Skip to main content

Living conditions and autonomy levels in COPD patients receiving non-invasive ventilation: impact on health related quality of life



Research on health-related quality of life (HRQL) has become increasingly important in recent decades. However, the impact of both living conditions and the level of autonomy impairments on HRQL in COPD patients receiving non-invasive ventilation (NIV) is still unclear.


The Severe Respiratory Insufficiency Questionnaire (SRI) was used to measure HRQL in a prospective cohort of COPD patients in whom home NIV was already established. Data on sociodemographics, clinical characteristics and standardized levels of autonomy impairment were evaluated. A multiple linear regression analysis was performed to identify the factors associated with a reduced HRQL.


A total of 137 patients (67.0 ± 7.8 years, 45% female) were assessed. The mean SRI Summary Score was 54.1 ± 16.9 (95%CI: 51.1–57.1; N = 127). Regular ambulatory care was provided in 76% of patients, but only 37% underwent pulmonary rehabilitation. Overall, 69% of patients lived with family members, while 31% lived alone (family situation). Autonomy impairment levels were most serious in 3%, serious in 14%, and significant in 29% of patients, while 54% had no impairments at all. Of note, higher levels of autonomy impairment were markedly associated with lower SRI scores (regression coefficient − 6.5 ± 1.1 per level; P < 0.001). In contrast, family situation (0.2 ± 3.0; P = 0.959), ambulatory care by a respiratory specialist (1.7 ± 3.6; P = 0.638), and pulmonary rehabilitation (− 0.8 ± 3.1; P = 0.802) did not appear to influence HRQL. Possible subgroup effects were evident for the factors “impaired autonomy” and “living in a nursing home” (P = 0.016).


A higher level of autonomy impairment has been identified as the major determinant of reduced HRQL in COPD-patients receiving long-term NIV, particularly in those living in a nursing home.

Trial Registration German Clinical Trials Register (DRKS00008759).

Peer Review reports


Long-term non-invasive ventilation (NIV) serves as an established treatment option for patients with chronic respiratory failure arising from various etiologies [1, 2]. COPD patients represent the largest proportion of those receiving long-term NIV therapy [3]. These patients are typically characterized by several co-morbidities, advanced age and severely reduced health-related quality of life (HRQL) [4,5,6,7]. Nevertheless, recent evidence suggests that long-term NIV is beneficial for these patients because it demonstrates the potential of long-term NIV to improve HRQL. [8, 9]. These positive therapy effects on HRQL are particularly evident in COPD patients [10]. However, a recently published meta-analysis reveals inconsistent data, particularly regarding quality of life outcomes due to a lack of disease-related studies [11].

Evidence for the potential benefits of long-term NIV therapy in chronic hypercapnic COPD patients is primarily derived from randomized controlled trials (RCTs) [8]. However, the number of patients ultimately randomized into these studies is typically lower than the number initially screened. For example, according to the landmark study by Murphy and colleagues on hospital readmission or death after an acute COPD exacerbation episode, 296 patients refused to participate, while only 116 patients were eventually randomized. In addition, many other patients (N = 1609) did not end up being randomized for a number of other reasons [12]. Thus, the process for allocating patients to RCTs is generally highly selective, and this also likely pertains to studies investigating complex interventions such as long-term NIV in severely ill patients who usually have a reduced level of autonomy. More specifically, it is possible that patients with impaired autonomy are less likely to be included in RCTs designed to assess the impact of long-term NIV in COPD patients [13].

Furthermore, it has been reported that COPD patients with both the highest degree of autonomy impairment and the need for long-term invasive mechanical ventilation following weaning failure have a severely compromised HRQL [14, 15]. Thus, a lower level of autonomy could have a negative impact on HRQL in COPD patients undergoing long-term NIV. This, however, has not yet been systematically investigated. In addition, it is unclear if HRQL is well preserved in NIV-dependent COPD patients who: (i) live in a nursing home, (ii) live alone instead of with family members, and (iii) do not receive regular outpatient care.

The aim of the present study was to evaluate the determinants of HRQL in patients with COPD on long-term NIV and to assess the health care infrastructure. It was hypothesized that long-term NIV-related HRQL is lower if: (i) patients do not receive regular outpatient care from a respiratory specialist, (ii) patients have not undergone pulmonary rehabilitation, (iii) patients live alone, and (iv) the patient's degree of autonomy is significantly impaired. If so, further RTCs would be needed to warrant the use of long-term NIV as a means of improving HRQL in patients with restricted autonomy and/or unfavourable living conditions.


This prospective, single-centre, observational cohort study was conducted at the Department of Pneumology at Cologne-Merheim Hospital, University Witten/Herdecke. The study protocol was approved by the Institutional Review Board for Human Studies at the University of Witten/Herdecke, and was performed in accordance with the ethical standards laid down in the Declaration of Helsinki (last revision: 2013) [16]. Written informed consent was obtained from all subjects or their legal guardian. The study was prospectively registered at the German Clinical Trials Register (DRKS00008759). The results presented in this article are reported according to the STROBE Statements for cohort studies [17]. The corresponding STROBE statement is available in the Additional file 1: Table S1.

Table 1 Patient characteristics and NIV data


The data were collected over a period of five years from June 2015 to July 2020. Patients who had already been established on non-invasive home mechanical ventilation according to national [1, 2] and international guidelines and recommendations [8] were consecutively screened for eligibility during outpatient follow-up visits or inpatient admissions. Only clinically stable patients in whom COPD was the primary underlying disease that led to the need for long-term NIV were included in the study. Non-COPD patients as well as those with an acute exacerbation (according to GOLD Guidelines) were excluded from the study [18].

Sample size and data collection

Since the study was planned as a pilot study, no formal sample size calculation was performed. At least 120 patients were planned for inclusion to ensure a reliable basis for the statistical analysis of a further study [19].

Data on sex, age, duration of NIV, and the condition associated with NIV initiation were collected for each of the following three groups: (1) patients with stable chronic hypercapnia, (2) patients with persistent hypercapnia following acute hypercapnic exacerbation, and (3) patients with prolonged and unsuccessful weaning; smoking status and index, long-term oxygen therapy (LTOT), ventilator settings and daily use of NIV. Patient adherence defined as the mean time in hours of use per day was determined by a readout of the ventilator’s built-in software. Oxygen was supplied both according to the patient’s individual needs and based on national and international guidelines [20,21,22].

HRQL was assessed by the Severe Respiratory Insufficiency Questionnaire (SRI), which was specifically developed and validated for patients with long-term NIV [6, 23]. The SRI has been shown to be particularly valuable for patients with COPD and chronic respiratory failure who require treatment with LTOT and/or long-term NIV [6, 24]. The SRI contains 49 items with 7 subscales that measure different aspects of HRQL (Respiratory Complaints, Physical Functioning, Attendant Symptoms and Sleep, Social Relationships, Anxiety, Psychological Well-Being, Social Functioning). Each subscale produces a score (0–100), with lower scores indicating a poorer HRQL. The subscales can be aggregated into one Summary Scale.

Following topic-focused interviews, further information on both home environment (nursing home vs. private home) and family situation (living alone vs. living with any family member) was provided; occupational status was also assessed. Finally, the use of the different parts of the health care infrastructure was determined: 1. Had patients ever received pulmonary rehabilitation? (yes vs. no), and 2. Does regular ambulatory care by a respiratory specialist take place? (yes vs. no).

Finally, the level of autonomy impairment was graded for each patient. For this purpose, the German health care system requires that all patients with impairments are externally evaluated by the Health Insurance Medical Service (Medizinischer Dienst der Krankenversicherung) according to standard criteria [25]. Accordingly, five impairment levels are defined: minor impairments (level 1), significant impairments (level 2), serious impairments (level 3), most serious impairments (level 4), most severe impairments to independence or ability that are associated with significant challenges for nursing care (level 5).

Data management and statistical analysis

Once collected, all data were entered into a standardised case report form (CRF), subsequently documented in a pseudonymous fashion, and archived electronically. The impact of the patient's care, family situation, and level of autonomy on HRQL was assessed. SRI scores were used only for the calculation if the proportion of missing values were less than 10%.

For the purpose of the study, a descriptive univariate analysis was performed by calculating the mean for each group classified by the manifestation of the variable separately (e.g. respiratory specialist, yes vs. no), with their 95% confidence interval (95% CIs). A multiple linear regression analysis was subsequently performed to assess the adjusted impact of the individual variables on HRQL. As a supplemental analysis, a linear regression analysis was conducted to investigate possible effects of different combinations of health care indicators.


A total of 273 patients were screened for eligibility, with 136 of them ultimately excluded from the study (Fig. 1). A total of 137 patients with COPD and pre-existing NIV were enrolled, with 127 patients (91%) having completed the SRI. Complete data sets were analysed to determine the attributes “level of autonomy impairment”, “pulmonary rehabilitation” and “family situation”. For the attribute “ambulatory care by a respiratory specialist”, data from one patient was not entered (data available from the remaining 99.3%).

Fig. 1

Flow diagram of subject recruitment and data availability. n Number; OSAS obstructive sleep apnea syndrome; OHS obesity hypoventilation syndrome; NMD neuromuscular diseases; SRI severe respiratory insufficiency questionnaire

Patient characteristics and data on NIV treatment are presented in Table 1. Regarding occupational status, 10% of patients were still employed or employable, while 24% were unemployable and 66% were retired. In addition, 95% of the patients lived in a private home environment, while just 5% lived in a nursing home. Data on patient care, family situation and autonomy level are illustrated in Fig. 2. Of note, 69 patients (54%) did not qualify for any level of impairment as externally graded by the Health Insurance Medical Service. Conversely, 58 patients (46%) were assigned an externally defined level of impairment, as outlined in Fig. 2. The mean SRI score was 54.1 ± 16.9 (95%CI 51.1–57.1). Detailed data on HRQL are provided in Table 2.

Fig. 2

Patient care, family situation and autonomy level in COPD patients receiving long-term NIV (N = 137)

Table 2 Severe Respiratory Insufficiency Questionnaire (SRI) scores (n = 127)

The results of univariate analysis of the SRI Summary Scale in terms of patient care, family situation and autonomy level are presented in Table 3. A multiple linear regression analysis of the SRI Summary Scale in relation to patient care, family situation and autonomy level is presented in Table 4. Importantly, SRI Summary Scale scores were mainly influenced by the level of autonomy impairment. Here, a higher level of impairment was predictive for a lower SRI Summary Scale score (− 6.5 ± 1.1; p ≤ 0.001), whereas family situation (0.2 ± 3.0; p = 0.959), no routine visits by pneumologist (1.7 ± 3.6; p = 0.638) or pneumological rehabilitation (− 0.8 ± 3.1; p = 0.802) was not associated with lower HRQL. The results of the SRI subscale scores are shown in Additional file 1: Tables S2, S3 and S4. The strong reductions in HRQL in patients with a higher impairment level of autonomy are evident in the subscales for physical functioning and anxiety (Fig. 3). The group of patients living in a nursing home was analysed separately in terms of demographic characteristics (Additional file 1: Table S5). A possible interaction effect was shown, whereby the combination of impaired level of autonomy and living in a nursing home particularly deteriorates HRQL (p = 0.016). Likewise, the factors "impairment levels of autonomy" and "living alone" trended towards a possible interaction effect (p = 0.097).

Table 3 Univariate analysis of the summary score of the severe respiratory insufficiency questionnaire (SRI) in relation to patient care, family situation and autonomy level (n = 127)
Table 4 Multiple linear regression analysis of the summary score of the Severe Respiratory Insufficiency Questionnaire (SRI) in relation to patient care, family situation and autonomy level, adjusted for different variables (n = 127)
Fig. 3

Domains of the Severe Respiratory Insufficiency (SRI) Questionnaire in patients receiving long-term non-invasive ventilation in the home setting (n = 127). RC: Respiratory complaints; PF: physical functioning; AS: attendant symptoms and sleep; SR: social relationships; AX: anxiety; WB: psychological well-being; SF: social functioning; SS: summary scale


The results of this study highlight the heterogeneous healthcare landscape of NIV-treated COPD patients, with particular emphasis on HRQL. The three main results are as follows: Firstly, there is lack of patient care following NIV establishment—at least in some patients—since 24% do not have regular outpatient follow-up by a respiratory specialist, while 63% had never undergone pulmonary rehabilitation. Secondly, impairments in autonomy were evident in many patients, with 46% of all patients having significant, serious or most serious impairments, as defined by standard German assessment criteria [25]. Thirdly, and most importantly, when HRQL was specifically measured by the SRI, it was found to be dramatically reduced in patients with higher levels of autonomy impairment, especially in those patients living in a nursing home.

These findings raise some important clinical considerations. The recent task force of the European Respiratory Society on “Long-term home NIV for the management of COPD” suggests the use of long-term NIV in chronic hypercapnic COPD-patients. This is primarily based on scientifically established improvements in subjective measures, which most importantly include HRQL. Several studies that applied the highly specific SRI reported improvements in the SRI Summary Scale after NIV initiation, ranging from no improvements to up to 11 points [12, 26,27,28]. However, the current study  shows that lower mean SRI scores were associated with higher levels of autonomy impairments. Here, NIV patients with serious and most serious levels of autonomy impairment had lower SRI scores than patients in all previous trials who had hypercapnic COPD prior to NIV commencement [12, 26,27,28,29].

Interestingly, a lack of outpatient pulmonary follow-up and rehabilitation did not have an impact on specific aspects of HRQL in COPD patients with long-term NIV. In addition, the patient's family situation did not influence HRQL. Thus, the level of autonomy impairment forms the major determinant of HRQL in these patients. Importantly, both physical and psychological aspects of HRQL were affected by autonomy impairments, particularly in terms of physical functioning and anxiety.

The pertinence of autonomy levels to HRQL has potentially important consequences, whereby we put forward two major suggestions: Firstly, in COPD patients with chronic hypercapnic failure who are subjected to long-term NIV treatment, all efforts should be made to improve the degree of autonomy. However, whether this actually leads to improvements in HRQL should be addressed in future trials. This also holds true for the question of whether pulmonary rehabilitation is capable of ameliorating these impairments and hence HRQL.

Secondly, future studies should address the question of whether long-term NIV therapy also leads to an improvement in HRQL in those patients who continue to have severely impaired levels of autonomy, even after long-term NIV has been established [12, 29]. Especially in patients who continue to have severely impaired levels of autonomy, therapy should be critically evaluated with regard to its necessity and potential modifications of the therapy regimen should also be discussed in collaboration with the patient. Indeed, recent studies have raised ethical concerns about the continuation of long-term mechanical ventilation in COPD patients with long-term invasive mechanical ventilation and severely impaired autonomy, especially when they have a severely reduced HRQL [14, 15, 30, 31]. Of note, these studies also showed that a poor HRQL was associated with the wish to stop mechanical ventilation, which would invariably lead to the death of the patient. Thus, palliative care for those who ultimately waive the option of NIV therapy should also be discussed for this patient group. Overall, this is an important topic that requires further investigation.

One limitation of this study is that it was designed as a single centre investigation in a single country. Even though the generalisation of the findings should be viewed with caution, the impact of autonomy levels on HRQL are suggested to be globally valid, particularly in view of the meaningful and sound results of the present study. In addition, we cannot exclude that the results are influenced by further confounders. Further studies are needed to identify the specific groups of patients who will benefit most from NIV therapy.


In summary, there are dramatic differences in HRQL amongst COPD patients with established long-term NIV, depending on the degree of autonomy impairment. Patients with either serious or most serious impairments have lower SRI scores than all of those previously reported in RCTs for COPD patients yet to commence NIV therapy. Thus, the present study has clearly identified the association of the level of autonomy impairments and health-related quality of life in severely ill COPD patients undergoing long-term NIV therapy.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.



Confidence interval


Chronic obstructive pulmonary disease


Case report form


Health-related quality of life


Long-term oxygen therapy


Non-invasive ventilation


Randomized controlled trials


Severe Respiratory Insufficiency Questionnaire


  1. 1.

    Windisch W, Geiseler J, Simon K, Walterspacher S, Dreher M, on behalf of the Guideline C. German National Guideline for Treating Chronic Respiratory Failure with Invasive and Non-Invasive Ventilation - Revised Edition 2017: Part 2. Respiration. 2018;96(2):171–203.

  2. 2.

    Windisch W, Geiseler J, Simon K, Walterspacher S, Dreher M, on behalf of the Guideline C. German National Guideline for Treating Chronic Respiratory Failure with Invasive and Non-Invasive Ventilation: Revised Edition 2017: Part 1. Respiration. 2018;96(1):66–97.

  3. 3.

    Cantero C, Adler D, Pasquina P, Uldry C, Egger B, Prella M, et al. Long-term noninvasive ventilation in the Geneva Lake Area: indications, prevalence, and modalities. Chest. 2020;158(1):279–91.

    Article  Google Scholar 

  4. 4.

    Cavaillès A, Brinchault-Rabin G, Dixmier A, Goupil F, Gut-Gobert C, Marchand-Adam S, et al. Comorbidities of COPD. Eur Respir Rev. 2013;22(130):454–75.

    Article  Google Scholar 

  5. 5.

    Duiverman ML. Noninvasive ventilation in stable hypercapnic COPD: what is the evidence? ERJ Open Res. 2018;4(2):00012–2018.

    Article  Google Scholar 

  6. 6.

    Windisch W, Budweiser S, Heinemann F, Pfeifer M, Rzehak P. The severe respiratory insufficiency questionnaire was valid for COPD patients with severe chronic respiratory failure. J Clin Epidemiol. 2008;61(8):848–53.

    Article  Google Scholar 

  7. 7.

    Windisch W. Quality of life in home mechanical ventilation study g. Impact of home mechanical ventilation on health-related quality of life. Eur Respir J. 2008;32(5):1328–36.

    Article  Google Scholar 

  8. 8.

    Ergan B, Oczkowski S, Rochwerg B, Carlucci A, Chatwin M, Clini E, et al. European respiratory society guidelines on long-term home non-invasive ventilation for management of COPD. Eur Respir J. 2019;54(3):1901003.

    Article  Google Scholar 

  9. 9.

    Majorski DS, Duiverman ML, Windisch W, Schwarz SB. Long-term noninvasive ventilation in COPD: current evidence and future directions. Expert Rev Respir Med. 2021;15:89–101.

    CAS  Article  Google Scholar 

  10. 10.

    Valko L, Baglyas S, Gyarmathy VA, Gal J, Lorx A. Home mechanical ventilation: quality of life patterns after six months of treatment. BMC Pulm Med. 2020;20(1):221.

    Article  Google Scholar 

  11. 11.

    Wilson ME, Dobler CC, Morrow AS, Beuschel B, Alsawas M, Benkhadra R, et al. Association of home noninvasive positive pressure ventilation with clinical outcomes in chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2020;323(5):455–65.

    Article  Google Scholar 

  12. 12.

    Murphy PB, Rehal S, Arbane G, Bourke S, Calverley PMA, Crook AM, et al. Effect of home noninvasive ventilation with oxygen therapy vs oxygen therapy alone on hospital readmission or death after an acute copd exacerbation: a randomized clinical trial. JAMA. 2017;317(21):2177–86.

    Article  Google Scholar 

  13. 13.

    Saturni S, Bellini F, Braido F, Paggiaro P, Sanduzzi A, Scichilone N, et al. Randomized controlled trials and real life studies Approaches and methodologies: a clinical point of view. Pulm Pharmacol Ther. 2014;27(2):129–38.

    CAS  Article  Google Scholar 

  14. 14.

    Huttmann SE, Magnet FS, Karagiannidis C, Storre JH, Windisch W. Quality of life and life satisfaction are severely impaired in patients with long-term invasive ventilation following ICU treatment and unsuccessful weaning. Ann Intensive Care. 2018;8(1):1–9.

    CAS  Article  Google Scholar 

  15. 15.

    Huttmann SE, Windisch W, Storre JH. Invasive home mechanical ventilation: living conditions and health-related quality of life. Respiration. 2015;89(4):312–21.

    Article  Google Scholar 

  16. 16.

    World Medical A. World medical association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191–4.

    Article  Google Scholar 

  17. 17.

    von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806–8.

    Article  Google Scholar 

  18. 18.

    Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report: gold executive summary. Arch Bronconeumol. 2017;53(3):128–49.

    Article  Google Scholar 

  19. 19.

    Viechtbauer W, Smits L, Kotz D, Budé L, Spigt M, Serroyen J, et al. A simple formula for the calculation of sample size in pilot studies. J Clin Epidemiol. 2015;68(11):1375–9.

    Article  Google Scholar 

  20. 20.

    Haidl P, Jany B, Geiseler J, Andreas S, Arzt M, Dreher M, et al. Leitlinie zur Langzeit-Sauerstofftherapie. Pneumologie. 2020;74(12):813–41.

    CAS  Article  Google Scholar 

  21. 21.

    Balfour-Lynn I, Field D, Gringras P, Hicks B, Jardine E, Jones R, et al. BTS guidelines for home oxygen in children. Thorax. 2009;64(2):1–26.

    Google Scholar 

  22. 22.

    Magnet FS, Schwarz SB, Callegari J, Criée C-P, Storre JH, Windisch W. Long-term oxygen therapy: comparison of the German and British Guidelines. Respiration. 2017;93(4):253–63.

    Article  Google Scholar 

  23. 23.

    Windisch W, Freidel K, Schucher B, Baumann H, Wiebel M, Matthys H, et al. The severe respiratory insufficiency (SRI) questionnaire: a specific measure of health-related quality of life in patients receiving home mechanical ventilation. J Clin Epidemiol. 2003;56(8):752–9.

    Article  Google Scholar 

  24. 24.

    Walterspacher S, July J, Kohlhäufl M, Rzehak P, Windisch W. The severe respiratory insufficiency questionnaire for subjects with COPD with long-term oxygen therapy. Respir Care. 2016;61(9):1186–91.

    Article  Google Scholar 

  25. 25.

    König J. Das neue Begutachtungsinstrument: Feststellung der Pflegebedürftigkeit durch den MDK: gezielt vorbereiten–souverän meistern. In: Der perfekte Weg zum richtigen Pflegegrad. Schlütersche Germany; 2016.

  26. 26.

    Duiverman ML, Wempe JB, Bladder G, Vonk JM, Zijlstra JG, Kerstjens HA, et al. Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients: a randomized controlled trial. Respir Res. 2011;12(1):1–10.

    Article  Google Scholar 

  27. 27.

    Köhnlein T, Windisch W, Köhler D, Drabik A, Geiseler J, Hartl S, et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. Lancet Respir Med. 2014;2(9):698–705.

    Article  Google Scholar 

  28. 28.

    Struik F, Sprooten R, Kerstjens H, Bladder G, Zijnen M, Asin J, et al. Nocturnal non-invasive ventilation in COPD patients with prolonged hypercapnia after ventilatory support for acute respiratory failure: a randomised, controlled, parallel-group study. Thorax. 2014;69(9):826–34.

    CAS  Article  Google Scholar 

  29. 29.

    Schwarz SB, Callegari J, Hamm C, Windisch W, Magnet FS. Is outpatient control of long-term non-invasive ventilation feasible in chronic obstructive pulmonary disease patients? Respiration. 2018;95(3):154–60.

    Article  Google Scholar 

  30. 30.

    Windisch W. Home mechanical ventilation: who cares about how patients die? Eur Respir Soc. 2010;35:955.

    CAS  Article  Google Scholar 

  31. 31.

    Vitacca M, Grassi M, Barbano L, Galavotti G, Sturani C, Vianello A, et al. Last 3 months of life in home-ventilated patients: the family perception. Eur Respir J. 2010;35(5):1064–71.

    CAS  Article  Google Scholar 

Download references


We acknowledge all participants for the effort they devoted to this study. We acknowledge Dr. Sandra Dieni, Ph.D. for helpful comments on the manuscript before submission.


Open Access funding enabled and organized by Projekt DEAL.

Author information




SBS: Substantial contributions to the conception and design of the work, interpretation of data, drafting the work, revising the document critically for intellectual content; TM: Substantial contributions to the conception and design of the work, statistical analysis, drafting the work, revising the document critically for intellectual content; DSM: Drafting the work, acquisition, analysis, and interpretation of data; MWS: drafting the work, acquisition, analysis, and interpretation of data; DK: acquisition and data management; FSM: conception and design of the work, interpretation of data; WW: Substantial contributions to the conception and design of the work, interpretation of data, drafting the work, revising the document critically for intellectual content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Wolfram Windisch.

Ethics declarations

Ethics approval and consent to participate

The study protocol was approved by the Institutional Review Board for Human Studies at the University of Witten/Herdecke. Written informed consent was obtained from all subjects or their legal guardian.

Consent for publication

Not applicable.

Competing interests

The author group is funded by the Innovation Fund for Health Services Research (01VSF1905) of the German Federal Joint Committee. The Cologne study group (SBS, DSM, MWS, WW) received open research grants from Weinmann/Germany, Vivisol/Germany, Heinen und Löwenstein/Germany, VitalAire/Germany, and Phillips Respironics/USA. SBS received travel grants from companies dealing with mechanical ventilation products; DSM received open research grant from Philips Respironics/USA. TM, MWS and DK have nothing to declare; FSM received speaking fees from companies dealing with mechanical ventilation products. WW received speaking fees from companies dealing with mechanical ventilation products.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Additional file 1.

Supplementary Tables.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Schwarz, S.B., Mathes, T., Majorski, D.S. et al. Living conditions and autonomy levels in COPD patients receiving non-invasive ventilation: impact on health related quality of life. BMC Pulm Med 21, 255 (2021).

Download citation


  • Non-invasive ventilation
  • Quality of life
  • Impairment of autonomy
  • COPD