Skip to main content

Table 1 Description of the patient populations and characteristics of the exercise training programs

From: Exercise training improves physical fitness in patients with pulmonary arterial hypertension: a systematic review and meta-analysis of controlled trials

Author Year Origin Design Patient population NYHA Age (year) Number at baseline Exercise intervention Control Assessment of physical fitness
Mereles et al. 2006 Germany Cross-over PAH (80%) or chronic pulmonary thromboembolic disease (20%) II - IV 50 Intervention: 15 (10 female/5 male); Control: 15 (10 female/5 male) 3 weeks in-hospital + 12 weeks home-based aerobic interval training along with resistance and respiratory exercises, 5 sessions/week, 30-60 min/session, 60-80% of peak HR Usual care 6MWT, CPET
Martinez-Quintana et al. 2010 Spain Parallel PAH associated with congenital heart disease II - IV 27.7 Intervention: 4 (2 female/2 male); Control: 4 (3 female, 1 male) 3 months supervised aerobic interval training and resistance exercise, 2 sessions/week, 30-60 min/session, 60-80% of peak HR Usual care 6MWT
Fox et al. 2011 Israel Parallel PAH (91%) or chronic thromboembolic PH (9%) II - III 51.5 Intervention: 11 (10 female/1 male); Control: 11 (5 female, 6 male) 3 months supervised continuous aerobic and resistance exercise, 2 sessions/week, 60 min/session, 60-80% of peak HR Usual care 6MWT, CPET
Ley et al. 2013 Germany Parallel PAH (80%) or chronic inoperable tromboembolic PH (20%) II - III 50.5 Intervention: 10 (8 female/2 male); Control: 10 (6 female, 4 male) 3 weeks supervised aerobic interval training along with resistance and respiratory exercises, 5 sessions/week, 30-60 min/session, 60-80% of peak HR Usual care 6MWT
Chan et al. 2013 USA Parallel PAH I - IV 54.4 Intervention: 13 (13 female/0 male); Control: 13 (13 female, 0 male) 10 weeks supervised treadmill walking, 3 sessions/week, 30-45 min/session, 70-80% of heart rate reserve + patient education Patient education only 6MWT, CPET
  1. 6MWT = 6-minute walking test; CPET = cardiopulmonary exercise testing; PAH = pulmonary arterial hypertension; PH = pulmonary hypertension.