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Table 1 Asthma study: inspiratory flow profile from acoustic monitoring

From: Inspiratory flow profile and usability of the NEXThaler, a multidose dry powder inhaler, in asthma and COPD

 

Asthma control

Total (N = 40)

Controlled (N = 20)

Partly controlled/ uncontrolled (N = 20)

Flow at BAM firing, L/min

 

 First inhalation

35.4 ± 9.5 (16.3–52.3)

34.5 ± 8.6 (23.1–50.4)

35.0 ± 9.0 (16.3–52.3)

 Second inhalation

34.6 ± 9.2 (14.4–50.8)

36.2 ± 9.0 (18.0–53.6)

35.4 ± 9.0 (14.4–53.6)

PIF, L/min

 

 First inhalation

70.5 ± 28.2 (39.9–123.9)

58.8 ± 20.1 (35.0–123.3)

64.6 ± 24.9 (35.0–123.9)

 Second inhalation

72.1 ± 25.6 (42.1–117.6)

63.0 ± 16.8 (44.2–117.4)

67.6 ± 21.9 (42.1–117.6)

Time to BAM firing, s

 

 First inhalation

0.06 (0.02–0.50)

0.08 (0.03–0.50)

0.07 (0.02–0.50)

 Second inhalation

0.07 (0.02–0.41)

0.08 (0.03–0.18)

0.07 (0.02–0.41)

Time to PIF, s

   

 First inhalation

0.47 (0.32–1.18)

0.50 (0.35–2.34)

0.48 (0.32–2.34)

 Second inhalation

0.46 (0.32–1.40)

0.56 (0.36–1.22)

0.48 (0.32–1.40)

Total inhalation time, s

 

 First inhalation

1.93 (0.39–3.62)

1.80 (0.78–4.09)

1.83 (0.39–4.09)

 Second inhalation

2.00 (0.49–3.49)

1.68 (0.67–3.54)

1.82 (0.49–3.54)

Total inhaled volume, L

 First inhalation

1.73 ± 0.96 (0.23–4.09)

1.39 ± 0.55 (0.50–2.67)

1.56 ± 0.79 (0.23–4.09)

 Second inhalation

1.68 ± 0.84 (0.28–3.89)

1.39 ± 0.55 (0.45–2.63)

1.53 ± 0.72 (0.28–3.89)

  1. Data are mean ± SD (range) for flow at BAM firing, PIF, and total inhaled volume, and median (range) for time to BAM firing, time to PIF, and total inhalation time
  2. BAM breath-actuated mechanism, PIF peak inspiratory flow