Skip to main content

Life-threatening hemoptysis accompanied by internal thoracic artery aneurysms in a 28-year-old perinatal woman: a case report



Life-threatening hemoptysis presents an immediate diagnostic and therapeutic challenge, especially during the perinatal period.

Case presentation

A 28-year-old perinatal woman with no significant past medical or surgical history presented with repeating hemoptysis and respiratory failure. Computed tomography revealed a 2.1 × 3.2  cm2 inhomogeneous tumorous lesion in the right superior mediastinum and a right main bronchus obstruction along with atelectasis of the right lung. Bronchoscopy showed a tumorous protrusion blocking the right main bronchus with active hemorrhage, and malignancy was suspected. Bronchial artery embolization (BAE) was performed to control the bleeding. The arteriogram revealed tortuosity, dilation and hypertrophy of the right bronchial arteries and aneurysms of the internal thoracic artery (ITA). The bleeding completely stopped after BAE. Bronchoscopy was performed again to remove residual blood clots. The patient recovered soon after the procedure and was discharged.


Life-threatening hemoptysis concomitant with ITA aneurysms, which may have a misleading clinical diagnosis and treatment options, has not been reported previously in perinatal women. BAE could be used as a first-line treatment irrespective of the underlying causes.

Peer Review reports


Hemoptysis is considered life threatening if, regardless of the degree, it is associated with respiratory failure from airway obstruction or hypotension [1]. Bronchiectasis, tuberculosis, and malignancies are the top three causes of this condition [1, 2]. However, the origin of the bleeding and the underlying etiology are often not immediately apparent, which may present an immediate diagnostic and therapeutic challenge. Here, we present a perinatal patient who had life-threatening hemoptysis concomitant with internal thoracic artery (ITA) aneurysms and pulmonary atelectasis, an extremely rare event for life-threatening hemoptysis management.

Case presentation

A 28-year-old G3P2A1 woman with no significant past medical or surgical history was admitted on postpartum day 4 and presented with repeating hemoptysis and increasing dyspnea. She coughed up 10–20 mL fresh blood for 4 days and complained of dyspnea that increased on exertion and was relieved by rest after spontaneous vaginal delivery. Her pregnancy and delivery were uneventful, with a healthy female child at 38 weeks and 1 day. Her first pregnancy was miscarried at 2 months, and her second pregnancy went well and gave birth to a girl by vaginal delivery. The girl is 3 years old and doing well. Social and family history were unremarkable.

On examination, the patient was alert and oriented, with temperature 37.5 °C, heart rate 125, respiratory rate 28, and oxygen saturation 88% on room air. Physical examination was significant for tachycardia; otherwise, the patient presented with a regular rhythm, dullness to percussion, decreased tactile fremitus, and no breath sounds to the right side. The skin showed no sign of petechiae and ecchymosis. Laboratory tests revealed fibrinogen (FIB) 5.82 g/L, thrombin time (TT) 11.5 s, prethrombin time ratio (PTR) 0.86, activated partial thromboplastin time (APTT) 26 s, prothrombin time (PT) 11 s, international normalized ratio (INR) of PT 0.88; D-dimer 620 μg/L; white blood cell count 11.2 × 109/L, Platelet count 223 × 109/L, Hemoglobin 88 g/L, Red blood cell count 4.05 × 1012/L; mean corpuscular volume (MCV) 78.8 fL, mean corpuscular hemoglobin (MCH) 21.7 pg, and mean corpuscular-hemoglobin concentration (MCHC) 276.0 g/L. The absolute counts and percentages of other blood cells were within the normal ranges. Arterial blood gas analysis on 5 L nasal cannula showed pH 7.385; pO2 78 mmHg; pCO2 32.5 mmHg, HCO3 22 mmol/L; O2 saturation 95.8 %, PaO2/FiO2 ratio 190. The rest of the laboratory results, including the comprehensive metabolic panel, inflammation markers, and pro-B-type natriuretic peptide (pro-BNP), were all within normal limits. Autoimmune and vasculitis panels were negative. Complement levels and immunoglobin levels were all unremarkable. Chest radiographs suggested right lung atelectasis (Fig. 1a). Although D-dimer and FIB were mildly elevated, the patient never complained of any epistaxis or bleeding gums; combined with a normal platelet count and the absence of petechiae and ecchymosis, hemoptysis caused by coagulation dysfunction was not supported. CT was further performed to determine the causes of bleeding, revealing a 2.1 × 3.2  cm2 inhomogeneous tumorous lesion in the right superior mediastinum and a right main bronchus obstruction along with right upper lobe obstructive pneumonia and atelectasis of the right lung, particularly the right middle and lower lobes (Fig. 1b–e). No evidence of pulmonary embolism. Flexible bronchoscopy showed a tumorous protrusion blocking the right main bronchus with active hemorrhage (Fig. 1f, g). Malignancy was suspected. Although the cause of the bleeding was unclear, biopsy was not performed because the irritation produced by the biopsy procedure may have caused rupture of unidentified aneurysms or repeating, massive bleeding. Interventional angiography and bronchial artery embolization (BAE) were performed instead. The arteriogram revealed tortuosity, dilation and hypertrophy of the right bronchial arteries (Fig. 2a). Angiography showed aneurysms of the internal thoracic artery (Fig. 2b). The right bronchial arteries were embolized with 500 μm polyvinyl alcohol particles and gelatin sponges. The aneurysms of the internal thoracic artery were embolized with a metal coil (Fig. 2c, d). A stent was placed in the opening of the right internal thoracic portion of the right subclavian artery. The bleeding completely stopped after BAE. Bronchoscopy was performed again to remove residual materials (Fig. 2e–g). Pathology confirmed these were blood clots (Fig. 2h). The patient recovered soon after the procedure (Fig. 2i) and received regular outpatient follow-up (Fig. 2j, k).

Fig. 1
figure 1

Chest radiograph indicating atelectasis of the right middle and lower lung (a). Computed tomography shows a 2.1 × 3.2 cm2 inhomogeneous tumorous lesion (yellow arrow) in the right superior mediastinum on axial views (b mediastinal windows; c lung windows) and coronal views (d mediastinal windows; e lung windows). Bronchoscopy shows tracheal carina (f) and right-side mainstem bronchus (g) blocked by a tumorous protrusion (green arrow) with active hemorrhage

Fig. 2
figure 2

Arteriogram revealing the tortuosity, dilation and hypertrophy of the right bronchial arteries (a). Aneurysms (yellow arrow) of the internal thoracic artery before (b) and after (c) metal coil embolization. Three-dimensional image shows aneurysms embolized by a metal coil (yellow arrow) (d). Bronchoscopy was used to remove blood clots (g), as confirmed by pathological examination (h), that were blocking the right-sided mainstem bronchus (e) and upper lobe bronchus (f). Chest radiograph indicates reexpansion of the right lung after removal of the clots (i). Follow-up CT shows the metal coil (yellow arrow) and the right lung returned to normal (j axial views; k coronal views)

Discussion and conclusions

Life-threatening hemoptysis is a medical emergency with high mortality presenting with several difficult diagnostic and therapeutic challenges. Identification of the underlying causes is important. A prospective study with 606 patients was performed to investigate the etiology of hemoptysis and revealed that compared with CT scans (77.3% of cases) and bronchoscopy (48.7% of cases), the combination of CT scan and bronchoscopy was able to diagnose the etiology of the hemorrhage in 83.9% of cases [2]. However, there are still some rare causes that can result in a misleading clinical diagnosis, such as antiphospholipid antibody syndrome (APS) [3] and pseudoaneurysm [4]. Additionally, in some cases, the diagnostic procedures involving bronchoscopy were difficult and risky. Maxeiner [5] reported an unfortunate atelectasis patient who died from massive arterial bleeding after a bronchoscopic biopsy, in which a pathologic bronchial artery was violated by the biopsy procedure. Unless for airway control and isolation of the bleeding airway, for patients whose life-threatening hemoptysis has an unknown cause, bronchoscopy should be performed cautiously. Interventional angiography combined with BAE may be an alternative option. BAE can help in diagnosing and controlling the bleeding since 90% of massive hemoptysis cases emanate from the bronchial vasculature [1]. Miyano et al. [6] reported that, irrespective of the underlying causes, BAE could achieve up to a 93.3% successful treatment rate in massive hemoptysis management. Controlling the active hemorrhage may serve as a cornerstone for the subsequent management process for life-threatening hemoptysis.

ITA aneurysms are rare and commonly misdiagnosed as malignant tumors [7,8,9]. They usually occur in patients after sternotomy, endovascular procedures, trauma, chest wall infections, atherosclerosis, connective tissue diseases, or vasculitis [7,8,9]. Our patient was an otherwise healthy young female, and none of these underlying conditions were found. However, the limitation of our finding is the lack of histological examination for ruling out any possible causes, such as IgG4-related aneurysms, another extremely rare cause of ITA aneurysms [9].

Pregnancy has been reportedly associated with the development of aneurysms, presumably due to the associated hemodynamic and hormonal changes [10, 11]. However, ITA aneurysms in perinatal women have rarely been reported. Morimatsu et al. [10] reported a patient with life-threatening massive hemothorax due to the rupture of an ITA aneurysm after a vaginal delivery. However, there was no evidence linking the ITA aneurysm and the hemoptysis in this patient. However, given the rarity of such events and the considerable risk of producing misleading clinical diagnosis and therapeutic options, a detailed presentation of our findings might be helpful for life-threatening hemoptysis management. To the best of our knowledge, this is the first report of life-threatening hemoptysis concomitant with ITA aneurysms in perinatal women. BAE could be used as a first-line treatment irrespective of the underlying causes.

Availability of data and materials

All data generated or analyzed during this study are included in this published article.





Thrombin time


Prethrombin time ratio


Activated partial thromboplastin time


Prothrombin time


International normalized ratio


Mean corpuscular volume


Mean corpuscular hemoglobin


Mean corpuscular-hemoglobin concentration


Computed tomography


Bronchial artery embolization


Internal thoracic artery


Pro-B-type natriuretic peptide


Activated partial thromboplastin time


Antiphospholipid antibody syndrome


  1. Davidson K, Shojaee S. Managing massive hemoptysis. Chest. 2020;157:77–88.

    Article  Google Scholar 

  2. Mondoni M, Carlucci P, Job S, Parazzini EM, Cipolla G, Pagani M, et al. Observational, multicentre study on the epidemiology of haemoptysis. Eur Respir J. 2018;51:1701813.

    Article  Google Scholar 

  3. Hyde R, Runnstrom M, Anderson A, Riley L, Ataya A. Primary antiphospholipid syndrome associated Liebman–Sachs endocarditis leading to diffuse alveolar hemorrhage: a case report. Respir Med Case Rep. 2018;25:181–3.

    PubMed  PubMed Central  Google Scholar 

  4. Albogami S, Touman AA. Rasmussen’s pseudoaneurysm—case report. Respir Med Case Rep. 2018;25:150–3.

    PubMed  PubMed Central  Google Scholar 

  5. Maxeiner H. Lethal hemoptysis caused by biopsy injury of an abnormal bronchial artery. Chest. 2001;119:1612–5.

    Article  CAS  Google Scholar 

  6. Miyano Y, Kanzaki M, Onuki T. Bronchial artery embolization: first-line option for managing massive hemoptysis. Asian Cardiovasc Thorac Ann. 2017;25:618–22.

    Article  Google Scholar 

  7. Heyn J, Zimmermann H, Klose A, Luchting B, Hinske C, Sadeghi-Azandaryani M. Idiopathic internal mammary artery aneurysm. J Surg Case Rep. 2014;2014:rju125.

    Article  Google Scholar 

  8. Piffaretti G, Carrafiello G, Franchin M, Ierardi AM, Mariscalco G, Castelli P, et al. Stent-graft repair of a true internal thoracic artery aneurysm. Ann Vasc Surg. 2015;29:1452.e11-5.

    PubMed  Google Scholar 

  9. Ho K, Joshi P, Wong D, Brusch A, Hockley J, Jansen S. Hybrid treatment of an isolated immunoglobulin G4-related internal thoracic artery aneurysm. J Vasc Surg Cases Innov Tech. 2018;4:331–4.

    Article  Google Scholar 

  10. Morimatsu Y, Koga T, Akiyoshi H, Koganemaru M, Sakamoto T, Aizawa H. Massive hemothorax due to rupture of internal thoracic artery aneurysm after vaginal delivery. Acta Obstet Gynecol Scand. 2007;86:504–5.

    Article  Google Scholar 

  11. Nussbaum ES, Goddard JK, Davis AR. A systematic review of intracranial aneurysms in the pregnant patient-a clinical conundrum. Eur J Obstet Gynecol Reprod Biol. 2020;254:79–86.

    Article  Google Scholar 

Download references


We thank Yongrou Yu, Guangdong Pharmaceutical University, Guangdong, China, for data acquisition.


This work was funded by the Natural Science Foundation of Guangdong, China (2021A1515012123); Science and Technology Program of Guangzhou, China (202002030036 and 202102010018); Guangdong Medical Science and Technology Research Fund (A2021013); Guangzhou Health Science and Technology Project (20211A011007). Funding, For data collection, manuscript creation and revision.

Author information

Authors and Affiliations



YL and YW discussed the data and wrote the manuscript. ZL, XH, ZM and CP helped discuss the data and finalize the manuscript. GC and DlZ provided the 3D images and finalized the manuscript. ZZ and SW planned and supervised the report. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Shuquan Wei.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Written consent was obtained from the patient for personal or clinical details along with any identifying images to be published in this study.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, Y., Wang, Y., Liang, Z. et al. Life-threatening hemoptysis accompanied by internal thoracic artery aneurysms in a 28-year-old perinatal woman: a case report. BMC Pulm Med 21, 171 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: