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  1. The GOLD 2011 document proposed a new classification system for COPD combining symptom assessment by COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores, and exacerbation risk...

    Authors: Sunmin Kim, Jisun Oh, Yu-Il Kim, Hee-Jung Ban, Yong-Soo Kwon, In-Jae Oh, Kyu-Sik Kim, Young-Chul Kim and Sung-Chul Lim
    Citation: BMC Pulmonary Medicine 2013 13:35
    Content type: Research article Published on:

  2. Gastro-esophageal reflux disease (GERD) predisposes to airway disease through a vagally-mediated esophago-bronchial reflex. This study investigates this vagal response to esophageal acid perfusion.

    Authors: D Lakmali Amarasiri, Arunasalam Pathmeswaran, H Janaka de Silva and Channa D Ranasinha
    Citation: BMC Pulmonary Medicine 2013 13:33
    Content type: Research article Published on:

  3. The role of antibiotics in treating mild or moderate exacerbations in patients with acute chronic obstructive pulmonary disease (COPD) is unclear. The aims were to: (i) describe patient characteristics associa...

    Authors: Rachael Boggon, Richard Hubbard, Liam Smeeth, Martin Gulliford, Jackie Cassell, Susan Eaton, Munir Pirmohamed and Tjeerd-Pieter van Staa
    Citation: BMC Pulmonary Medicine 2013 13:32
    Content type: Research article Published on:

  4. Combined pulmonary fibrosis and emphysema (CPFE) is an umbrella term encompassing upper lobe emphysema and lower lobe pulmonary fibrosis with pathogenesis elusive. The aim of our study was to investigate the i...

    Authors: Argyris Tzouvelekis, George Zacharis, Anastasia Oikonomou, Dimitrios Mikroulis, George Margaritopoulos, Anastasios Koutsopoulos, Antonis Antoniadis, Andreas Koulelidis, Paschalis Steiropoulos, Panagiotis Boglou, Matina Bakali, Marios Froudarakis and Demosthenes Bouros
    Citation: BMC Pulmonary Medicine 2013 13:31
    Content type: Research article Published on:

  5. Immunocompromised patients, particularly after lung transplantation, are at high risk to develop atypical forms of pulmonary infections including influenza A/H1N1. Acute Fibrinous and Organizing Pneumonia (AFO...

    Authors: Claudia Otto, Daniela Huzly, Lars Kemna, Annegret Hüttel, Christoph Benk, Siegbert Rieg, Till Ploenes, Martin Werner and Gian Kayser
    Citation: BMC Pulmonary Medicine 2013 13:30
    Content type: Case report Published on:

  6. Continuous positive airway pressure (CPAP) treatment improves the risk of cardiovascular events in patients suffering from severe sleep apnea-hypopnea syndrome (SAHS) but its effect on the link between delta p...

    Authors: Fabrice Jurysta, Chantal Kempenaers, Jean-Pol Lanquart, André Noseda, Philippe van de Borne and Paul Linkowski
    Citation: BMC Pulmonary Medicine 2013 13:29
    Content type: Research article Published on:

  7. The current study aimed to investigate the release of myocardial high-sensitive Troponin T (hsTnT) in patients with pulmonary arterial hypertension (PAH) in response to maximal physical exercise.

    Authors: Mirko Völkers, David Rohde, Thomas Zelniker, Celine S Weiss, Evangelos Giannitsis, Hugo A Katus and F Joachim Meyer
    Citation: BMC Pulmonary Medicine 2013 13:28
    Content type: Research article Published on:

  8. Laboratory-induced dyspnea (breathing discomfort) in healthy subjects is widely used to study perceptual mechanisms, yet the relationship between laboratory-induced dyspnea in healthy volunteers and spontaneou...

    Authors: Carl R O’Donnell, Richard M Schwartzstein, Robert W Lansing, Tegan Guilfoyle, Daniel Elkin and Robert B Banzett
    Citation: BMC Pulmonary Medicine 2013 13:27
    Content type: Research article Published on:

  9. Indacaterol is a novel, once-daily (od), inhaled, long-acting ß2-agonist bronchodilator for maintenance treatment of airflow limitation in patients with COPD. The aim of this study was to evaluate the efficacy of...

    Authors: Jiangna Han, Lu Dai and Nanshan Zhong
    Citation: BMC Pulmonary Medicine 2013 13:26
    Content type: Research article Published on:

  10. Recently it has been revealed that lung adenocarcinomas with distinct gene mutations or fusions are associated with particular histopathological entities. For example, epidermal growth factor receptor (EGFR) g...

    Authors: Ikuo Matsuda, Kengo Takeuchi, Shinjiro Mizuguchi, Masahide Kaji, Kayo Ueda, Kazuhiro Teramura and Seiichi Hirota
    Citation: BMC Pulmonary Medicine 2013 13:25
    Content type: Case report Published on:

  11. There is little data on the effect of exercise on markers of airway inflammation in human asthmatics. The main objective of this review is to determine the effects of physical training on markers of airway inf...

    Authors: Vanessa Luks, Andrew Burkett, Lucy Turner and Smita Pakhale
    Citation: BMC Pulmonary Medicine 2013 13:24
    Content type: Research article Published on:

  12. We earlier showed that 4-phenylbutyrate (PB) can induce cathelicidin LL-37 expression synergistically with 1,25-dihydroxyvitamin D3 in a lung epithelial cell line. We aimed to evaluate a therapeutic dose of PB al...

    Authors: Akhirunnesa Mily, Rokeya Sultana Rekha, S M Mostafa Kamal, Evana Akhtar, Protim Sarker, Zeaur Rahim, Gudmundur H Gudmundsson, Birgitta Agerberth and Rubhana Raqib
    Citation: BMC Pulmonary Medicine 2013 13:23
    Content type: Research article Published on:

  13. The use of budesonide/formoterol in a single inhaler for both maintenance and reliever therapy is a recommended option for treatment of persistent asthma not responding well to inhaled corticosteroid (ICS) alone.

    Authors: Nanshan Zhong, Jiangtao Lin, Parthiv Mehta, Pintip Ngamjanyaporn, Tzu-Chin Wu and Faisal Yunus
    Citation: BMC Pulmonary Medicine 2013 13:22
    Content type: Research article Published on:

  14. High-frequency airway clearance (HFCWC) assist devices generate either positive or negative trans-respiratory pressure excursions to produce high-frequency, small-volume oscillations in the airways.

    Authors: Antonello Nicolini, Federica Cardini, Norma Landucci, Sergio Lanata, Maura Ferrari-Bravo and Cornelius Barlascini
    Citation: BMC Pulmonary Medicine 2013 13:21
    Content type: Research article Published on:

  15. Leukotriene receptor antagonists (LTRAs) are well established in the management of outpatient asthma. However, there is very little information as to their role in acute asthma exacerbations. We hypothesized t...

    Authors: Ali Bin Sarwar Zubairi, Nawal Salahuddin, Ali Khawaja, Safia Awan, Adil Aijaz Shah, Ahmed Suleman Haque, Shahid Javed Husain, Nisar Rao and Javaid Ahmad Khan
    Citation: BMC Pulmonary Medicine 2013 13:20
    Content type: Research article Published on:

  16. Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In the past, a dose exceeding 15–50 μg w...

    Authors: Ole Janssen, Frank Schaumann, Olaf Holz, Bianca Lavae-Mokhtari, Lutz Welker, Carla Winkler, Heike Biller, Norbert Krug and Jens M Hohlfeld
    Citation: BMC Pulmonary Medicine 2013 13:19
    Content type: Research article Published on:

  17. According to international guidelines, the goal of asthma management is to achieve and maintain control of the disease, which can be assessed using composite measures. Prospective studies are required to deter...

    Authors: Fulvio Braido, Guy Brusselle, Eleonora Ingrassia, Gabriele Nicolini, David Price, Nicolas Roche, Joan B Soriano and Heinrich Worth
    Citation: BMC Pulmonary Medicine 2013 13:18
    Content type: Study protocol Published on:

  18. Favorable effects of formal pulmonary rehabilitation in selected moderate to severe COPD patients are well established. Few data are available on the effects and costs of integrated disease management (IDM) pr...

    Authors: Annemarije L Kruis, Melinde RS Boland, Catharina H Schoonvelde, Willem JJ Assendelft, Maureen PMH Rutten-van Mölken, Jacobijn Gussekloo, Apostolos Tsiachristas and Niels H Chavannes
    Citation: BMC Pulmonary Medicine 2013 13:17
    Content type: Study protocol Published on:

  19. Penicillium species are among the most common fungi present in the environment and are usually considered non-pathogenic to humans. However, in immunocompromised hosts they can be virulent pathogens and can caus...

    Authors: Chiyako Oshikata, Naomi Tsurikisawa, Akemi Saito, Maiko Watanabe, Yoichi Kamata, Maki Tanaka, Takahiro Tsuburai, Hiroyuki Mitomi, Kosuke Takatori, Hiroshi Yasueda and Kazuo Akiyama
    Citation: BMC Pulmonary Medicine 2013 13:16
    Content type: Case report Published on:

  20. Current asthma management guidelines are based on the level of asthma control. The impact of asthma control on health care resources and quality of life (QoL) is insufficiently studied. EUCOAST study was desig...

    Authors: Marianne Doz, Christos Chouaid, Laure Com-Ruelle, Eduardo Calvo, Max Brosa, Julien Robert, Laurent Decuypère, Celine Pribil, Alicia Huerta and Bruno Detournay
    Citation: BMC Pulmonary Medicine 2013 13:15
    Content type: Research article Published on:

  21. F-fluorodeoxyglucose positron emission tomography (FDG-PET) is increasingly used to investigate for malignancy in the evaluation of pulmonary nodules, yet both active tuberculosis (TB) and malignancy have high...

    Authors: Scott K Heysell, Tania A Thomas, Costi D Sifri, Patrice K Rehm and Eric R Houpt
    Citation: BMC Pulmonary Medicine 2013 13:14
    Content type: Case report Published on:

  22. Reduced plasma nitrate (NOx) levels and increased urinary norepinephrine (U-NE) levels have been described in severe obstructive sleep apnea (OSA), and are reverted by continuous positive airway pressure (CPAP). ...

    Authors: Paula Pinto, Cristina Bárbara, Joseph M Montserrat, Rita S Patarrão, Maria P Guarino, Miguel M Carmo, Maria P Macedo, Cristina Martinho, Rita Dias and Maria JM Gomes
    Citation: BMC Pulmonary Medicine 2013 13:13
    Content type: Research article Published on:

  23. Non-invasive mechanical ventilation (NIV) in patients with acute respiratory failure has been traditionally determined based on clinical assessment and changes in blood gases, with NIV support pressures manual...

    Authors: Killen Harold Briones Claudett, Monica Briones Claudett, Miguel Chung Sang Wong, Alberto Nuques Martinez, Ricardo Soto Espinoza, Mayra Montalvo, Antonio Esquinas Rodriguez, Gumersindo Gonzalez Diaz and Michelle Grunauer Andrade
    Citation: BMC Pulmonary Medicine 2013 13:12
    Content type: Research article Published on:

  24. The editors of BMC Pulmonary Medicine would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).

    Authors: Tim Shipley
    Citation: BMC Pulmonary Medicine 2013 13:7
    Content type: Reviewer acknowledgement Published on:

  25. Phenotyping asthma according to airway inflammation allows identification of responders to targeted therapy. Induced sputum is technically demanding. We aimed to identify predictors of sputum inflammatory phen...

    Authors: Florence N Schleich, Maité Manise, Jocelyne Sele, Monique Henket, Laurence Seidel and Renaud Louis
    Citation: BMC Pulmonary Medicine 2013 13:11
    Content type: Research article Published on:

  26. Obstructive sleep apnea (OSA) is a common disease, affecting approximately 2% of women and 4% of men residing in Western communities. No systematically reviewed data are available about the prevalence of this ...

    Authors: Aibek E Mirrakhimov, Talant Sooronbaev and Erkin M Mirrakhimov
    Citation: BMC Pulmonary Medicine 2013 13:10
    Content type: Research article Published on:

  27. The increased use of computed tomography pulmonary angiography (CTPA) is often justified by finding alternative diagnoses explaining patients’ symptoms. However, this has not been rigorously examined.

    Authors: Subani Chandra, Pralay K Sarkar, Divay Chandra, Nicole E Ginsberg and Rubin I Cohen
    Citation: BMC Pulmonary Medicine 2013 13:9
    Content type: Research article Published on:

  28. Interstitial lung disease encompasses a diverse group of chronic lung conditions characterised by distressing dyspnoea, fatigue, reduced exercise tolerance and poor health-related quality of life. Exercise tra...

    Authors: Leona Dowman, Christine F McDonald, Catherine Hill, Annemarie Lee, Kathryn Barker, Claire Boote, Ian Glaspole, Nicole Goh, Annemarie Southcott, Angela Burge, Rebecca Ndongo, Alicia Martin and Anne E Holland
    Citation: BMC Pulmonary Medicine 2013 13:8
    Content type: Study protocol Published on:

  29. The aim of our study was to validate a Greek translation of the Berlin Questionnaire (BQ) for obstructive sleep apnoea syndrome (OSAS) and to explore whether this screening questionnaire could be used to help ...

    Authors: Izolde Bouloukaki, Ioannis D Komninos, Charalampos Mermigkis, Katerina Micheli, Maria Komninou, Violeta Moniaki, Eleni Mauroudi, Nikolaos M Siafakas and Sophia E Schiza
    Citation: BMC Pulmonary Medicine 2013 13:6
    Content type: Research article Published on:

  30. Acute exacerbations of chronic bronchitis (AECB), including chronic obstructive pulmonary disease (AECOPD), represent a substantial patient burden. Few data exist on outpatient antibiotic management for AECB/A...

    Authors: Alexander Chuchalin, Maryna Zakharova, Dejan Dokic, Mahir Tokić, Hans-Peter Marschall and Thomas Petri
    Citation: BMC Pulmonary Medicine 2013 13:5
    Content type: Research article Published on:

  32. Focal ground-glass opacity (GGO) on thin-section computed tomography (CT) may be seen in atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ that has recently been renamed from bronchioloalveolar ca...

    Authors: Noriko Sudo, Atsushi Nambu, Takana Yamakawa, Masashi Kawamoto, Shozo Fujino, Masato Watanabe, Kunio Mizuguchi and Masao Tago
    Citation: BMC Pulmonary Medicine 2013 13:3
    Content type: Case report Published on:

  33. No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function.

    Authors: Alexandra Enocson, Richard Hubbard, Tricia McKeever, Nigel Russell, Jennifer Byrne, Emma Das-Gupta, Lynne Watson and Andrew W Fogarty
    Citation: BMC Pulmonary Medicine 2013 13:2
    Content type: Research article Published on:

  34. Functional exercise capacity in people with asbestos related pleural disease (ARPD) is unknown and there are no data on health-related quality of life (HRQoL). The primary aims were to determine whether functi...

    Authors: Marita T Dale, Zoe J McKeough, Phillip A Munoz, Peter Corte, Peter TP Bye and Jennifer A Alison
    Citation: BMC Pulmonary Medicine 2013 13:1
    Content type: Research article Published on:

  35. Symptom-based questionnaires can be a cost effective tool enabling identification and diagnosis of patients with respiratory illnesses in resource limited setting. This study aimed to determine the correlation...

    Authors: Imran Naeem Abbasi, Adeel Ahsan and Asaad Ahmed Nafees
    Citation: BMC Pulmonary Medicine 2012 12:81
    Content type: Research article Published on:

  36. Acute asthma attacks remain a frequent cause of emergency department (ED) visits and hospital admission. Many factors encourage patients to seek asthma treatment at the emergency department. These factors may ...

    Authors: Hamdan AL-Jahdali, Ahmed Anwar, Abdullah AL-Harbi, Salim Baharoon, Rabih Halwani, Abdulllah Al Shimemeri and Saleh Al-Muhsen
    Citation: BMC Pulmonary Medicine 2012 12:80
    Content type: Research article Published on:

  39. During the past decades, numerous efforts have been made to decrease the death rate among lung cancer patients. Nonetheless, the improvement in long-term survival has been limited and lung cancer is still a de...

    Authors: Marlies E Heuvers, Joost P Hegmans, Bruno H Stricker and Joachim G Aerts
    Citation: BMC Pulmonary Medicine 2012 12:77
    Content type: Debate Published on:

  40. Oil tanks containing a mixture of hydrocarbons, including sulphuric compounds, exploded and caught fire in an industrial harbour. This study assesses airway symptoms and lung function in the nearby population ...

    Authors: Jens-Tore Granslo, Magne Bråtveit, Bjørg Eli Hollund, Ågot Irgens, Cecilie Svanes, Nils Magerøy and Bente Elisabeth Moen
    Citation: BMC Pulmonary Medicine 2012 12:76
    Content type: Research article Published on:

  41. Little is known concerning the degree to which initiation of sildenafil for pulmonary arterial hypertension (PAH) impacts patterns of healthcare utilization and costs.

    Authors: Ariel Berger, John Edelsberg, Simon Teal, Marko A Mychaskiw and Gerry Oster
    Citation: BMC Pulmonary Medicine 2012 12:75
    Content type: Research article Published on:

  42. Glycopyrronium bromide (NVA237) is an inhaled long-acting muscarinic antagonist in development for treatment of COPD. This study compared the efficacy and safety of once-daily (OD) and twice-daily (BID) glycop...

    Authors: Helen Arievich, Tim Overend, Didier Renard, Michael Gibbs, Vijay Alagappan, Michael Looby and Donald Banerji
    Citation: BMC Pulmonary Medicine 2012 12:74
    Content type: Research article Published on:

  43. Objective measurement of airflow obstruction by spirometry is an essential part of the diagnosis of asthma or COPD. During exacerbations, the feasibility and utility of spirometry to confirm the diagnosis of a...

    Authors: Valentin Prieto Centurion, Frank Huang, Edward T Naureckas, Carlos A Camargo Jr, Jeffrey Charbeneau, Min J Joo, Valerie G Press and Jerry A Krishnan
    Citation: BMC Pulmonary Medicine 2012 12:73
    Content type: Research article Published on:

  44. Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a recently reported group of disorders characterized by fibrotic thickening of the pleural and subpleural parenchyma predominantly in the upper lobes. We ...

    Authors: Hideki Kusagaya, Yutaro Nakamura, Masato Kono, Yusuke Kaida, Shigeki Kuroishi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Koshimizu, Koshi Yokomura, Naoki Inui, Takafumi Suda, Thomas V Colby and Kingo Chida
    Citation: BMC Pulmonary Medicine 2012 12:72
    Content type: Research article Published on:

  45. Chronic obstructive pulmonary disease (COPD) is a respiratory condition characterised by dyspnoea, excessive sputum production, chronic cough, bronchitis and emphysema. Functionally, exercise tolerance is poor...

    Authors: Trentham Furness, Nicole Bate, Liam Welsh, Geraldine Naughton and Christian Lorenzen
    Citation: BMC Pulmonary Medicine 2012 12:71
    Content type: Study protocol Published on:

  46. Although Group A beta hemolytic streptococcus (GABHS) can cause bacterial pharyngitis, the most common etiology is viral; despite this viral etiology, antibiotics are commonly prescribed for this infection in ind...

    Authors: Amber Hanif Palla, Rafeeq Alam Khan, Anwar H Gilani and Fawziah Marra
    Citation: BMC Pulmonary Medicine 2012 12:70
    Content type: Research article Published on:

  47. There is some evidence that singing lessons may be of benefit to patients with chronic obstructive pulmonary disease (COPD). It is not clear how much of this benefit is specific to singing and how much relates...

    Authors: Victoria M Lord, Victoria J Hume, Julia L Kelly, Phoene Cave, Judith Silver, Maya Waldman, Chris White, Cayley Smith, Rebecca Tanner, Melissa Sanchez, William D-C Man, Michael I Polkey and Nicholas S Hopkinson
    Citation: BMC Pulmonary Medicine 2012 12:69
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Pulmonary Medicine 2014 14:181

  48. The measurement of fractional concentration of nitric oxide in exhaled air (FeNO) is valuable for the assessment of airway inflammation. Offline measurement of FeNO has been used in some epidemiologic studies....

    Authors: Yoshiko Yoda, Naruhito Otani, Hideki Hasunuma, Hiroshi Kanegae and Masayuki Shima
    Citation: BMC Pulmonary Medicine 2012 12:68
    Content type: Research article Published on:

  49. This study investigated the efficacy and safety of a new asthma therapy combining fluticasone propionate and formoterol fumarate (fluticasone/formoterol; flutiform ®), administered twice daily (b.i.d.) via a sing...

    Authors: Robert A Nathan, Anthony D’Urzo, Viktor Blazhko and Kirsten Kaiser
    Citation: BMC Pulmonary Medicine 2012 12:67
    Content type: Research article Published on:

  50. Mechanical ventilation (MV) is imperative in many forms of acute respiratory failure (ARF) in COPD patients. Previous studies have shown the difficulty to identify parameters predicting the outcome of COPD pat...

    Authors: Ketty Langlet, Thierry Van Der Linden, Claire Launois, Caroline Fourdin, Philippe Cabaret, Nadia Kerkeni, Coralie Barbe, François Lebargy and Gaetan Deslée
    Citation: BMC Pulmonary Medicine 2012 12:66
    Content type: Research article Published on:
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BMC Pulmonary Medicine

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