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  1. Content type: Research article

    Co-existence or subsequent isolation of multiple nontuberculous mycobacteria (NTM) species in same patient has been reported. However, clinical significance of these observations is unclear. The aim of this st...

    Authors: Jong Sik Lee, Jong Hyuk Lee, Soon Ho Yoon, Taek Soo Kim, Moon-Woo Seong, Sung Koo Han and Jae-Joon Yim

    Citation: BMC Pulmonary Medicine 2017 17:213

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  3. Content type: Research article

    Because of a limited number of reports, we aimed to investigate the clinical characteristics of patients with Legionella pneumonia due to non-Legionella pneumophila serogroup 1 and the diagnostic usefulness of th...

    Authors: Akihiro Ito, Tadashi Ishida, Yasuyoshi Washio, Akio Yamazaki and Hiromasa Tachibana

    Citation: BMC Pulmonary Medicine 2017 17:211

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  4. Content type: Research article

    We previously reported that the ILVBL gene on chromosome 19p13.1 was associated with the risk for aspirin-exacerbated respiratory disease (AERD) and the percent decline of forced expired volume in one second (FEV...

    Authors: Hun Soo Chang, Jong Sook Park, Ho Sung Lee, Jiwon Lyu, Ji-Hye Son, Inseon S. Choi, Hyoung Doo Shin and Choon-Sik Park

    Citation: BMC Pulmonary Medicine 2017 17:210

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  5. Content type: Research article

    Pneumonia poses a significant burden to the U.S. health-care system. However, there are few data focusing on severe pneumonia, particularly cases of pneumonia associated with specialized care in intensive care...

    Authors: Aaron D. Storms, Jufu Chen, Lisa A. Jackson, James D. Nordin, Allison L. Naleway, Jason M. Glanz, Steven J. Jacobsen, Eric S. Weintraub, Nicola P. Klein, Paul M. Gargiullo and Alicia M. Fry

    Citation: BMC Pulmonary Medicine 2017 17:208

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  6. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with variable clinical manifestations, structural changes, and treatment responses. In a cohort study, we performed a baseline cluster an...

    Authors: Suhyun Kim, Myoung-Nam Lim, Yoonki Hong, Seon-Sook Han, Seung-Joon Lee and Woo Jin Kim

    Citation: BMC Pulmonary Medicine 2017 17:209

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  7. Content type: Research article

    Uncertainly prevails with regard to the use of inhalation or instillation steroids to prevent bronchopulmonary dysplasia in preterm infants. The meta-analysis with sequential analysis was designed to evaluate ...

    Authors: Zhi-Qun Zhang, Ying Zhong, Xian-Mei Huang and Li-Zhong Du

    Citation: BMC Pulmonary Medicine 2017 17:207

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  8. Content type: Research article

    Patients with cystic fibrosis (CF) have airway inflammation that contributes to symptoms and to pulmonary function derangement. Current drugs used to diminish airway inflammation improve the clinical and spiro...

    Authors: Mario H. Vargas, Rosangela Del-Razo-Rodríguez, Amando López-García, José Luis Lezana-Fernández, Jaime Chávez, María E. Y. Furuya and Juan Carlos Marín-Santana

    Citation: BMC Pulmonary Medicine 2017 17:206

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  9. Content type: Research article

    Previous studies have suggested that DNA double-strand break (DSB) repair is an important protective pathway after damage. The ataxia telangiectasia mutated (ATM) gene plays an important role in the DNA DSB re...

    Authors: Zhipeng Yan, Xiang Tong, Yao Ma, Sitong Liu, Lingjing Yang, Xin Yang, Xue Yang, Min Bai and Hong Fan

    Citation: BMC Pulmonary Medicine 2017 17:205

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  10. Content type: Research article

    Acute respiratory distress syndrome (ARDS) is potentially underrecognized by clinicians. Early recognition and subsequent optimal treatment of patients with ARDS may be facilitated by usage of biomarkers. Surf...

    Authors: Jinkyeong Park, Maria Pabon, Augustine M. K. Choi, Ilias I. Siempos, Laura E. Fredenburgh, Rebecca M. Baron, Kyeongman Jeon, Chi Ryang Chung, Jeong Hoon Yang, Chi-Min Park and Gee Young Suh

    Citation: BMC Pulmonary Medicine 2017 17:204

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  11. Content type: Research article

    NKX2–1, a key molecule in lung development, is highly expressed in non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma (ADK), where it is a diagnostic marker. Studies of the prognostic role...

    Authors: Jorge Moisés, Alfons Navarro, Sandra Santasusagna, Nuria Viñolas, Laureano Molins, José Ramirez, Jeisson Osorio, Adela Saco, Joan Josep Castellano, Carmen Muñoz, Sara Morales, Mariano Monzó and Ramón María Marrades

    Citation: BMC Pulmonary Medicine 2017 17:197

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  12. Content type: Research article

    Assessment of delays in seeking care and diagnosis of tuberculosis is essential to evaluate effectiveness of tuberculosis control programs, and identify programmatic impediments. Thus, this review of studies a...

    Authors: Fentabil Getnet, Meaza Demissie, Nega Assefa, Bizatu Mengistie and Alemayehu Worku

    Citation: BMC Pulmonary Medicine 2017 17:202

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  13. Content type: Research article

    No drugs have been approved for the treatment of patients with pulmonary hypertension (PH) secondary to idiopathic pulmonary fibrosis (IPF), particularly those with idiopathic honeycomb lung. This study was co...

    Authors: Yosuke Tanaka, Mitsunori Hino and Akihiko Gemma

    Citation: BMC Pulmonary Medicine 2017 17:200

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  14. Content type: Research article

    In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (...

    Authors: Hirofumi Kamata, Takanori Asakura, Shoji Suzuki, Ho Namkoong, Kazuma Yagi, Yohei Funatsu, Satoshi Okamori, Shunsuke Uno, Yoshifumi Uwamino, Hiroshi Fujiwara, Tomoyasu Nishimura, Makoto Ishii, Tomoko Betsuyaku and Naoki Hasegawa

    Citation: BMC Pulmonary Medicine 2017 17:198

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  15. Content type: Research article

    Acute respiratory failure (ARF) is a common and life-threatening medical emergency in patients admitted to the hospital. Currently, there is a lack of large-scale evidence on the use of high-flow nasal cannula...

    Authors: Youfeng Zhu, Haiyan Yin, Rui Zhang and Jianrui Wei

    Citation: BMC Pulmonary Medicine 2017 17:201

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  16. Content type: Case report

    To improve the understanding of acute fibrinous and organizing pneumonia (AFOP), we present one case of AFOP proven by percutaneous lung biopsy along with clinical features, chest imaging and pathology.

    Authors: Shengsong Chen, Hong Zhou, Lingling Yu, Bo Tong, Zuke Xiao and Sisi Fan

    Citation: BMC Pulmonary Medicine 2017 17:203

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  17. Content type: Research article

    Bronchopulmonary dysplasia (BPD) is a neonatal chronic lung disease characterized by impaired pulmonary alveolar development in preterm infants. Until now, little is known about the molecular and cellular basi...

    Authors: Cheng Cai, Jiajun Qiu, Gang Qiu, Yihuan Chen, Zhijun Song, Juan Li and Xiaohui Gong

    Citation: BMC Pulmonary Medicine 2017 17:199

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  18. Content type: Research article

    Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the most common reason for the hospitalization and death of pulmonary patients. The use of antibiotics as adjuvant therapy for AECOPD, ho...

    Authors: Hai-Lin Zhang, Min Tan, Ai-Min Qiu, Zhang Tao and Chang-Hui Wang

    Citation: BMC Pulmonary Medicine 2017 17:196

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  19. Content type: Research article

    Previous studies have indicated that chitinase 3-like 1 (CHI3L1) gene rs4950928 polymorphism and acidic mammalian chitinase (AMCase or CHIA) gene rs10494132 polymorphism are associated with the risk of asthma....

    Authors: Yanting Zhu, Xin Yan, Cui Zhai, Lan Yang and Manxiang Li

    Citation: BMC Pulmonary Medicine 2017 17:193

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  20. Content type: Research article

    Excessive daytime sleepiness may be determined by a number of factors including personal characteristics, co-morbidities and socio-economic conditions. In this study we identified factors associated with exces...

    Authors: Ina van der Spuy, Chandima P. Karunanayake, James A. Dosman, Kathleen McMullin, Gaungming Zhao, Sylvia Abonyi, Donna C. Rennie, Joshua Lawson, Shelley Kirychuk, Judith MacDonald, Laurie Jimmy, Niels Koehncke, Vivian R. Ramsden, Mark Fenton, Gregory P. Marchildon, Malcolm King…

    Citation: BMC Pulmonary Medicine 2017 17:192

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  21. Content type: Research article

    Macrophages stand at the forefront of both innate and adapted immunity through their capacities to recognize, engulf, and eliminate foreign particles, and to stimulate adapted immune cells. They are also invol...

    Authors: Jingzhu Lv, Xiaoyan He, Hongtao Wang, Zhaohua Wang, Gabriel T. Kelly, Xiaojing Wang, Yin Chen, Ting Wang and Zhongqing Qian

    Citation: BMC Pulmonary Medicine 2017 17:194

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  22. Content type: Research article

    Recent studies have shown that both adenosine monophosphate activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are energy sensors and are related to autophagy. Our recent reports have...

    Authors: Di Gui, Zhimin Cui, Lin Zhang, Chang Yu, Dan Yao, Min Xu, Mayun Chen, Peiliang Wu, Guoping Li, Liangxing Wang and Xiaoying Huang

    Citation: BMC Pulmonary Medicine 2017 17:191

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  23. Content type: Research article

    It is crucial to develop novel diagnostic approaches for determining if peripheral lung nodules are malignant, as such nodules are frequently detected due to the increased use of chest computed tomography scan...

    Authors: Akifumi Uchida, Takuya Samukawa, Tomohiro Kumamoto, Masahiro Ohshige, Kazuhito Hatanaka, Yoshihiro Nakamura, Keiko Mizuno, Ikkou Higashimoto, Masami Sato and Hiromasa Inoue

    Citation: BMC Pulmonary Medicine 2017 17:195

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  24. Content type: Research article

    Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three techn...

    Authors: Frederik Trinkmann, Johannes Götzmann, Daniel Saur, Michele Schroeter, Katharina Roth, Ksenija Stach, Martin Borggrefe, Joachim Saur, Ibrahim Akin and Julia D. Michels

    Citation: BMC Pulmonary Medicine 2017 17:185

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  25. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. The study aimed to determine and compare the prevalence of COPD in the general population aged 45-74 years old accor...

    Authors: Edgardo Sobrino, Vilma E. Irazola, Laura Gutierrez, Chung-Shiuan Chen, Fernando Lanas, Matías Calandrelli, Jacqueline Ponzo, Nora Mores, Pamela Serón, Allison Lee, Jiang He and Adolfo L. Rubinstein

    Citation: BMC Pulmonary Medicine 2017 17:187

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  26. Content type: Research article

    Transbronchial biopsy for peripheral pulmonary lesions is generally performed under X-ray fluoroscopy. Virtual bronchoscopic navigation (VBN) is a method in which virtual images of the bronchial route to the l...

    Authors: Fumihiro Asano, Takashi Ishida, Naofumi Shinagawa, Noriaki Sukoh, Masaki Anzai, Kenya Kanazawa, Akifumi Tsuzuku and Satoshi Morita

    Citation: BMC Pulmonary Medicine 2017 17:184

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  27. Content type: Research article

    Systemic morphine has evidence to support its use for reducing breathlessness in patients with severe chronic obstructive pulmonary disease (COPD). The effectiveness of the nebulized route, however, has not ye...

    Authors: Piotr Janowiak, Małgorzata Krajnik, Zygmunt Podolec, Tomasz Bandurski, Iwona Damps-Konstańska, Piotr Sobański, David C. Currow and Ewa Jassem

    Citation: BMC Pulmonary Medicine 2017 17:186

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  28. Content type: Research article

    Gene expression changes in the structural cells of the airways are thought to play a role in the development of asthma and airway hyperresponsiveness. This includes changes to smooth muscle contractile machine...

    Authors: Christopher D. Pascoe, Ma’en Obeidat, Bryna A. Arsenault, Yunlong Nie, Stephanie Warner, Dorota Stefanowicz, Samuel J. Wadsworth, Jeremy A. Hirota, S. Jasemine Yang, Delbert R. Dorscheid, Chris Carlsten, Tillie L. Hackett, Chun Y. Seow and Peter D. Paré

    Citation: BMC Pulmonary Medicine 2017 17:189

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  29. Content type: Research article

    Pulmonary exacerbations (PEx) in school aged children and adults with cystic fibrosis (CF) lead to increased morbidity and lung function decline. However, the effect of exacerbations in young children with CF ...

    Authors: Jordana E. Hoppe, Brandie D. Wagner, Scott D. Sagel, Frank J. Accurso and Edith T. Zemanick

    Citation: BMC Pulmonary Medicine 2017 17:188

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  30. Content type: Research article

    Accumulating evidence suggests that high-density lipoprotein (HDL) cholesterol is associated with pulmonary function and pulmonary disorders. The aim of this study was to evaluate the association between HDL c...

    Authors: Ji Hye Park, Seyeon Mun, Dong Phil Choi, Joo Young Lee and Hyeon Chang Kim

    Citation: BMC Pulmonary Medicine 2017 17:190

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  31. Content type: Research article

    Equitable access to affordable medicines and diagnostic tests is an integral component of optimal clinical care of patients with asthma and chronic obstructive pulmonary disease (COPD). In Uganda, we lack cont...

    Authors: Davis Kibirige, Leaticia Kampiire, David Atuhe, Raymond Mwebaze, Winceslaus Katagira, Winters Muttamba, Rebecca Nantanda, William Worodria and Bruce Kirenga

    Citation: BMC Pulmonary Medicine 2017 17:179

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  32. Content type: Research article

    The ability of interleukins (ILs) to differentiate tuberculous pleural effusion from other types of effusion is controversial. The aim of our study was to summarize the evidence for its use of ruling out or in...

    Authors: Ni Zeng, Chun Wan, Jiangyu Qin, Yanqiu Wu, Ting Yang, Yongchun Shen, Fuqiang Wen and Lei Chen

    Citation: BMC Pulmonary Medicine 2017 17:180

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  33. Content type: Research article

    Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a valuable life support in acute respiratory distress syndrome (ARDS) in adult patients. However, the success of VV-ECMO is known to be influenced by...

    Authors: Meng-Yu Wu, Yu-Sheng Chang, Chung-Chi Huang, Tzu-I Wu and Pyng-Jing Lin

    Citation: BMC Pulmonary Medicine 2017 17:181

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  34. Content type: Research article

    Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk. This study aim to assess differences in changes in arterial stiffness of two groups of patients, defined as having daytime sleepi...

    Authors: Maria Alexandra Mineiro, Pedro Marques da Silva, Marta Alves, Ana Luísa Papoila, Maria João Marques Gomes and João Cardoso

    Citation: BMC Pulmonary Medicine 2017 17:182

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  35. Content type: Research article

    Despite the recent increasing worldwide attention towards pulmonary hypertension (PH), its epidemiology remains poorly described in Africa. Accordingly, we performed a systematic review and meta-analysis of PH...

    Authors: Jean Joel Bigna, Jean Jacques Noubiap, Jobert Richie Nansseu and Leopold Ndemnge Aminde

    Citation: BMC Pulmonary Medicine 2017 17:183

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  36. Content type: Research article

    Guidelines recommend timely evaluation of patients with suspected lung cancer. We evaluated the impact of a Rapid Investigation Clinic (RIC) on timeliness of lung cancer diagnosis and treatment between Februar...

    Authors: Nicole Ezer, Asma Navasakulpong, Kevin Schwartzman, Linda Ofiara and Anne V. Gonzalez

    Citation: BMC Pulmonary Medicine 2017 17:178

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  37. Content type: Research article

    Inhaled corticosteroids are recommended as the first-line controller medication for childhood asthma owing to their multiple clinical benefits. However, heterogeneity in the response towards these drugs remain...

    Authors: Yi-Fan Wu, Ming-Wei Su, Bor-Luen Chiang, Yao-Hsu Yang, Ching-Hui Tsai and Yungling L. Lee

    Citation: BMC Pulmonary Medicine 2017 17:176

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  38. Content type: Research article

    Patients with primary spontaneous pneumothorax (PSP) usually complain of sudden-onset dyspnea and pleuritic chest pain. However, asymptomatic PSP has been incidentally detected on chest X-rays. In this study, ...

    Authors: Akihisa Mitani, Yukichika Hakamata, Megumi Hosoi, Masafumi Horie, Yoko Murano, Akira Saito, Shintaro Yanagimoto, Shoji Tsuji, Kazuhiko Yamamoto and Takahide Nagase

    Citation: BMC Pulmonary Medicine 2017 17:177

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  39. Content type: Research article

    When epidermal growth factor receptor (EGFR) gene mutation-positive non-small cell lung cancer (NSCLC) acquires resistance to the initial tyrosine kinase inhibitor (TKI) treatment, reassessing the tumor DNA by...

    Authors: Sakurako Uozu, Kazuyoshi Imaizumi, Teppei Yamaguchi, Yasuhiro Goto, Kenji Kawada, Tomoyuki Minezawa, Takuya Okamura, Ken Akao, Masamichi Hayashi, Sumito Isogai, Mitsushi Okazawa, Naozumi Hashimoto and Yoshinori Hasegawa

    Citation: BMC Pulmonary Medicine 2017 17:175

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  40. Content type: Research article

    Idiopathic pulmonary fibrosis (IPF) is an irreversible interstitial pulmonary disease featured by high mortality, chronic and progressive course, and poor prognosis with unclear etiology. Currently, more studi...

    Authors: Feng Yan, Zhensong Wen, Rui Wang, Wenling Luo, Yufeng Du, Wenjun Wang and Xianyang Chen

    Citation: BMC Pulmonary Medicine 2017 17:174

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  41. Content type: Case report

    Alectinib, a second-generation anaplastic lymphoma kinase (ALK) inhibitor, is a key drug for ALK rearranged lung adenocarcinoma. Interstitial lung disease (ILD) is an important adverse effect of alectinib, whi...

    Authors: Tatsuya Nitawaki, Yoshihiko Sakata, Kodai Kawamura and Kazuya Ichikado

    Citation: BMC Pulmonary Medicine 2017 17:173

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  42. Content type: Correction

    After publication of this work [1] it was noticed three author names were spelt incorrectly. Liudmila Iashyna should be Liudmyla Iashyna, Marina Polyanskaya should be Maryna Polianska and Elcan Mamamdbayov should...

    Authors: Yuriy Feshchenko, Liudmyla Iashyna, Damilya Nugmanova, Olga Gyrina, Maryna Polianska, Alexander Markov, Maryna Moibenko, Janina Makarova, Luqman Tariq, Marcelo Horacio S. Pereira, Eljan Mammadbayov, Irada Akhundova and Averyan Vasylyev

    Citation: BMC Pulmonary Medicine 2017 17:171

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    The original article was published in BMC Pulmonary Medicine 2017 17:131

  43. Content type: Correction

    After publication of this work [1] it was noticed that the author name Rachael L. DiSantostefano was not spelt correctly as there was a space in her surname between ‘Di’ and ‘Santostefano’.

    Authors: Céline El Baou, Rachael L. DiSantostefano, Rafael Alfonso-Cristancho, Elizabeth A. Suarez, David Stempel, Mark L. Everard and Neil Barnes

    Citation: BMC Pulmonary Medicine 2017 17:172

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    The original article was published in BMC Pulmonary Medicine 2017 17:31

  44. Content type: Research article

    Several studies have investigated the prevalence and risk factors of depression in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obs...

    Authors: Matthieu Hein, Jean-Pol Lanquart, Gwenolé Loas, Philippe Hubain and Paul Linkowski

    Citation: BMC Pulmonary Medicine 2017 17:165

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  45. Content type: Research article

    Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of ...

    Authors: Diana J. Leeming, Inger Byrjalsen, Jannie M. B. Sand, Asger R. Bihlet, Peter Lange, Ruth Thal-Singer, Bruce E. Miller, Morten A. Karsdal and Jørgen Vestbo

    Citation: BMC Pulmonary Medicine 2017 17:164

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  46. Content type: Research article

    Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthm...

    Authors: Collin R. Brooks, Christine J. Van Dalen, Elizabeth Harding, Ian F. Hermans and Jeroen Douwes

    Citation: BMC Pulmonary Medicine 2017 17:169

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  47. Content type: Research article

    Pneumocystis jirovecii pneumonia (PCP) is an opportunistic fungal infection that is associated with a high morbidity and mortality in immunocompromised individuals. In this study, we a...

    Authors: J. Kehrmann, B. Veckollari, D. Schmidt, O. Schildgen, V. Schildgen, N. Wagner, M. Zeschnigk, L. Klein-Hitpass, O. Witzke, J. Buer and J. Steinmann

    Citation: BMC Pulmonary Medicine 2017 17:170

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  48. Content type: Research article

    Although pleural fluid lactate dehydrogenase (LDH) and adenosine deaminase (ADA) levels are often used to distinguish between tuberculous pleural effusion (TPE) and parapneumonic pleural effusion (PPE), this c...

    Authors: Jinlin Wang, Jun Liu, Xiaohong Xie, Panxiao Shen, Jianxing He and Yunxiang Zeng

    Citation: BMC Pulmonary Medicine 2017 17:168

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  49. Content type: Research article

    N-terminal pro-brain-type natriuretic peptide (NT-proBNP) is currently used as a surrogate marker for disease severity in pulmonary hypertension (PH). However, NT-proBNP tends to have a high variability and ma...

    Authors: T. M. Berghaus, J. Kutsch, C. Faul, W. von Scheidt and M. Schwaiblmair

    Citation: BMC Pulmonary Medicine 2017 17:167

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  50. Content type: Research article

    Previously reported prognostic tools for patients with resected non-small cell lung cancer (NSCLC) include factors found postoperatively, but not preoperatively. However, it would be important to predict patie...

    Authors: Shogo Kumagai, Satoshi Marumo, Machiko Arita, Keiji Yamanashi, Ryota Sumitomo, Yosuke Otake, Tsuyoshi Shoji, Motonari Fukui, Toshiro Katayama, Norihito Okumura and Cheng-Long Huang

    Citation: BMC Pulmonary Medicine 2017 17:166

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