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  1. The prognostic value of extravascular lung water indices (EVLWI) has been widely investigated, which is determined by lung ultrasound B-lines. However, the clinical value of lung ultrasound B-lines for determi...

    Authors: Zhen Zhao, Li Jiang, Xiuming Xi, Qi Jiang, Bo Zhu, Meiping Wang, Jin Xing and Dan Zhang
    Citation: BMC Pulmonary Medicine 2015 15:98
  2. Debate exists regarding which endpoints most sensitively reflect day-to-day variation in chronic obstructive pulmonary disease (COPD) symptoms and are most useful in clinical practice to predict COPD exacerbat...

    Authors: Christine R. Jenkins, Dirkje S. Postma, Antonio R. Anzueto, Barry J. Make, Stefan Peterson, Göran Eriksson and Peter M. Calverley
    Citation: BMC Pulmonary Medicine 2015 15:97
  3. Pneumonia is the 2nd leading cause of years of life lost worldwide and is a common cause of adult admissions to hospital in sub-Saharan Africa. Risk factors for adult pneumonia are well characterised in develo...

    Authors: Hannah Jary, Jane Mallewa, Mulinda Nyirenda, Brian Faragher, Robert Heyderman, Ingrid Peterson, Stephen Gordon and Kevin Mortimer
    Citation: BMC Pulmonary Medicine 2015 15:96
  4. Accumulated to-date gene microarray data on Acute Respiratory Distress Syndrome (ARDS) in the Gene Expression Omnibus (GEO) represent a rich source for identifying new unsuspected targets and mechanisms of ARD...

    Authors: Dmitry N. Grigoryev, Dilyara I. Cheranova, Suman Chaudhary, Daniel P. Heruth, Li Qin Zhang and Shui Q. Ye
    Citation: BMC Pulmonary Medicine 2015 15:95
  5. Bacterial infection of the lower respiratory tract is believed to play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and acute exacerbations of COPD (AECOPD). This study inve...

    Authors: Huaying Wang, Xiao Gu, Yuesong Weng, Tao Xu, Zhongming Fu, Weidong Peng and Wanjun Yu
    Citation: BMC Pulmonary Medicine 2015 15:94
  6. Activities of daily living in patients with chronic obstructive pulmonary disease (COPD) are limited by exertional dyspnea and reduced exercise capacity. The aims of the study were to examine longitudinal chan...

    Authors: Bente Frisk, Jon A. Hardie, Birgitte Espehaug, Liv I. Strand, Rolf Moe-Nilssen, Tomas M. L. Eagan, Per S. Bakke and Einar Thorsen
    Citation: BMC Pulmonary Medicine 2015 15:93
  7. The FinnishIPF registry is a prospective, longitudinal national registry study on the epidemiology of idiopathic pulmonary fibrosis (IPF). It was designed to describe the characteristics, management and progno...

    Authors: Jaana Kaunisto, K. Kelloniemi, E. Sutinen, U. Hodgson, A. Piilonen, R. Kaarteenaho, R. Mäkitaro, M. Purokivi, E. Lappi-Blanco, S. Saarelainen, H. Kankaanranta, A. Mursu, M. Kanervisto, E-R. Salomaa and M. Myllärniemi
    Citation: BMC Pulmonary Medicine 2015 15:92
  8. Umeclidinium (UMEC; long-acting muscarinic antagonist) plus vilanterol (VI; long-acting beta2 agonist [LABA]) and the LABA/inhaled corticosteroid fluticasone propionate/salmeterol (FP/SAL) are approved maintenanc...

    Authors: Dave Singh, Sally Worsley, Chang-Qing Zhu, Liz Hardaker and Alison Church
    Citation: BMC Pulmonary Medicine 2015 15:91
  9. Current data for the utility of radial endobronchial ultrasound (EBUS) in investigating peripheral lung lesions (PLLs) has been restricted to populations with low pulmonary tuberculosis (TB) incidence. The aim...

    Authors: Adrian Chan, Anantham Devanand, Su Ying Low and Mariko Siyue Koh
    Citation: BMC Pulmonary Medicine 2015 15:90
  10. There is emerging evidence regarding the efficacy of exercise training to improve exercise capacity for individuals with non-small cell lung cancer (NSCLC). Cardiopulmonary exercise testing (CPET) is the gold ...

    Authors: Catherine L. Granger, Linda Denehy, Selina M. Parry, Joel Martin, Tim Dimitriadis, Maeve Sorohan and Louis Irving
    Citation: BMC Pulmonary Medicine 2015 15:89
  11. Although no report has demonstrated the efficacy of corticosteroid therapy for autoimmune pulmonary alveolar proteinosis (aPAP), we sometimes encounter patients who have received this therapy for various reaso...

    Authors: Keiichi Akasaka, Takahiro Tanaka, Nobutaka Kitamura, Shinya Ohkouchi, Ryushi Tazawa, Toshinori Takada, Toshio Ichiwata, Etsuro Yamaguchi, Masaki Hirose, Toru Arai, Kentaro Nakano, Takahito Nei, Haruyuki Ishii, Tomohiro Handa, Yoshikazu Inoue and Koh Nakata
    Citation: BMC Pulmonary Medicine 2015 15:88
  12. The majority of cases with severe pulmonary alveolar proteinosis (PAP) are caused by auto-antibodies against GM-CSF. A multitude of genetic and exogenous causes are responsible for few other cases. Goal of thi...

    Authors: Matthias Griese, Ralf Zarbock, Ulrich Costabel, Jenna Hildebrandt, Dirk Theegarten, Michael Albert, Antonia Thiel, Andrea Schams, Joanna Lange, Katazyrna Krenke, Traudl Wesselak, Carola Schön, Matthias Kappler, Helmut Blum, Stefan Krebs, Andreas Jung…
    Citation: BMC Pulmonary Medicine 2015 15:87
  13. The significance of commensal oropharyngeal flora (COF) as a potential cause of ventilator-associated pneumonia (VAP) is scarcely investigated and consequently unknown. Therefore, the aim of this study was to ...

    Authors: Johannes B. J. Scholte, Johan I. M. van der Velde, Catharina F. M. Linssen, Helke A. van Dessel, Dennis C. J. J. Bergmans, Paul H. M. Savelkoul, Paul M. H. J. Roekaerts and Walther N. K. A. van Mook
    Citation: BMC Pulmonary Medicine 2015 15:86

    The Erratum to this article has been published in BMC Pulmonary Medicine 2015 15:104

  14. Previously, we showed that treatment with the Rho-kinase inhibitor Y-27632 was able to control airway responsiveness, inflammation, remodeling, and oxidative stress in an animal model of asthma, suggesting tha...

    Authors: Patricia Angeli Pigati, Renato Fraga Righetti, Samantha Souza Possa, Beatriz Saraiva Romanholo, Adriana Palmeira Dias Rodrigues, Anelize Sartori Alves dos Santos, Débora Gonçalves Xisto, Mariana Alves Antunes, Carla Máximo Prado, Edna Aparecida Leick, Milton de Arruda Martins, Patrícia Rieken Macedo Rocco and Iolanda de Fátima Lopes Calvo Tibério
    Citation: BMC Pulmonary Medicine 2015 15:85
  15. Telehealth has the potential to improve asthma management through regular monitoring of lung function and/or asthma symptoms by health professionals in conjunction with feedback to patients. Although the benef...

    Authors: Elida Zairina, Michael J. Abramson, Christine F. McDonald, Jonathan Li, Thanuja Dharmasiri, Kay Stewart, Susan P. Walker, Eldho Paul and Johnson George
    Citation: BMC Pulmonary Medicine 2015 15:84
  16. The maximal expiratory flow at 50 % of the forced vital capacity (MEF50) is the flow where half of forced vital capacity (FVC) remains to be exhaled. A reduced MEF50 has been suggested as a surrogate marker of sm...

    Authors: Gülmisal Güder, Susanne Brenner, Stefan Störk, Matthias Held, Berna DL Broekhuizen, Jan-Willem J Lammers, Arno W Hoes and Frans H Rutten
    Citation: BMC Pulmonary Medicine 2015 15:83
  17. Recruitment maneuvers (RM) and positive end expiratory pressure (PEEP) are the cornerstone of the open lung strategy during ventilation, particularly during acute lung injury (ALI). However, these intervention...

    Authors: Camille Doras, Morgan Le Guen, Ferenc Peták and Walid Habre
    Citation: BMC Pulmonary Medicine 2015 15:82
  18. Idiopathic pulmonary fibrosis (IPF) is a severe and progressive respiratory disease with poor prognosis. Despite the positive outcomes from recent clinical trials, there is still no cure for this disease. Pre-...

    Authors: Louise Organ, Barbara Bacci, Emmanuel Koumoundouros, Garry Barcham, Marjorie Milne, Wayne Kimpton, Chrishan Samuel and Ken Snibson
    Citation: BMC Pulmonary Medicine 2015 15:81
  19. Impaired epithelial barrier function renders the airway vulnerable to environmental triggers associated with the pathogenesis of bronchial asthma. We investigated the influence of protocadherin-1 (PCDH1), a susce...

    Authors: Yutaka Kozu, Yasuhiro Gon, Shuichiro Maruoka, Kuroda Kazumichi, Akiko Sekiyama, Hiroyuki Kishi, Yasuyuki Nomura, Minoru Ikeda and Shu Hashimoto
    Citation: BMC Pulmonary Medicine 2015 15:80
  20. The interleukin 17A (IL-17A) which is located on chromosome 6p and has been linked to chronic inflammation, is an important candidate gene conferring coal workers’ pneumoconiosis (CWP). The purpose of this study ...

    Authors: Ruhui Han, Xiaoming Ji, Baiqun Wu, Ting Wang, Lei Han, Jingjin Yang, Baoli Zhu and Chunhui Ni
    Citation: BMC Pulmonary Medicine 2015 15:79
  21. The clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) positive granulomatosis with polyangiitis (GPA) remain unclear, as does the difference between MPO-ANCA positive G...

    Authors: Satoshi Ikeda, Machiko Arita, Kenta Misaki, Yumiko Kashiwagi, Yuhei Ito, Hirotaka Yamada, Machiko Hotta, Akihiro Nishiyama, Akihiro Ito, Maki Noyama, Takashi Koyama, Kenji Notohara and Tadashi Ishida
    Citation: BMC Pulmonary Medicine 2015 15:78
  22. There are not enough data on the epidemiology of asthma in the Kingdom of Saudi Arabia (KSA). We analyzed data from a national household survey conducted in KSA in 2013 to estimate prevalence, associated risk ...

    Authors: Maziar Moradi-Lakeh, Charbel El Bcheraoui, Farah Daoud, Marwa Tuffaha, Hannah Kravitz, Mohammad Al Saeedi, Mohammed Basulaiman, Ziad A. Memish, Mohammad A. AlMazroa, Abdullah A. Al Rabeeah and Ali H. Mokdad
    Citation: BMC Pulmonary Medicine 2015 15:77
  23. Even through narrowing of the upper-airway plays an important role in the generation of obstructive sleep apnea (OSA), the peripheral airways is implicated in pre-obese and obese OSA patients, as a result of d...

    Authors: Arikin Abdeyrim, Yongping Zhang, Nanfang Li, Minghua Zhao, Yinchun Wang, Xiaoguang Yao, Youledusi Keyoumu and Ting Yin
    Citation: BMC Pulmonary Medicine 2015 15:76
  24. Propionibacterium acnes was found in lungs and lymph nodes of patients with sarcoidosis and may induce hypersensitivity type granuloma formation. Data regarding the immune response to P. acnes of European sarcoid...

    Authors: Jonas Christian Schupp, Sandrine Tchaptchet, Niklas Lützen, Peggy Engelhard, Joachim Müller-Quernheim, Marina A Freudenberg and Antje Prasse
    Citation: BMC Pulmonary Medicine 2015 15:75
  25. Quantitative computed tomography (CT) analysis has been proposed as a means of objectively assessing fibrotic interstitial pneumonia (IP) including idiopathic pulmonary fibrosis (IPF). We investigated whether ...

    Authors: Kiminobu Tanizawa, Tomohiro Handa, Sonoko Nagai, Toyohiro Hirai, Takeshi Kubo, Tsuyoshi Oguma, Isao Ito, Yutaka Ito, Kizuku Watanabe, Kensaku Aihara, Kohei Ikezoe, Toru Oga, Kazuo Chin, Takateru Izumi and Michiaki Mishima
    Citation: BMC Pulmonary Medicine 2015 15:74
  26. We have recently demonstrated the efficacy of balance training in addition to Pulmonary Rehabilitation (PR) at improving measures of balance associated with an increased risk of falls in individuals with Chron...

    Authors: Samantha L. Harrison, Marla K. Beauchamp, Kathryn Sibley, Tamara Araujo, Julia Romano, Roger S. Goldstein and Dina Brooks
    Citation: BMC Pulmonary Medicine 2015 15:73
  27. Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, is predominantly expressed in airway epithelial cells. While SCGB3A2 is known to have anti-inflammatory, growth factor, an...

    Authors: Yan Cai, Mitsuhiro Yoneda, Takeshi Tomita, Reiko Kurotani, Minoru Okamoto, Taketomo Kido, Hiroyuki Abe, Wayne Mitzner, Arjun Guha and Shioko Kimura
    Citation: BMC Pulmonary Medicine 2015 15:72
  28. Although sedation is often required for agitated patients undergoing noninvasive ventilation (NIV), reports on its practical use have been few. This study aimed to evaluate the efficacy and safety of sedation ...

    Authors: Takeshi Matsumoto, Keisuke Tomii, Ryo Tachikawa, Kojiro Otsuka, Kazuma Nagata, Kyoko Otsuka, Atsushi Nakagawa, Michiaki Mishima and Kazuo Chin
    Citation: BMC Pulmonary Medicine 2015 15:71
  29. It has been recognized that despite previous stability some patients with idiopathic pulmonary fibrosis (IPF) experience acute clinical deteriorations called acute exacerbations of idiopathic pulmonary fibrosi...

    Authors: Frunze Petrosyan, Daniel A. Culver and Anita J. Reddy
    Citation: BMC Pulmonary Medicine 2015 15:70
  30. Chronic obstructive pulmonary disease (COPD) patients often have dysphagia through age and several co-morbidities, leading to aspiration pneumonia (AsP). COPD patients also have increased risk of developing co...

    Authors: Yasuhiro Yamauchi, Hideo Yasunaga, Hiroki Matsui, Wakae Hasegawa, Taisuke Jo, Kazutaka Takami, Kiyohide Fushimi and Takahide Nagase
    Citation: BMC Pulmonary Medicine 2015 15:69
  31. Silibinin has been known for its role in anti-cancer and radio-protective effect. Radiation therapy for treating lung cancer might lead to late-phase pulmonary inflammation and fibrosis. Thus, this study aimed...

    Authors: Yeonghoon Son, Hae June Lee, Jin Kyung Rho, Soo Young Chung, Chang Geun Lee, Kwangmo Yang, Sung Ho Kim, Minyoung Lee, In Sik Shin and Joong Sun Kim
    Citation: BMC Pulmonary Medicine 2015 15:68
  32. Staphylococcus aureus (SA) is the most prevalent organism infecting the respiratory tract of CF children, and remains the second most prevalent organism in CF adults. During early childhood, SA infections are ass...

    Authors: Heather G. Ahlgren, Andrea Benedetti, Jennifer S. Landry, Joanie Bernier, Elias Matouk, Danuta Radzioch, Larry C. Lands, Simon Rousseau and Dao Nguyen
    Citation: BMC Pulmonary Medicine 2015 15:67
  33. Silicosis is an occupational disease for which no effective treatment is currently known. Systemic administration of bone marrow-derived mononuclear cells (BMDMCs) has shown to be safe in lung diseases. Howeve...

    Authors: Marcelo M. Morales, Sérgio A. L. Souza, Luiz Paulo Loivos, Marina A. Lima, Amir Szklo, Leandro Vairo, Taís H. K. Brunswick, Bianca Gutfilen, Miquéias Lopes-Pacheco, Alberto J. Araújo, Alexandre P. Cardoso, Regina C. Goldenberg, Patricia R. M. Rocco, Lea M. B. Fonseca and José R. Lapa e Silva
    Citation: BMC Pulmonary Medicine 2015 15:66
  34. Heliox is a mixture of oxygen and helium which reduces airway resistance in patients with airway obstruction. In clinical practice, patients breathing spontaneously receive heliox via an open circuit. Recently...

    Authors: Ivana Jurickova, Karel Roubík and Martin Muller
    Citation: BMC Pulmonary Medicine 2015 15:65
  35. Systemic inflammation is present in chronic obstructive pulmonary disease (COPD). A whey peptide-based enteral diet reduce inflammation in patients with COPD, but its effect on COPD development has not been de...

    Authors: Koichi Tomoda, Kaoru Kubo, Kazuo Dairiki, Taketo Yamaji, Yoshifumi Yamamoto, Yasue Nishii, Atsuhiro Nakamura, Masanori Yoshikawa, Kaoru Hamada and Hiroshi Kimura
    Citation: BMC Pulmonary Medicine 2015 15:64
  36. Exercise has been studied as a prognostic marker for patients with cystic fibrosis (CF), as well as a tool for improving their quality of life and analyzing lung disease. In this context, the aim of the presen...

    Authors: Paloma Lopes Francisco Parazzi, Fernando Augusto de Lima Marson, Maria Angela Gonçalves de Oliveira Ribeiro, Celize Cruz Bresciani de Almeida, Luiz Cláudio Martins, Ilma Aparecida Paschoal, Adyleia Aparecida Dalbo Contrera Toro, Camila Isabel Santos Schivinski and Jose Dirceu Ribeiro
    Citation: BMC Pulmonary Medicine 2015 15:63
  37. Recent vasodilating drugs have improved prognosis of Pulmonary arterial hypertension (PAH). Some reports describe the merits of combination therapies for PAH, and this study evaluated the efficacy and safety o...

    Authors: Mai Kimura, Yuichi Tamura, Makoto Takei, Tsunehisa Yamamoto, Tomohiko Ono, Jun Fujita, Masaharu Kataoka, Masataka Kuwana, Toru Satoh and Keiichi Fukuda
    Citation: BMC Pulmonary Medicine 2015 15:62
  38. The impact of bronchiectasis on sedentary behaviour and physical activity is unknown. It is important to explore this to identify the need for physical activity interventions and how to tailor interventions to...

    Authors: Judy M Bradley, Jason J Wilson, Kate Hayes, Lisa Kent, Suzanne McDonough, Mark A Tully, Ian Bradbury, Alison Kirk, Denise Cosgrove, Rory Convery, Martin Kelly, Joseph Stuart Elborn and Brenda O’Neill
    Citation: BMC Pulmonary Medicine 2015 15:61
  39. Protective ventilation with lower tidal volume (VT) and higher positive end-expiratory pressure (PEEP) reduces the negative additive effects of mechanical ventilation during systemic inflammatory response syndrom...

    Authors: Jesper Sperber, Miklós Lipcsey, Anders Larsson, Anders Larsson, Jan Sjölin and Markus Castegren
    Citation: BMC Pulmonary Medicine 2015 15:60
  40. The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis ...

    Authors: Daniela Savi, Marcello Di Paolo, Nicholas Simmonds, Paolo Onorati, Mattia Internullo, Serena Quattrucci, Banya Winston, Pierantonio Laveneziana and Paolo Palange
    Citation: BMC Pulmonary Medicine 2015 15:59
  41. Little is known about the relationship between hemoglobin concentrations, functional status and health related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD). Our aim was to investigate...

    Authors: Marcello Ferrari, Lorenzo Manea, Kamel Anton, Paola Bruzzone, Mara Meneghello, Francesco Zamboni, Luigi Purgato, Lucia Cazzoletti, Pietro Ferrari and Renato Testi
    Citation: BMC Pulmonary Medicine 2015 15:58
  42. Previous studies indicated that the single nucleotide polymorphisms (SNPs) in TLR9 gene might be associated with Tuberculosis (TB) risk. However, the results are inconsistent and inconclusive.

    Authors: Zhi Chen, Wei Wang, Jianqin Liang, Jinhe Wang, Shisheng Feng and Guangyu Zhang
    Citation: BMC Pulmonary Medicine 2015 15:57
  43. Physical training has been shown to improve exercise capabilities in patients with asthma. Most studies focused on children and younger adults. Previously, the maximum program duration was six months. It is no...

    Authors: Andreas Meyer, Sabine Günther, Timm Volmer, Karin Taube and Hans J Baumann
    Citation: BMC Pulmonary Medicine 2015 15:56
  44. After the SMART trial evaluating the safety of salmeterol (long-acting beta-2-agonist (LABA)) in asthma patients, regulatory actions were taken to promote a guideline-adherent prescribing of LABA only to patie...

    Authors: Marietta Rottenkolber, Rainald Fischer, Luisa Ibáñez, Joan Fortuny, Robert Reynolds, Justyna Amelio, Roman Gerlach, Martin Tauscher, Petra Thürmann, Joerg Hasford and Sven Schmiedl
    Citation: BMC Pulmonary Medicine 2015 15:55
  45. Pompe disease is a progressive metabolic myopathy. Involvement of respiratory muscles leads to progressive pulmonary dysfunction, particularly in supine position. Diaphragmatic weakness is considered to be the...

    Authors: Stephan CA Wens, Pierluigi Ciet, Adria Perez-Rovira, Karla Logie, Elizabeth Salamon, Piotr Wielopolski, Marleen de Bruijne, Michelle E Kruijshaar, Harm AWM Tiddens, Pieter A van Doorn and Ans T van der Ploeg
    Citation: BMC Pulmonary Medicine 2015 15:54
  46. During the pathological destruction of lung tissue, neutrophil elastase (NE) degrades elastin, one of the major constituents of lung parenchyma. However there are no non-invasive methods to quantify NE degrada...

    Authors: Jacob H Kristensen, Morten A Karsdal, Jannie MB Sand, Nicholas Willumsen, Claudia Diefenbach, Birte Svensson, Per Hägglund and Diana J Oersnes-Leeming
    Citation: BMC Pulmonary Medicine 2015 15:53
  47. Dietary nitrate supplementation has been shown to decrease the oxygen cost of exercise and prolong exercise tolerance, as measured by sub-maximal exercise endurance distance and time at 85% V̇O2max, in both elite...

    Authors: Paul Leong, Jane E Basham, Theresa Yong, Adrian Chazan, Paul Finlay, Sara Barnes, Phillip G Bardin and Donald Campbell
    Citation: BMC Pulmonary Medicine 2015 15:52
  48. This pilot study, conducted on a 1/97th representative sample of French claims data, prepared a project to assess the effectiveness of Montelukast (MTL-4) as add-on therapy for asthma in infants (6–24 months) ...

    Authors: Manon Belhassen, Gérard de Pouvourville, Laurent Laforest, Jacques Brouard, Jacques de Blic, Brigitte Fauroux, Valérie Laigle, Céline Chanut-Vogel, Liliane Lamezec and Eric Van Ganse
    Citation: BMC Pulmonary Medicine 2015 15:51
  49. Oxidative stress (OS) and reduced nitric oxide (NO) bioavailability contribute to the pathogenesis of pulmonary hypertension (PH). Whether there are associations between OS and NO signaling biomarkers and whet...

    Authors: Shuai Zhang, Ting Yang, Xiaomao Xu, Meng Wang, Linye Zhong, Yuanhua Yang, Zhenguo Zhai, Fei Xiao and Chen Wang
    Citation: BMC Pulmonary Medicine 2015 15:50
  50. Cystic fibrosis (CF) is a genetic disease characterized by complex polymicrobial communities within the lower respiratory tract. S. pneumoniae, while a well-defined pathogen in the general population, has rarely ...

    Authors: Christina S Thornton, Erin L Brown, Joenel Alcantara, Harvey R Rabin and Michael D Parkins
    Citation: BMC Pulmonary Medicine 2015 15:49

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