Skip to main content

Table 3 Logistic regression analyses for multiple organ involvement in sarcoidosis

From: Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis

 

Univariate analysis

Multivariate analysis

Set 1

Set 2

Set 3

Variables

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Agea

0.98 (0.95–1.02)

0.339

0.99 (0.94–1.04)

0.716

0.98 (0.93–1.02)

0.300

1.01 (0.95–1.06)

0.815

Sex, male

0.55 (0.18–1.67)

0.293

0.64 (0.15–2.67)

0.537

0.53 (0.13–2.19)

0.383

0.72 (0.16–3.25)

0.664

BMIb

1.01 (0.82–1.25)

0.930

      

Serum ACE, ≥ 21.4 IU/L

1.08 (0.99–1.18)

0.096

2.41 (0.64–9.14))

0.196

2.40 (0.64–9.03)

0.195

2.53 (0.62–10.30)

0.195

Radiographic stage, ≥ II

1.27 (0.41–3.95)

0.676

      

Pulmonary function test

        

FVC % predictedc

0.97 (0.93–1.02)

0.240

      

FEV1/FVCc

1.00 (0.98–1.01)

0.692

      

Bronchoalveolar lavage

        

 Lymphocytesc

1.01 (0.97–1.04)

0.767

      

 CD4/CD8 ratio, ≥ 3.5

0.99 (0.29–3.39)

0.992

      

n-3 PUFAs, high

0.23 (0.07–0.74)

0.013

0.33 (0.09–1.24)

0.101

    

n-6 PUFAs, high

0.30 (0.09–1.05)

0.059

  

0.43 (0.11–1.67)

0.225

  

n-3/n-6 ratio, high

0.16 (0.05–0.53)

0.003

    

0.14 (0.03–0.61)

0.009

SFAs, high

0.16 (0.03–0.76)

0.022

0.25 (0.05–1.35)

0.107

0.25 (0.05–1.34)

0.105

0.16 (0.03–0.96)

0.045

MUFAs, high

1.00 (0.18–5.69)

1.000

      
  1. The cutoff value for each long-chain fatty acid was determined by the Youden Index in receiver operating characteristic curve analysis (Supplementary Table 2). The Akaike Information criteria for Sets 1, 2, and 3 were 74.1, 75.4, and 69.1, respectively. OR, odds ratio; CI, confidence interval; BMI, body mass index; ACE, angiotensin-converting enzyme; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 s; SFAs, saturated fatty acids; PUFAs, polyunsaturated fatty acids; MUFAs, monounsaturated fatty acids
  2. aPer 1-year increase
  3. bPer 1-kg/m2 increase
  4. cPer 1% increase