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Table 4 Postoperative complications during hospitalization in the ICU and short-term outcomes of the recipients stratified by preoperative BMI; univariate analysis

From: Impact of recipient and donor pretransplantation body mass index on early postosperative complications after lung transplantation

 

Overall,

N = 304 (100%)

Recipient underweight

N = 41 (13%)

Recipient normal weight

N = 130 (43%)

Recipient overweight/obesity,

N = 133 (44%)

p value

At admission in ICU

 SAPS II score, med [IQR]

44 [39–53]

44 [37–50]

44 [38–52]

44 [39–54]

0.28

 SOFA score, med [IQR]

8 [6–10]

8 [6–9]

8 [6–10]

8 [7–10]

0.23

 Lactatemia > 3 mmol/L, n (%)

108 (36)

16 (39)

42 (32)

50 (38)

0.59

 Lactatemia > 2 mmol/L, n (%)

185 (61)

29 (71)

76 (58)

80 (60)

0.36

Hemodynamic status during hospitalization in ICU

 Duration of catecholamine administration, days, med [IQR]

2 [1–4]

2 [1–3.5]

2 [1–4]

2 [1–5]

0.28

 ECMO support after surgery, n (%)

64 (21)

9 (22)

21 (16)

34 (26)

0.17

 Duration of ECMO support, days, med [IQR]

0 [0–2]

0 [0–1]

0 [0–2]

0 [0–2]

0.15

 Atrial fibrilation, n (%)

114 (38)

12 (29)

46 (36)

56 (43)

0.25

 MOF syndrome, n (%)

100 (33)

14 (34)

39 (30)

47 (36)

0.59

Respiratory complications

 Duration of MV, med [IQR]

3 [1–17]

3[1–12]

3 [1–10]

4 [1–26]

0.091

 PGD, n (%)

161 (53)

17 (41)

60 (46)

84 (63)

0.006

 Grade 3 PGD

117 (38)

14 (34)

40 (31)

63 (47)

0.018

 NBA during hospitalization in ICU, n (%)

89 (29)

8 (20)

30 (23)

51 (39)

0.008

 Duration of NBA administration, days, med [IQR]

0 [0–1]

0 [0–0]

0 [0–1]

0 [0–2]

0.020

 Prone positionning, n (%)

43 (14)

2 (5)

13 (10)

28 (21)

0.007

 Number of sessions of prone positionning, med [IQR]

0 [0–0]

0 [0–0]

0 [0–0]

0 [0–0]

0.011

 Extubation failure, n (%)

55 (22)

9 (27)

27 (25)

19 (18)

0.43

 Tracheostomy for ventilation weaning, n (%)

85 (28)

9 (22)

27 (21)

49 (37)

0.008

Infectious complications

 Septic shock, n (%)

90 (30)

9 (22)

35 (27)

46 (35)

0.19

 Number of pneumonias, med [IQR]

1 [1, 2]

1 [1, 2]

1 [1, 2]

1 [1, 2]

0.41

Renal complications

 AKI, n (%)

145 (48)

21 (51)

59 (46)

65 (49)

0.82

 KDIGO score, med [IQR], n (%)

1 [0–2]

1 [0–2]

1 [0–2]

1 [0–3]

0.29

 KDIGO 3, n (%)

60 (20)

9 (22)

17 (13)

34 (26)

0.036

 Renal replacement therapy, n (%)

48 (16)

7 (17)

14 (11)

27 (20)

0.11

Surgical complications

 Thoracic surgical reintervention, n (%)

61 (20)

7 (17)

25 (19)

29 (22)

0.77

 Abdominal surgery, n (%)

31 (10)

6 (15)

8 (6)

17 (13)

0.10

Other complications

 Bonchial anastomotic dehiscence, n (%)

40 (16)

2 (6)

14 (13)

24 (21)

0.072

 Antibody-mediated rejection, n (%)

81 (27)

10 (24)

32 (25)

39 (30)

0.62

 Acute cellular rejection, n (%)

40 (13)

5 (12)

13 (10)

22 (17)

0.28

Outcome

 Duration of ICU stay, days, med [IQR]

17 [9–31]

18 [10–28]

15 [10–26]

18 [11–41]

0.15

 Death on day-90, n (%)

52 (17)

5 (12)

24 (18)

23 (17)

0.65

 Death at one year, n (%)

86 (28)

9 (22)

37 (28)

40 (30)

0.60

  1. Quantitative variables were compared using Mann-Withney U test; qualitative datas using Chi-2 tests
  2. SAPS II simplified acute physiology score II, SOFA sequential organ failure assessment, ICU intensive care unit, ECMO extracorporeal membrane oxygenation, MOF multiorgan failure, PGD primary graft dysfunction, NBA neuroblocking agent, AKI acute kidney injury, RRT renal replacement therapy, KDIGO kidney disease improving global outcome