Articles
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Citation: BMC Pulmonary Medicine 2012 12:7
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Interleukin 6, lipopolysaccharide-binding protein and interleukin 10 in the prediction of risk and etiologic patterns in patients with community-acquired pneumonia: results from the German competence network CAPNETZ
The aim of our study was to investigate the predictive value of the biomarkers interleukin 6 (IL-6), interleukin 10 (IL-10) and lipopolysaccharide-binding protein (LBP) compared with clinical CRB and CRB-65 se...
Citation: BMC Pulmonary Medicine 2012 12:6 -
A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome
The tissue factor (TF)-dependent extrinsic pathway has been suggested to be a central mechanism by which the coagulation cascade is locally activated in the lungs of patients with acute lung injury and acute r...
Citation: BMC Pulmonary Medicine 2012 12:5 -
Population prevalence of asthma and its determinants based on European Community Respiratory Health Survey in the United Arab Emirates
No population study has explored the population distribution of adult asthma in the United Arab Emirates (UAE). The objective is to estimate asthma prevalence in general population in UAE.
Citation: BMC Pulmonary Medicine 2012 12:4 -
The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis
In cystic fibrosis (CF) patients, it has been suggested that systemic inflammation may be an important risk factor for poor health outcomes. The relationship of plasma inflammatory biomarkers to lung function ...
Citation: BMC Pulmonary Medicine 2012 12:3 -
Systemic air embolism during percutaneous core needle biopsy of the lung: frequency and risk factors
Detection of risk factors for an air embolism in the left atrium, left ventricle, or systemic circulation (systemic air embolism, SAE) during a percutaneous core needle biopsy (PCNB) of the thorax.
Citation: BMC Pulmonary Medicine 2012 12:2 -
Up-to-date on mortality in COPD - report from the OLIN COPD study
The poor recognition and related underdiagnosis of COPD contributes to an underestimation of mortality in subjects with COPD. Data derived from population studies can advance our understanding of the true burd...
Citation: BMC Pulmonary Medicine 2012 12:1 -
Comparison of resource use by COPD patients on inhaled therapies with long-acting bronchodilators: a database study
The purpose of this analysis was to compare health care costs and utilization among COPD patients who had long-acting beta-2 agonist (LABA) OR long-acting muscarinic antagonist (LAMA); LABA AND LAMA; or LABA, LAM...
Citation: BMC Pulmonary Medicine 2011 11:61 -
Rapid effects of extrafine beclomethasone dipropionate/formoterol fixed combination inhaler on airway inflammation and bronchoconstriction in asthma: a randomised controlled trial
The dose-dependent anti-inflammatory effects of a recent fixed combination of extrafine beclomethasone dipropionate/formoterol (BDP/F) were investigated using non-invasive markers of inflammation, exhaled nitr...
Citation: BMC Pulmonary Medicine 2011 11:60 -
Risk of herpes zoster in patients prescribed inhaled corticosteroids: a cohort study
Little is known concerning risk factors for herpes zoster in the general population. We hypothesised that inhaled corticosteroids (ICS) are a risk factor for herpes zoster especially among users of inhibitors ...
Citation: BMC Pulmonary Medicine 2011 11:59 -
Non-invasive ventilation (NIV) as an aid to rehabilitation in acute respiratory disease
Non-invasive ventilation (NIV) can increase exercise tolerance, reduce exercise induced desaturation and improve the outcome of pulmonary rehabilitation in patients with chronic respiratory disease. It is not ...
Citation: BMC Pulmonary Medicine 2011 11:58 -
Observational study on efficacy of negative expiratory pressure test proposed as screening for obstructive sleep apnea syndrome among commercial interstate bus drivers - protocol study
Obstructive sleep apnea (OSA) is a respiratory disease characterized by the collapse of the extrathoracic airway and has important social implications related to accidents and cardiovascular risk. The main obj...
Citation: BMC Pulmonary Medicine 2011 11:57 -
Long-term effects of intravenous iloprost in patients with idiopathic pulmonary arterial hypertension deteriorating on non-parenteral therapy
The majority of patients with idiopathic pulmonary arterial hypertension (IPAH) in functional classes II and III are currently being treated with non-parenteral therapies, including endothelin receptor antagon...
Citation: BMC Pulmonary Medicine 2011 11:56 -
Caregivers' perceived adequacy of support in end-stage lung disease: results of a population survey
End-stage lung disease (ESLD) is a frequent cause of death. What are the differences in the supports needed by caregivers of individuals with ESLD at end of life versus other life-limiting diagnoses?
Citation: BMC Pulmonary Medicine 2011 11:55 -
Dust exposure and chronic respiratory symptoms among coffee curing workers in Kilimanjaro: a cross sectional study
Coffee processing causes organic dust exposure which may lead to development of respiratory symptoms. Previous studies have mainly focused on workers involved in roasting coffee in importing countries. This st...
Citation: BMC Pulmonary Medicine 2011 11:54 -
Asthma control cost-utility randomized trial evaluation (ACCURATE): the goals of asthma treatment
Despite the availability of effective therapies, asthma remains a source of significant morbidity and use of health care resources. The central research question of the ACCURATE trial is whether maximal doses ...
Citation: BMC Pulmonary Medicine 2011 11:53 -
Verifying a questionnaire diagnosis of asthma in children using health claims data
Childhood asthma prevalence is widely measured by parental proxy report of physician-diagnosed asthma in questionnaires. Our objective was to validate this measure in a North American population.
Citation: BMC Pulmonary Medicine 2011 11:52 -
Efficacy and safety of inhaled formoterol 4.5 and 9 μg twice daily in Japanese and European COPD patients: Phase III study results
This study evaluated the efficacy and safety of the long-acting β2-agonist formoterol in patients with moderate-to-severe COPD.
Citation: BMC Pulmonary Medicine 2011 11:51 -
Lung function reduction and chronic respiratory symptoms among workers in the cement industry: a follow up study
There are only a few follow-up studies of respiratory function among cement workers. The main aims of this study were to measure total dust exposure, to examine chronic respiratory symptoms and changes in lung...
Citation: BMC Pulmonary Medicine 2011 11:50 -
Psychosocial risk factors for hospital readmission in COPD patients on early discharge services: a cohort study
Hospital readmission for acute exacerbation of COPD (AECOPD) occurs in up to 30% of patients, leading to excess morbidity and poor survival. Physiological risk factors predict readmission, but the impact of mo...
Citation: BMC Pulmonary Medicine 2011 11:49 -
Anti-asthma medication prescribing to children in the Lombardy Region of Italy: chronic versus new users
Although anti-asthma medications are amongst those most frequently under or over prescribed it is generally accepted that prescriptions for such agents can be used as a proxy for disease prevalence. The aims o...
Citation: BMC Pulmonary Medicine 2011 11:48 -
Pulmonary venous occlusion and death in pulmonary arterial hypertension: survival analyses using radiographic surrogates
Recent studies find that a considerable number of patients with pulmonary arterial hypertension (PAH) develop fibrous obstruction of the pulmonary veins. Such obstruction more commonly accompanies connective t...
Citation: BMC Pulmonary Medicine 2011 11:47 -
Elevated placenta growth factor predicts pneumonia in patients with chronic obstructive pulmonary disease under inhaled corticosteroids therapy
An increased incidence of pneumonia in patients with chronic obstructive pulmonary disease (COPD) under inhaled corticosteroid (ICS) therapy was noticed in previous studies. We performed a prospective study to...
Citation: BMC Pulmonary Medicine 2011 11:46 -
Acute inhalation of hypertonic saline does not improve mucociliary clearance in all children with cystic fibrosis
Little is known of how mucociliary clearance (MCC) in children with cystic fibrosis (CF) and normal pulmonary function compares with healthy adults, or how an acute inhalation of 7% hypertonic saline (HS) aero...
Citation: BMC Pulmonary Medicine 2011 11:45 -
A unique protein profile of peripheral neutrophils from COPD patients does not reflect cytokine-induced protein profiles of neutrophils in vitro
Inflammation, both local and systemic, is a hallmark of chronic obstructive pulmonary disease (COPD). Inflammatory mediators such as TNFα and GM-CSF are secreted by lung epithelium, alveolar macrophages and ot...
Citation: BMC Pulmonary Medicine 2011 11:44 -
How do COPD patients respond to exacerbations?
Although timely treatment of COPD exacerbations seems clinically important, nearly half of these exacerbations remain unreported and subsequently untreated. Recent studies have investigated incidence and impac...
Citation: BMC Pulmonary Medicine 2011 11:43 -
Creating scenarios of the impact of copd and their relationship to copd assessment test (CAT™) scores
The COPD Assessment Test (CAT™) is a new short health status measure for routine use. New questionnaires require reference points so that users can understand the scores; descriptive scenarios are one way of d...
Citation: BMC Pulmonary Medicine 2011 11:42 -
Tachykinin receptors antagonism for asthma: a systematic review
Tachykinins substance P, neurokinin A and neurokinin B seem to account for asthma pathophysiology by mediating neurogenic inflammation and several aspects of lung mechanics. These neuropeptides act mainly by t...
Citation: BMC Pulmonary Medicine 2011 11:41 -
Asthma control in patients receiving inhaled corticosteroid and long-acting beta2-agonist fixed combinations. A real-life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation
Although patients have more problems using metered dose inhalers, clinical comparisons suggest they provide similar control to dry powder inhalers. Using real-life situations this study was designed to evaluat...
Citation: BMC Pulmonary Medicine 2011 11:40 -
The asthma candidate gene NPSR1 mediates isoform specific downstream signalling
Neuropeptide S Receptor 1 (NPSR1, GPRA, GPR154) was first identified as an asthma candidate gene through positional cloning and has since been replicated as an asthma and allergy susceptibility gene in several in...
Citation: BMC Pulmonary Medicine 2011 11:39 -
Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol
Acute bronchitis is one of the most prevalent respiratory infections in primary care, and in more than 90% of the cases antibiotics are prescribed, mainly when purulent expectoration is present. However, this ...
Citation: BMC Pulmonary Medicine 2011 11:38 -
Why is spirometry underused in the diagnosis of the breathless patient: a qualitative study
Use of spirometry is essential for the accurate diagnosis of respiratory disease but it is underused in both primary and specialist care. In the current study, we have explored the reasons for this underuse.
Citation: BMC Pulmonary Medicine 2011 11:37 -
Systematic review with meta-analysis of the epidemiological evidence relating smoking to COPD, chronic bronchitis and emphysema
Smoking is a known cause of the outcomes COPD, chronic bronchitis (CB) and emphysema, but no previous systematic review exists. We summarize evidence for various smoking indices.
Citation: BMC Pulmonary Medicine 2011 11:36 -
Sputum and nasal lavage lung-specific biomarkers before and after smoking cessation
Little is known about the effect of smoking cessation on airway inflammation. Secretory Leukocyte Protease Inhibitor (SLPI), Clara Cell protein 16 (CC16), elafin and human defensin beta-2 (HBD-2) protect human...
Citation: BMC Pulmonary Medicine 2011 11:35 -
Detection and follow-up of chronic obstructive pulmonary disease (COPD) and risk factors in the Southern Cone of Latin America. the pulmonary risk in South America (PRISA) study
The World Health Organization has estimated that by 2030, chronic obstructive pulmonary disease will be the third leading cause of death worldwide. Most knowledge of chronic obstructive pulmonary disease is ba...
Citation: BMC Pulmonary Medicine 2011 11:34 -
Static and dynamic mechanics of the murine lung after intratracheal bleomycin
Despite its widespread use in pulmonary fibrosis research, the bleomycin mouse model has not been thoroughly validated from a pulmonary functional standpoint using new technologies. Purpose of this study was t...
Citation: BMC Pulmonary Medicine 2011 11:33 -
Antibiotic consumption in children prior to diagnosis of asthma
Asthma is difficult to diagnose in children and at times misdiagnosis of an infection can occur. However, little is known about the magnitude and patterns of antibiotic consumption in children with asthma rela...
Citation: BMC Pulmonary Medicine 2011 11:32 -
Cardiac safety of indacaterol in healthy subjects: a randomized, multidose, placebo- and positive-controlled, parallel-group thorough QT study
Indacaterol is a novel once-daily ultra long-acting β2-agonist for the treatment of chronic obstructive pulmonary disease. It is known that β2-agonists, like other adrenergic compounds, can prolong the QT-interva...
Citation: BMC Pulmonary Medicine 2011 11:31 -
Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension?
Pulmonary hypertension (PH) is a life-threatening disease with poor prognosis. Encouraging efforts have been made to target the main vasoproliferative aspects of the disease. Promising emerging therapeutics ar...
Citation: BMC Pulmonary Medicine 2011 11:30 -
Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target
The role of microRNAs (miRNAs) in regulating gene expression is currently an area of intense interest. Relatively little is known, however, about the role of miRNAs in inflammatory and immunologically-driven d...
Citation: BMC Pulmonary Medicine 2011 11:29 -
Fluticasone/formoterol combination therapy is as effective as fluticasone/salmeterol in the treatment of asthma, but has a more rapid onset of action: an open-label, randomized study
The inhaled corticosteroid (ICS) fluticasone propionate (fluticasone) and the long-acting β2-agonist (LABA) formoterol fumarate (formoterol) are being made available as a combination product (fluticasone/formoter...
Citation: BMC Pulmonary Medicine 2011 11:28 -
(Correcting) misdiagnoses of asthma: a cost effectiveness analysis
The prevalence of physician-diagnosed-asthma has risen over the past three decades and misdiagnosis of asthma is potentially common. Objective: to determine whether a secondary-screening-program to establish a...
Citation: BMC Pulmonary Medicine 2011 11:27 -
Incidence, risk factors and mortality of tuberculosis in Danish HIV patients 1995-2007
Human Immunodeficiency Virus (HIV) infection predisposes to tuberculosis (TB). We described incidence, risk factors and prognosis of TB in HIV-1 infected patients during pre (1995-1996), early (1997-1999), and...
Citation: BMC Pulmonary Medicine 2011 11:26 -
Short term effects of exercise training on exercise capacity and quality of life in patients with pulmonary arterial hypertension: protocol for a randomised controlled trial
Advances in the understanding and management of pulmonary arterial hypertension have enabled earlier diagnosis and improved prognosis. However, despite best available therapy, symptoms of exertional dyspnoea a...
Citation: BMC Pulmonary Medicine 2011 11:25 -
Chronic virus infections supress atopy but not asthma in a set of children from a large latin american city: a cross-section study
The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries. An explanation for these trends is that increa...
Citation: BMC Pulmonary Medicine 2011 11:24 -
A crossover study of short burst oxygen therapy (SBOT) for the relief of exercise-induced breathlessness in severe COPD
Previous small studies suggested SBOT may be ineffective in relieving breathlessness after exercise in COPD.
Citation: BMC Pulmonary Medicine 2011 11:23 -
Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma
KL-6 is a high-molecular-weight glycoprotein classified as a human MUC1 mucin. It was hypothesized that KL-6 could be detectable in the circulating blood and especially in airway secretions in lung diseases as...
Citation: BMC Pulmonary Medicine 2011 11:22 -
The reliability of an arabic version of the self-administered standardized chronic respiratory disease questionnaire (CRQ-SAS)
To produce a conceptually equivalent Arabic version to the original Self-Administered Chronic Respiratory Disease Questionnaire with standardized dyspnea domain (CRQ-SAS) and to assess its reliability.
Citation: BMC Pulmonary Medicine 2011 11:21 -
Does pulmonary rehabilitation address cardiovascular risk factors in patients with COPD?
Patients with COPD have an increased risk of cardiovascular disease. Whilst pulmonary rehabilitation has proven benefit for exercise tolerance and quality of life, any effect on cardiovascular risk has not bee...
Citation: BMC Pulmonary Medicine 2011 11:20 -
Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction
A significant number of young people start smoking at an age of 13-15, which means that serious smoking-evoked changes may have been occurred by their twenties. Surfactant proteins (SP) and matrix metalloprote...
Citation: BMC Pulmonary Medicine 2011 11:19
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