F McDonald
    Citation: BMC Pulmonary Medicine 2013 13:57
  13. Genetic variation within GSTM2-5 genes may interfere with detoxification of environmental compounds, thereby having a detrimental effect on lung function following exposures such as tobacco smoke. We aim to inves...

    Authors: Melannie Alexander, Wilfried Karmaus, John W Holloway, Hongmei Zhang, Graham Roberts, Ramesh J Kurukulaaratchy, Syed Hasan Arshad and Susan Ewart
    Citation: BMC Pulmonary Medicine 2013 13:56
  14. Hyponatremia based on syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH) is observed in up to 15% of patients with small cell lung cancer (SCLC). The electrolyte imbalance is associated with...

    Authors: Claudia Petereit, Okan Zaba, Ishak Teber, Heike Lüders and Christian Grohé
    Citation: BMC Pulmonary Medicine 2013 13:55
  15. Although chronic obstructive pulmonary disease (COPD) is a major global health burden there is a lack of patient awareness of disease severity, particularly in relation to exacerbations.

    Authors: Neil Barnes, Peter MA Calverley, Alan Kaplan and Klaus F Rabe
    Citation: BMC Pulmonary Medicine 2013 13:54
  16. Recent studies suggest that the incidence of idiopathic pulmonary fibrosis (IPF) is rising. Accurate epidemiological data on IPF, however, are sparse and the results of previous studies are contradictory. This...

    Authors: Jaana Kaunisto, Eija-Riitta Salomaa, Ulla Hodgson, Riitta Kaarteenaho and Marjukka Myllärniemi
    Citation: BMC Pulmonary Medicine 2013 13:53
  17. The importance of the lung parenchyma in the pathophysiology of asthma has previously been demonstrated. Considering that nitric oxide synthases (NOS) and arginases compete for the same substrate, it is worthw...

    Authors: Luciana RCRB Aristoteles, Renato F Righetti, Nathalia Montouro Pinheiro, Rosana B Franco, Claudia M Starling, Julie CP da Silva, Patrícia Angeli Pigati, Luciana C Caperuto, Carla M Prado, Marisa Dolhnikoff, Milton A Martins, Edna A Leick and Iolanda FLC Tibério
    Citation: BMC Pulmonary Medicine 2013 13:52
  18. Gastroesophageal reflux disease (GERD) is one of the most common causes of chronic cough and a potential risk factor for exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was ...

    Authors: Jinhee Kim, Jin Hwa Lee, Yuri Kim, Kyungjoo Kim, Yeon-Mok Oh, Kwang Ha Yoo, Chin Kook Rhee, Hyoung Kyu Yoon, Young Sam Kim, Yong Bum Park, Sei Won Lee and Sang Do Lee
    Citation: BMC Pulmonary Medicine 2013 13:51
  19. Standardised evidenced-based materials and mechanisms to facilitate the delivery of the education component of pulmonary rehabilitation are not widely available. The aims of this study were: 1) to adapt the se...

    Authors: Denise Cosgrove, Joseph MacMahon, Jean Bourbeau, Judy M Bradley and Brenda O’Neill
    Citation: BMC Pulmonary Medicine 2013 13:50
  20. The six-minute walk test (6MWT) is a simple, low tech, safe and well established, self-paced assessment tool to quantify functional exercise capacity in adults. The definition of normal 6MWT in children is esp...

    Authors: Silvia Ulrich, Florian F Hildenbrand, Ursula Treder, Manuel Fischler, Stephan Keusch, Rudolf Speich and Margrit Fasnacht
    Citation: BMC Pulmonary Medicine 2013 13:49
  21. Chronic lung diseases are marked by progressive inflammation, tissue damage and remodelling. Bone marrow-derived progenitor cells may contribute to these processes. The objectives of this study were to (1) to ...

    Authors: Sarah E Gilpin, Kalvin Lung, Geoffrey T de Couto, Marcelo Cypel, Masaaki Sato, Lianne G Singer, Shaf Keshavjee and Thomas K Waddell
    Citation: BMC Pulmonary Medicine 2013 13:48
  22. Heparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and system...

    Authors: Daniel F McAuley, Cecilia M O’Kane, Thelma R Craig, Murali Shyamsundar, Heiko Herwald and Karim Dib
    Citation: BMC Pulmonary Medicine 2013 13:47
  23. It remains unclear to what extent asthma in adults is linked to allergic rhinitis (AR), gastroesophageal reflux disease (GERD), and acetylsalicylic acid exacerbated respiratory disease (AERD), and how these co...

    Authors: Henriette Steppuhn, Ute Langen, Christa Scheidt-Nave and Thomas Keil
    Citation: BMC Pulmonary Medicine 2013 13:46
  24. The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and the Medical Outcomes Study Short Form 36 (SF-36) are widely used to assess patient-reported outcome in individuals with pulmonary hypertension ...

    Authors: James Twiss, Stephen McKenna, Louise Ganderton, Sue Jenkins, Mitra Ben-L’amri, Kevin Gain, Robin Fowler and Eli Gabbay
    Citation: BMC Pulmonary Medicine 2013 13:45
  25. Tumors with a massive inflammatory infiltration are described in several organs. There is agreement about considering the inflammatory infiltration as the host’s immune response to neoplastic cells; such neopl...

    Authors: Alessandro Del Gobbo, Stefano Fiori, Gabriella Gaudioso, Mario Nosotti, Guido Coggi, Silvano Bosari and Stefano Ferrero
    Citation: BMC Pulmonary Medicine 2013 13:44
  26. Exhaled breath volatile organic compound (VOC) analysis for airway disease monitoring is promising. However, contrary to nitric oxide the method for exhaled breath collection has not yet been standardized and ...

    Authors: Andras Bikov, Koralia Paschalaki, Ron Logan-Sinclair, Ildiko Horváth, Sergei A Kharitonov, Peter J Barnes, Omar S Usmani and Paolo Paredi
    Citation: BMC Pulmonary Medicine 2013 13:43
  27. Serum levels of N–terminal proB–type natriuretic peptide (NT–proBNP) are elevated in patients acute respiratory distress syndrome (ARDS). Recent studies showed a lower incidence of acute cor pulmonale in ARDS ...

    Authors: Rogier M Determann, Annick ANM Royakkers, Jacqueline Schaefers, Anita M de Boer, Jan M Binnekade, Jan P van Straalen and Marcus J Schultz
    Citation: BMC Pulmonary Medicine 2013 13:42
  28. Chronic Obstructive Pulmonary Disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible and usually progressive. Current guidelines, among which the Dutch, have so far ...

    Authors: Janwillem Kocks, Corina de Jong, Marjolein Y Berger, Huib AM Kerstjens and Thys van der Molen
    Citation: BMC Pulmonary Medicine 2013 13:41
  29. There is insufficient evidence of the cost-effectiveness of Chronic Obstructive Pulmonary Disease (COPD) Disease Management (COPD-DM) programs. The aim of this review is to evaluate the economic impact of COPD...

    Authors: Melinde RS Boland, Apostolos Tsiachristas, Annemarije L Kruis, Niels H Chavannes and Maureen PMH Rutten-van Mölken
    Citation: BMC Pulmonary Medicine 2013 13:40
  30. A clear relationship between asthma and obesity has been reported, but the mechanisms remain unclear. The aim of this study was to evaluate the influence of obesity on eosinophil activity (chemotaxis and adhes...

    Authors: Milena Baptistella Grotta, Dalize M Squebola-Cola, Adyleia ADC Toro, Maria Angela GO Ribeiro, Silvia B Mazon, Jose D Ribeiro and Edson Antunes
    Citation: BMC Pulmonary Medicine 2013 13:39
  31. The majority of the global population cannot afford existing asthma pharmacotherapy. Physical training as an airway anti-inflammatory therapy for asthma could potentially be a non-invasive, easily available, a...

    Authors: Smita Pakhale, Vanessa Luks, Andrew Burkett and Lucy Turner
    Citation: BMC Pulmonary Medicine 2013 13:38
  32. The aim of this substudy of the ghrelin treatment, multicenter, randomized, double-blind, placebo-controlled trial was to investigate the effects of ghrelin administration on exercise capacity and the underlyi...

    Authors: Keisuke Miki, Ryoji Maekura, Noritoshi Nagaya, Seigo Kitada, Mari Miki, Kenji Yoshimura, Yoshitaka Tateishi, Masaharu Motone, Toru Hiraga, Masahide Mori and Kenji Kangawa
    Citation: BMC Pulmonary Medicine 2013 13:37
  33. The imbalance between proteases and antiproteases has been proposed to participate to the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. Gene level variation in different metallopr...

    Authors: Mari K Kukkonen, Emmi Tiili, Tapio Vehmas, Panu Oksa, Päivi Piirilä and Ari Hirvonen
    Citation: BMC Pulmonary Medicine 2013 13:36
  34. The GOLD 2011 document proposed a new classification system for COPD combining symptom assessment by COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores, and exacerbation risk...

    Authors: Sunmin Kim, Jisun Oh, Yu-Il Kim, Hee-Jung Ban, Yong-Soo Kwon, In-Jae Oh, Kyu-Sik Kim, Young-Chul Kim and Sung-Chul Lim
    Citation: BMC Pulmonary Medicine 2013 13:35
  35. Bronchiectasis is a progressive and fatal disease despite the available treatment regimens. Gastroesophageal reflux (GER) may play an important role in the progression of bronchiectasis. However, active anti-r...

    Authors: Zhi-Wei Hu, Zhong-Gao Wang, Yu Zhang, Ji-Min Wu, Jian-Jun Liu, Fang-Fang Lu, Guang-Chang Zhu and Wei-Tao Liang
    Citation: BMC Pulmonary Medicine 2013 13:34
  36. Gastro-esophageal reflux disease (GERD) predisposes to airway disease through a vagally-mediated esophago-bronchial reflex. This study investigates this vagal response to esophageal acid perfusion.

    Authors: D Lakmali Amarasiri, Arunasalam Pathmeswaran, H Janaka de Silva and Channa D Ranasinha
    Citation: BMC Pulmonary Medicine 2013 13:33
  37. The role of antibiotics in treating mild or moderate exacerbations in patients with acute chronic obstructive pulmonary disease (COPD) is unclear. The aims were to: (i) describe patient characteristics associa...

    Authors: Rachael Boggon, Richard Hubbard, Liam Smeeth, Martin Gulliford, Jackie Cassell, Susan Eaton, Munir Pirmohamed and Tjeerd-Pieter van Staa
    Citation: BMC Pulmonary Medicine 2013 13:32
  38. Combined pulmonary fibrosis and emphysema (CPFE) is an umbrella term encompassing upper lobe emphysema and lower lobe pulmonary fibrosis with pathogenesis elusive. The aim of our study was to investigate the i...

    Authors: Argyris Tzouvelekis, George Zacharis, Anastasia Oikonomou, Dimitrios Mikroulis, George Margaritopoulos, Anastasios Koutsopoulos, Antonis Antoniadis, Andreas Koulelidis, Paschalis Steiropoulos, Panagiotis Boglou, Matina Bakali, Marios Froudarakis and Demosthenes Bouros
    Citation: BMC Pulmonary Medicine 2013 13:31
  39. Immunocompromised patients, particularly after lung transplantation, are at high risk to develop atypical forms of pulmonary infections including influenza A/H1N1. Acute Fibrinous and Organizing Pneumonia (AFO...

    Authors: Claudia Otto, Daniela Huzly, Lars Kemna, Annegret Hüttel, Christoph Benk, Siegbert Rieg, Till Ploenes, Martin Werner and Gian Kayser
    Citation: BMC Pulmonary Medicine 2013 13:30
  40. Continuous positive airway pressure (CPAP) treatment improves the risk of cardiovascular events in patients suffering from severe sleep apnea-hypopnea syndrome (SAHS) but its effect on the link between delta p...

    Authors: Fabrice Jurysta, Chantal Kempenaers, Jean-Pol Lanquart, André Noseda, Philippe van de Borne and Paul Linkowski
    Citation: BMC Pulmonary Medicine 2013 13:29
  41. The current study aimed to investigate the release of myocardial high-sensitive Troponin T (hsTnT) in patients with pulmonary arterial hypertension (PAH) in response to maximal physical exercise.

    Authors: Mirko Völkers, David Rohde, Thomas Zelniker, Celine S Weiss, Evangelos Giannitsis, Hugo A Katus and F Joachim Meyer
    Citation: BMC Pulmonary Medicine 2013 13:28
  42. Laboratory-induced dyspnea (breathing discomfort) in healthy subjects is widely used to study perceptual mechanisms, yet the relationship between laboratory-induced dyspnea in healthy volunteers and spontaneou...

    Authors: Carl R O’Donnell, Richard M Schwartzstein, Robert W Lansing, Tegan Guilfoyle, Daniel Elkin and Robert B Banzett
    Citation: BMC Pulmonary Medicine 2013 13:27
  43. Indacaterol is a novel, once-daily (od), inhaled, long-acting ß2-agonist bronchodilator for maintenance treatment of airflow limitation in patients with COPD. The aim of this study was to evaluate the efficacy of...

    Authors: Jiangna Han, Lu Dai and Nanshan Zhong
    Citation: BMC Pulmonary Medicine 2013 13:26
  44. Recently it has been revealed that lung adenocarcinomas with distinct gene mutations or fusions are associated with particular histopathological entities. For example, epidermal growth factor receptor (EGFR) g...

    Authors: Ikuo Matsuda, Kengo Takeuchi, Shinjiro Mizuguchi, Masahide Kaji, Kayo Ueda, Kazuhiro Teramura and Seiichi Hirota
    Citation: BMC Pulmonary Medicine 2013 13:25
  45. There is little data on the effect of exercise on markers of airway inflammation in human asthmatics. The main objective of this review is to determine the effects of physical training on markers of airway inf...

    Authors: Vanessa Luks, Andrew Burkett, Lucy Turner and Smita Pakhale
    Citation: BMC Pulmonary Medicine 2013 13:24
  46. We earlier showed that 4-phenylbutyrate (PB) can induce cathelicidin LL-37 expression synergistically with 1,25-dihydroxyvitamin D3 in a lung epithelial cell line. We aimed to evaluate a therapeutic dose of PB al...

    Authors: Akhirunnesa Mily, Rokeya Sultana Rekha, S M Mostafa Kamal, Evana Akhtar, Protim Sarker, Zeaur Rahim, Gudmundur H Gudmundsson, Birgitta Agerberth and Rubhana Raqib
    Citation: BMC Pulmonary Medicine 2013 13:23
  47. The use of budesonide/formoterol in a single inhaler for both maintenance and reliever therapy is a recommended option for treatment of persistent asthma not responding well to inhaled corticosteroid (ICS) alone.

    Authors: Nanshan Zhong, Jiangtao Lin, Parthiv Mehta, Pintip Ngamjanyaporn, Tzu-Chin Wu and Faisal Yunus
    Citation: BMC Pulmonary Medicine 2013 13:22
  48. High-frequency airway clearance (HFCWC) assist devices generate either positive or negative trans-respiratory pressure excursions to produce high-frequency, small-volume oscillations in the airways.

    Authors: Antonello Nicolini, Federica Cardini, Norma Landucci, Sergio Lanata, Maura Ferrari-Bravo and Cornelius Barlascini
    Citation: BMC Pulmonary Medicine 2013 13:21

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