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  1. The aim is to assess the validity and reliability of transbronchial needle aspiration (TBNA) of mediastinal and hilar adenopathies and to evaluate factors predictive of TBNA outcome.

    Authors: Alberto Fernández-Villar, Maribel Botana, Virginia Leiro, Ana González, Cristina Represas and Alberto Ruano-Raviña
    Citation: BMC Pulmonary Medicine 2010 10:24
  2. 8-Isoprostane (8-IP) is a marker of lipid peroxidation. Elevated concentrations have been reported in BAL fluid and exhaled breath condensate (EBC) in sarcoidosis (S). To validate the prognostic value of this ...

    Authors: Wojciech J Piotrowski, Zofia Kurmanowska, Adam Antczak, Jerzy Marczak and Paweł Górski
    Citation: BMC Pulmonary Medicine 2010 10:23
  3. Liver dysfunction reflects the status of heart failure, with congestion and low perfusion of the liver serving as causative mechanisms. Previous studies demonstrated relationship between the results of liver f...

    Authors: Yasuko Takeda, Yutaka Takeda, Shigehiro Tomimoto, Tomomitsu Tani, Hitomi Narita and Genjiro Kimura
    Citation: BMC Pulmonary Medicine 2010 10:22
  4. A large number of studies have investigated the effects of high tidal volume ventilation in mouse models. In contrast data on very short term effects of low tidal volume ventilation are sparse. Therefore we in...

    Authors: Hans P Hauber, Dörte Karp, Torsten Goldmann, Ekkehard Vollmer and Peter Zabel
    Citation: BMC Pulmonary Medicine 2010 10:21

    The Erratum to this article has been published in BMC Pulmonary Medicine 2012 12:7

  5. While lipopolysaccharide (LPS) from Gram-negative bacteria has been shown to augment inflammation in ventilated lungs information on the effect of Gram-positive bacteria is lacking. Therefore the effect of LPS...

    Authors: Hans P Hauber, Dörte Karp, Torsten Goldmann, Ekkehard Vollmer and Peter Zabel
    Citation: BMC Pulmonary Medicine 2010 10:20
  6. Few studies have been carried out on acute effects of cement dust exposure. This study is conducted to investigate the associations between current "total" dust exposure and acute respiratory symptoms and resp...

    Authors: Zeyede K Zeleke, Bente E Moen and Magne Bråtveit
    Citation: BMC Pulmonary Medicine 2010 10:19
  7. Right ventricular dilatation in the setting of acute pulmonary embolism is associated with an adverse prognosis. Treatment with a pulmonary vasodilator has never been studied systematically. We evaluated the e...

    Authors: Albertus J Kooter, Richard G IJzerman, Otto Kamp, Anco B Boonstra and Yvo M Smulders
    Citation: BMC Pulmonary Medicine 2010 10:18
  8. Pulsus paradoxus estimated by dynamic change in area under the oximeter plethysmograph waveform (PEP) might provide a measure of acute asthma severity. Our primary objective was to determine how well PEP corre...

    Authors: Donald H Arnold, Cathy A Jenkins and Tina V Hartert
    Citation: BMC Pulmonary Medicine 2010 10:17
  9. Obesity and asthma have reached epidemic proportions in the US. Their concurrent rise over the last 30 years suggests that they may be connected. Numerous observational studies support a temporally-correct, do...

    Authors: Jun Ma, Peg Strub, Carlos A Camargo Jr, Lan Xiao, Estela Ayala, Christopher D Gardner, A Sonia Buist, William L Haskell, Phillip W Lavori and Sandra R Wilson
    Citation: BMC Pulmonary Medicine 2010 10:16
  10. The prevalence of anemia in the intensive care unit is well-described. Less is known, however, of the prevalence of anemia in hospitalized patients with lesser illness severity or without organ dysfunction. Co...

    Authors: Michael C Reade, Lisa Weissfeld, Derek C Angus, John A Kellum and Eric B Milbrandt
    Citation: BMC Pulmonary Medicine 2010 10:15
  11. There is much interest in the possibility that perinatal factors may influence the risk of disease in later life. We investigated the influence of maternal and perinatal factors on subsequent hospital admissio...

    Authors: Rebekah Davidson, Stephen E Roberts, Clare J Wotton and Michael J Goldacre
    Citation: BMC Pulmonary Medicine 2010 10:14
  12. Smoking cessation is the best possible way to prevent the progression of smoking related airway diseases. However, the effect and time scale of smoking cessation on airway inflammation/remodelling are largely ...

    Authors: Noora Louhelainen, Harri Stark, Witold Mazur, Paula Rytilä, Ratko Djukanovic and Vuokko L Kinnula
    Citation: BMC Pulmonary Medicine 2010 10:13
  13. Despite recommendations for outpatient management, low risk patients with lower respiratory tract infections (LRTIs) are often hospitalized. This survey analyzed perceptions of physicians, nurses, patients and...

    Authors: Claudia Baehni, Sabine Meier, Pamela Spreiter, Ursula Schild, Katharina Regez, Rita Bossart, Robert Thomann, Claudine Falconnier, Mirjam Christ-Crain, Sabina De Geest, Beat Müller and Philipp Schuetz
    Citation: BMC Pulmonary Medicine 2010 10:12
  14. Indacaterol is a novel, once-daily (o.d.) inhaled, long-acting β 2-agonist in development for chronic obstructive pulmonary disease (COPD). This 12-week, double-blind study compared the efficacy, safety, and tole...

    Authors: Gregory Feldman, Thomas Siler, Niyati Prasad, Damon Jack, Simon Piggott, Roger Owen, Mark Higgins and Benjamin Kramer
    Citation: BMC Pulmonary Medicine 2010 10:11
  15. Health status, dyspnea and psychological status are important clinical outcomes in chronic obstructive pulmonary disease (COPD). However, forced expiratory volume in one second (FEV1) measured by spirometry, the ...

    Authors: Akane Haruna, Toru Oga, Shigeo Muro, Tadashi Ohara, Susumu Sato, Satoshi Marumo, Daisuke Kinose, Kunihiko Terada, Michiyoshi Nishioka, Emiko Ogawa, Yuma Hoshino, Toyohiro Hirai, Kazuo Chin and Michiaki Mishima
    Citation: BMC Pulmonary Medicine 2010 10:10
  16. Heart failure (HF) and sleep apnoea (SA) association has been recognized but whether it results from confounding factors (hypertension, ischaemia, obesity) remains unclear.

    Authors: Susana Ferreira, Anabela Marinho, Marta Patacho, Elisabete Santa-Clara, Cristina Carrondo, João Winck and Paulo Bettencourt
    Citation: BMC Pulmonary Medicine 2010 10:9
  17. Pandemic Influenza A (H1N1) 2009 is a novel viral infection that emerged in March 2009. This is the first report addressing the clinical course of patients with cystic fibrosis (CF) and H1N1 infection.

    Authors: Megan W France, Szeanna Tai, Phillip J Masel, Vanessa L Moore, Tracy L McMahon, Alexander J Ritchie and Scott C Bell
    Citation: BMC Pulmonary Medicine 2010 10:8
  18. Previous health economic studies recommend either a dual screening strategy [tuberculin skin test (TST) followed by interferon-γ-release assay (IGRA)] or a single one [IGRA only] for latent tuberculosis infect...

    Authors: Anil Pooran, Helen Booth, Robert F Miller, Geoff Scott, Motasim Badri, Jim F Huggett, Graham Rook, Alimuddin Zumla and Keertan Dheda
    Citation: BMC Pulmonary Medicine 2010 10:7
  19. Preventing ventilator-associated lung injury (VALI) has become pivotal in mechanical ventilation of patients with acute lung injury (ALI) or its more severe form, acute respiratory distress syndrome (ARDS). In...

    Authors: Rogier M Determann, Annick ANM Royakkers, Jack J Haitsma, Haibo Zhang, Arthur S Slutsky, V Marco Ranieri and Marcus J Schultz
    Citation: BMC Pulmonary Medicine 2010 10:6
  20. Non-cystic fibrosis bronchiectasis is characterised by sputum production, exercise limitation and recurrent infections. Although pulmonary rehabilitation is advocated for this patient group, its effects are un...

    Authors: Annemarie L Lee, Nola Cecins, Catherine J Hill, Anne E Holland, Linda Rautela, Robert G Stirling, Phillip J Thompson, Christine F McDonald and Sue Jenkins
    Citation: BMC Pulmonary Medicine 2010 10:5
  21. Nitric oxide (NO) shows differing concentrations in lower and upper airways. Patients after total laryngectomy are the only individuals, in whom a complete separation of upper and lower airways is guaranteed. ...

    Authors: Matthias F Kramer, Bernhard Olzowy, Annette Bihler, Dorothea de la Motte, Dennis Nowak, Rudolf A Jörres and Holger Dressel
    Citation: BMC Pulmonary Medicine 2010 10:4
  22. IL-13 has been implicated in the development of airway inflammation and hyperresponsiveness. This study investigated the multiple-dose pharmacokinetics and safety profile of human anti-IL-13 antibody (CAT-354)...

    Authors: Dave Singh, Binita Kane, Nestor A Molfino, Raffaella Faggioni, Lorin Roskos and Ashley Woodcock
    Citation: BMC Pulmonary Medicine 2010 10:3
  23. Urinary incontinence (UI) is a distressing problem for older people. To investigate the relationship between UI and respiratory symptoms among middle-aged and older men, a community-based study was conducted i...

    Authors: Fumi Hirayama, Andy H Lee, Tetsuo Hiramatsu and Yoshimasa Tanikawa
    Citation: BMC Pulmonary Medicine 2010 10:2
  24. Poor adherence with prescribed asthma medication is a major barrier to positive treatment outcomes. This study was designed to determine the effect of a once-daily administration of mometasone furoate administ...

    Authors: David Price, Anne Robertson, Kevin Bullen, Cynthia Rand, Rob Horne and Heribert Staudinger
    Citation: BMC Pulmonary Medicine 2010 10:1
  25. Airway inflammation and airway hyperresponsiveness (AHR) are two characteristic features of asthma. Fractional exhaled nitric oxide (FENO) has shown good correlation with AHR in asthmatics. Less information is...

    Authors: Valérie Demange, Abraham Bohadana, Nicole Massin and Pascal Wild
    Citation: BMC Pulmonary Medicine 2009 9:53
  26. Early detection of exacerbations by COPD patients initiating prompt interventions has shown to be clinically relevant. Until now, research failed to identify the effectiveness of a written individualized Actio...

    Authors: Jaap CA Trappenburg, Lieselotte Koevoets, Gerdien H de Weert-van Oene, Evelyn M Monninkhof, Jean Bourbeau, Thierry Troosters, Theo JM Verheij, Jan-Willem J Lammers and Augustinus JP Schrijvers
    Citation: BMC Pulmonary Medicine 2009 9:52
  27. High levels of exhaled carbon monoxide (eCO) are a marker of airway or lung inflammation. We investigated whether hypo- or hyperventilation can affect measured values.

    Authors: Franco Cavaliere, Carmen Volpe, Riccardo Gargaruti, Andrea Poscia, Michele Di Donato, Giovanni Grieco and Umberto Moscato
    Citation: BMC Pulmonary Medicine 2009 9:51
  28. Spirometry is a cost-effective diagnostic tool for evaluation of lung function and for case-finding in a resource-limited setting. The acceptance of this test depends on the awareness of its indications and th...

    Authors: Olufemi O Desalu, Olusegun A Busari, Cajetan C Onyedum, Fatai K Salawu, Olusegun A Obateru, Kelechukwu C Nwogu and Alakija K Salami
    Citation: BMC Pulmonary Medicine 2009 9:50
  29. Despite consensus criteria, diagnosing acute lung injury, or its more severe form acute respiratory distress syndrome (ALI/ARDS) remains challenging. Adding objective measures, such as plasma levels of biologi...

    Authors: Rogier M Determann, Julian L Millo, Sam Waddy, Rene Lutter, Chris S Garrard and Marcus J Schultz
    Citation: BMC Pulmonary Medicine 2009 9:49
  30. The collection of exhaled breath condensate (EBC) is a suitable and non-invasive method for evaluation of airway inflammation. Several studies indicate that the composition of the condensate and the recovery o...

    Authors: Frank Hoffmeyer, Monika Raulf-Heimsoth, Volker Harth, Jürgen Bünger and Thomas Brüning
    Citation: BMC Pulmonary Medicine 2009 9:48
  31. Previous studies have shown conflicting results for the association between TLR4 polymorphism (Asp299Gly) and lung function. We investigated the influence of TLR4 Asp299Gly, a polymorphism, on lung function in...

    Authors: Punam Pahwa, Chandima P Karunanayake, Donna C Rennie, Yue Chen, David A Schwartz and James A Dosman
    Citation: BMC Pulmonary Medicine 2009 9:46
  32. To determine whether oral administration of geranylgeranylacetone (GGA), a nontoxic anti-ulcer drug that is an inducer of heat shock protein (HSP) 70, protects against drug-induced lung injury/fibrosis in vivo.

    Authors: Takayoshi Fujibayashi, Naozumi Hashimoto, Mayumi Jijiwa, Yoshinori Hasegawa, Toshihisa Kojima and Naoki Ishiguro
    Citation: BMC Pulmonary Medicine 2009 9:45
  33. Tigecycline, an expanded broad-spectrum glycylcycline, exhibits in vitro activity against many common pathogens associated with community-acquired pneumonia (CAP), as well as penetration into lung tissues that...

    Authors: Cristina Tanaseanu, Slobodan Milutinovic, Petre I Calistru, Janos Strausz, Marius Zolubas, Valeriy Chernyak, Nathalie Dartois, Nathalie Castaing, Hassan Gandjini and C Angel Cooper
    Citation: BMC Pulmonary Medicine 2009 9:44
  34. Asthma and COPD are major health problems and an extensive burden for the patient and the health care system. Patient education has been recommended, but the influence on knowledge and health outcomes is not f...

    Authors: Margareta Emtner, Anna Hedin, Mikael Andersson and Christer Janson
    Citation: BMC Pulmonary Medicine 2009 9:43
  35. Epidemiological research into the role of traffic pollution on chronic respiratory and allergic disease has focused primarily on children. Studies in adults, in particular those based on objective outcomes suc...

    Authors: Mar Pujades-Rodríguez, Tricia McKeever, Sarah Lewis, Duncan Whyatt, John Britton and Andrea Venn
    Citation: BMC Pulmonary Medicine 2009 9:42
  36. Lithuania is a country with a high incidence of tuberculosis (TB), despite a high coverage with bacille Calmette-Guerin (BCG) vaccination. Until now the only method used to detect latent TB infection was the t...

    Authors: Edita Hansted, Angele Andriuskeviciene, Raimundas Sakalauskas, Rimantas Kevalas and Brigita Sitkauskiene
    Citation: BMC Pulmonary Medicine 2009 9:41
  37. Solitary endobronchial papillomas (SEP) are rare tumors and most of them are described by case report. A misdiagnosis is common with viral related papillomas. A histopathological classification has recently pe...

    Authors: Fabrice Paganin, Martine Prevot, Jean Baptiste Noel, Marie Frejeville, Claude Arvin-Berod and Arnaud Bourdin
    Citation: BMC Pulmonary Medicine 2009 9:40
  38. The lung consists of at least seven compartments with relevance to immune reactions. Compartment 1 - the bronchoalveolar lavage (BAL), which represents the cells of the bronchoalveolar space: From a diagnostic...

    Authors: Thomas Tschernig and Reinhard Pabst
    Citation: BMC Pulmonary Medicine 2009 9:39
  39. Multicentre drug use evaluations are described in the literature infrequently and usually publish only the results. The purpose of this paper is to describe the experience of Queensland hospitals participating...

    Authors: Lisa K Pulver, Susan E Tett and Judith Coombes
    Citation: BMC Pulmonary Medicine 2009 9:38
  40. There is a substantial body of evidence on the efficacy of yoga in the management of bronchial asthma. Many studies have reported, as the effects of yoga on bronchial asthma, significant improvements in pulmon...

    Authors: Ramaprabhu Vempati, Ramesh Lal Bijlani and Kishore Kumar Deepak
    Citation: BMC Pulmonary Medicine 2009 9:37
  41. Heart surgery is associated with an occurrence of pulmonary complications. The aim of this study was to determine whether pre-surgery respiratory physiotherapy reduces the incidence of post-surgery pulmonary c...

    Authors: Isabel Yánez-Brage, Salvador Pita-Fernández, Alberto Juffé-Stein, Ursicino Martínez-González, Sonia Pértega-Díaz and Ángeles Mauleón-García
    Citation: BMC Pulmonary Medicine 2009 9:36
  42. Cardiac Troponin T (cTnT) elevation during exacerbations of chronic obstructive pulmonary disease (COPD) is associated with increased mortality the first year after hospital discharge. The factors associated w...

    Authors: Pål H Brekke, Torbjørn Omland, Stein Harald Holmedal, Pål Smith and Vidar Søyseth
    Citation: BMC Pulmonary Medicine 2009 9:35
  43. In asthma interleukin (IL)-13 is increased in the airway compared with non-asthmatic eosinophilic bronchitis. Whether this differential expression is specific to the airway or is more generalised is uncertain.

    Authors: Salman Siddiqui, Glenn Cruse, Susan Mckenna, William Monteiro, Vijay Mistry, Andrew Wardlaw and Christopher Brightling
    Citation: BMC Pulmonary Medicine 2009 9:34
  44. N-chlorotaurine, a long-lived oxidant produced by human leukocytes, can be applied in human medicine as an endogenous antiseptic. Its antimicrobial activity can be enhanced by ammonium chloride. This study was...

    Authors: Ralf Geiger, Benedikt Treml, Anna Pinna, Linn Barnickel, Harald Prossliner, Hannes Reinstadler, Michael Pilch, Maria Hauer, Christoph Walther, Hans-Jörg Steiner, Thomas Giese, Andreas Wemhöner, Sabine Scholl-Bürgi, Waldemar Gottardi, Roland Arnitz, Consolato Sergi…
    Citation: BMC Pulmonary Medicine 2009 9:33
  45. Statins have anti-inflammatory and immunomodulating properties which could possibly influence inflammatory airways disease. We assessed evidence for disease modifying effects of statin treatment in patients wi...

    Authors: Claudia C Dobler, Keith K Wong and Guy B Marks
    Citation: BMC Pulmonary Medicine 2009 9:32
  46. To evaluate the sensitivity, specificity and predictive values of spirometry for the diagnosis of chronic obstructive pulmonary disease (COPD) and asthma in patients suspected of suffering from an obstructive ...

    Authors: Antonius Schneider, Lena Gindner, Lisa Tilemann, Tjard Schermer, Geert-Jan Dinant, Franz Joachim Meyer and Joachim Szecsenyi
    Citation: BMC Pulmonary Medicine 2009 9:31
  47. Due to large-scale destruction, changes in membrane diffusion (Dm) may occur in cystic fibrosis (CF), in correspondence to alterations observed by computed tomography (CT). Dm can be easily quantified via the ...

    Authors: Holger Dressel, Laura Filser, Rainald Fischer, Katharina Marten, Ullrich Müller-Lisse, Dorothea de la Motte, Dennis Nowak, Rudolf M Huber and Rudolf A Jörres
    Citation: BMC Pulmonary Medicine 2009 9:30
  48. Exercise-related respiratory symptoms in the diagnosis of exercise-induced bronchoconstriction (EIB) have poor predictive value. The aim of this study was to evaluate how athletes presenting with these symptom...

    Authors: James H Hull, Peter J Hull, Jonathan P Parsons, John W Dickinson and Les Ansley
    Citation: BMC Pulmonary Medicine 2009 9:29
  49. Increased respiratory rate (tachypnea) is frequently observed as a clinical sign of influenza pneumonia in pediatric patients admitted to the hospital. We previously demonstrated that influenza infection of ad...

    Authors: Elman L Trias, Arash Hassantoufighi, Gregory A Prince and Maryna C Eichelberger
    Citation: BMC Pulmonary Medicine 2009 9:28

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