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Fig. 7 | BMC Pulmonary Medicine

Fig. 7

From: miR-125b-5p upregulation by TRIM28 induces cisplatin resistance in non-small cell lung cancer through CREB1 inhibition

Fig. 7

TRIM28 induces DDP resistance in NSCLC by upregulating the expression of miR-125b-5p. A CCK8 assay to detect DDP resistance in TRIM28 plasmid/ TRIM28 siRNA-treated A549/DDP cells. B, C Apoptosis analysis in A549/DDP cells following transfection using TRIM28 plasmid/TRIM28 siRNA upon treatment with the indicated concentrations of DDP (6.25 μg/mL). D CCK8 assay was used to detect DDP resistance in A549/DDP cells upon stimulation with the indicated concentrations of DDP (6.25 μg/mL) for the following conditions: a. Control mimic + Control siRNA; b. Control mimic + TRIM28 siRNA; c. miR-125b-5p mimic + Control siRNA; d. miR-125b-5p mimic + TRIM28 siRNA. E, F Apoptosis analysis for A549/DDP cells following transfection described in D with DDP. **p < 0.01, ***p < 0.001

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BMC Pulmonary Medicine

ISSN: 1471-2466

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