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Development, effectiveness and cost-effectiveness of a new out-patient Breathlessness Support Service: study protocol of a phase III fast-track randomised controlled trial
© Bausewein et al.; licensee BioMed Central Ltd. 2012
Received: 3 July 2012
Accepted: 12 September 2012
Published: 19 September 2012
Breathlessness is a common and distressing symptom affecting many patients with advanced disease both from malignant and non-malignant origin. A combination of pharmacological and non-pharmacological measures is necessary to treat this symptom successfully. Breathlessness services in various compositions aim to provide comprehensive care for patients and their carers by a multiprofessional team but their effectiveness and cost-effectiveness have not yet been proven. The Breathlessness Support Service (BSS) is a newly created multiprofessional and interdisciplinary outpatient service at a large university hospital in South East London. The aim of this study is to develop and evaluate the effectiveness and cost effectiveness of this multidisciplinary out–patient BSS for the palliation of breathlessness, in advanced malignant and non-malignant disease.
The BSS was modelled based on the results of qualitative and quantitative studies, and systematic literature reviews. A randomised controlled fast track trial (RCT) comprising two groups: 1) intervention (immediate access to BSS in addition to standard care); 2) control group (standard best practice and access to BSS after a waiting time of six weeks). Patients are included if suffering from breathlessness on exertion or at rest due to advanced disease such as cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), interstitial lung disease (ILD) or motor neurone disease (MND) that is refractory to maximal optimised medical management. Both quantitative and qualitative outcomes are assessed in face to-face interviews at baseline, after 6 and 12 weeks. The primary outcome is patients' improvement of mastery of breathlessness after six weeks assessed on the Chronic Respiratory Disease Questionnaire (CRQ). Secondary outcomes for patients include breathlessness severity, symptom burden, palliative care needs, service use, and respiratory measures (spirometry). For analyses, the primary outcome, mastery of breathlessness after six weeks, will be analysed using ANCOVA. Selection of covariates will depend on baseline differences between the groups. Analyses of secondary outcomes will include patients’ symptom burden other than breathlessness, physiological measures (lung function, six minute walk distance), and caregiver burden.
Breathlessness services aim to meet the needs of patients suffering from this complex and burdensome symptom and their carers. The newly created BSS is different to other current services as it is run in close collaboration of palliative medicine and respiratory medicine to optimise medical care of patients. It also involves professionals from various medical, nursing, physiotherapy, occupational therapy and social work background.
Breathlessness is a common, distressing symptom in advanced malignant and non-malignant disease, causing considerable disability for patients, and anxiety and social isolation for family and carers [1–3]. Breathlessness is particularly prevalent and difficult to manage in the late terminal stages of disease. Studies have shown that 94% of patients with chronic lung disease , 78% of those with lung cancer  and more than 50% of patients with heart disease  suffer from breathlessness in the last year of life. Most studies examining the progression of breathlessness in cancer over time show increased severity of breathlessness towards death [7, 8]. The US SUPPORT study reported that around 70% of COPD patients experienced moderate to severe breathlessness in the last six months of life, increasing to more than 80% over the final 3 days . As a result, breathlessness in end-stage disease is responsible for significant healthcare resource usage with up to 60% hospital admission rates in patients presenting with breathlessness to a cancer treatment centre .
Once treatment aimed at slowing progression of the underlying disease has been optimised, palliation of breathlessness usually involves a combination of pharmacological (opioids, benzodiazepines, oxygen therapy) and non-pharmacological (rollator devices, fan therapy, breathing control) strategies but one single intervention will probably not help sufficiently with breathlessness . Multidisciplinary rehabilitation programmes, incorporating exercise training and education, have been shown to reduce breathlessness and improve exercise capacity in COPD , heart failure , and cancer . However, patients with advanced disease are often too ill to attend pulmonary rehabilitation programmes. In the 1990s, Corner et al developed and tested a nursing clinic for lung cancer patients offering breathing control, activity pacing, relaxation techniques, and psychosocial support [14, 15]. In a multi-centre RCT, the intervention group had significantly less breathlessness, better performance status, and lower levels of depression compared to best usual care . Based on these experiences, Booth et al developed a multiprofessional Breathlessness Intervention Service (BIS) [16, 17] which is currently under evaluation following the MRC framework for complex interventions . The BIS is offering specialist advice to manage breathlessness in patients with disease of any aetiology. The accessibility of breathlessness services is, however, not uniform across the NHS. Difficulties with provision result, in part, from a lack of evidence as to the most effective, and cost-effective, organisational strategies.
We therefore designed a study to develop and evaluate a new multiprofessional and interdisciplinary Breathlessness Support Service (BSS) in Southeast London for people suffering from breathlessness due to advanced disease and their families/carers. We present the protocol of the intervention and the trial to ensure independence of the results and to stimulate criticism and suggestions from the journal readers.
Aims and objectives
The aim of this study is to develop and evaluate the effectiveness and cost effectiveness of a multidisciplinary out–patient Breathlessness Support Service (BSS) for the palliation of breathlessness, in advanced malignant and non-malignant disease at King’s College Hospital London.
To assess the effect of the BSS on patients’ mastery of breathlessness and other breathlessness measures.
To assess the effect of the BSS on physiological outcome measures.
To assess the effect of the BSS on caregiver burden.
To compare NHS resource usage and costs in the two study arms.
To explore patients’ experiences using the BSS.
Modelling and development of BSS
The BSS was designed following the Medical Research Council (MRC) Guidance for the development and evaluation of complex interventions [18, 19]. This approach has been used to develop and evaluate a range of services and interventions in palliative care [16, 20]. This phase III study builds on already completed pre-clinical/ theoretical (0), modelling (I) and exploratory (II) phases which are described below.
Phase 0: preclinical/ theoretical phase
The theoretical basis of the BSS was established by reviewing published literature on the impact of breathlessness on healthcare usage in palliative care, and evaluations of breathlessness services that are already in place. The magnitude of the reduction in healthcare resource usage by existing breathlessness advisory services [21, 22] and corroborative evidence from related rehabilitative and educational programmes [12, 13] was also sought. Evidence for the efficacy of pharmacological and non-pharmacological palliation of breathlessness was reviewed [13, 23–25]. This allowed specification of the active ingredients of the intervention, in terms of both the personnel mix and management strategies that would be offered in the service.
Phase I: modelling
We conducted qualitative interviews with over 80 patients with COPD, motor neuron disease, and cancer, and their families and caregivers both in the clinical setting (rehabilitation classes, out-patient clinics)[26–29], and informally in patient groups such as the British Lung Foundation Breathe Easy groups. Patients’, carers’ and healthcare professionals’ views on factors precipitating emergency health resource use, such as Accident and Emergency visits were also sought. The issues raised have focussed our intervention and include: need to provide educational and training material, need to have a multi-professional approach, need to include an optional home visit assessment, the need to have a plan of how to deal with crises and need to include support for caregivers. These patient interviews have helped to define our target group, to better understand the relationships between the proposed components of the breathlessness service, and the potential for improved cost-effectiveness of the service compared to best usual medical care. In addition, we have consulted widely within the King’s College Hospital Trust.
The BSS is provided as an outpatient clinic based in the Cicely Saunders Institute at King’s College Hospital in Southeast London. The hospital serves an estimated population of 3.5 million people, and has approximately 1400 hospital admissions for breathlessness (=3700 bed days) per year. The area has a network of palliative care services including hospices, community services and hospital support teams, co-ordinated through the South London Palliative Care Network and other regionally based networks.
Study design of phase III RCT
A randomised controlled fast track trial (RCT) comprising two groups: 1) intervention (immediate access to BSS in addition to standard care); 2) control group (standard best practice and access to BSS after a waiting time of six weeks). Consenting participants are randomly allocated to one of the groups after baseline assessment. The fast track design gives all patients the opportunity to access the service. Patients will continue to have the same access to specialist medical and palliative care services as was available to them prior to entry into the trial. This approach is based on a similar study design developed by Higginson et al, to evaluate the effectiveness of a new palliative care and neurology service for patients severely affected by Multiple Sclerosis .
Patients suffering from breathlessness on exertion or at rest due to advanced disease such as cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), interstitial lung disease (ILD) or motor neurone disease (MND). The underlying disease should be optimally medically managed. Patients must be able to engage with short term physiotherapy. If patients are suffering from acute exacerbations, they are put on a waiting list for two weeks and are then entered into the trial.
Patients with breathlessness of unknown cause, and patients with a primary diagnosis of chronic hyperventilation syndrome are excluded from study participation. Patients are also excluded if they are too ill to come to the clinic, and are unable to provide informed consent either due to cognitive problems or to the severity of their illness.
The BSS is a multi-professional and interdisciplinary service provided by two doctors, a clinical nurse specialist for lung cancer, a respiratory physiotherapist, an occupational therapist, and a social worker. Doctors come from a palliative medicine and a respiratory medicine background.
Details of Breathlessness Support Service
Type of contact with clinic
Content of meeting
First outpatient clinic visit
Contact with respiratory medicine
· explore the symptom of breathlessness and its triggers
· establish underlying cause of breathlessness
· optimise disease-orientated management
· review of previous investigations
Contact with palliative medicine
· experience of breathlessness
· development of crises plan
· burden on patient & family
· symptom burden (other than breathlessness)
· psychosocial & spiritual issues
· introduction of non-pharmacological measures such as rollator and hand-held fan
Week 2 – 3 Week 2 - 3
Home visit Telephone call
Based on the patients’ needs as assessed during home visit:
· review of the positions of breathlessness
· provision of a walking aid
· breathing control techniques and anxiety-panic cycle
· management of exacerbations in COPD
· home programme of exercise (DVD, personalised sheet)
· cough minimisation techniques
· pacing and fatigue management
· sputum clearance techniques
· ambulatory oxygen assessments
· referral to pulmonary rehabilitation
Occupational therapy input
· assessment of ADL (mobility / transfers, self care and domestic ADL)
· assessment for aids and minor adoptions and referral for provision of equipment
· wheelchair prescription
· education on planning, pacing and energy conservation techniques to patients and carers
· referral to other community services (local / out of area), as appropriate
· assessment of need for social support and liaison with the BSS social worker, as appropriate
· liaison with the BSS team regarding interventions and feedback
Social worker input
patient and or carer assessment including understanding of disease and symptoms & information needs and coping strategies
Week 4 - 5
second clinic visit
Contact with palliative medicine
· re-evaluation of breathlessness and other symptoms
· checking of interventions
· referral to medical and/or palliative care services if appropriate
· discharge from service
At the first meeting, patients receive an information pack with five fact sheets on breathlessness, a breathlessness mantra, a relaxation CD, a hand-held fan, and information about cooling the face, e.g. with a small spray bottle spraying fine mist. The fact sheets were developed by Sara Booth et al in Addenbrooke’s Hospital, Cambridge (http://www.cuh.org.uk/addenbrookes/services/clinical/breathlessness_intervention_service/patient_information_leaflets.html), containing information on breathlessness: information and commonly asked questions; managing breathlessness; handheld fan; positions to ease breathlessness; a distraction technique: using the five senses. If necessary, patients are also provided with information more tailored to their specific needs.
The patients receive a letter after the clinic visits with copies to the GPs and the referrers summarizing what has been discussed and recommended.
After the first appointment in the clinic and initial screening of patients’ needs, the physiotherapist (PT) in liaison with the occupational therapist (OT) provides support within three weeks of patient’s first attendance at the clinic. After arranging a suitable time by telephone either PT or OT visits the patients at home or a joint home visit is considered, as necessary. OT and PT aim to facilitate independence, safety and quality in daily activities, using a client centred approach. The visits aim to identify and modify domestic factors that may be negatively impacting on breathlessness and create an individualised functional programme. The therapists also refer to other rehabilitation if appropriate.
Following their initial clinic visit each patient and/or carer will be contacted via telephone by the BSS social worker and assessed to see whether subsequent social work involvement is indicated or referral to other supportive services are required.
Patients randomised to the control group continue with optimal medical management as prescribed by their healthcare provider with the same access to generalist (GP, district nurse) and specialist medical (respiratory, cardiology, neurology) and palliative care services (community, hospital, hospice) as was available to them prior to entry into the trial. After the final assessment (6-7 weeks), patients will be entered into the intervention arm of the study (the BSS).
Participants are recruited to the study by referral from respiratory medicine, pulmonary rehabilitation, cardiology, palliative care services, community services, and GPs. The referring clinicians gain permission from patients for their details to be passed to the study team. The clinical research fellow (CRF), using a standard protocol, screens referrals and sends a letter giving information about the trial of the new service and an invitation to participate, before telephoning patients several days after receipt of the letter to agree consent. The CRF then arranges an appointment for the baseline assessment with the patient and, ideally, the carer. This first appointment takes place in the patient’s home. At this appointment, written informed consent for participation in the study is obtained from participants.
Randomisation and blinding
Allocation to the intervention group (IG) or control group is performed by the Clinical Trials Unit at King’s College London, following the baseline interview, independently of the research and clinical team. As the group under study is heterogeneous with regard to some key variables, minimisation was chosen as a method for allocation in order to minimise the imbalance between the treatment groups with respect to baseline characteristics . Factors considered are cancer versus non-cancer, breathlessness severity (NRS >3), presence of an informal caregiver and ethnicity (white versus other). The BSS clinical administrator is informed about the allocation via e-mail and sends appointment letters to patients and arranges subsequent clinic appointments. This allows the CRF and the research nurses to be blind to which study arm patients have been assigned. Patients are asked not to tell the CRF and research nurses to which arm they were allocated.
Timing of data collection
Subsequently, patients complete a second telephone questionnaire as previously described between week nine and ten of the study (t4). Finally baseline measures are repeated between week 12 and 13 in all patients (t5), these data will be used for analysis of secondary outcomes.
Measures for each time point
4 weeks (telephone)
8 weeks (telephone)
Chronic Respiratory Disease Questionnaire (CRQ)
Palliative Care Outcome Scale (POS)
POS Symptom Scale (POS-S)
London Chest Activity of Daily Living Scale (LCADL)
Hospital Anxiety and Depression Scale (HADS)
Zarit Burden Inventory
Client Service Receipt Inventory (CSRI)
Both quantitative and qualitative outcomes are assessed. Baseline data includes age, sex, clinical diagnosis, height, weight and smoking history. Data are collected from participants by face-to-face interviews at two time-points and telephone interviews.
Primary outcome measure
The primary outcome is improvement of mastery of breathlessness after 6 weeks, as assessed by a change in the score in the Mastery domain of the Chronic Respiratory Disease Questionnaire (CRQ) . Questions within this domain relate to breathlessness. The CRQ is a multidimensional tool, and is one of the most widely used measures of quality of life (QOL) in chronic respiratory disease. The CRQ is an interview administered questionnaire, but a self-administered version maintains validity and responsiveness .
Secondary outcome measure
A Numerical Rating Scale (NRS)  is used as secondary outcome measure to assess the intensity of the sensation of breathlessness on average, at worst, at rest and on exertion over the last 24 hours. The NRS correlates highly with the visual analogue dyspnoea scale , and has the advantage of being able to be used during the telephone assessments. In addition, we included the Dyspnoea 12, a newly validated measure which provides a global score of breathlessness severity that incorporates both “physical” and “affective” aspects, and can measure dyspnoea in a variety of diseases .
The Palliative care Outcome Scale (POS) and POS-symptoms are used to assess and quantify palliative care symptoms in addition to breathlessness . The London Chest Activity of Daily Living Scale (LCADL) is used to assess the impact of the service on activities of daily living. The LCADL has been used as an outcome measure in COPD, and has been shown to be valid, reliable and responsive to change . The Hospital Anxiety and Depression Score is used to screen patients for anxiety and depression , and the EQ-5D  is used as a generic health-related QOL measure. EQ-5D is a standardised instrument for use as a measure of health outcome and is especially suited to cost-effectiveness analyses as it can be used to generate quality-adjusted life years (QALYs). It is applicable to a wide range of health conditions and treatments, and provides a simple descriptive profile and a single index value for health status. Carer burden is assessed using the Zarit Burden Inventory .
Contacts with the BSS are recorded centrally. The Client Service Receipt Inventory (CSRI) is used to record other service use in the three-month period prior to baseline assessment and then for each follow-up period. The CSRI has been used in over 200 studies to assess costs and takes approximately 20 minutes to complete. Services included will be health care (primary and secondary), medication, social care and informal care from family/friends. The CSRI has not previously been used specifically in a breathless population, therefore we adapted the CSRI for this study. Lost work time for patients and carers will be recorded.
These include spirometry (forced expiratory volume in 1s [FEV1, slow vital capacity [VC], peak expiratory flow rate [PEF]), performed in accordance with the American Thoracic Society guidelines . The highest value for FEV1, VC and PEF from three reproducible efforts will be recorded and compared to predicted normal values . Pulse oximetry is measured at rest and during the six minute walk test  in all participants.
When attending the clinic, patients are asked to perform a six minute walk test as a field test of exercise capacity. The distance walked (6 minute walk distance, [6MWD]) has demonstrated strong correlation with peak rate of oxygen uptake, maximum work rate  and prognosis in patients with lung cancer  and chronic respiratory disease .
Patients experience with the BSS
Sampling frame for qualitative interviews
Non-cancer (COPD/ CHF/ILD etc.)
Severity of breathlessness
NRS < 3
4 – 6
4 – 6
NRS ≥ 3
4 – 6
4 – 6
4 – 6
4 – 6
4 – 6
4 – 6
< 50 years
2 – 3
2 – 3
50 – 65 years
2 – 3
2 – 3
≥ 65 years
2 – 3
2 – 3
living with caregiver
4 – 6
4 – 6
4 – 6
4 – 6
4 – 6
4 – 6
4 – 6
4 – 6
Sample size calculation
There are limited data to provide estimates for a sample size calculation and this study will inform calculations for the future. Based on the primary outcome, the mastery domain on the CRQ to detect a mean difference of 0.70 on this 7 point scale with a standard deviation of 1 , and at 5% significance level, power of 80% we would require at least 33 patients in each group. Due to the advanced stage of illness in the patients we estimate an attrition rate of 40% which means that we would aim to recruit at least 110 patients, which over 12 months, would be 9-10 patients per month. With over 1,000 admissions for breathlessness per year, this should be achieved.
First, we aim to understand missing data in the study and proportions and reasons for drop out. Second, we will compare baseline data between the intervention and the control group using parametric and non-parametric tests as appropriate. Third, the primary outcome, mastery of breathlessness after six weeks, will be analysed using a t-test if there are no differences between groups or ANCOVA with selection of co-variates depending on baseline differences between the groups. Analyses of secondary outcomes will include patients’ symptom burden other than breathlessness, physiological measures, and caregiver burden.
Dealing with missing data will include various imputation methods. The alpha level for all statistical analyses will be set at two-sided 0.05. All analyses will be performed using SPSS software.
Qualitative interviews will be tape-recorded, transcribed verbatim and analysed using content analysis. NVivo is used to facilitate qualitative analyses.
The service use data recorded with the CSRI will be combined with appropriate unit cost information (for example the annual compendium produced by the Personal Social Services Research Unit at the University of Kent). The costs of the BSS itself will be estimated using local accounting data and information on activity rates. Informal care costs will be estimated using the unit cost of a homecare worker. Lost employment will be costed using average wage rates. Cost data are generally skewed and therefore to make comparisons between the groups bootstrapping methods will be used. Cost-effectiveness will be assessed by combining the data on costs with the data on the mastery domain of the CRQ. Cost-utility estimates will be made using QALYs generated from the EQ-5D. If costs are higher and outcomes better for the BSS then incremental cost-effectiveness ratios will be generated which will indicate the extra cost incurred to achieve an extra unit of outcome. Uncertainty around cost-effectiveness and cost-utility estimates will be explored by resampling from the dataset using bootstrapping, calculating cost and outcome differences for each resample and plotting these on cost-effectiveness planes. Cost-effectiveness acceptability curves will be used to show the probability that the BSS is more cost-effective than usual care for a range of values placed on a unit improvement in outcome.
Project advisory group
A multidisciplinary project advisory group (PAG) has been established for the duration of the study. The PAG includes clinicians and researchers, and others working with breathless patients. The specialities of respiratory medicine and palliative medicine are represented on the PAG, as are local services that linked with the new breathlessness support service. A patient and carer representative are also PAG members. The PAG meets regularly and also make contact by e-mail and telephone with the project team.
Ethics approval for the study was gained from the King’s College Hospital ethics committee (Ref. 10/H0808/17). The study meets the requirements of the local Research Governance Framework. The study protocol is registered with ClinicalTrials.gov (NCT01165034).
The complexity of breathlessness, the needs of patients with advanced disease living with this distressing symptom, and the burden of their carers demand a combination of various pharmacological and non-pharmacological interventions. To provide these, various types of breathlessness services have been developed over the last years but their effectiveness and especially cost-effectiveness remains to be shown.
The BSS introduced here was developed following the MRC framework for complex interventions. Building on previous own research [13, 26–28, 47] and experiences from colleagues in Cambridge [16, 17, 48] we modelled our service to fit the needs of an ethnically diverse population in South East London. Although there are some similarities to the BIS in Cambridge such as multi-professional support, service for cancer and non-cancer patients, and short-term intervention with consecutive discharge of patients, there are also some pronounced differences. We recognised the need to introduce respiratory expertise in such a service and therefore run, for the first time, an interdisciplinary breathlessness service with colleagues from palliative medicine and respiratory medicine. This allows us to provide special expertise to optimise treatment of the underlying disease but also to include physiological measures in the assessment of patients and the evaluation of the service such as lung function and exercise capacity to better describe the sample and to understand the potential effects of the interventions provided. The composition of professionals being involved in the service has been extended in comparison to other services and includes the expertise of a nurse, an occupational therapist and a social worker. In contrast to the Cambridge Service with provision of the BIS mainly in patients’ homes  is the predominant provision of the BSS as an outpatient clinic with one home visit by the physiotherapist or the occupational therapist between two clinic visits.
This study is funded by an NIHR-grant from Research for Patient Benefit (PB-PG-0808-17311). This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG- PB-PG-0808-17311). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. We thank members of the Project Advisory Group for their invaluable input (Dr Jack Barker, Dr Patrick White, Jenny Taylor, Tracey Mathieson, Gao Wei, Tracey Fleming, Laura Stuart, Christine Burchill, Graham Martin, Sarah Bellas, Dr Barry Gray, Dr Rachael Garrod, Dr Sarah Booth).
- National Institute for Clinical Excellence (NICE): Lung cancer. The diagnosis and treatment of lung cancer. National Collaborating Centre for Acute Care. 2005, http://guidance.nice.org.uk/CG121,Google Scholar
- Katsura H, Kanemaru A, Yamada K, Motegi T, Wakabayashi R, Kida K: Long-term effectiveness of an inpatient pulmonary rehabilitation program for elderly COPD patients: Comparison between young-elderly and old-elderly groups. Respirology. 2004, 9: 230-236. 10.1111/j.1440-1843.2004.00561.x.View ArticlePubMedGoogle Scholar
- Rennard S, Decramer M, Calverley PM, Pride NB, Soriano JB, Vermeire PA, Vestbo J: Impact of COPD in North America and Europe in 2000: subjects' perspective of Confronting COPD International Survey. Eur Respir J. 2002, 20 (4): 799-805. 10.1183/09031936.02.03242002.View ArticlePubMedGoogle Scholar
- Lynn J, Ely EW, Zhong Z, McNiff KL, Dawson NV, Connors A, Desbiens NA, Claessens M, McCarthy EP: Living and dying with chronic obstructive pulmonary disease. J Am Geriatr Soc. 2000, 48 (5 Suppl): S91-100.View ArticlePubMedGoogle Scholar
- Edmonds P, Karlsen S, Khan S, Addington-Hall J: A comparison of the palliative care needs of patients dying from chronic respiratory diseases and lung cancer. Palliat Med. 2001, 15 (4): 287-295. 10.1191/026921601678320278.View ArticlePubMedGoogle Scholar
- Austin J, Williams R, Ross L, Moseley L, Hutchison S: Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure. Eur J Heart Fail. 2005, 7 (3): 411-417. 10.1016/j.ejheart.2004.10.004.View ArticlePubMedGoogle Scholar
- Seow H, Barbera L, Sutradhar R, Howell D, Dudgeon D, Atzema C, Liu Y, Husain A, Sussman J, Earle C: Trajectory of performance status and symptom scores for patients with cancer during the last six months of life. J Clin Oncol. 2011, 29 (9): 1151-1158. 10.1200/JCO.2010.30.7173.View ArticlePubMedGoogle Scholar
- Reuben DB, Mor V: Dyspnea in terminally ill cancer patients. Chest. 1986, 89 (2): 234-236. 10.1378/chest.89.2.234.View ArticlePubMedGoogle Scholar
- Escalante CP, Martin CG, Elting LS, Cantor SB, Harle TS, Price KJ, Kish SK, Manzullo EF, Rubenstein EB: Dyspnea in cancer patients: Etiology, resource utilization, and survival-Implications in a managed care world. Cancer. 1996, 78 (6): 1314-1319. 10.1002/(SICI)1097-0142(19960915)78:6<1314::AID-CNCR21>3.0.CO;2-2.View ArticlePubMedGoogle Scholar
- Higginson IJ: Refractory breathlessness: oxygen or room air?. Lancet. 2010, 376 (9743): 746-748. 10.1016/S0140-6736(10)61346-3.View ArticlePubMedGoogle Scholar
- D-C Man W, Polkey MI, Donaldson N, Gray BJ, Moxham J: Community pulmonary rehabilitation after hospitalisation for acute exacerbations of chronic obstructive pulmonary disease: randomised controlled study. BMJ. 2004, 329 (7476): 1209-10.1136/bmj.38258.662720.3A.View ArticleGoogle Scholar
- Coats AJS, Adamopoulos S, Meyer TE, Conway J, Sleight P: Effects of physical training in chronic heart failure. Lancet. 1990, 335 (8681): 63-66. 10.1016/0140-6736(90)90536-E.View ArticlePubMedGoogle Scholar
- Bausewein C, Booth S, Gysels M, Higginson Irene J: Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases. Cochrane Database of Systematic Reviews. 2008, 2: CD005623-PubMedGoogle Scholar
- Bredin M: Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer. BMJ. 1999, 318: 901-904. 10.1136/bmj.318.7188.901.View ArticlePubMedPubMed CentralGoogle Scholar
- Corner J, Plant H, A'Hern R, Bailey C: Non-pharmacological intervention for breathlessness in lung cancer. Pall Med. 1996, 10 (4): 299-305. 10.1177/026921639601000405.View ArticleGoogle Scholar
- Booth S: The impact of a breathlessness intervention service (BIS) on the lives of patients with intractable dyspnoea: a qualitative phase 1 study. Palliat Support Care. 2006, 4: 287-293.View ArticlePubMedGoogle Scholar
- Farquhar M, Higginson I, Fagan P, Booth S: The feasibility of a single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease. BMC Palliative Care. 2009, 8 (1): 9-10.1186/1472-684X-8-9.View ArticlePubMedPubMed CentralGoogle Scholar
- Campbell M, Fitzpatrick R, Haines A, Kinmonth AL, Sandercock P, Spiegelhalter D, Tyrer P: Framework for design and evaluation of complex interventions to improve health. BMJ. 2000, 321 (7262): 694-696. 10.1136/bmj.321.7262.694.View ArticlePubMedPubMed CentralGoogle Scholar
- Medical Research Council: Medical Research Council. MRC framework for development and evaluation of RCTs for complex interventions to improve health. 2000, LondonGoogle Scholar
- Higginson I, Vivat B, Silber E, Saleem T, Burman R, Hart S, Edmonds P: Study protocol: delayed intervention randomised controlled trial within the Medical Research Council (MRC) Framework to assess the effectiveness of a new palliative care service. BMC Palliat Care. 2006, 5 (1): 7-10.1186/1472-684X-5-7.View ArticlePubMedPubMed CentralGoogle Scholar
- Moore S, Corner J, Haviland J, Wells M, Salmon E, Normand C, Brada M, Smith I: Nurse led follow up and conventional medical follow up in management of patients with lung cancer: randomised trial. BMJ. 2002, 325 (7373): 1145-10.1136/bmj.325.7373.1145.View ArticlePubMedPubMed CentralGoogle Scholar
- Rabow MW, Dibble SL, Pantilat SZ, McPhee SJ: The Comprehensive Care Team: A Controlled Trial of Outpatient Palliative Medicine Consultation. Arch Intern Med. 2004, 164 (1): 83-91. 10.1001/archinte.164.1.83.View ArticlePubMedGoogle Scholar
- Abernethy AP, Currow DC, Frith P, Fazekas BS, McHugh A, Bui C: Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ. 2003, 327 (7414): 523-528. 10.1136/bmj.327.7414.523.View ArticlePubMedPubMed CentralGoogle Scholar
- Jennings Anne L, Davies Andrew N, Higgins Julian PT, Anzures-Cabrera J, Broadley Karen E: Opioids for the palliation of breathlessness in advanced disease and terminal illness. Cochrane Database of Systematic Reviews. 2001, 4: CD002066-Google Scholar
- Abernethy AP, McDonald CF, Frith PA, Clark K, Herndon JE, Marcello J, Young IH, Bull J, Wilcock A, Booth S, et al: Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet. 2010, 376 (9743): 784-793. 10.1016/S0140-6736(10)61115-4.View ArticlePubMedPubMed CentralGoogle Scholar
- Gysels MH, Higginson IJ: Caring for a person in advanced illness and suffering from breathlessness at home: Threats and resources. Palliat Support Care. 2009, 7 (02): 153-162. 10.1017/S1478951509000200.View ArticlePubMedGoogle Scholar
- Gysels M, Higginson I: Self-management for breathlessness in COPD: the role of pulmonary rehabilitation. J Chronic Dis. 2009, 6 (3): 133-140. 10.1177/1479972309102810.View ArticleGoogle Scholar
- Gysels M, Higginson IJ: Access to Services for Patients with Chronic Obstructive Pulmonary Disease: The Invisibility of Breathlessness. J Pain Symptom Manage. 2008, 36 (5): 451-460. 10.1016/j.jpainsymman.2007.11.008.View ArticlePubMedGoogle Scholar
- Gysels MH, Higginson IJ: The lived experience of breathlessness and its implications for care: a qualitative comparison in cancer, COPD, heart failure and MND. BMC Palliat Care. 2011, 10: 15-10.1186/1472-684X-10-15.View ArticlePubMedPubMed CentralGoogle Scholar
- Altman DG: Practical Statistics for Medical Research, First Edition edn. 1991, London: Chapman & HallGoogle Scholar
- Sewell L, Singh SJ, Williams JEA, Collier R, Morgan MDL: How long should outpatient pulmonary rehabilitation be? A randomised controlled trial of 4 weeks versus 7 weeks. Thorax. 2006, 61 (9): 767-771. 10.1136/thx.2005.048173.View ArticlePubMedPubMed CentralGoogle Scholar
- Guyatt GH, Berman LB, Townsend M, Pugsley SO, Chambers LW: A measure of quality of life for clinical trials in chronic lung disease. Thorax. 1987, 42 (10): 773-778. 10.1136/thx.42.10.773.View ArticlePubMedPubMed CentralGoogle Scholar
- Schunemann HJ, Goldstein R, Mador MJ, McKim D, Stahl E, Puhan M, Griffith LE, Grant B, Austin P, Collins R, et al: A randomised trial to evaluate the self-administered standardised chronic respiratory questionnaire. Eur Respir J. 2005, 25 (1): 31-40. 10.1183/09031936.04.00029704.View ArticlePubMedGoogle Scholar
- Gift A, Narsavage G: Validity of the numeric rating scale as a measure of dyspnea. Am J Respir Crit Care Med. 1998, 7 (3): 200-204.Google Scholar
- Yorke J, Moosavi SH, Shuldham C, Jones PW: Quantification of dyspnoea using descriptors: development and initial testing of the Dyspnoea-12. Thorax. 2010, 65 (1): 21-26. 10.1136/thx.2009.118521.View ArticlePubMedGoogle Scholar
- Hearn J, Higginson IJ: Development and validation of a core outcome measure for palliative care: the palliative care outcome scale. Palliative Care Core Audit Project Advisory Group. Qual Health Care. 1999, 8 (4): 219-227. 10.1136/qshc.8.4.219.View ArticlePubMedPubMed CentralGoogle Scholar
- Garrod R, Paul EA, Wedzicha JA: An evaluation of the reliability and sensitivity of the London Chest Activity of Daily Living Scale (LCADL). Resp Med. 2002, 96 (9): 725-730. 10.1053/rmed.2002.1338.View ArticleGoogle Scholar
- Zigmond AS, Snaith RP: The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand. 1983, 67 (6): 361-370. 10.1111/j.1600-0447.1983.tb09716.x.View ArticlePubMedGoogle Scholar
- Williams A: The Role of the EUROQOL Instrument in QALY Calculations Centre for Health Economics. University of York. 1995, http://www.york.ac.uk/media/che/documents/papers/discussionpapers/CHE%20Discussion%20Paper%20130.pdf,Google Scholar
- Bédard M, Molloy DW, Squire L, Dubois S, Lever JA, O'Donnell M: The Zarit Burden Interview. Gerontologist. 2001, 41 (5): 652-657. 10.1093/geront/41.5.652.View ArticlePubMedGoogle Scholar
- American Thoracic Society: Standardization of Spirometry, 1994 Update. ATS. Am J Respir Crit Care Med. 1995, 3: 1107-1136.Google Scholar
- American Thoracic Society: ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002, 166 (1): 111-117.View ArticleGoogle Scholar
- Hill K, Jenkins SC, Cecins N, Philippe DL, Hillman DR, Eastwood PR: Estimating Maximum Work Rate During Incremental Cycle Ergometry Testing From Six-Minute Walk Distance in Patients With Chronic Obstructive Pulmonary Disease. Arch Phys Med Rehabil. 2008, 89 (9): 1782-1787. 10.1016/j.apmr.2008.01.020.View ArticlePubMedGoogle Scholar
- Kasymjanova G, Correa JA, Kreisman H, Dajczman E, Pepe C, Dobson S, Lajeunesse L, Sharma R, Small D: Prognostic Value of the Six-Minute Walk in Advanced Non-small Cell Lung Cancer. J Thorac Oncol. 2009, 4 (5): 602-607. 10.1097/JTO.0b013e31819e77e8. 610.1097/JTO.1090b1013e31819e31877e31818View ArticlePubMedGoogle Scholar
- Celli BR, Cote CG, Marin JM, Casanova C, Montes de Oca M, Mendez RA, Pinto Plata V, Cabral HJ: The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease. N Eng J Med. 2004, 350 (10): 1005-1012. 10.1056/NEJMoa021322.View ArticleGoogle Scholar
- Puhan MA, Guyatt GH, Goldstein R, Mador J, McKim D, Stahl E, Griffith L, Schünemann HJ: Relative responsiveness of the Chronic Respiratory Questionnaire. St. Georges Respiratory Questionnaire and four other health-related quality of life instruments for patients with chronic lung disease. Resp Med. 2007, 101 (2): 308-316. 10.1016/j.rmed.2006.04.023.View ArticleGoogle Scholar
- Bausewein C, Booth S, Gysels M, Kuhnbach R, Haberland B, Higginson IJ: Understanding breathlessness: cross-sectional comparison of symptom burden and palliative care needs in chronic obstructive pulmonary disease and cancer. J Palliat Med. 2010, 13 (9): 1109-1118. 10.1089/jpm.2010.0068.View ArticlePubMedGoogle Scholar
- Farquhar M, Higginson IJ, Fagan P, Booth S: Results of a pilot investigation into a complex intervention for breathlessness in advanced chronic obstructive pulmonary disease (COPD): Brief report. Palliat Support Care. 2010, 2: 143-149. Epub 2010 Mar 23View ArticleGoogle Scholar
- Booth S, Moffat C, Farquhar M, Higginson IJ, Burkin J: Developing a breathlessness intervention service for patients with palliative and supportive care needs, irrespective of diagnosis. J Palliat Care. 2011, 27 (1): 28-36.PubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2466/12/58/prepub
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