| | Intervention group | P | Control group | P | Intervention group D (T0 minus T1) | Control group D (T0 minus T1) | P |
|---|
T0 | T1 | T0 | T1 |
|---|
6MWD, m | 545 ± 79 | 618 ± 69 | < 0.001 | 525 ± 106 | 526 ± 109 | 0.875 | − 73 ± 24 | − 1 ± 19 | < 0.001 |
Initial Borg-Dyspnea | 0 (0–0.25) | 0 (0–0) | 0.102 | 0 (0–0) | 0 (0–0) | 1 | 0 (0–0.25) | 0 (0–0) | 0.083 |
End Borg-Dyspnea | 2 (0.75–3) | 1 (0.5–1.5) | 0.003 | 1 (0.5–2) | 0.75 (0.5–2) | 0.257 | 1 (0.5–1.75) | 0 (0–0.38) | 0.002 |
Initial Borg-Fatigue | 0 (0–0) | 0 (0–0) | 1 | 0 (0–0) | 0 (0–0) | 1 | 0 (0–0) | 0 (0–0) | 1.0 |
End Borg-Fatigue | 0.5 (0.5–2) | 0.5 (0–1) | 0.016 | 0.75 (0.5–1) | 0.75 (0.5–1) | 1 | 0.5 (0–0.75) | 0 (0–0) | 0.022 |
PETCO2, mmHg | 36 ± 3 | 34 ± 3 | < 0.001 | 36 ± 3 | 36 ± 3 | 0.082 | 2 ± 1 | − 0.25 ± 0.45 | < 0.001 |
- Definition of abbreviations: 6MWD = 6-min walking distance; Initial Borg-Dyspnea = Modified Borg scale for dyspnea at the beginning of the 6-min walk test; End Borg-Dyspnea = Modified Borg scale for dyspnea at the end of the 6-min walk test; Initial Borg-Fatigue = Modified Borg scale for fatigue at the beginning of the 6-min walk test; End Borg-Fatigue = Modified Borg scale for fatigue at the end of the 6-min walk test; PETCO2 = partial pressure of end-tidal carbon dioxide. Data are shown as mean ± SD or median ([Q1, Q3]). T0 refers to the time when subjects were enrolled. T1 refers to the time when subjects were followed up at 2 months after enrollment. D (Difference) refers to the value at T0 minus the value at T1 (D = T0 minus T1). In order to determine the statistical significance, we used independent sample t test, Mann–Whitney U test, paired t-test or Wilcoxon test
