The economic burden of pulmonary arterial hypertension in Spain

BMC Pulmonary Medicine

Table 4 IC resource consumption during 1-year follow-up by FC, and unit costs

	Frequency of lost work (number of hours or % of patients)				Unit cost (€)
	FC I-II	FC III	FC IV	Ref	EUR	Ref
Labour productivity losses
Reduction of working hours	7%	0%	0%	[39]	6.14€	[105]
Work days lost due to disability	180	0	0	[18]	15.23€	[83]
Temporary leave	20%	0%	0%	[39]
Permanent leave	53%	86%	100%	[39]
Early retirement	7%	14%	0%	[39]
Total Time lost	119.1	138.1	358.4
Time lost due to medical visits	17.5	25.7	43.6	[66, 67]	15.23€	[83]
Time lost due to hospitalisations	74.9	87.4	183.4	[67]
Time lost due to supportive services	17.7	13.0	113.4	[39]
Time lost due to tests	9.0	12.0	18.0	[10, 68]

(1) For early retirement and permanent disability leave, losses of 100% of working hours (1,581 h per year) were considered. (2) For temporary leave, 75% of the annual working hours (1,191 h) were considered. (3) In the HPE-ORG survey, out of 2 patients who reported a reduction in working hours, only 1 gave details on the size of this reduction (40%, 632 h per year). (4) In the study by Joish (2014), 180 h lost (29.6 days) were reported per patient with PAH. It was assumed that all these hours are lost by patients in FC I-II, since all patients in the other classes have a 100% loss due to other causes. (5) The cost / hour for all types of job loss is based on the annual wages of all occupations, both sexes, from the INE. The exception is the unit cost of the reduction of the working day, which is based on the average wages of all the part-time occupations of the INE

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