- Research article
- Open Access
- Open Peer Review
Variable course of disease of rheumatoid arthritis-associated usual interstitial pneumonia compared to other subtypes
© The Author(s). 2016
- Received: 19 May 2016
- Accepted: 19 July 2016
- Published: 27 July 2016
In rheumatoid arthritis-associated interstitial lung disease (RA-ILD), occurring in 10 % of patients with patients with RA, usual interstitial pattern (UIP) has shown to associate with poor prognosis but more detailed data about the course of the disease in different subtypes is limited. Our aim was to compare the disease course of patients with RA-ILD categorized into either UIP or other types of ILDs.
Clinical and radiological information of 59 patients with RA-ILD were re-assessed and re-classified into UIP or non-UIP groups, followed by a between-group comparison of demographic data, lung function, survival, cause of death and comorbidities.
The majority of patients (n = 35/59.3 %) showed a radiological UIP-like pattern in high resolution computed tomography. The median survival was 92 months (95 % CI 62.8–121.2) in the UIP-group and 137 months (95 % CI 31.0–243.0) in the non-UIP-group (p = 0.417). Differences in course of disease were found in the number of hospitalizations for respiratory reasons (mean 1.9 ± 2.6 in UIP vs. 0.5 ± 0.9 in non-UIP group, p = 0.004), the use of oxygen therapy (8/22.9 % UIP patients vs. 0 non-UIP patients, p = 0.016), number of deaths (23/65.7 % vs. 10/41.7 %, p = 0.046) and decline in diffusion capacity (56 ± 20.6 vs. 69 ± 20.2, p = 0.021). Dyspnea and inspiratory crackles were detected more often in the UIP group. RA-ILD was the most common primary cause of death (39.4 % of cases). Hypertension, coronary artery disease, chronic obstructive pulmonary disease, heart insufficiency, diabetes and asthma were common comorbidities. ILD preceded RA diagnosis in 13.6 % of patients.
The course of the disease in RA-UIP patients is different from the other RA-ILD subtypes. Several comorbidities associated commonly with RA-ILD, although ILD was the predominant primary cause of death.
- High-resolution computed tomography
- Cause of death
Interstitial lung disease (ILD) is a rather common extra-articular manifestation of rheumatoid arthritis (RA) and a major cause of morbidity and mortality in RA patients [1, 2]. Approximately 10 % of patients with RA may develop clinically evident ILD with respiratory symptoms and/or a decline in pulmonary function tests . In asymptomatic RA patients, high-resolution computed tomography (HRCT) scans commonly reveal evidence of interstitial lung involvement, and a large proportion of those with subclinical disease deteriorate with time [4, 5]. However, the clinical course of RA-ILD is highly heterogenic, as some patients remain stable for years, even decades, while others develop an insidious progressive disease .
While the overall mortality in RA has declined, the numbers of deaths due to RA-ILD have increased , although the results of studies investigating survival have been variable. Some studies have reported survival of 3 years, similar to that of idiopathic pulmonary fibrosis (IPF) [8, 9], whereas in others the prognosis of RA-ILD has been significantly better, with median survival of approximately 6–8 years [10, 11].
Since it lacks its own distinctive classification, the subtypes of RA-ILD have been categorized according to the subdivisions of the idiopathic interstitial pneumonias (IIP) . Unlike the situation in other connective tissue diseases (CTD), the most common radiologic and histopathologic pattern of RA-ILD is usual interstitial pneumonia (UIP), whereas nonspecific interstitial pneumonia (NSIP) and other subtypes also exist to a lesser extent . The clinical significance of these different histological and radiological patterns has become nowadays more important since the RA-ILD patient with the UIP pattern (RA-UIP) seems to have a significantly worse prognosis and reduced survival compared to other types such as NSIP and organizing pneumonia (OP) [11, 14–16]. Other differences in the course of the disease in distinct RA-ILD subtypes, in addition to the difference in survival, have not been widely studied so far.
Recently the significance of radiologic and histopathological subtyping of RA-ILD was highlighted as one important area for future investigation . Little is known about concomitant diseases or causes of death of RA-ILD patients. The few studies that have addressed cause of death in these patients, have been unanimous that the majority of deaths are due to respiratory disease either after an exacerbation, infection or simply due to the steady progression of the ILD [11, 13, 18].
The aims of this study were to investigate the numbers and subtypes of the patients with RA-ILD treated in Kuopio University Hospital (KUH), in Eastern Finland, during 2000–2015. The course of the disease, survival, co-morbidities and cause of death were evaluated and compared between UIP and non-UIP cases.
Search and evaluation of data
A total of 1047 patients were identified and their patient records were evaluated. At baseline, the patients with ILD but without RA (i.e. patients with IIP, other connective tissue disorders (CTD) or allergic alveolitis) and those with RA, whose visits to pulmonology clinic were because of some other lung diseases (such as asthma, chronic obstructive pulmonary disease (COPD), obstructive sleep apnea) were excluded. We also excluded suspected but not confirmed RA-ILD patients, for whom HRCT, or other comparable radiological examination capable of allowing reliable analysis of the lung parenchyma were not available, as were those patients whose RA diagnosis was not certain according to the 1987 classification criteria , or who developed later mixed CTD- like symptoms.
Another 38 patients were excluded subsequently after the evaluation by the radiologist and/or after a multidisciplinary discussion due to the very minor signs or nonspecific features for ILD, leaving a total of 59 RA-ILD patients to be studied in detail and classified.
Clinical information was gathered from the patient records of KUH, primary health care centers and other hospitals using a specially designed form. Demographic data included date of birth, sex, occupation, smoking habits, exposure to asbestos, radiation therapy of the thorax region, date of RA diagnosis, date of the first visit to pulmonology clinic due to ILD, comorbidities, death certificates, use of long term oxygen therapy, symptoms and respiratory status findings at baseline, laboratory test results including rheumatoid factor (RF) and antinuclear antibody (ANA) titer and surgery due to RA. Antibodies against cyclic citrullinated peptide were not available for half of the patients. The results of lung function tests, such as spirometry including forced vital capacity (FVC), forced expiratory volume (FEV1) and diffusion capacity to carbon monoxide (DLCO), were gathered at baseline and, when available, during the follow-up at 6 months, 1 year, 2 year and so on annually, including also the most recent available results. Any medication in use prior to ILD diagnosis and also lifelong medication used for RA were recorded. Histological data also was collated. The numbers of hospitalizations due to either respiratory problems (including infections, suspected drug reactions and suspected acute exacerbations) or cardiac problems like unstable angina pectoris, myocardial infarctions, arrhythmias and cardiac failures were collected. Data from death certificates was also collected.
An experienced radiologist evaluated baseline HRCTs from these 59 patients. Radiological ILD categorization was conducted according to the 2013 IIP classification . The radiological RA-UIP criteria were applied from those of IPF . Mainly patients with a definite UIP pattern were included in the UIP group (32 out of 35, 91.4 %). Three patients who displayed a slightly upper (n = 2) or mid-lung (n = 1) predominated distribution, were included after a multidisciplinary discussion. Patients with possible UIP, i.e. a subpleural and basal predominated reticular abnormality without honeycombing, are not included in the UIP group. When available, an additional HRCT during the follow-up was also evaluated to reveal the progression of the lung disease.
The study protocol was approved by the Ethical Committee of Kuopio University Hospital (statement 17/2013).
The distribution of the continuous variables was verified with Shapiro-Wilk test. If distribution was normally divided, the comparison was made using an independent T-test, otherwise Mann–Whitney U-test was applied. The chi-squared test or Fisher test, when appropriate, was used for categorical variables. Sex, smoking habits, laboratory results and the numbers of deaths are calculated as percentages. Age at the time of RA-ILD diagnosis and lung function results are expressed as mean ± SD. The mean values of the first and most recent available FVCs and DLCOs were calculated in both UIP- and non-UIP groups to determine whether there had been any change in lung function. The mean values of both groups were compared using the independent T-test to evaluate possible differences in lung function tests at the time of RA-ILD diagnosis and also the difference in lung function development. In survival analyses, we excluded the patient who did not have an underlying ILD preceding acute DAD changes. Survival analysis was done using the Kaplan-Meier method and survival curves were compared using the log-rank test. Survival time was calculated from the first visit to the pulmonology clinic due to ILD to the date of death or November 4, 2015 when the vital status was ascertained. Survival results are expressed as median (95 % confidence interval).
We considered a p-value <0.05 as statistically significant. All data was analyzed using IBM Statistics SPSS software, version 21.0.
Radiologic findings and demographics
Clinical characteristics of the patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD), which have been classified according to the presence or absence of usual interstitial pneumonia (UIP) pattern in high resolution computed tomography (HRCT)
(n = 59)
(n = 35, 59.3 %)
(n = 24, 40.7 %)
(UIP vs. non-UIP)
66 ± 11.1
66 ± 11.9
67 ± 10.0
ᅟPos. anti-CCP antibodyd
FVC % pred
85 ± 17.0
82 ± 17.1
89 ± 16.5
DLCO % pred
71 ± 18.1
72 ± 20.7
70 ± 13.3
ᅟMTX, when ILD diagnosed
ᅟBiological drugs, ever
The majority (35/59.3 %) of the patients showed a radiological UIP-pattern in HRCT and the remainder were NSIP (8/13.6 %), OP (7/11.9 %) and 8 patients whose radiological features remained nonspecific, which we termed as unclassified (13.6 %). A diffuse alveolar damage (DAD) pattern was detected in one patient without an underlying ILD, thus likely representing RA-DAD. Additional two DAD patterns were seen in patients with OP and UIP diagnoses prior to DAD.
No statistically significant differences were observed between groups with respect to age, smoking, baseline lung functions or RA serology. Thirty-five (61.4 %) patients suffered from dyspnea and 31 (60.8 %) from cough. Cough was equally common in both groups, but dyspnea occurred more often in the UIP group (p = 0.022). Inspiratory crackles were more common in UIP than in non-UIP patients (p = 0.007) (Table 1).
Medication for RA and RA-ILD
The medications of the patients with RA-ILD
Ever used for RA or ILD N (%)
Used at the time of ILD diagnosis N (%)
Discontinued due to ILD diagnosis N (%)
9 out of 15 (60.0)
2 out of 16 (12.5)
2 out of 2 (100.0)
Most i.e. 6/7 (85.7 %) RA-OP patients received glucocorticoid treatment for their lung disease and the seventh patient recovered without extra treatment. Of the six steroid-treated RA-OP patients, 5 recovered completely but one did not exhibit a clear beneficial response to treatment. Five of the eight (62.5 %) RA-NSIP patients were treated with high doses of prednisolone two of them enjoying at least a partial response. Two NSIP patients received cyclophosphamide treatment, but both deteriorated despite the treatment. In five RA-UIP patients, high-dose cyclophosphamide plus high-dose steroid treatment was provided but without any positive responses.
Survival of the patients (months) according to gender and smoking in subgroups
RA-ILD (n = 59)
RA-UIP (n = 35, 59.3 %)
RA-non-UIP (n = 24, 40.7 %)
P-value (UIP vs. non-UIP)
(p = 0.305)
(p = 0.777)
(p = 0.093)
(p = 0.525)
(p = 0.921)
(p = 0.218)
Factors associating with the differential course of disease in the patients with rheumatoid arthritis associated usual interstitial pattern (RA-UIP) and non-UIP patterns (RA-non-UIP)
(n = 59)
(n = 35, 59.3 %)
(n = 24, 40.7 %)
Hospitalization due to respiratory illness
1.29 ± 2.2 (0–11)
1.9 ± 2.6 (0–11)
0.5 ± 0.9 (0–4)
Hospitalization due to cardiac illness
0.6 ± 1.2 (0–5)
0.7 ± 1.3 (0–5)
0.4 ± 1.2 (0–4)
Latest FVC % pred
82 ± 21.2
78 ± 22.9
87 ± 17.2
(Baseline FVC %)
85 ± 17.0
82 ± 17.1
89 ± 16.5
Latest DLCO % pred
61 ± 21.3
56 ± 20.6
69 ± 20.2
(Baseline DLCO %)
71 ± 18.1
72 ± 20.7
70 ± 13.3
Number of deaths
Causes of death
The average age at death was 75.0 ± 9.1 years, ranging from 54.8 to 91.7 years. The UIP patients died slightly younger than their non-UIP counterparts (73.6 ± 9.8 vs. 78.2 ± 6.5, p = 0.187).
Pneumonia and CAD were equally common as the immediate cause of death (both 10/30.3 %; 6 UIP, 4 non-UIP) and RA-ILD (5/15.2 %; 4 UIP, 1 non-UIP) was also prevalent. Lung cancer, RA, diabetes, RA associated secondary amyloidosis with renal failure, acute pancreatitis, diabetes, intestinal tuberculosis and gastroenteritis represented immediate causes of death of single cases.
Timing of diagnosis
In eight patients (13.6 %), ILD preceded RA diagnosis. In three of these cases (2 UIP, 1 OP) the RA diagnosis was made within one year after the ILD diagnosis, but in five cases (3 UIP, 1 OP, 1 unclassified) joint symptoms and RA diagnosis appeared over one year after the ILD diagnosis (range 2.17–9.58 years). In two cases (3.4 %) RA and ILD were diagnosed simultaneously. The RA diagnosis date was missing in one case. ILD followed the diagnosis of RA in 48 patients after a variable period of time i.e. 6/12.5 % within a year, 13/27.1 % within 3 years and 19/39.6 % within 5 years. The longest time interval between RA and ILD was 52.1 years.
Course of disease
Several factors were indicative of ILD progression i.e. oxygen treatment, hospitalizations and decline of diffusion capacity to carbon monoxide (DLCO) (Table 4). All patients (n = 8) using oxygen therapy belonged to the UIP group (p = 0.016). The number of hospitalizations due to respiratory causes was significantly higher in UIP compared to non-UIP (p = 0.004). The latest available DLCO results were significantly lower in UIP (p = 0.021). Forced vital capacity (% predicted) (FVC %) showed a trend towards a greater decline in the UIP group, (p = 0.091).
This study revealed that the course of disease in the patients with RA-ILD was variable in subtypes categorized according to either the presence or absence of the UIP-pattern in HRCT. The patients with RA-UIP used oxygen, suffered from hospitalizations due to respiratory reasons and suffered an accelerated decline of lung function more often than those with non-UIP subtype. Moreover, several comorbidities were very common, and in addition to RA-ILD, CAD was a common primary cause of death.
The distribution of genders was almost equal supporting previous findings that male sex is a risk factor for ILD [5, 8, 21], minding that RA is twice as common in females . The proportion of patients with UIP (59.3 %) and the amount of cases (13.7 %) in which ILD preceded articular disease were similar as described recently . Dyspnea and inspiratory crackles were more common in the patients with UIP, in agreement with previous results . The lung disease was more progressive in the UIP group based on the number of deaths, use of oxygen, hospitalization due respiratory reasons and decline of pulmonary function, especially DLCO. Some of the hospitalizations may have been attributable to acute exacerbations, known to occur mostly in UIP patterned RA-ILD . In summary, our findings support previous studies suggesting that RA-UIP follows a distinctive pathological course [13, 25].
ILD was the primary cause of death in the majority of subjects, especially in the UIP group, although this did not reach statistical significance in our small study population. A previous study also indicated that RA-ILD patients were most likely to die of ILD or RA itself . A recent Finnish study revealed that CAD was responsible for 43 % of deaths of RA patients  whereas in Korea, malignancies were the major cause of death in these patients . The high percentage (39.4 %) of ILD as a primary cause of death indicates that even though several comorbidities often coexist, ILD remains the leading cause of death. The immediate causes of deaths did not exhibit any significant differences between the UIP and non-UIP groups.
CAD was a major comorbidity in RA-ILD. Previously, the risk of CAD and hypertension has been shown to increase in RA already at disease onset . One novel finding was that asthma was more common in females, although an association between asthma and RA has been previously detected . COPD was observed in almost 30 % of patients, in line with a recent study revealing a 48 % prevalence of emphysema . COPD was more common in men, although this may be attributable to different smoking habits between the genders. COPD was also more prevalent in UIP patients even though smoking was similar in both groups. GER, previously claimed to be associated with IPF , or hypothyroidism thought to be more common in RA , were not prevalent in our study.
Previously published studies of survival of the patients with RA-ILD have revealed variable results. Some have reported survival as being as poor as in IPF i.e. approximately 3 years [8, 33, 34] but others have revealed longer survival times i.e. 7–8 years [10, 11], durations in line with the present study. Furthermore, the lifespan of RA-UIP has been shown to be shorter than that of the other subtypes . The median survival in our study was shorter in patients with UIP than in their non-UIP counterparts (92 vs 137 months) but this result did not reach statistical significance. Male gender has been recognized as a risk factor for RA-ILD mortality in previous studies . In our study, survival analyses revealed a tendency that non-UIP, but not UIP, females and non-smokers, lived longer.
Identifying the RA-ILD patients from hospital registers was challenging since two different diagnosis codes were needed and, moreover, medical records of hundreds of patients had to be reviewed before we could gather this study population, which is similar in size as the majority of published reports, except for a few multicenter studies . In fact, this sample size can be considered as representative since approximately 248,400 people live in the KUH region. In addition, we intentionally excluded the patients with only minor changes in HRCT since our purpose was to study the verifiably clinically relevant RA-ILD. The retrospective protocol of the data collection may have caused some inaccuracies and missing data. Categorization into either UIP or non-UIP groups was based on radiological evaluation, since histological data was limited. The radiological categorization can nonetheless be considered as reasonably reliable, since a definite UIP pattern in a HRCT scan has been demonstrated to be a sensitive and specific way of detecting the histopathologic UIP pattern in both IPF and RA-ILD [36–38]. Therefore we are confident that the UIP group reliably consists of true RA-UIP patients, although it is possible that some of the patients in the NSIP or unclassified group may be suffering from histological UIP. One obvious limitation of this study is the fact that the re-categorization of the patients was performed by one radiologist. However, a large proportion of the HRCT scans were evaluated in a multidisciplinary discussion. In this study, due to its retrospective nature, it was not possible to evaluate thoroughly the effects of therapeutic interventions since the patients had received highly variable treatments for RA and ILD without being followed with a standardized protocol as was also the case in a previously published investigation .
In summary, we detected several differences in disease course between RA-UIP and RA-non-UIP confirming the existing impression, that the UIP patterned ILD is more severe than the other subtypes of RA-ILD. In addition, even though several comorbidities often coexist with RA-ILD, the ILD itself seems to cause the majority of the deaths in these patients.
ANA, antinuclear antibodies; CAD, coronary artery disease; CCP, cyclic citrullinated peptide; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CTD, connective tissue diseases; DAD, diffuse alveolar damage; DLCO, diffusion capacity to carbon monoxide; FVC, forced vital capacity; GER, gastro-esophageal reflux; HRCT, high-resolution computed tomography; IIP, idiopathic interstitial pneumonias; ILD, interstitial lung disease; IPF, idiopathic pulmonary fibrosis; KUH, Kuopio University Hospital; MDD, multidisciplinary discussion; NSIP, nonspecific interstitial pneumonia; OP, organizing pneumonia; RA, rheumatoid arthritis; RA-DAD, rheumatoid arthritis-associated diffuse alveolar damage; RA-ILD, rheumatoid arthritis-associated interstitial pneumonia; RA-NSIP, rheumatoid arthritis-associated nonspecific interstitial pneumonia; RA-OP, rheumatoid arthritis-associated organizing pneumonia; RA-UIP, rheumatoid arthritis-associated usual interstitial pneumonia; RF, rheumatoid factor; SD, standard deviation; UIP, usual interstitial pneumonia
The authors wish to thank Ewen MacDonald for providing assistance with the language.
The study was supported by the Finnish Anti-Tuberculosis Association, the Jalmari and Rauha Ahokas Foundation, the Väinö and Laina Kivi Foundation, The Research Foundation of the Pulmonary Diseases, The Kuopio region Respiratory Foundation and a state subsidy to the Kuopio University Hospital.
Availability of data and materials
We cannot share our original data. It has been gathered in a detailed manner and minding that our population is relatively small in this Eastern-Finland hospital, we could not ascertain individuals’ anonymity.
HN collected the study material, analyzed the data and prepared the draft of the manuscript and takes responsibility for the integrity of the data and accuracy of the data analysis. MP contributed to the study design, analyses of data and planning of the data collection form. MK participated in planning of the data collection form. H-PK performed the radiological analyses and planned radiological data collection form. TS was responsible for the statistical analyses. RK designed and managed the study, planned the data collection form and interpreted data. All authors participated in manuscript preparation. All authors read and approved the final manuscript.
Hanna Nurmi: Consulting fees from Boehringer-Ingelheim and Roche Oy. Congress travel grants from Boehringer-Ingelheim, Lilly Oncology, Novartis, Orion Pharma and GlaxoSmithKline.
Minna Purokivi: Personal fees from Boehringer-Ingelheim, Chiesi, Intermune, Orion Pharma, Roche and Takeda Leiras. Congress travel grants from Boehringer-Ingelheim and Takeda Leiras Miia Kärkkäinen: Consulting fee from Boehringer-Ingelheim. Congress travel grants from Intermune, Boehringer-Ingelheim and Roche.
Hannu-Pekka Kettunen: Consulting fees from Siemens and Roche.
Riitta Kaarteenaho: Congress travel grants from Intermune, Boehringer-Ingelheim, Orion Pharma and Roche.
Tuomas Selander: No conflicts of interests.
Ethics approval and consent to participate
The study protocol was approved by the Ethical Committee of Kuopio University Hospital (statement 17/2013). In this retrospective study, the majority of the patients are deceased and no consents for publications were gathered.
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