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Table 2 QUADAS-2 Quality Assessment results

From: Diagnostic accuracy of nasal nitric oxide for establishing diagnosis of primary ciliary dyskinesia: a meta-analysis

Study

Risk of bias

Applicability concerns

Patient selection

Index test

Reference Standard

Flow and timing

Patient selection

Index test

Reference standard

Boon 2014 [30]

L

U

L

L

L

L

L

Mateos Coral 2011 [31]

U

L

L

L

U

L

L

Piacentini 2008 [25]

U

L

L

L

U

L

L

Santamaria 2008 [28]

L

U

L

L

L

L

L

Montela 2012 [27]

U

L

U

L

L

L

L

Corbelli 2004 [23]

L

U

L

L

L

L

L

Narang 2002 [26]

L

L

L

L

L

L

L

Harris 2014 [14]

L

U

L

L

L

L

L

Leigh 2013 [7]

L

L

L

L

L

L

L

Marthin 2011 [22]

L

U

L

L

L

L

L

Moreno Galdo 2010 [29]

U

U

L

L

U

L

L

Beydon M 2015 [25]

L

L

L

U

L

L

L

  1. QUADAS 2 consists of four key domains covering patient selection, index test, reference standard and flow of patients through the study and timing of the index test and reference standard (“flow and timing”). Each domain is assessed in terms of the risk of bias and the first three are also assessed in terms of concerns regarding applicability
  2. U: Unknown, L: Low, H: High