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  1. Pulmonary hypertension (PH) is a life-threatening disease with poor prognosis. Encouraging efforts have been made to target the main vasoproliferative aspects of the disease. Promising emerging therapeutics ar...

    Authors: Jan K Hennigs, Gunhild Keller, Hans Jörg Baumann, Friedemann Honecker, Stefan Kluge, Carsten Bokemeyer, Tim H Brümmendorf and Hans Klose
    Citation: BMC Pulmonary Medicine 2011 11:30
  2. The inhaled corticosteroid (ICS) fluticasone propionate (fluticasone) and the long-acting β2-agonist (LABA) formoterol fumarate (formoterol) are being made available as a combination product (fluticasone/formoter...

    Authors: Anna Bodzenta-Lukaszyk, Andrzej Dymek, Kirsten McAulay and Heikki Mansikka
    Citation: BMC Pulmonary Medicine 2011 11:28
  3. The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries. An explanation for these trends is that increa...

    Authors: Rafael V Veiga, Sergio S Cunha, Vitor CC Dattoli, Álvaro C Cruz, Phillip J Cooper, Laura C Rodrigues, Maurício L Barreto and Neuza M Alcantara-Neves
    Citation: BMC Pulmonary Medicine 2011 11:24
  4. KL-6 is a high-molecular-weight glycoprotein classified as a human MUC1 mucin. It was hypothesized that KL-6 could be detectable in the circulating blood and especially in airway secretions in lung diseases as...

    Authors: Nobuhisa Ishikawa, Witold Mazur, Tuula Toljamo, Katri Vuopala, Mikko Rönty, Yasushi Horimasu, Nobuoki Kohno and Vuokko L Kinnula
    Citation: BMC Pulmonary Medicine 2011 11:22
  5. To produce a conceptually equivalent Arabic version to the original Self-Administered Chronic Respiratory Disease Questionnaire with standardized dyspnea domain (CRQ-SAS) and to assess its reliability.

    Authors: Mohamed S Al Moamary and Hani M Tamim
    Citation: BMC Pulmonary Medicine 2011 11:21
  6. Patients with COPD have an increased risk of cardiovascular disease. Whilst pulmonary rehabilitation has proven benefit for exercise tolerance and quality of life, any effect on cardiovascular risk has not bee...

    Authors: Nichola S Gale, James M Duckers, Stephanie Enright, John R Cockcroft, Dennis J Shale and Charlotte E Bolton
    Citation: BMC Pulmonary Medicine 2011 11:20
  7. A significant number of young people start smoking at an age of 13-15, which means that serious smoking-evoked changes may have been occurred by their twenties. Surfactant proteins (SP) and matrix metalloprote...

    Authors: Helen Ilumets, Witold Mazur, Tuula Toljamo, Noora Louhelainen, Pentti Nieminen, Hideo Kobayashi, Nobuhisa Ishikawa and Vuokko L Kinnula
    Citation: BMC Pulmonary Medicine 2011 11:19
  8. The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known.

    Authors: Gary M Hunninghake, Jen-hwa Chu, Sunita S Sharma, Michael H Cho, Blanca E Himes, Angela J Rogers, Amy Murphy, Vincent J Carey and Benjamin A Raby
    Citation: BMC Pulmonary Medicine 2011 11:17
  9. The immune modulating properties of statins may benefit smokers with asthma. We tested the hypothesis that short-term treatment with atorvastatin improves lung function or indices of asthma control in smokers ...

    Authors: Georgina Braganza, Rekha Chaudhuri, Charles McSharry, Christopher J Weir, Iona Donnelly, Lisa Jolly, Jane Lafferty, Suzanne M Lloyd, Mark Spears, Frances Mair and Neil C Thomson
    Citation: BMC Pulmonary Medicine 2011 11:16
  10. Direct smear examination with Ziehl-Neelsen (ZN) staining for the diagnosis of pulmonary tuberculosis (PTB) is cheap and easy to use, but its low sensitivity is a major drawback, particularly in HIV seropositi...

    Authors: Luciene C Scherer, Rosa D Sperhacke, Carla Jarczewski, Patrícia I Cafrune, Candice T Michelon, Rubia Rupenthal, Marta Osorio Ribeiro, Antonio Ruffino Netto, Maria LR Rossetti and Afrânio L Kritski
    Citation: BMC Pulmonary Medicine 2011 11:15
  11. Interleukin-9 (IL-9)-targeted therapies may offer a novel approach for treating asthmatics. Two randomized placebo-controlled studies were conducted to assess the safety profile and potential efficacy of multi...

    Authors: Joseph M Parker, Chad K Oh, Craig LaForce, S David Miller, David S Pearlman, Chenxiong Le, Gabriel J Robbie, Wendy I White, Barbara White and Nestor A Molfino
    Citation: BMC Pulmonary Medicine 2011 11:14
  12. Chronic obstructive pulmonary disease (COPD) remains a major public health problem that affects the quality of life of patients, however smoking cessation may emeliorate the functional effects of COPD and alte...

    Authors: George Papadopoulos, Constantine I Vardavas, Maria Limperi, Apostolos Linardis, George Georgoudis and Panagiotis Behrakis
    Citation: BMC Pulmonary Medicine 2011 11:13
  13. Endotoxins are ubiquitously present in the environment and constitute a significant component of ambient air. These substances have been shown to modulate the allergic response, however a consensus has yet to ...

    Authors: Sudha Natarajan, Jiyoun Kim, Jacqueline Bouchard, William Cruikshank and Daniel G Remick
    Citation: BMC Pulmonary Medicine 2011 11:12
  14. In mechanically ventilated preterm infants with respiratory distress syndrome (RDS), exogenous surfactant application has been demonstrated both to decrease DNA-synthesis but also and paradoxically to increase...

    Authors: Andreas Wemhöner, Paul Jennings, Thomas Haller, Mario Rüdiger and Georg Simbruner
    Citation: BMC Pulmonary Medicine 2011 11:11
  15. Progressive airway inflammation and susceptibility to the airway colonisation and infection are characteristic for the pathophysiology of chronic obstructive pulmonary disease (COPD). Antimicrobial peptides (A...

    Authors: Ellen Andresen, Christoph Lange, Daniela Strodthoff, Torsten Goldmann, Nicole Fischer, Hany Sahly, Detlev Branscheid and Holger Heine
    Citation: BMC Pulmonary Medicine 2011 11:10
  16. Patients with COPD on long term oxygen therapy frequently do not adhere to their prescription, and they frequently do not use their ambulatory oxygen systems as intended. Reasons for this lack of adherence are...

    Authors: Elizabeth Arnold, Anne Bruton, Maggie Donovan-Hall, Angela Fenwick, Bridget Dibb and Elizabeth Walker
    Citation: BMC Pulmonary Medicine 2011 11:9
  17. Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of...

    Authors: Neil C Thomson, Adalberto S Rubin, Robert M Niven, Paul A Corris, Hans Christian Siersted, Ronald Olivenstein, Ian D Pavord, David McCormack, Michel Laviolette, Narinder S Shargill and Gerard Cox
    Citation: BMC Pulmonary Medicine 2011 11:8
  18. Therapeutic adherence of patients with chronic obstructive pulmonary disease (COPD) is poor. It is therefore necessary to determine the magnitude of non-adherence to develop strategies to correct this behaviou...

    Authors: Pilar Barnestein-Fonseca, José Leiva-Fernández, Francisca Vidal-España, Antonio García-Ruiz, Daniel Prados-Torres and Francisca Leiva-Fernández
    Citation: BMC Pulmonary Medicine 2011 11:6
  19. Adherence with tobramycin inhalation solution (TIS) during routine cystic fibrosis (CF) care may differ from recommended guidelines and affect health care utilization.

    Authors: Becky A Briesacher, Alexandra L Quittner, Lisa Saiman, Patricia Sacco, Hassan Fouayzi and Lynne M Quittell
    Citation: BMC Pulmonary Medicine 2011 11:5
  20. A key strategy in improving care for people with chronic obstructive pulmonary disease (COPD) is the provision of pulmonary rehabilitation programmes. Pulmonary rehabilitation programmes have been successful i...

    Authors: Kathy Murphy, Dympna Casey, Declan Devane, Adeline Cooney, Bernard McCarthy, Lorraine Mee, Martina Nichulain, Andrew W Murphy, John Newell and Eamon O' Shea
    Citation: BMC Pulmonary Medicine 2011 11:4
  21. Chemical irritation of airway mucosa elicits a variety of reflex responses such as coughing, apnea, and laryngeal closure. Inhaled irritants can activate either chemosensitive free nerve endings, laryngeal tas...

    Authors: Marco Tizzano, Mirko Cristofoletti, Andrea Sbarbati and Thomas E Finger
    Citation: BMC Pulmonary Medicine 2011 11:3
  22. Since the first outbreak of a respiratory illness caused by H1N1 virus in Mexico, several reports have described the need of intensive care or extracorporeal membrane oxygenation (ECMO) assistance in young and...

    Authors: Giovanni Cianchi, Manuela Bonizzoli, Andrea Pasquini, Massimo Bonacchi, Giovanni Zagli, Marco Ciapetti, Guido Sani, Stefano Batacchi, Simona Biondi, Pasquale Bernardo, Chiara Lazzeri, Valtere Giovannini, Alberta Azzi, Rosanna Abbate, Gianfranco Gensini and Adriano Peris
    Citation: BMC Pulmonary Medicine 2011 11:2
  23. Airway Bypass is a catheter-based, bronchoscopic procedure in which new passageways are created that bypass the collapsed airways, enabling trapped air to exit the lungs. The Exhale Airway Stents for Emphysema...

    Authors: Pallav L Shah, Dirk-Jan Slebos, Paulo FG Cardoso, Edward J Cetti, Gerhard W Sybrecht and Joel D Cooper
    Citation: BMC Pulmonary Medicine 2011 11:1
  24. Smoking is the major etiologic factor in COPD, yet the exact underlying pathogenetic mechanisms have not been elucidated. Since a few years, there is mounting evidence that a specific immune response, partly p...

    Authors: Corry-Anke Brandsma, Wim Timens, Marie Geerlings, Henrike Jekel, Dirkje S Postma, Machteld N Hylkema and Huib AM Kerstjens
    Citation: BMC Pulmonary Medicine 2010 10:64
  25. Breathlessness is a debilitating and distressing symptom in a wide variety of diseases and still a difficult symptom to manage. An integrative review of systematic reviews of non-pharmacological and pharmacolo...

    Authors: Chris D Bailey, Richard Wagland, Rasha Dabbour, Ann Caress, Jaclyn Smith and Alex Molassiotis
    Citation: BMC Pulmonary Medicine 2010 10:63
  26. Salamanca, Mexico occupied fourth place nationally in contaminating emissions. The aim of the study was to determine the impact of air pollution on the frequency of pulmonary function alterations and respirato...

    Authors: Benigno Linares, Juan M Guizar, Norma Amador, Alfonso Garcia, Victor Miranda, Jose R Perez and Rocío Chapela
    Citation: BMC Pulmonary Medicine 2010 10:62
  27. Smokers usually have a lower Body Mass Index (BMI) when compared to non-smokers. Such a relationship, however, has not been fully studied in obese and morbidly obese patients. The objective of this study was t...

    Authors: Raquel Chatkin, Claudio C Mottin and José M Chatkin
    Citation: BMC Pulmonary Medicine 2010 10:61
  28. Pulmonary function testing is a key procedure in the work-up of patients who are suspected of having asthma and chronic obstructive lung disease (COPD). Therein, clinical visits and pulmonary function tests (P...

    Authors: Frank J Visser, Milena JMM van der Vegt, Gert Jan van der Wilt and Julius P Janssen
    Citation: BMC Pulmonary Medicine 2010 10:60
  29. Monomers of the collectin surfactant associated protein-A (SP-A) are arranged in trimers and higher oligomers. The state of oligomerization differs between individuals and likely affects SP-A's functional prop...

    Authors: Stefanie M Heinrich and Matthias Griese
    Citation: BMC Pulmonary Medicine 2010 10:59
  30. Several studies have been published in the literature on the diagnostic accuracy of NT-pro-BNP for pleural effusions from heart failure in the last decade. The purpose of our study was to perform a systematic ...

    Authors: Surinder Janda and John Swiston
    Citation: BMC Pulmonary Medicine 2010 10:58
  31. Mechanical ventilation augments lung inflammation resulting from exposure to microbial products. The objective of this study was to test the hypothesis that ventilator-associated immune modulation requires MyD...

    Authors: Carrie D Chun, W Conrad Liles, Charles W Frevert, Robb W Glenny and William A Altemeier
    Citation: BMC Pulmonary Medicine 2010 10:57
  32. Pseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like" odour that has been iden...

    Authors: Amy J Scott-Thomas, Mona Syhre, Philip K Pattemore, Michael Epton, Richard Laing, John Pearson and Stephen T Chambers
    Citation: BMC Pulmonary Medicine 2010 10:56
  33. We examined the influence of overweight and obesity on pulmonary function, exercise tolerance, quality of life and response to pulmonary rehabilitation in COPD.

    Authors: Francesco Sava, Louis Laviolette, Sarah Bernard, Marie-Josée Breton, Jean Bourbeau and François Maltais
    Citation: BMC Pulmonary Medicine 2010 10:55
  34. Kikuchi-Fujimoto's disease (KFD), also called histiocytic necrotizing lymphadenitis, is a rare, idiopathic and self-limited condition usually characterized by cervical lymphadenopathy and fever, most often aff...

    Authors: Alberto Garcia-Zamalloa, Jorge Taboada-Gomez, Pilar Bernardo-Galán, Fernandez-Martinez Magdalena, Laura Zaldumbide-Dueñas and Mario Ugarte-Maiztegui
    Citation: BMC Pulmonary Medicine 2010 10:54
  35. Pulmonary surfactant D (SP-D) has important regulatory functions for innate immunity and has been implicated as a biomarker for chronic obstructive pulmonary disease (COPD). We hypothesized that COPD patients ...

    Authors: Jayaji M Moré, Dennis R Voelker, Lori J Silveira, Michael G Edwards, Edward D Chan and Russell P Bowler
    Citation: BMC Pulmonary Medicine 2010 10:53
  36. The ability to objectively differentiate exacerbations of chronic obstructive pulmonary disease (COPD) from day-to-day symptom variations would be an important development in clinical practice and research. We...

    Authors: John R Hurst, Gavin C Donaldson, Jennifer K Quint, James JP Goldring, Anant RC Patel and Jadwiga A Wedzicha
    Citation: BMC Pulmonary Medicine 2010 10:52
  37. A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is...

    Authors: Stylianos Bournazos, Jacob Grinfeld, Karen M Alexander, John T Murchison, William A Wallace, Pauline McFarlane, Nikhil Hirani, A John Simpson, Ian Dransfield and Simon P Hart
    Citation: BMC Pulmonary Medicine 2010 10:51
  38. International guidelines recommend long-acting bronchodilators in patients who remain symptomatic despite adequate treatment with short-acting bronchodilators. The purpose of this study is to estimate the effe...

    Authors: Ann Van den Bruel, Jeannine Gailly and Mattias Neyt
    Citation: BMC Pulmonary Medicine 2010 10:50
  39. Gastro-oesophageal reflux disease (GORD) symptoms are common in asthma and have been extensively studied, but less so in the Asian continent. Reflux-associated respiratory symptoms (RARS) have, in contrast, be...

    Authors: Lakmali D Amarasiri, Arunasalam Pathmeswaran, H Janaka de Silva and Channa D Ranasinha
    Citation: BMC Pulmonary Medicine 2010 10:49
  40. Tiotropium is reimbursed since March 2004 in Belgium for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Questions however remain on this product's value for money. The purpose of this study is ...

    Authors: Mattias Neyt, Stephan Devriese, Nancy Thiry and Ann Van den Bruel
    Citation: BMC Pulmonary Medicine 2010 10:47
  41. As more patients with cystic fibrosis (CF) reach adulthood and participate in age-appropriate activities (e.g. employment, dating), disclosure of medical status becomes more important. This study assessed rate...

    Authors: Avani C Modi, Alexandra L Quittner and Michael P Boyle
    Citation: BMC Pulmonary Medicine 2010 10:46
  42. Pneumonia, and particularly nosocomial (NP) and ventilator-associated pneumonias (VAP), results in high morbidity and costs. NPs in particular are likely to be caused by Pseudomonas aeruginosa (PA), ~20% of which...

    Authors: Marya D Zilberberg, Joyce Chen, Samir H Mody, Andrew M Ramsey and Andrew F Shorr
    Citation: BMC Pulmonary Medicine 2010 10:45
  43. Chlamydia pneumoniae (C pn) infection causes an acute inflammation in the respiratory system that may become persistent, but little is known about the long-term respiratory effects of C pn infections. Aim: To es...

    Authors: Thorarinn Gislason, Vilmundur Guðnason, Bryndis Benediktsdottir, Isleifur Olafsson, Thor Aspelund, Bjarni Thjodleifsson and Christer Janson
    Citation: BMC Pulmonary Medicine 2010 10:44
  44. Asthma in children is an emerging public health problem in South America. So far, research in this part of the world is limited. This paper presents the methodology and description of the data acquisition of a...

    Authors: Anja Boneberger, Katja Radon, Jennifer Baer, Leonie Kausel, Michael Kabesch, Daniel Haider, Rudolf Schierl, Rüdiger von Kries and Mario Calvo
    Citation: BMC Pulmonary Medicine 2010 10:43
  45. We assessed the relationship between physiologic parameters, computed tomography patterns, 6 minute walk distance (6MWD) and the distance-saturation product [DSP; defined as the product of the 6MWD and the low...

    Authors: Esam H Alhamad, Shaffi Ahmad Shaik, Majdy M Idrees, Mohammed O Alanezi and Arthur C Isnani
    Citation: BMC Pulmonary Medicine 2010 10:42
  46. Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies to alleviate symptoms. Learning to sing requ...

    Authors: Victoria M Lord, Phoene Cave, Victoria J Hume, Elizabeth J Flude, Amanda Evans, Julia L Kelly, Michael I Polkey and Nicholas S Hopkinson
    Citation: BMC Pulmonary Medicine 2010 10:41

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