Skip to content

Advertisement

  • Case report
  • Open Access
  • Open Peer Review

Successful resumption of tocilizumab for rheumatoid arthritis after resection of a pulmonary Mycobacterium avium complex lesion: a case report

  • 1,
  • 1Email author,
  • 2,
  • 1,
  • 1,
  • 2,
  • 3,
  • 4,
  • 2 and
  • 1
BMC Pulmonary Medicine201515:126

https://doi.org/10.1186/s12890-015-0130-z

  • Received: 19 July 2015
  • Accepted: 15 October 2015
  • Published:
Open Peer Review reports

Abstract

Background

Biological agents inhibiting TNF-α and other molecules involved in inflammatory cascade have been increasingly used to treat rheumatoid arthritis (RA). However, it remains controversial whether biological agents can be used safely in a patient with an underlying chronic infectious disease.

Case presentation

A 63-year-old woman who had been treated with tocilizumab (TCZ), anti-interleukin-6 receptor antibody, for RA presented to our outpatient clinic due to hemoptysis. She was diagnosed with pulmonary Mycobacterium avium complex (MAC) infection, and high-resolution computed tomography (HRCT) showed a single cavitary lesion in the right upper lobe. After diagnosis of pulmonary MAC disease, TCZ was discontinued and combination chemotherapy with clarithromycin, rifampicin, ethambutol and amikacin was started for MAC pulmonary disease. Since the lesion was limited in the right upper lobe as a single cavity formation, she underwent right upper lobectomy. As her RA symptoms were deteriorated around the operation, TCZ was resumed. After resumption of TCZ, her RA symptoms improved and a recurrence of pulmonary MAC infection has not been observed for more than 1 year.

Conclusion

This case suggested that TCZ could be safely reintroduced after the resection of a pulmonary MAC lesion. Although the use of biological agents is generally contraindicated in patients with pulmonary MAC disease, especially in those with a fibrocavitary lesion, a multimodality intervention for MAC including both medical and surgical approaches may enable introduction or resumption of biological agents.

Keywords

  • Biological agents
  • Mycobacterium avium complex (MAC)
  • Resection
  • Rheumatoid arthritis
  • Tocilizumab

Background

Various types of biological agents such as infliximab and tocilizumab (TCZ) have been increasingly used to treat rheumatoid arthritis (RA) because of their effectiveness [1, 2]. RA patients are often complicated by pulmonary lesion including interstitial pneumonia and bronchiectasis that is vulnerable to infection [3, 4]. According to the recent systematic review, both standard-dose and high-dose biological agents are associated with the increased risk of serious infections, compared with traditional disease-modifying anti-rheumatic drugs (DMARDs) [5]. With respect to the difference in susceptibility between the classes of biologics, no difference in the risk of infection has been reported between TCZ and others, although the Cochrane review in 2011 reported that abatacept, cytotoxic T lymphocyte antigen 4-immunoglobulin, was significantly less likely to cause infection than infliximab and TCZ [6]. Moreover, it has been shown that biological agents are associated with a significant increase in mycobacterial diseases [7]. Concerning the types of mycobacterial diseases, Winthrop and coworkers reported that nontuberculous mycobacteria (NTM) infections were more common than tuberculosis among patients receiving biologics [8]. Especially in Japan, the most recent nationwide survey revealed that the incidence rate of pulmonary NTM disease (14.7 persons per 100,000 person-years) may exceed that of tuberculosis in general population, and that Japan may have one of the highest incidence rates of pulmonary NTM disease worldwide [9]. Whereas tuberculosis can usually be controlled by the standard chemotherapy, no effective chemotherapy has been established against Mycobacterium avium complex (MAC), leading to aggravation of MAC infection during immunosuppressive therapy [10, 11]. According to Japanese postmarketing surveillance of TCZ in RA patients, the incidence of NTM infections (0.22 %) is higher than that of tuberculosis (0.05 %) [12]. Although many of RA patients have underlying pulmonary lesions and other risk factors for potential NTM infection, it is still controversial whether biological agents can be a risk of exacerbation of pre-existing pulmonary NTM disease [11]. Consequently, a strategy for the management of NTM in RA patients subjected to treatment with biologics remains to be established.

In this report, a case of pulmonary MAC disease in an RA patient who successfully resumed TCZ after the resection of a single cavitary lesion is presented. Although the use of biological agents is generally contraindicated in patients with pulmonary MAC disease, especially in those with a fibrocavitary lesion, a multimodality approach for MAC may enable introduction or resumption of biological agents. This report is in compliance with the Helsinki Declaration.

Case presentation

In September 2013, a 63-year-old woman was referred to our outpatient clinic due to hemoptysis and a pulmonary lesion on high-resolution computed tomography (HRCT). Her height was 165.0 cm and body weight was 46.0 kg. The patient never smoked but had a medical history of Crohn’s disease, which remained in remission, and RA that was diagnosed in 2010 according to the criteria of the American College of Rheumatology. She had been treated with prednisolone (PSL) (5 mg/day) and methotrexate (12 mg/week). Because the disease activity was not properly controlled with these medications, methotrexate was stopped and 360 mg of TCZ was administered intravenously once every 4 weeks from October 2011. At this time, the visual analogue scale (VAS) was 37 mm and the disease activity score (DAS) 28–C-reactive protein (CRP) was 3.81. When TCZ was introduced, her chest radiograph was normal (Fig. 1a), but HRCT showed a small nodular shadow in the right upper lobe of the lung (Fig. 1b). Although the patient had no respiratory symptoms with no pathogenic bacteria isolated from the sputum, she was prescribed 400 mg/day clarithromycin (CAM) as a monotherapy before her referral to our department. Two years after the initiation of TCZ, she was admitted for hemoptysis, and a chest radiograph showed infiltration and cavity formation in the right upper lobe (Fig. 1c). HRCT also showed consolidation, cavity formation, bronchiectasis, and centrilobular nodules in the right upper lobe (Fig. 1d). When admitted, her body temperature was 36.4 °C. Coarse crackles were auscultated over the right upper lung field and joint pain was positive in her left wrist, right elbow, and metatarsophalangeal joints of the right third and fourth toes. There were no abnormal findings on complete blood counts and biochemistry tests except for mild leukocytopenia (white blood cells, 3300/μL) (Table 1). The anti-glycopeptidolipid core IgA antibody was positive (2.44 U/mL), and the QuantiFERON® TB Gold test was negative. Pulmonary MAC disease was diagnosed because the sputum culture was positive for MAC twice. A Broth MIC® NTM showed that the isolated MAC was sensitive to CAM (minimum inhibitory concentration, 1 μg/mL) despite 2-year monotherapy with CAM. Combination chemotherapy with 800 mg/day of CAM, 450 mg/day of rifampicin (RFP), 500 mg/day of ethambutol (EB), and thrice weekly intravenous amikacin (600 mg/per dose) were started. Because TCZ might have contributed to the exacerbation of the pulmonary MAC disease, TCZ therapy was discontinued after the diagnosis of pulmonary MAC disease. In addition, PSL was tapered to 2 mg/day, and nonsteroidal anti-inflammatory drugs were started for RA. At this time, the disease activity of her RA was relatively stable (VAS, 6 mm; DAS 28-CRP, 1.99).
Fig. 1
Fig. 1

Serial changes on chest X-ray and chest computed tomography findings. a Chest X-ray taken immediately before starting tocilizumab (TCZ), showing subtle nodular infiltrates. b CT scan taken immediately before starting TCZ, showing a small nodular shadow in the right upper lobe (arrowhead). c Chest X-ray taken when the patient developed hemoptysis 2 years after starting TCZ, showing infiltration and cavity formation in the right upper lung field (arrowhead). d CT scan taken when the patient developed hemoptysis 2 years after starting TCZ, showing consolidation, cavity formation, bronchiectasis, and centrilobular nodules in the right upper lobe (arrowhead)

Table 1

Laboratory findings on admission

Complete blood count

 White blood cells

3300/μL

  Band cells + Seg cells

54.1 %

  Lymphocytes

32.7 %

  Monocytes

8.1 %

  Eosinophil granulocytes

4.5 %

  Basophil granulocytes

0.6 %

 Hemoglobin

13.8 g/dL

 Mean corpuscular volume

94/fL

 Platelets

182 × 103 /μL

Biochemistry

 Total protein

6.4 g/dL

 Albumin

4.2 g/dL

 Total bilirubin

0.7 mg/dL

 Glutamic oxaloacetic transaminase

20 IU/L

 Glutamic pyruvic transaminase

14 IU/L

 Lactate dehydrogenase

180 IU/L

 Urea nitrogen

11.2 mg/dL

 Creatinine

0.64 mg/dL

 Sodium

143.2 mEq/L

 Potassium

3.9 mEq/L

 Chloride

109 mEq/L

 Alkaline phosphatase

197 IU/L

 Gamma-glutamyl transferase

13 IU/L

Serological studies

 C-reactive protein

0.01 mg/dL

 Matrix metalloproteinase 3

42.2 ng/mL

 β-D-glucan

<3.0 pg/mL

Aspergillus antigen

0.0 COI

Cryptococcus antigen

0.0 COI

 QuantiFERON® TB Gold test

Negative

 Anti-glycopeptidolipid core IgA antibody

2.44 U/mL

Although 3 months of anti-MAC treatment improved the consolidation and centrilobular nodules, the cavitary lesion and bronchiectasis were still significant on chest X-ray and HRCT (Fig. 2a, b). Her right upper lobe was resected (Fig. 3), since her lesion was limited to a single lobe and the cavitary lesion seemed refractory to drug therapy. As expected, tissue culture of the resected specimen tested positive for MAC. Although her pulmonary MAC lesion was totally removed with the operation and microbiological examinations remained negative, CAM, RFP, and EB were continued to prevent a relapse of MAC pulmonary disease. Because she reported deterioration of her joint symptoms around the time of the operation (VAS, 38 mm; DAS 28-CRP, 4.07), TCZ was resumed 1 month after resection.
Fig. 2
Fig. 2

Serial changes on chest X-ray and chest computed tomography findings. a Chest X-ray taken 3 months after chemotherapy against Mycobacterium avium complex (MAC), showing improved infiltration (arrowhead). b CT scan taken 3 months after chemotherapy against MAC, showing diminished consolidation and centrilobular nodules in the right upper lobe (arrowhead). c Chest X-ray taken 1 year after resuming TCZ, showing no abnormal findings other than the postoperative findings after the right upper lobectomy. d CT scan taken 1 year after resuming TCZ, showing no postoperative findings of right upper lobectomy

Fig. 3
Fig. 3

Photograph and photomicrographs of the lung. a Photograph of a cross-sectional specimen from the resected right upper lung. b Photomicrographs showing an epithelioid granuloma with necrosis (bar, 5 mm). c Photomicrographs showing an epithelioid granuloma with necrosis (bar, 500 μm). d Photomicrograph showing Langhans giant cells (arrowheads) and epithelioid cells (arrow) (bar, 100 μm)

Two months after the restarting of TCZ, her joint symptoms had totally improved; the VAS improved from 38 to 3 mm, and DAS 28-CRP improved from 4.07 to 1.06. In terms of the pulmonary MAC disease, no new lesion was found by HRCT at 1 year after the resumption of TCZ (Fig. 2c, d).

Conclusions

MAC is one of the most common opportunistic pathogens in RA patients on biological agents [13]. Although most immunocompetent patients with MAC infection maintain a stable clinical course for years, immunocompromised patients often show rapid progression of the disease. Previous MAC infections in RA patients are a particularly controversial issue, because the aggravation of MAC infection requires abandoning effective treatment with biological agents [11, 14]. However, some case reports and the new joint statement published by the Japanese Respiratory Society (JRS), Japan College of Rheumatology (JCR), and Japanese Society for Tuberculosis (JSTB) in 2014 proposed that, in certain RA patients with pulmonary MAC disease, biological agents can be safely used in combination with chemotherapy for pulmonary MAC disease [15, 16]. In the case series by Mori and colleagues, anti-TNF agents could be safely reintroduced in seven patients without exacerbation of the MAC infection [14]. Nakahara and coworkers also described a case of successful reintroduction of TCZ without aggravation of MAC infection under the standard chemotherapy [15]. However, there has been no report of surgical resection of MAC lesion followed by successful reintroduction of biologics. In this regard, this is the first case report which indicates that biological agents might be safely resumed after surgery.

In this case, HRCT taken before the initiation of TCZ treatment showed small nodular opacity in the right upper lobe, suggesting pre-existing MAC disease. Since monotherapy with macrolides can induce macrolide-resistance, it is not an appropriate treatment in the presence of MAC disease [17]. Therefore, bronchoscopy should have been performed to make a diagnosis of pulmonary MAC disease so that combination chemotherapy could be introduced at an earlier time point.

After the exacerbation of pulmonary MAC disease, HRCT showed consolidation, cavity formation, bronchiectasis, and centrilobular nodules that were localized only in the right upper lobe. According to the JSTB statement about the resection of pulmonary NTM disease, a single cavity lesion is a good candidate for surgery to suppress the activity of pulmonary NTM disease [18]. From this standpoint, our approach to eradicating MAC lesions was appropriate.

According to the recent joint statement, patients with NTM are in principle prohibited from using biological agents [18]. The statement also mentioned that using biological agents could be considered with full evaluation of the risk and benefit, only in the following cases: (i) the causative pathogen is MAC; (ii) the radiographic features are of the nodular/bronchiectatic type; (iii) the existing pulmonary lesion is limited; (iv) the patient’s general performance status is good; (v) chemotherapy against NTM could be given in the long term with a good treatment response; and (vi) biological agents are strongly needed because of the high disease activity of RA. It also stated that using biologics in those with a fibrocavitary lesion of NTM is a contraindication [18]. The present case indicated the possibility of safe reintroduction of biological agents after resection, even in cases with a fibrocavitary lesion, when the cavitary lesion is localized in a single lobe. Since no difference in the risk of infection has been reported between TCZ and other biological agents [7], we considered that this strategy might be applied not only for TCZ but also for other biologics.

One of the discussion points is the validity of surgical resection against MAC disease. In this case, her hemoptysis disappeared after 3 months of chemotherapy and the infiltrates around the cavity were also resolved. However, the cavitary lesion, which could discharge mycobacteria and might predispose the patient to later recurrence, was not changed. In general, the cavitary lesion of MAC patients is difficult to be resolved by chemotherapy alone and is good indication for surgical resection [18, 19]. Especially for this patient with high disease activity of RA, we thought it reasonable to remove the cavitary lesion surgically in order to resume biological agents.

Another discussion point is the duration of concurrent chemotherapy against MAC as well as perioperative chemotherapy. It was possible to discontinue the chemotherapy against MAC when the MAC lesion was totally removed by surgery. However, it was assumed that chemotherapy should be continued to prevent the growth of minimal MAC lesion, which was undetectable by HRCT. A retrospective review of pulmonary resection in patients with NTM showed that postoperative chemotherapy might contribute to decreasing the relapse rate [20]. The JSTB statement about the resection of pulmonary NTM disease also recommended postoperative adjuvant chemotherapy [18]. In any case, careful follow-up to monitor the re-emergence of the MAC lesion or other opportunistic infections is needed as long as the patient is receiving biological agents.

In conclusion, an RA case for which TCZ was safely reintroduced after resection of the pulmonary MAC lesion was presented. Although the use of biological agents is generally contraindicated in patients with pulmonary MAC disease, especially with a fibrocavitary lesion, a multimodality approach for MAC may be considered in order to use biological agents safely.

Consent

Abbreviations

RA: 

Rheumatoid arthritis

TCZ: 

Tocilizumab

MAC: 

Mycobacterium avium complex

HRCT: 

High-resolution computed tomography

DMARDs: 

Disease-modifying anti-rheumatic drugs

NTM: 

Nontuberculous mycobacteria

PSL: 

Prednisolone

VAS: 

Visual analogue scale

DAS: 

Disease activity score

CRP: 

C-reactive protein

CAM: 

Clarithromycin

RFP: 

Rifampicin

EB: 

Ethambutol

JRS: 

Japanese Respiratory Society

JCR: 

Japan College of Rheumatology

JSTB: 

Japanese Society for Tuberculosis

Declarations

Acknowledgements

No funding to declare.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
(2)
Division of Rheumatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
(3)
Division of General Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan
(4)
Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Tokyo, Japan

References

  1. Takeuchi T, Kameda H. The Japanese experience with biologic therapies for rheumatoid arthritis. Nat Rev Rheumatol. 2010;6(11):644–52.View ArticlePubMedGoogle Scholar
  2. Woodrick RS, Ruderman EM. Safety of biologic therapy in rheumatoid arthritis. Nat Rev Rheumatol. 2011;7(11):639–52.View ArticlePubMedGoogle Scholar
  3. Jani M, Hirani N, Matteson EL, Dixon WG. The safety of biologic therapies in RA-associated interstitial lung disease. Nat Rev Rheumatol. 2014;10(5):284–94.View ArticlePubMedGoogle Scholar
  4. Furst DE. The risk of infections with biologic therapies for rheumatoid arthritis. Semin Arthritis Rheum. 2010;39(5):327–46.View ArticlePubMedGoogle Scholar
  5. Singh JA, Cameron C, Noorbaloochi S, Cullis T, Tucker M, Christensen R, et al. Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis. Lancet. 2015;386(9990):258–65.View ArticlePubMedGoogle Scholar
  6. Singh JA, Wells GA, Christensen R, Tanjong Ghogomu E, Maxwell L, Macdonald JK, et al. Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst Rev. 2011;2:CD008794.PubMedGoogle Scholar
  7. Kourbeti IS, Ziakas PD, Mylonakis E. Biologic therapies in rheumatoid arthritis and the risk of opportunistic infections: a meta-analysis. Clin Infect Dis. 2014;58(12):1649–57.View ArticlePubMedGoogle Scholar
  8. Winthrop KL, Yamashita S, Beekmann SE, Polgreen PM. Mycobacterial and other serious infections in patients receiving anti-tumor necrosis factor and other newly approved biologic therapies: case finding through the Emerging Infections Network. Clin Infect Dis. 2008;46(11):1738–40.View ArticlePubMedGoogle Scholar
  9. Namkoong H, Kurashima A, Morimoto K,·Hoshino Y, Hasegawa N, Manabu A,·Mitarai S: Nationwide Survey on the Epidemiology of Pulmonary Nontuberculous Mycobacterial in Japan. The annual meeting of American Thoracic Society 2015/05.Google Scholar
  10. Henkle E, Winthrop KL. Nontuberculous mycobacteria infections in immunosuppressed hosts. Clin Chest Med. 2015;36(1):91–9.View ArticlePubMedGoogle Scholar
  11. Winthrop KL, Iseman M. Bedfellows: mycobacteria and rheumatoid arthritis in the era of biologic therapy. Nat Rev Rheumatol. 2013;9(9):524–31.View ArticlePubMedGoogle Scholar
  12. Yamamoto K, Goto H, Hirao K, Nakajima A, Origasa H, Tanaka K, et al. Longterm Safety of Tocilizumab: Results from 3 Years of Followup Postmarketing Surveillance of 5573 Patients with Rheumatoid Arthritis in Japan. J Rheumatol. 2015;42(8):1368–75.View ArticlePubMedGoogle Scholar
  13. van Ingen J, Boeree MJ, Dekhuijzen PN, van Soolingen D. Mycobacterial disease in patients with rheumatic disease. Nat Clin Pract Rheumatol. 2008;4(12):649–56.View ArticlePubMedGoogle Scholar
  14. Mori S, Tokuda H, Sakai F, Johkoh T, Mimori A, Nishimoto N, et al. Radiological features and therapeutic responses of pulmonary nontuberculous mycobacterial disease in rheumatoid arthritis patients receiving biological agents: a retrospective multicenter study in Japan. Mod Rheumatol. 2012;22(5):727–37.PubMed CentralView ArticlePubMedGoogle Scholar
  15. Nakahara H, Kamide Y, Hamano Y, Hosokawa T, Nishide M, Lin Y, et al. A case report of a patient with rheumatoid arthritis complicated with Mycobacterium avium during tocilizumab treatment. Mod Rheumatol. 2011;21(6):655–9.View ArticlePubMedGoogle Scholar
  16. Biological agents and pulmonary diseases - the statement of the management - the Japanese Respiratory Society, the Japan college of Rheumatology and the Japanese Society for Tuberculosis. (in Japanese) 2014.Google Scholar
  17. Griffith DE, Brown-Elliott BA, Langsjoen B, Zhang Y, Pan X, Girard W, et al. Clinical and molecular analysis of macrolide resistance in Mycobacterium avium complex lung disease. Am J Respir Crit Care Med. 2006;174(8):928–34.View ArticlePubMedGoogle Scholar
  18. The Nontuberculous Mycobacteria Committee of Japanese Society for Tuberculosis. The statement of surgery against Mycobacterium avium comlex lung disease. Kekkaku. 2008;83(12):527–8.Google Scholar
  19. Yu JA, Weyant MJ, Mitchell JD. Surgical treatment of atypical mycobacterial infections. Thorac Surg Clin. 2012;22(3):277–85.View ArticlePubMedGoogle Scholar
  20. Shiraishi Y, Katsuragi N, Kita H, Hyogotani A, Saito MH, Shimoda K. Adjuvant surgical treatment of nontuberculous mycobacterial lung disease. Ann Thorac Surg. 2013;96(1):287–91.View ArticlePubMedGoogle Scholar

Copyright

© Namkoong et al. 2015

Advertisement