Articles

Procalcitonin and C-reactive protein perform better than the neutrophil/lymphocyte count ratio in evaluating hospital acquired pneumonia

The relationship between biomarkers and hospital-acquired pneumonia (HAP) is understudied, especially in severe cases admitted to the intensive care unit (ICU). Compared with community-acquired pneumonia (CAP)...

Authors: Nan Zheng, Dongmei Zhu and Yi Han

Hippocratic concepts of acute and urgent respiratory diseases still relevant to contemporary medical thinking and practice: a scoping review

The collected works of Hippocrates were searched for concepts on the diagnosis, prognosis, and treatment of acute and urgent respiratory diseases, with the objective to trace their origins in the Hippocratic Coll...

Authors: Georgios Stefanakis, Vasileia Nyktari, Alexandra Papaioannou and Helen Askitopoulou

Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects

Several lung structural and functional abnormalities may occur associated with aging, including emphysema. In this study, we evaluated the frequency and risk factors associated with emphysema in respiratory as...

Authors: Ivette Buendia-Roldan, Alexia Palma-Lopez, Danaireth Chan-Padilla, Iliana Herrera, Mariel Maldonado, Rosario Fernández, David Martínez-Briseño, Mayra Mejia and Moises Selman

MIR205HG acts as a ceRNA to expedite cell proliferation and progression in lung squamous cell carcinoma via targeting miR-299-3p/MAP3K2 axis

Long noncoding RNAs (lncRNAs) have been associated with many types of cancers, but their molecular mechanisms in lung squamous cell carcinoma (LUSC) have not been fully studied. Therefore, the current study in...

Authors: Limin Liu, Yulei Li, Ruifang Zhang, Chun Li, Jing Xiong and Yuan Wei

Findings from a pilot randomised trial of a social network self-management intervention in COPD

Self-Management Support (SMS), refers to the actions taken by individuals to recognise and manage their own health. It is increasingly recognised that individuals with chronic obstructive pulmonary disease (CO...

Authors: Lindsay Welch, Rosanna Orlando, Sharon X. Lin, Ivaylo Vassilev and Anne Rogers

Pulmonary cryptococcosis coexisting with central type lung cancer in an immuocompetent patient: a case report and literature review

Pulmonary Cryptococcosis is a common fungal infection mainly caused by Cryptococcus neoformans/C.gattii species in immunocompromised patients. Cases of pulmonary cryptococcosis in patients with normal immune func...

Authors: Kelin Yao, Xiaofang Qiu, Hongjie Hu, Yuxin Han, Wenming Zhang, Ruiming Xia, Liang Wang and Jieming Fang

Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial

Ceftriaxone (CTRX) and ampicillin/sulbactam (ABPC/SBT) are recommended by various guidelines as the first-line antibiotics for community-acquired pneumonia (CAP). However, which of these antibiotics is more ef...

Authors: Nobuyoshi Hamao, Isao Ito, Satoshi Konishi, Naoya Tanabe, Masahiro Shirata, Issei Oi, Mitsuhiro Tsukino, Hisako Matsumoto, Yoshiro Yasutomo, Seizo Kadowaki and Toyohiro Hirai

Management of initial colonisations with Burkholderia species in France, with retrospective analysis in five cystic fibrosis Centres: a pilot study

Whereas Burkholderia infections are recognized to impair prognosis in cystic fibrosis (CF) patients, there is no recommendation to date for early eradication therapy. The aim of our study was to analyse the curre...

Authors: Vianney Gruzelle, Hélène Guet-Revillet, Christine Segonds, Stéphanie Bui, Julie Macey, Raphaël Chiron, Marine Michelet, Marlène Murris-Espin and Marie Mittaine

Combination of 1.1 mm flexible cryoprobe with conventional guide sheath and therapeutic bronchoscope in biopsy of apical upper lobe solitary pulmonary nodule

Lung cancer is frequently situated peripherally in the upper lobes of the lung. Acquiring adequate tissue from this difficult-to-reach area remains a challenge. Transbronchial cryobiopsy (TBCB) has the ability...

Authors: Sze Shyang Kho, Chan Sin Chai, Larry Ellee Nyanti, Adam Malik bin Ismail and Siew Teck Tie

Treatment of superimposed preeclampsia on chronic hypertension in a twin pregnancy with automatic continuous positive airway pressure: a case report

Obstructive sleep apnoea (OSA) is related with adverse pregnancy outcomes, including preeclampsia. However, there are small studies about treatment of OSA with automatic continuous positive airway pressure (CP...

Authors: Mi Sun Kim, Myoung Jin Moon, Yoon Hee Lee, Kyu Young Chae and Eun Hee Ahn

Recovery from hypoxemia and Hypercapnia following noninvasive pressure support ventilation in a patient with statin-associated necrotizing myopathy: a case report

Statin-associated necrotizing myopathy (SANM) is a rare autoimmune disorder caused by administration of statins. SANM is characterized by weakness due to necrosis and regeneration of myofibers. Here we report ...

Authors: Yuriko Yamamura, Yoshinori Matsumoto, Koh Tadokoro, Yasuyuki Ohta, Kota Sato, Toru Yamashita, Masahiro Yamamura, Ken-Ei Sada, Koji Abe and Jun Wada

Changes in REVEAL risk score in patients with pulmonary arterial hypertension treated with macitentan in clinical practice: results from the PRACMA study

Macitentan is a dual endothelin receptor antagonist indicated for the long-term treatment of pulmonary arterial hypertension (PAH). We evaluated the change over time in REVEAL risk score in incident and preval...

Authors: Pilar Escribano-Subias, Raquel López, Luis Almenar, María Lázaro, Ian Forn, Anna Torrent, Isabel Blanco and Joan Albert Barberà

Clinical characteristics and organ system involvement in sarcoidosis: comparison of the University of Minnesota Cohort with other cohorts

Sarcoidosis is a systemic granulomatous disease of unknown etiology. Clinical cohort studies of different populations are important to understand the high variability in clinical presentation and disease cours...

Authors: Hok Sreng Te, David M. Perlman, Chetan Shenoy, Daniel J. Steinberger, Rebecca J. Cogswell, Henri Roukoz, Erik J. Peterson, Lin Zhang, Tadashi L. Allen and Maneesh Bhargava

LncRNA WTAPP1 promotes cancer cell invasion and migration in NSCLC by downregulating lncRNA HAND2-AS1

Long non-coding RNA (lncRNA) Wilms Tumor 1 Associated Protein Pseudogene 1 (WTAPP1) has been reported to be a critical player in the angiogenesis and migration of endothelial progenitor cells, while its involv...

Authors: Li Zhang, Chengyan Jin, Guiyun Yang, Bin Wang, Peiyan Hua and Yan Zhang

MiR-449b-5p targets lncRNA PSMG3-AS1 to suppress cancer cell proliferation in lung adenocarcinoma

PSMG3-AS1 has been characterized as an oncogenic lncRNA in breast cancer, while its role in other cancers is unknown. This study investigated the role of PSMG3-AS1 in lung adenocarcinoma (LUAD).

Authors: Na Yue, Ming Ye, Ran Zhang and Yunquan Guo

Evaluation of time courses of agreement between minutely obtained transcutaneous blood gas data and the gold standard arterial data from spontaneously breathing Asian adults, and various subgroup analyses

Usual clinical practice for arterial blood gas analysis (BGA) in conscious patients involves a one-time arterial puncture to be performed after a resting period of 20–30 min. The aim of this study was to evalu...

Authors: Akira Umeda, Masahiro Ishizaka, Masamichi Tasaki, Tateki Yamane, Taiji Watanabe, Yasushi Inoue, Taichi Mochizuki, Yasumasa Okada and Sarah Kesler

Clinical characteristics and survival of Chinese patients diagnosed with pulmonary arterial hypertension who carry BMPR2 or EIF2KAK4 variants

Variants in the gene encoding bone morphogenetic protein receptor type II (BMPR2) are the most common genetic cause of pulmonary arterial hypertension (PAH), whereas biallelic variants in the eukaryotic translati...

Authors: Qixian Zeng, Hang Yang, Bingyang Liu, Yanyun Ma, Zhihong Liu, Qianlong Chen, Wenke Li, Qin Luo, Zhihui Zhao, Zhou Zhou and Changming Xiong

Recurrent pneumothorax and intrapulmonary cavitary lesions in a male patient with vascular Ehlers-Danlos syndrome and a novel missense mutation in the COL3A1 gene: a case report

Vascular Ehlers-Danlos syndrome (vEDS) is a rare autosomal dominant hereditary collagen disease caused by a defect or deficiency in the pro-α1 chain of type III procollagen encoded by the COL3A1 gene. Patients...

Authors: Tingting Wan, Jinyan Ye, Peiliang Wu, Mengshi Cheng, Baihong Jiang, Hailong Wang, Jianmin Li, Jun Ma, Liangxing Wang and Xiaoying Huang

Health-related quality of life associates with change in FEV₁ in COPD: results from the COSYCONET cohort

Forced expiratory volume in one second (FEV₁) characterizes the pathophysiology of COPD and different trajectories of FEV₁ decline have been observed in patients with COPD (e.g. gradual or episodic). There is lim...

Authors: Johanna I. Lutter, Rudolf A. Jörres, Kathrin Kahnert, Larissa Schwarzkopf, Michael Studnicka, Stefan Karrasch, Holger Schulz, Claus F. Vogelmeier and Rolf Holle

Clinical implication of plasma exchange on life-threatening antineutrophil cytoplasmic antibody-associated vasculitis

We assessed the rate of and predictors for all-cause mortality in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) receiving plasma exchange (PLEX) and evaluated the surviva...

Authors: Pil Gyu Park, Byung-Woo Yoo, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

Comparison of sputum induction and bronchoscopy in diagnosis of sputum smear-negative pulmonary tuberculosis: a systemic review and meta-analysis

Pulmonary tuberculosis is one of the most common infectious diseases worldwide. Patients with suspected pulmonary tuberculosis with negative smear are recommended to undergo further tests including sputum indu...

Authors: Wen Luo, Yihua Lin, Zhibin Li, Wanyu Wang and Yonghong Shi

Correction to: Assessment of stigma in patients with cystic fibrosis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Smita Pakhale, Michael Armstrong, Crystal Holly, Rojiemiahd Edjoc, Ena Gaudet, Shawn Aaron, Giorgio Tasca, William Cameron and Louise Balfour

Prognosis of patients with acute exacerbation of combined pulmonary fibrosis and emphysema: a retrospective single-centre study

Previous analyses of combined pulmonary fibrosis and emphysema (CPFE) cohorts have provided conflicting data on the survival of patients with CPFE. Therefore, the aim of this study was to investigate the clini...

Authors: Yuichi Ikuyama, Atsuhito Ushiki, Makoto Kosaka, Jumpei Akahane, Yuichi Mukai, Taisuke Araki, Yoshiaki Kitaguchi, Kazunari Tateishi, Kazuhisa Urushihata, Masanori Yasuo, Hiroshi Yamamoto and Masayuki Hanaoka

Supervised pulmonary hypertension exercise rehabilitation (SPHERe): study protocol for a multi-centre randomised controlled trial

Supervised cardio-pulmonary rehabilitation may be safe and beneficial for people with pulmonary hypertension (PH) in groups 1 (pulmonary arterial hypertension) and 4 (chronic thromboembolic disease), particula...

Authors: Gordon McGregor, Julie Bruce, Stuart Ennis, James Mason, Ranjit Lall, Chen Ji, Harbinder Sandhu, Kate Seers, Prithwish Banerjee, Alastair Canaway, Katie Booth, Stephanie J. C. Taylor, Elizabeth Robertson, Tamar Pincus, Sally Singh, David Fitzmaurice…

Multivariate joint modeling to identify markers of growth and lung function decline that predict cystic fibrosis pulmonary exacerbation onset

Attenuated decreases in lung function can signal the onset of acute respiratory events known as pulmonary exacerbations (PEs) in children and adolescents with cystic fibrosis (CF). Univariate joint modeling fa...

Authors: E. R. Andrinopoulou, J. P. Clancy and R. D. Szczesniak

Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report

Primary Ciliary Dyskinesia (PCD) is also known as immotile-cilia syndrome, an autosomal recessive disorder of ciliary function, leading to mucus retention in the respiratory system in childhood. Our knowledge ...

Authors: Fuad Al Mutairi, Randa Alkhalaf, Abdullah Alkhorayyef, Fayhan Alroqi, Alyafee Yusra, Muhammad Umair, Fetaini Nouf, Amjad Khan, Alharbi Meshael, Aleidi Hamad, Alaujan Monira, Abdulaziz Asiri, Kheloud M. Alhamoudi and Majid Alfadhel

Values of different specimen preparation methods for the diagnosis of lung cancer by endobronchial ultrasound guided transbronchial needle aspiration

Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has been become an important procedure for the diagnosis and staging of lung cancer. Our research identified the effects of differen...

Authors: Youzu Xu, Jian Lin, Meifang Chen, Haihong Zheng and Jiaxi Feng

Concordance for changes in allergic asthma domain variables after short-term corticosteroid therapy

Asthma is a complex syndrome with multiple domains including symptoms, lung function, asthma control, and airway inflammation. A study of Fenom PRO™, a novel monitor for exhaled nitric oxide (FeNO), provided a...

Authors: Philip E. Silkoff, Mark Sarno, Solomon Ssenyange, Vivek Balasubramanyam, Brian Awabdy and Ryan Leard

Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients

Fluoroquinolones (FQs) are potential drugs that inhibit DNA synthesis and are used in the treatment of multidrug-resistant tuberculosis (TB) and short-term anti-TB regimens. In recent years, a high proportion ...

Authors: Saba Kabir, Zarfishan Tahir, Nadia Mukhtar, Muhammad Sohail, Muhammad Saqalein and Abdul Rehman

Chronic obstructive pulmonary disease, lung function and risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies

The association between chronic obstructive pulmonary disease (COPD), lung function and risk of type 2 diabetes mellitus (T2DM) remains controversial. We performed a meta-analysis to clarify this issue.

Authors: Yang Peng, Guo-Chao Zhong, Lingxiao Wang, Lijuan Guan, Ao Wang, Kai Hu and Jing Shen

Digital versus analogue chest drainage system in patients with primary spontaneous pneumothorax: a randomized controlled trial

Patients with a primary spontaneous pneumothorax (PSP) who are treated with chest tube drainage are traditionally connected to an analogue chest drainage system, containing a water seal and using a visual meth...

Authors: Dieuwertje Ruigrok, Peter W. A. Kunst, Marielle M. J. Blacha, Ben Tomlow, Jacobine W. Herbrink, Eva J. Japenga, Wim Boersma, Paul Bresser, Ivo van der Lee and Kris Mooren

Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report

Brain is one of the most common target organ of lung cancer metastasis, while descriptions of intraventricular carcinomatosis could hardly be found among previous cases. To date no cases from lung adenocarcino...

Authors: Chen Kong, Dan Zhou, Ning Wu and Chong Bai

Efficacy of revefenacin, a long-acting muscarinic antagonist for nebulized therapy, in patients with markers of more severe COPD: a post hoc subgroup analysis

Revefenacin, a once-daily, long-acting muscarinic antagonist delivered via standard jet nebulizer, increased trough forced expiratory volume in 1 s (FEV₁) in patients with moderate to very severe chronic obstruct...

Authors: James F. Donohue, Edward Kerwin, Chris N. Barnes, Edmund J. Moran, Brett Haumann and Glenn D. Crater

Baseline low ALT activity is associated with increased long-term mortality after COPD exacerbations

COPD exacerbations have negative impact on patients’ survival. Several risk factors for grave outcomes of such exacerbations have been descried. Muscle dysfunction and mass loss were shown to impact negatively...

Authors: N. Lasman, M. Shalom, N. Turpashvili, G. Goldhaber, Y. Lifshitz, E. Leibowitz, G. Berger, G. Saltzman-Shenhav, A. Brom, D. Cohen, C. Avaky and G. Segal

Concurrent cardiac sarcoidosis and obstructive sleep apnea presenting as arrhythmias

Cardiac involvement is a rare and potentially fatal presentation of sarcoidosis. Obstructive sleep apnea may complicate sarcoidosis.

Authors: Foteini Malli, Fotini Bardaka, Konstantinos I. Gourgoulianis and Zoe Daniil

Correction to: Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis

Following publication of the original article [1], the authors have flagged that there is an error in Fig. 3.

Authors: Takumi Yoshikawa, Mitsuo Otsuka, Hirofumi Chiba, Kimiyuki Ikeda, Yuki Mori, Yasuaki Umeda, Hirotaka Nishikiori, Koji Kuronuma and Hiroki Takahashi

Validation of the Hungarian version of the SRI Questionnaire

Home mechanical ventilation is a reliable treatment for patients suffering from chronic respiratory failure, improving survival and quality of life. Prevalence has been increasing worldwide as a result of evol...

Authors: Luca Valko, Szabolcs Baglyas, Laszlo Kunos, Attila Terray-Horvath, Andras Lorx, Janos Gal and Wolfram Windisch

CT differential diagnosis of COVID-19 and non-COVID-19 in symptomatic suspects: a practical scoring method

Although typical and atypical CT image findings of COVID-19 are reported in current studies, the CT image features of COVID-19 overlap with those of viral pneumonia and other respiratory diseases. Hence, it is...

Authors: Lin Luo, Zhendong Luo, Yizhen Jia, Cuiping Zhou, Jianlong He, Jianxun Lyu and Xinping Shen

Efficacy, safety, and tolerability of combined pirfenidone and N-acetylcysteine therapy: a systematic review and meta-analysis

While antifibrotic drugs significantly decrease lung function decline in idiopathic pulmonary fibrosis (IPF), there is still an unmet need to halt disease progression. Antioxidative therapy with N-acetylcystei...

Authors: Hanyu Shi, Dawei Yin, Francesco Bonella, Michael Kreuter, Ute Oltmanns, Xuren Li, Shouchun Peng and Luqing Wei

Development of chronic lung impairment in Mozambican TB patients and associated risks

Pulmonary tuberculosis (PTB) is frequently associated with chronic respiratory impairment despite microbiological cure. There are only a few clinical research studies that describe the course, type and severit...

Authors: Celso Khosa, Nilesh Bhatt, Isabel Massango, Khalide Azam, Elmar Saathoff, Abhishek Bakuli, Friedrich Riess, Olena Ivanova, Michael Hoelscher and Andrea Rachow

Longitudinal changes in health-related quality of life according to clinical course among patients with non-tuberculous mycobacterial pulmonary disease: a prospective cohort study

Improvement in health-related quality of life (HRQL) has been suggested as an alternative treatment goal of non-tuberculous mycobacterial pulmonary disease (NTM-PD). This study was performed to elucidate the l...

Authors: Nakwon Kwak, Sung A Kim, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee and Jae-Joon Yim

The effect of 50% oxygen on PtCO₂ in patients with stable COPD, bronchiectasis, and neuromuscular disease or kyphoscoliosis: randomised cross-over trials

High-concentration oxygen therapy causes increased arterial partial pressure of carbon dioxide (PaCO₂) in patients with COPD, asthma, pneumonia, obesity and acute lung injury. The objective of these studies was t...

Authors: Janine Pilcher, Darmiga Thayabaran, Stefan Ebmeier, Mathew Williams, Geraldine Back, Hamish Collie, Michael Richards, Susan Bibby, Ruth Semprini, Mark Weatherall and Richard Beasley

Complications and mortality of venovenous extracorporeal membrane oxygenation in the treatment of neonatal respiratory failure: a systematic review and meta-analysis

Extracorporeal membrane oxygenation (ECMO) has been increasingly used for severe neonatal respiratory failure refractory to conventional treatments. To systematically evaluate the complications and mortality o...

Authors: Jing Xiong, Li Zhang and Lei Bao

Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study

Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the...

Authors: Auyon J. Ghosh, Matthew Moll, Lystra P. Hayden, Jessica Bon, Elizabeth Regan and Craig P. Hersh

A multicentre retrospective observational study on Polish experience of pirfenidone therapy in patients with idiopathic pulmonary fibrosis: the PolExPIR study

Pirfenidone is an antifibrotic agent approved for the treatment of idiopathic pulmonary fibrosis (IPF). The drug is available for Polish patients with IPF since 2017. The PolExPIR study aimed to describe the r...

Authors: Sebastian Majewski, Adam J. Białas, Małgorzata Buchczyk, Paweł Gomółka, Katarzyna Górska, Hanna Jagielska-Len, Agnieszka Jarzemska, Ewa Jassem, Dariusz Jastrzębski, Aleksander Kania, Marek Koprowski, Rafał Krenke, Jan Kuś, Katarzyna Lewandowska, Magdalena M. Martusewicz-Boros, Kazimierz Roszkowski-Śliż…

A diver’s dilemma – a case report on bronchopulmonary sequestration

An asymptomatic SCUBA (Self-contained underwater breathing apparatus) diver was discovered to have an intralobar bronchopulmonary sequestration during routine pre-course screening. This is the first reported c...

Authors: Timothy Xin Zhong Tan, Andrew Yunkai Li, James Jie Sng, Mark Lim, Zhi Xiang Tan, Hope Xian’en Ang, Boon Hor Ho, David Zhiwei Law and Anne Ann Ling Hsu

How people with chronic obstructive pulmonary disease perceive their illness: a qualitative study between mind and body

Although many studies on people with Chronic Obstructive Pulmonary Disease (COPD) have examined the mutual impact of physical status and emotional experience, there is limited knowledge about the way COPD peop...

Authors: Marta Pozzar, Eleonora Volpato, Chiara Valota, Francesco Pagnini and Paolo Innocente Banfi

A randomized, controlled, repeat-dose study of batefenterol/fluticasone furoate compared with placebo in the treatment of COPD

Batefenterol (BAT) is a bi-functional molecule with both muscarinic antagonist and β₂-adrenoceptor agonist pharmacology. This Phase II, randomized, placebo-controlled, double-blind study evaluated the safety and ...

Authors: Courtney Crim, Mark Gotfried, Selwyn Spangenthal, Michael Watkins, Amanda Emmett, Catriona Crawford, Charlotte Baidoo and Ramiro Castro-Santamaria

Vaping induced pneumonitis: a small community hospital’s case series and analysis

Electronic cigarettes/e-cigarettes (ECs), or vaping, is currently the most popular form of smoking amongst youth in the United States. ECs are battery-powered devices that vaporize a liquid that comes in small...

Authors: Andrew L. Silverman, Haseeb Siddique, Vikas Kumar, Thuy-Hong Le and Joseph Ng

PROCEEDINGS OF THE 17 ^th ITALIAN CONVENTION OF FFC INVESTIGATORS IN CYSTIC FIBROSIS

Authors: