Tracheal adenoid cystic carcinoma masquerading asthma: A case report
© Kokturk et al; licensee BioMed Central Ltd. 2004
Received: 23 May 2004
Accepted: 19 October 2004
Published: 19 October 2004
Tracheal tumors are often misdiagnosed as asthma and are treated with inhaled steroids and bronchodilators without resolution.
Here, a patient with tracheal adenoid cystic carcinoma who had been previously diagnosed with difficult asthma was reported. The possibility of the presence of localized airway obstruction was raised when the flow-volume curve suggesting fixed airway obstruction, was obtained.
The presenting case report emphasizes the fact that not all wheezes are asthma. It is critical to bear in mind that if a patient does not respond to appropriate anti-asthma therapy, localized obstructions should be ruled out before establishing the diagnosis of asthma.
Tracheal tumors are uncommon and often overlooked until they reach to an advanced stage. The presenting symptoms are typically prolonged cough and wheezing that can be misdiagnosed as asthma . Therefore, making precise diagnosis of tracheal tumor may be extremely challenging.
Here, a patient with tracheal adenoid cystic carcinoma who had been previously diagnosed with difficult asthma was reported.
A 29 year-old man was referred to our hospital with a 2-year history of paroxysmal attacks of dyspnea, dry cough and wheezing. He had smoked 2 packs/day cigarettes for 3 years and has been ex-smoker for 5 years. He experienced frequent sudden-onset coughing episodes followed by the development of dyspnea and wheezing a year ago. He was previously diagnosed with difficult asthma and treated with high dose inhaled corticosteroids (1600 μg budesonide) and bronchodilators. Since he was unresponsive to the therapy, he has applied to several institutions for multiple times to seek medical attention.
The patient underwent resection surgery. At the operational site, there were severe adhesions between the mediastinal surface and the trachea. Therefore, a conservative surgery was performed. The tumor was seen on the right anterolateral wall of the trachea being expanded submucosally from the carina to the proximal end of the trachea.
The patient underwent adjuvant radiation therapy after the operation. CT scan of the neck revealed resolution of the tumor (Figure 2b). Now, 3 months after the operation, the patient has remained well.
Primary tracheal tumors are rare with the incidence of less than 0.1 % [2, 3]. The majority of tracheal tumors in adults are malignant and the most common ones are squamous cell carcinoma and adenoid cystic carcinoma (cylindroma). Tumors of the larynx and lungs are respectively, 75 and 180 times more common than malignant tracheal tumors [3, 4]. Benign tracheal tumors such as lipoma, hamartoma and neurilemmoma are much more rare than malignant tracheal tumors [2, 5, 6].
Clinical manifestations of tracheal tumors are developed as a consequence of tumor bulk and location. Patients with tracheal tumor often have exertional shortness of breath, prolonged cough or a new onset of wheezing, which is frequently misdiagnosed as asthma. Patients are usually initially managed accordingly. However, tumor may occlude 75 % of the lumen before leading symptoms. In the literature, most of the reports highlight that there is always a remarkable delay of establishing accurate diagnosis as a result of misdiagnosis of asthma [1, 5, 7]. Pearson et al have reported a 2-month to 2-year delay in diagnosis in their series from Toronto General Hospital . Therefore, adult-onset asthma that increases the severity despite the adequate therapy should alert one to the possibility of a central obstructing lesion . In such patients, a flow-volume curve may provide extremely valuable data and may lead the clinician toward accurate diagnosis.
Another diagnostic challenge of tracheal tumor is the fact that it can occasionally be visualized by plain chest X-ray. CT scan of the chest or magnetic resonance imaging may yield more valuable data on the site and length of the tracheal lesion . The cornerstone diagnostic modality is bronchoscopy .
In the presenting report, the patient had been mistakenly diagnosed with difficult asthma because of the presence of uncontrolled asthmatic symptoms and poor lung functions despite the use of high doses corticosteroids. Nevertheless, the flow-volume curve typically displayed localized fixed obstruction of central airways. This led us to have a work-up of CT scan and FOB to rule out upper airway obstructions.
Adenoid cystic carcinomas are smooth, firm, and well-circumscribed lesions. These tumors grow extremely slowly. Patients have been known to survive for 10 to 15 years with multiple lung metastases. Spread tends to occur submucosally .
The optimal therapeutic approach is surgical resection and reconstruction. The surgeon should be aware of the fact that the apparent gross margin of the tumor is usually still involved with the tumor cells so that the resection should be done at least 1 cm beyond the gross tumor margin. Postoperative irradiation was recommended by most of the authors [1, 9]. Long-term postoperative follow-up is important to discover recurrences.
In this case, postoperative irradiation on curative doses has been applied for a month. Control bronchoscopic examination revealed near-complete remission.
The presenting case report emphasizes the fact that not all wheezes are asthma. It is critical to bear in mind that if a patient does not respond to appropriate anti-asthma therapy, localized airway obstructions should be rule out before establishing the diagnosis of asthma.
The patient who has been illustrated in this report has given a signed written consent for the publication of the study.
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