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Table 1 Main results of MR analysis

From: Mendelian randomization analysis to analyze the genetic causality between different levels of obesity and different allergic diseases

Outcome

No. SNP

IVW

MR Egger

OR(95%CI)

p

OR(95%CI)

p

Obesity

     

Childhood allergy (age < 16)

47

1.108(1.003-1.223)

0.043

1.061(0.810-1.389)

0.668

Allergic asthma

47

1.091(1.010-1.179)

0.027

1.078(0.871-1.334)

0.493

Allergic rhinitis

47

1.061(0.994-1.132)

0.075

1.125(0.943-1.342)

0.198

Atopic dermatitis

47

1.097(1.033-1.164)

0.002

1.125(0.957-1.322)

0.161

Eczema

47

1.044(0.984-1.108)

0.151

1.184(1.007-1.391)

0.047

Allergic urticaria

47

1.141(0.995-1.309)

0.059

0.942(0.649-1.368)

0.756

Allergic purpura

47

1.205(0.972-1.493)

0.088

1.178(0.657-2.113)

0.585

Allergic conjunctivitis

47

0.965(0.917-1.015)

0.162

0.998(0.870-1.145)

0.975

Lactose intolerance

47

0.878(0.694-1.112)

0.282

0.926(0.483-1.774)

0.817

Childhood allergy (age < 16)

     

Obesity

27

1.030(0.978-1.084)

0.263

0.986(0.883-1.102)

0.808

Allergic asthma

     

Obesity

37

1.060(1.004-1.119)

0.035

1.061(0.916-1.230)

0.436

Atopic dermatitis

     

Obesity

71

0.989(0.947-1.032)

0.601

1.001(0.906-1.107)

0.980

Obesity class 1

     

Childhood allergy (age < 16)

41

1.165(1.034-1.313)

0.012

1.106(0.805-1.519)

0.538

Allergic asthma

41

1.097(1.004-1.198)

0.040

1.045(0.825-1.324)

0.716

Atopic dermatitis

41

1.085(0.996-1.181)

0.060

1.122(0.893-1.409)

0.330

Obesity class 2

     

Childhood allergy (age < 16)

26

1.110(1.003-1.229)

0.044

1.174(0.894-1.541)

0.262

Allergic asthma

26

0.985(0.911-1.066)

0.714

1.057(0.855-1.308)

0.613

Atopic dermatitis

26

1.046(0.983-1.114)

0.155

1.063(0.896-1.260)

0.492

Obesity class 3

     

Childhood allergy (age < 16)

11

1.090(1.000-1.188)

0.052

0.995(0.745-1.328)

0.971

Allergic asthma

11

1.063(0.983-1.150)

0.128

1.291(1.012-1.645)

0.070

Atopic dermatitis

11

1.064(1.010-1.121)

0.019

1.102(0.926-1.312)

0.301

  1. MR: Mendelian randomization; IVW: Inverse variance weighted; No. SNP: number of SNPs
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BMC Pulmonary Medicine

ISSN: 1471-2466

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