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  1. A few studies have assessed the short-term effects of low-dose nicotine e-cigarettes, while data about nicotine-free e-cigarettes (NF e-cigarettes) are scanty. Concerns have been expressed about the use of NF ...

    Authors: Marco Ferrari, Alessandro Zanasi, Elena Nardi, Antonio Maria Morselli Labate, Piero Ceriana, Antonella Balestrino, Lara Pisani, Nadia Corcione and Stefano Nava
    Citation: BMC Pulmonary Medicine 2015 15:120
  2. Perceived sleep quality may play an important role in diagnosis and therapy for obstructive sleep apnea (OSA). However, few studies have assessed factors that are associated with perceived sleep quality in OSA...

    Authors: Meng-Ni Wu, Chiou-Lian Lai, Ching-Kuan Liu, Li-Min Liou, Chen-Wen Yen, Sharon Chia-Ju Chen, Cheng-Fang Hsieh, Sun-Wung Hsieh, Feng-Cheng Lin and Chung-Yao Hsu
    Citation: BMC Pulmonary Medicine 2015 15:117
  3. Several cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strate...

    Authors: James B. Geake, David W. Reid, Bart J. Currie and Scott C. Bell
    Citation: BMC Pulmonary Medicine 2015 15:116
  4. Among adolescent novice smokers, craving is often the first, and is the most reported, symptom of nicotine dependence. Until now, little has been known about the development of craving symptoms in novice smoke...

    Authors: Marloes Kleinjan, Rutger C.M.E. Engels and Joseph R. DiFranza
    Citation: BMC Pulmonary Medicine 2015 15:115
  5. Pseudomonas aeruginosa is a pathogen associated with cystic fibrosis that has potential to decrease lung function and cause respiratory failure. Paranasal sinuses are increasingly recognised as potential reservoi...

    Authors: Barry Linnane, Linda Kearse, Nuala H. O’ Connell, John Fenton, Miranda G. Kiernan and Colum P. Dunne
    Citation: BMC Pulmonary Medicine 2015 15:114
  6. Angiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases. The aim of the study was to compare the angiogenic profile of patients with sarcoidosis and idiopathic pu...

    Authors: Dariusz Ziora, Dariusz Jastrzębski, Mariusz Adamek, Zenon Czuba, Jerzy Kozielski J., Alicja Grzanka and Alicja Kasperska-Zajac
    Citation: BMC Pulmonary Medicine 2015 15:113
  7. Very few data exist on the management of community-acquired pneumonia (CAP) in patients admitted to hospitals in the Gulf region. The objectives of this study were to describe treatment patterns for CAP in 38 ...

    Authors: Bassam Mahboub, Ashraf Al Zaabi, Ola Mohamed Al Ali, Raees Ahmed, Michael S. Niederman and Rania El-Bishbishi
    Citation: BMC Pulmonary Medicine 2015 15:112
  8. Chronic Obstructive Pulmonary Disease (COPD) is characterized by lung and systemic inflammation as well as airway goblet cell hyperplasia (GCH). Mucin production is activated in part by stimulation of the epid...

    Authors: Victor Kim, William D. Cornwell, Michelle Oros, Heba Durra, Gerard J. Criner and Thomas J. Rogers
    Citation: BMC Pulmonary Medicine 2015 15:111
  9. Interstitial lung diseases (ILDs) are common in patients with connective tissue diseases (CTDs). Although the diagnosis of an underlying CTD in ILD (CTD-ILD) affects both prognosis and treatment, it is sometim...

    Authors: Tsutomu Hamada, Takuya Samukawa, Tomohiro Kumamoto, Kazuhito Hatanaka, Go Tsukuya, Masuki Yamamoto, Kentaro Machida, Masaki Watanabe, Keiko Mizuno, Ikkou Higashimoto, Yoshikazu Inoue and Hiromasa Inoue
    Citation: BMC Pulmonary Medicine 2015 15:110

    The Erratum to this article has been published in BMC Pulmonary Medicine 2016 16:117

  10. The aim of this study was to investigate the influence of the specific inhalation challenge (SIC) on changes of pH values in exhaled breath condensate (EBC) in patients with hypersensitivity pneumonitis (HP).

    Authors: I. Ojanguren, M J Cruz, A. Villar, M. Sanchez-Ortiz, F. Morell and X. Munoz
    Citation: BMC Pulmonary Medicine 2015 15:109
  11. Nontuberculous mycobacteria are well known to be a cause of hot tub lung, however, to our knowledge, there exists no case report of humidifier lung induced by mycobacteria.

    Authors: Harue Utsugi, Yutaka Usui, Fuyumi Nishihara, Minoru Kanazawa and Makoto Nagata
    Citation: BMC Pulmonary Medicine 2015 15:108
  12. Flexible, fibreoptic bronchoscopy (FFB) and bronchoalveolar lavage (BAL) have been used for diagnostic purposes in critically ill ventilated patients. The additional diagnostic value compared to tracheal aspir...

    Authors: R M Schnabel, K van der Velden, A Osinski, G Rohde, P M H J Roekaerts and D C J J Bergmans
    Citation: BMC Pulmonary Medicine 2015 15:107
  13. Vitamin D is well known for its function in calcium homeostasis and bone mineralisation, but is increasingly studied for its potential immunomodulatory properties. Vitamin D deficiency is a common problem in p...

    Authors: Rachida Rafiq, Floor E. Aleva, Jasmijn A. Schrumpf, Yvonne F. Heijdra, Christian Taube, Johannes MA Daniels, Paul Lips, Pierre M. Bet, Pieter S. Hiemstra, André JAM van der Ven, Martin den Heijer and Renate T. de Jongh
    Citation: BMC Pulmonary Medicine 2015 15:106
  14. Obstructive sleep apnea (OSA) is characterized by repeated episodes of obstruction of the upper airway. Numerous studies have indicated a relationship between OSA and metabolic syndrome (MS), but the results r...

    Authors: Shaoyong Xu, Yi Wan, Ming Xu, Jie Ming, Ying Xing, Fei An and Qiuhe Ji
    Citation: BMC Pulmonary Medicine 2015 15:105
  15. Authors: Johannes B. J. Scholte, Johan I. M. van der Velde, Catharina F. M. Linssen, Helke A. van Dessel, Dennis C. J. J. Bergmans, Paul H. M. Savelkoul, Paul M. H. J. Roekaerts and Walther N. K. A. van Mook
    Citation: BMC Pulmonary Medicine 2015 15:104

    The original article was published in BMC Pulmonary Medicine 2015 15:86

  16. Xpert MTB/RIF has been shown to have a superior sensitivity to microscopy for acid fast bacilli (AFB) in sputum and has been recommended as a standard first line investigation for pulmonary tuberculosis (PTB)....

    Authors: Dewald A. Barnard, Elvis M. Irusen, Johannes W. Bruwer, Danté Plekker, Andrew C. Whitelaw, Jacobus D. Deetlefs and Coenraad F. N. Koegelenberg
    Citation: BMC Pulmonary Medicine 2015 15:103
  17. Continuous Positive Airway Pressure (CPAP) remains the reference treatment for moderate to severe forms of the Sleep Apnea/Hypopnea Syndrome (SAHS). Compliance to the treatment appears to be a key factor to im...

    Authors: Kamila Sedkaoui, Ludivine Leseux, Sandrine Pontier, Nicole Rossin, Paul Leophonte, Jean-Louis Fraysse and Alain Didier
    Citation: BMC Pulmonary Medicine 2015 15:102
  18. IL-4 and IL-13 play a critical yet poorly understood role in orchestrating the recruitment and activation of effector cells of the asthmatic response and driving the pathophysiology of allergic asthma. The hou...

    Authors: Bahar Liravi, David Piedrafita, Gary Nguyen and Robert J. Bischof
    Citation: BMC Pulmonary Medicine 2015 15:101
  19. DLCO is the product of the CO transfer coefficient (KCO) by the “accessible” alveolar volume (VA). In theory, the same DLCO may result from various combinations of KCO and VA values, each of which reflect differe...

    Authors: Jean Pastre, Laurent Plantier, Carole Planes, Raphaël Borie, Hilario Nunes, Christophe Delclaux and Dominique Israël-Biet
    Citation: BMC Pulmonary Medicine 2015 15:100
  20. Epidemiological evidence demonstrates that exposure to traffic-derived pollution worsens respiratory symptoms in asthmatics, but controlled human exposure studies have failed to provide a mechanism for this ef...

    Authors: Annelie F Behndig, Karthika Shanmuganathan, Laura Whitmarsh, Nikolai Stenfors, Joanna L Brown, Anthony J Frew, Frank J Kelly, Ian S Mudway, Thomas Sandström and Susan J Wilson
    Citation: BMC Pulmonary Medicine 2015 15:99
  21. The prognostic value of extravascular lung water indices (EVLWI) has been widely investigated, which is determined by lung ultrasound B-lines. However, the clinical value of lung ultrasound B-lines for determi...

    Authors: Zhen Zhao, Li Jiang, Xiuming Xi, Qi Jiang, Bo Zhu, Meiping Wang, Jin Xing and Dan Zhang
    Citation: BMC Pulmonary Medicine 2015 15:98
  22. Debate exists regarding which endpoints most sensitively reflect day-to-day variation in chronic obstructive pulmonary disease (COPD) symptoms and are most useful in clinical practice to predict COPD exacerbat...

    Authors: Christine R. Jenkins, Dirkje S. Postma, Antonio R. Anzueto, Barry J. Make, Stefan Peterson, Göran Eriksson and Peter M. Calverley
    Citation: BMC Pulmonary Medicine 2015 15:97
  23. Pneumonia is the 2nd leading cause of years of life lost worldwide and is a common cause of adult admissions to hospital in sub-Saharan Africa. Risk factors for adult pneumonia are well characterised in develo...

    Authors: Hannah Jary, Jane Mallewa, Mulinda Nyirenda, Brian Faragher, Robert Heyderman, Ingrid Peterson, Stephen Gordon and Kevin Mortimer
    Citation: BMC Pulmonary Medicine 2015 15:96
  24. Accumulated to-date gene microarray data on Acute Respiratory Distress Syndrome (ARDS) in the Gene Expression Omnibus (GEO) represent a rich source for identifying new unsuspected targets and mechanisms of ARD...

    Authors: Dmitry N. Grigoryev, Dilyara I. Cheranova, Suman Chaudhary, Daniel P. Heruth, Li Qin Zhang and Shui Q. Ye
    Citation: BMC Pulmonary Medicine 2015 15:95
  25. Bacterial infection of the lower respiratory tract is believed to play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and acute exacerbations of COPD (AECOPD). This study inve...

    Authors: Huaying Wang, Xiao Gu, Yuesong Weng, Tao Xu, Zhongming Fu, Weidong Peng and Wanjun Yu
    Citation: BMC Pulmonary Medicine 2015 15:94
  26. Activities of daily living in patients with chronic obstructive pulmonary disease (COPD) are limited by exertional dyspnea and reduced exercise capacity. The aims of the study were to examine longitudinal chan...

    Authors: Bente Frisk, Jon A. Hardie, Birgitte Espehaug, Liv I. Strand, Rolf Moe-Nilssen, Tomas M. L. Eagan, Per S. Bakke and Einar Thorsen
    Citation: BMC Pulmonary Medicine 2015 15:93
  27. The FinnishIPF registry is a prospective, longitudinal national registry study on the epidemiology of idiopathic pulmonary fibrosis (IPF). It was designed to describe the characteristics, management and progno...

    Authors: Jaana Kaunisto, K. Kelloniemi, E. Sutinen, U. Hodgson, A. Piilonen, R. Kaarteenaho, R. Mäkitaro, M. Purokivi, E. Lappi-Blanco, S. Saarelainen, H. Kankaanranta, A. Mursu, M. Kanervisto, E-R. Salomaa and M. Myllärniemi
    Citation: BMC Pulmonary Medicine 2015 15:92
  28. Umeclidinium (UMEC; long-acting muscarinic antagonist) plus vilanterol (VI; long-acting beta2 agonist [LABA]) and the LABA/inhaled corticosteroid fluticasone propionate/salmeterol (FP/SAL) are approved maintenanc...

    Authors: Dave Singh, Sally Worsley, Chang-Qing Zhu, Liz Hardaker and Alison Church
    Citation: BMC Pulmonary Medicine 2015 15:91
  29. Current data for the utility of radial endobronchial ultrasound (EBUS) in investigating peripheral lung lesions (PLLs) has been restricted to populations with low pulmonary tuberculosis (TB) incidence. The aim...

    Authors: Adrian Chan, Anantham Devanand, Su Ying Low and Mariko Siyue Koh
    Citation: BMC Pulmonary Medicine 2015 15:90
  30. There is emerging evidence regarding the efficacy of exercise training to improve exercise capacity for individuals with non-small cell lung cancer (NSCLC). Cardiopulmonary exercise testing (CPET) is the gold ...

    Authors: Catherine L. Granger, Linda Denehy, Selina M. Parry, Joel Martin, Tim Dimitriadis, Maeve Sorohan and Louis Irving
    Citation: BMC Pulmonary Medicine 2015 15:89
  31. Although no report has demonstrated the efficacy of corticosteroid therapy for autoimmune pulmonary alveolar proteinosis (aPAP), we sometimes encounter patients who have received this therapy for various reaso...

    Authors: Keiichi Akasaka, Takahiro Tanaka, Nobutaka Kitamura, Shinya Ohkouchi, Ryushi Tazawa, Toshinori Takada, Toshio Ichiwata, Etsuro Yamaguchi, Masaki Hirose, Toru Arai, Kentaro Nakano, Takahito Nei, Haruyuki Ishii, Tomohiro Handa, Yoshikazu Inoue and Koh Nakata
    Citation: BMC Pulmonary Medicine 2015 15:88
  32. The majority of cases with severe pulmonary alveolar proteinosis (PAP) are caused by auto-antibodies against GM-CSF. A multitude of genetic and exogenous causes are responsible for few other cases. Goal of thi...

    Authors: Matthias Griese, Ralf Zarbock, Ulrich Costabel, Jenna Hildebrandt, Dirk Theegarten, Michael Albert, Antonia Thiel, Andrea Schams, Joanna Lange, Katazyrna Krenke, Traudl Wesselak, Carola Schön, Matthias Kappler, Helmut Blum, Stefan Krebs, Andreas Jung…
    Citation: BMC Pulmonary Medicine 2015 15:87
  33. The significance of commensal oropharyngeal flora (COF) as a potential cause of ventilator-associated pneumonia (VAP) is scarcely investigated and consequently unknown. Therefore, the aim of this study was to ...

    Authors: Johannes B. J. Scholte, Johan I. M. van der Velde, Catharina F. M. Linssen, Helke A. van Dessel, Dennis C. J. J. Bergmans, Paul H. M. Savelkoul, Paul M. H. J. Roekaerts and Walther N. K. A. van Mook
    Citation: BMC Pulmonary Medicine 2015 15:86

    The Erratum to this article has been published in BMC Pulmonary Medicine 2015 15:104

  34. Previously, we showed that treatment with the Rho-kinase inhibitor Y-27632 was able to control airway responsiveness, inflammation, remodeling, and oxidative stress in an animal model of asthma, suggesting tha...

    Authors: Patricia Angeli Pigati, Renato Fraga Righetti, Samantha Souza Possa, Beatriz Saraiva Romanholo, Adriana Palmeira Dias Rodrigues, Anelize Sartori Alves dos Santos, Débora Gonçalves Xisto, Mariana Alves Antunes, Carla Máximo Prado, Edna Aparecida Leick, Milton de Arruda Martins, Patrícia Rieken Macedo Rocco and Iolanda de Fátima Lopes Calvo Tibério
    Citation: BMC Pulmonary Medicine 2015 15:85
  35. Telehealth has the potential to improve asthma management through regular monitoring of lung function and/or asthma symptoms by health professionals in conjunction with feedback to patients. Although the benef...

    Authors: Elida Zairina, Michael J. Abramson, Christine F. McDonald, Jonathan Li, Thanuja Dharmasiri, Kay Stewart, Susan P. Walker, Eldho Paul and Johnson George
    Citation: BMC Pulmonary Medicine 2015 15:84
  36. The maximal expiratory flow at 50 % of the forced vital capacity (MEF50) is the flow where half of forced vital capacity (FVC) remains to be exhaled. A reduced MEF50 has been suggested as a surrogate marker of sm...

    Authors: Gülmisal Güder, Susanne Brenner, Stefan Störk, Matthias Held, Berna DL Broekhuizen, Jan-Willem J Lammers, Arno W Hoes and Frans H Rutten
    Citation: BMC Pulmonary Medicine 2015 15:83
  37. Recruitment maneuvers (RM) and positive end expiratory pressure (PEEP) are the cornerstone of the open lung strategy during ventilation, particularly during acute lung injury (ALI). However, these intervention...

    Authors: Camille Doras, Morgan Le Guen, Ferenc Peták and Walid Habre
    Citation: BMC Pulmonary Medicine 2015 15:82
  38. Idiopathic pulmonary fibrosis (IPF) is a severe and progressive respiratory disease with poor prognosis. Despite the positive outcomes from recent clinical trials, there is still no cure for this disease. Pre-...

    Authors: Louise Organ, Barbara Bacci, Emmanuel Koumoundouros, Garry Barcham, Marjorie Milne, Wayne Kimpton, Chrishan Samuel and Ken Snibson
    Citation: BMC Pulmonary Medicine 2015 15:81
  39. Impaired epithelial barrier function renders the airway vulnerable to environmental triggers associated with the pathogenesis of bronchial asthma. We investigated the influence of protocadherin-1 (PCDH1), a susce...

    Authors: Yutaka Kozu, Yasuhiro Gon, Shuichiro Maruoka, Kuroda Kazumichi, Akiko Sekiyama, Hiroyuki Kishi, Yasuyuki Nomura, Minoru Ikeda and Shu Hashimoto
    Citation: BMC Pulmonary Medicine 2015 15:80
  40. The interleukin 17A (IL-17A) which is located on chromosome 6p and has been linked to chronic inflammation, is an important candidate gene conferring coal workers’ pneumoconiosis (CWP). The purpose of this study ...

    Authors: Ruhui Han, Xiaoming Ji, Baiqun Wu, Ting Wang, Lei Han, Jingjin Yang, Baoli Zhu and Chunhui Ni
    Citation: BMC Pulmonary Medicine 2015 15:79
  41. The clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) positive granulomatosis with polyangiitis (GPA) remain unclear, as does the difference between MPO-ANCA positive G...

    Authors: Satoshi Ikeda, Machiko Arita, Kenta Misaki, Yumiko Kashiwagi, Yuhei Ito, Hirotaka Yamada, Machiko Hotta, Akihiro Nishiyama, Akihiro Ito, Maki Noyama, Takashi Koyama, Kenji Notohara and Tadashi Ishida
    Citation: BMC Pulmonary Medicine 2015 15:78
  42. There are not enough data on the epidemiology of asthma in the Kingdom of Saudi Arabia (KSA). We analyzed data from a national household survey conducted in KSA in 2013 to estimate prevalence, associated risk ...

    Authors: Maziar Moradi-Lakeh, Charbel El Bcheraoui, Farah Daoud, Marwa Tuffaha, Hannah Kravitz, Mohammad Al Saeedi, Mohammed Basulaiman, Ziad A. Memish, Mohammad A. AlMazroa, Abdullah A. Al Rabeeah and Ali H. Mokdad
    Citation: BMC Pulmonary Medicine 2015 15:77
  43. Even through narrowing of the upper-airway plays an important role in the generation of obstructive sleep apnea (OSA), the peripheral airways is implicated in pre-obese and obese OSA patients, as a result of d...

    Authors: Arikin Abdeyrim, Yongping Zhang, Nanfang Li, Minghua Zhao, Yinchun Wang, Xiaoguang Yao, Youledusi Keyoumu and Ting Yin
    Citation: BMC Pulmonary Medicine 2015 15:76
  44. Propionibacterium acnes was found in lungs and lymph nodes of patients with sarcoidosis and may induce hypersensitivity type granuloma formation. Data regarding the immune response to P. acnes of European sarcoid...

    Authors: Jonas Christian Schupp, Sandrine Tchaptchet, Niklas Lützen, Peggy Engelhard, Joachim Müller-Quernheim, Marina A Freudenberg and Antje Prasse
    Citation: BMC Pulmonary Medicine 2015 15:75
  45. Quantitative computed tomography (CT) analysis has been proposed as a means of objectively assessing fibrotic interstitial pneumonia (IP) including idiopathic pulmonary fibrosis (IPF). We investigated whether ...

    Authors: Kiminobu Tanizawa, Tomohiro Handa, Sonoko Nagai, Toyohiro Hirai, Takeshi Kubo, Tsuyoshi Oguma, Isao Ito, Yutaka Ito, Kizuku Watanabe, Kensaku Aihara, Kohei Ikezoe, Toru Oga, Kazuo Chin, Takateru Izumi and Michiaki Mishima
    Citation: BMC Pulmonary Medicine 2015 15:74
  46. We have recently demonstrated the efficacy of balance training in addition to Pulmonary Rehabilitation (PR) at improving measures of balance associated with an increased risk of falls in individuals with Chron...

    Authors: Samantha L. Harrison, Marla K. Beauchamp, Kathryn Sibley, Tamara Araujo, Julia Romano, Roger S. Goldstein and Dina Brooks
    Citation: BMC Pulmonary Medicine 2015 15:73
  47. Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, is predominantly expressed in airway epithelial cells. While SCGB3A2 is known to have anti-inflammatory, growth factor, an...

    Authors: Yan Cai, Mitsuhiro Yoneda, Takeshi Tomita, Reiko Kurotani, Minoru Okamoto, Taketomo Kido, Hiroyuki Abe, Wayne Mitzner, Arjun Guha and Shioko Kimura
    Citation: BMC Pulmonary Medicine 2015 15:72
  48. Although sedation is often required for agitated patients undergoing noninvasive ventilation (NIV), reports on its practical use have been few. This study aimed to evaluate the efficacy and safety of sedation ...

    Authors: Takeshi Matsumoto, Keisuke Tomii, Ryo Tachikawa, Kojiro Otsuka, Kazuma Nagata, Kyoko Otsuka, Atsushi Nakagawa, Michiaki Mishima and Kazuo Chin
    Citation: BMC Pulmonary Medicine 2015 15:71
  49. It has been recognized that despite previous stability some patients with idiopathic pulmonary fibrosis (IPF) experience acute clinical deteriorations called acute exacerbations of idiopathic pulmonary fibrosi...

    Authors: Frunze Petrosyan, Daniel A. Culver and Anita J. Reddy
    Citation: BMC Pulmonary Medicine 2015 15:70
  50. Chronic obstructive pulmonary disease (COPD) patients often have dysphagia through age and several co-morbidities, leading to aspiration pneumonia (AsP). COPD patients also have increased risk of developing co...

    Authors: Yasuhiro Yamauchi, Hideo Yasunaga, Hiroki Matsui, Wakae Hasegawa, Taisuke Jo, Kazutaka Takami, Kiyohide Fushimi and Takahide Nagase
    Citation: BMC Pulmonary Medicine 2015 15:69

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