Welty-Wolf KE, Carraway MS, Ortel TL, Piantadosi CA: Coagulation and inflammation in acute lung injury. Thromb Haemost. 2002, 88 (1): 17-25.
CAS
PubMed
Google Scholar
Wygrecka M, Jablonska E, Guenther A, Preissner KT, Markart P: Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases. Thromb Haemost. 2008, 99 (3): 494-501.
CAS
PubMed
Google Scholar
Chambers RC: Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?. Br J Pharmacol. 2008, 153 (Suppl 1): S367-S378.
CAS
PubMed
PubMed Central
Google Scholar
Idell S: Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med. 2003, 31 (4 Suppl): S213-S220.
Article
CAS
PubMed
Google Scholar
Martin DM, Boys CW, Ruf W: Tissue factor: molecular recognition and cofactor function. FASEB J. 1995, 9 (10): 852-859.
CAS
PubMed
Google Scholar
Camerer E, Kolsto AB, Prydz H: Cell biology of tissue factor, the principal initiator of blood coagulation. Thromb Res. 1996, 81 (1): 1-41. 10.1016/0049-3848(95)00209-X.
Article
CAS
PubMed
Google Scholar
Coughlin SR: Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost. 2005, 3 (8): 1800-1814. 10.1111/j.1538-7836.2005.01377.x.
Article
CAS
PubMed
Google Scholar
Riewald M, Ruf W: Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA. 2001, 98 (14): 7742-7747. 10.1073/pnas.141126698.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB: The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax. 2007, 62 (7): 608-616. 10.1136/thx.2006.063305.
Article
PubMed
PubMed Central
Google Scholar
Bastarache JA, Fremont RD, Kropski JA, Bossert FR, Ware LB: Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2009, 297 (6): L1035-L1041. 10.1152/ajplung.00214.2009.
Article
CAS
PubMed
PubMed Central
Google Scholar
Idell S, Koenig KB, Fair DS, Martin TR, McLarty J, Maunder RJ: Serial abnormalities of fibrin turnover in evolving adult respiratory distress syndrome. Am J Physiol. 1991, 261 (4 Pt 1): L240-L248.
CAS
PubMed
Google Scholar
Jiao JA, Kelly AB, Marzec UM, Nieves E, Acevedo J, Burkhardt M, Edwards A, Zhu XY, Chavaillaz PA, Wong A, Wong JL, Egan JO, Taylor D, Rhode PR, Wong HC: Inhibition of acute vascular thrombosis in chimpanzees by an anti-human tissue factor antibody targeting the factor × binding site. Thromb Haemost. 2010, 103 (1): 224-233.
Article
CAS
PubMed
Google Scholar
Welty-Wolf KE, Carraway MS, Ortel TL, Ghio AJ, Idell S, Egan J, Zhu X, Jiao JA, Wong HC, Piantadosi CA: Blockade of tissue factor-factor × binding attenuates sepsis-induced respiratory and renal failure. Am J Physiol Lung Cell Mol Physiol. 2006, 290 (1): L21-L31.
Article
CAS
PubMed
Google Scholar
Morrow DA, Murphy SA, McCabe CH, Mackman N, Wong HC, Antman EM: Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial. Eur Heart J. 2005, 26 (7): 682-688. 10.1093/eurheartj/ehi094.
Article
CAS
PubMed
Google Scholar
Vincent JL, Artigas A, Petersen LC, Meyer C: A multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial assessing safety and efficacy of active site inactivated recombinant factor VIIa in subjects with acute lung injury or acute respiratory distress syndrome. Crit Care Med. 2009, 37 (6): 1874-1880. 10.1097/CCM.0b013e31819fff2c.
Article
CAS
PubMed
Google Scholar
Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA: Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med. 2008, 178 (6): 618-623. 10.1164/rccm.200803-419OC.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schouten M, Wiersinga WJ, Levi M, van der Poll T: Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol. 2008, 83 (3): 536-545.
Article
CAS
PubMed
Google Scholar
Mackman N: The many faces of tissue factor. J Thromb Haemost. 2009, 7 (Suppl 1): 136-139.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lobo ED, Hansen RJ, Balthasar JP: Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci. 2004, 93 (11): 2645-2668. 10.1002/jps.20178.
Article
CAS
PubMed
Google Scholar
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001, 344 (10): 699-709. 10.1056/NEJM200103083441001.
Article
CAS
PubMed
Google Scholar
Warren BL, Eid A, Singer P, Pillay SS, Carl P, Novak I, Chalupa P, Atherstone A, Penzes I, Kubler A, Knaub S, Keinecke HO, Heinrichs H, Schindel F, Juers M, Bone RC, Opal SM: Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA. 2001, 286 (15): 1869-1878.
CAS
PubMed
Google Scholar
Abraham E, Reinhart K, Opal S, Demeyer I, Doig C, Rodriguez AL, Beale R, Svoboda P, Laterre PF, Simon S, Light B, Spapen H, Stone J, Seibert A, Peckelsen C, De Deyne C, Postier R, Pettila V, Artigas A, Percell SR, Shu V, Zwingelstein C, Tobias J, Poole L, Stolzenbach JC, Creasey AA: Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA. 2003, 290 (2): 238-247. 10.1001/jama.290.2.238.
Article
CAS
PubMed
Google Scholar
Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, Francois B, Guy JS, Bruckmann M, Rea-Neto A, Rossaint R, Perrotin D, Sablotzki A, Arkins N, Utterback BG, Macias WL: Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med. 2005, 353 (13): 1332-1341. 10.1056/NEJMoa050935.
Article
CAS
PubMed
Google Scholar
Nadel S, Goldstein B, Williams MD, Dalton H, Peters M, Macias WL, Abd-Allah SA, Levy H, Angle R, Wang D, Sundin DP, Giroir B: Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet. 2007, 369 (9564): 836-843. 10.1016/S0140-6736(07)60411-5.
Article
CAS
PubMed
Google Scholar
White B, Schmidt M, Murphy C, Livingstone W, O'Toole D, Lawler M, O'Neill L, Kelleher D, Schwarz HP, Smith OP: Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line. Br J Haematol. 2000, 110 (1): 130-134. 10.1046/j.1365-2141.2000.02128.x.
Article
CAS
PubMed
Google Scholar
Hancock WW, Grey ST, Hau L, Akalin E, Orthner C, Sayegh MH, Salem HH: Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses. Transplantation. 1995, 60 (12): 1525-1532. 10.1097/00007890-199560120-00026.
Article
CAS
PubMed
Google Scholar
Feistritzer C, Sturn DH, Kaneider NC, Djanani A, Wiedermann CJ: Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C. J Allergy Clin Immunol. 2003, 112 (2): 375-381. 10.1067/mai.2003.1609.
Article
CAS
PubMed
Google Scholar
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W: Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 2002, 296 (5574): 1880-1882. 10.1126/science.1071699.
Article
CAS
PubMed
Google Scholar
Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV: Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003, 9 (3): 338-342. 10.1038/nm826.
Article
CAS
PubMed
Google Scholar
Mosnier LO, Zlokovic BV, Griffin JH: The cytoprotective protein C pathway. Blood. 2007, 109 (8): 3161-3172. 10.1182/blood-2006-09-003004.
Article
CAS
PubMed
Google Scholar
Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR: Roles of protease-activated receptors in a mouse model of endotoxemia. Blood. 2006, 107 (10): 3912-3921. 10.1182/blood-2005-08-3130.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ramachandran R, Hollenberg MD: Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol. 2008, 153 (S1): S263-S282.
Article
CAS
PubMed
Google Scholar
Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA: Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005, 175 (4): 2598-2605.
Article
CAS
PubMed
Google Scholar
Scotton CJ, Krupiczojc MA, Konigshoff M, Mercer PF, Lee YC, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC: Increased local expression of coagulation factor × contributes to the fibrotic response in human and murine lung injury. J Clin Invest. 2009, 119 (9): 2550-2563.
CAS
PubMed
PubMed Central
Google Scholar
Howell DC, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC: Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol. 2005, 166 (5): 1353-1365. 10.1016/S0002-9440(10)62354-1.
Article
CAS
PubMed
PubMed Central
Google Scholar