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Prognosis of pulmonary fibrosis presenting with a usual interstitial pneumonia pattern on computed tomography in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis: a retrospective single-center study

BMC Pulmonary Medicine volume 19, Article number: 194 (2019) Cite this article

Abstract

Background

Myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis (MPO-ANCA nephritis) is occasionally accompanied by lung abnormalities such as pulmonary fibrosis. However, the clinical features of pulmonary fibrosis in patients with MPO-ANCA nephritis have not been well documented. This study was performed to compare the prognosis of a usual interstitial pneumonia (UIP) pattern of lung fibrosis in patients with MPO-ANCA nephritis with the prognosis of idiopathic pulmonary fibrosis (IPF).

Methods

We retrospectively reviewed the medical records of 126 patients with MPO-ANCA nephritis and identified 31 with a UIP pattern of lung fibrosis on high-resolution or thin-slice computed tomography (CT). We compared the characteristics and prognosis of these patients with those of 32 patients with IPF. In 18 patients from both groups, we assessed and compared the decline in lung volume over time using three-dimensional (3D) CT images reconstructed from thin-section CT data.

Results

The numbers of male and female patients were nearly equal among patients with MPO-ANCA nephritis exhibiting a UIP pattern; in contrast, significant male dominancy was observed among patients with IPF (p = 0.0021). Significantly fewer smokers were present among the patients with MPO-ANCA nephritis with a UIP pattern than among those with IPF (p = 0.0062). There was no significant difference in the median survival time between patients with MPO-ANCA nephritis with a UIP pattern (50.8 months) and IPF (55.8 months; p = 0.65). All patients with IPF in this cohort received antifibrotic therapy (pirfenidone or nintedanib). Almost half of the deaths that occurred in patients with MPO-ANCA nephritis with a UIP pattern were caused by non-respiratory-related events, whereas most deaths in patients with IPF were caused by respiratory failure such as acute exacerbation. In the 3D CT lung volume analyses, the rate of decline in lung volume was equivalent in both groups.

Conclusions

MPO-ANCA nephritis with a UIP pattern on CT may have an unfavorable prognosis equivalent to that of IPF with a UIP pattern treated with antifibrotic agents.

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Background

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) includes three main types of diseases: microscopic polyangiitis (MPA), granulomatous polyangiitis (GPA), and eosinophilic granulomatous polyangiitis. GPA and MPA are frequently accompanied by glomerulonephritis within 2 years after the onset of vasculitis [1, 2]. Pulmonary fibrosis develops less frequently than glomerulonephritis in patients with AAV. Among the three types of AAV, MPA, which is strongly associated with myeloperoxidase ANCA (MPO-ANCA), is most frequently accompanied by pulmonary fibrosis (15–47% of cases) [3,4,5,6]. MPO-ANCA-associated vasculitis more frequently occurs in Japanese patients, whereas proteinase-3 ANCA-associated vasculitis is more common in Europe and the United States [7]. Because both glomerulonephritis and pulmonary fibrosis are known to be unfavorable prognostic factors in patients with AAV, management of pulmonary fibrosis in patients with MPO-ANCA-related nephritis (MPO-ANCA nephritis) is a critical clinical problem [8, 9]. In the real-world setting, nephrologists often consult with pulmonologists about the management of pulmonary fibrosis in patients with MPO-ANCA nephritis. Some previous studies have addressed the relationship between MPO-ANCA and pulmonary fibrosis, showing that MPO-ANCA positivity is associated with a poor prognosis of pulmonary fibrosis [10]. However, because these studies focused mainly on pulmonary fibrosis, they may have included patients whose vasculitis activities were indolent or silent. Thus, the detailed clinical features of pulmonary fibrosis in patients with overt ANCA-related pathological conditions (i.e., those affecting other organs such as the kidney) have not been fully elucidated.

Previous studies have shown that a usual interstitial pneumonia (UIP) pattern is the most prevalent pattern on high-resolution computed tomography (HRCT) in patients with MPO-ANCA-associated interstitial pneumonia [11]. A UIP pattern on HRCT is a distinct CT finding characterized by honeycombing, reticular shadows, and traction bronchiectasis [12]. Idiopathic pulmonary fibrosis (IPF), which typically exhibits the UIP pattern on HRCT as well as the pathological pattern of UIP, has a significantly worse prognosis than chronic fibrotic idiopathic interstitial pneumonia [12, 13]. The aim of this study was to compare the clinical features and prognosis of pulmonary fibrosis showing a UIP pattern in patients with MPO-ANCA nephritis versus IPF.

Patients and methods

Patients

We retrospectively reviewed the records of 126 consecutive patients with MPO-ANCA nephritis who visited the Department of Nephrology in Fujita Health University Hospital from 2008 to 2018. Among these patients, we identified 31 patients who had lung fibrosis with a UIP pattern on thin-section CT (TSCT) or HRCT. All 31 patients had visited the Department of Respiratory Medicine for consultation within 1 month after the nephrologist first noted co-existing lung fibrosis. We simultaneously selected 32 patients with IPF who had been diagnosed and treated at Fujita Health University Hospital from 2011 to 2018. The diagnosis of IPF or a UIP pattern on CT was based on the criteria in the clinical practice guideline of the American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association [13]. The patients with IPF comprised 9 patients with a pathologically proven diagnosis obtained by thoracoscopic biopsy and 23 patients diagnosed by typical HRCT findings (UIP pattern) along with other consistent clinical findings. We excluded patients with serum ANCA positivity from among the patients with IPF. All patients with IPF had received antifibrotic therapy with either pirfenidone or nintedanib for at least 6 months. Overall survival was defined as the time from the first hospital visit (in IPF patients) or initial consultation with the pulmonologist for co-existing lung fibrosis (in ANCA-nephritis patients) to the date of death or last follow-up visit.

Evaluation of HRCT findings

CT (0.5 mm slices) images were generated using a non-enhanced multidetector CT system (Aquilion One; Toshiba Medical Systems, Tokyo, Japan). The CT scan parameters were as follows: tube current, automatic exposure control SD7; tube voltage, 120 kV; rotation speed, 0.5 s/rot; table speed, BP 1.39; reconstruction filter, FC51 AIDR 3D WEAK; window width, 1600; and window level, − 600. We used automatic exposure control, the volume helical scan mode, and multi-planar reconstruction images. Three observers, including two experts in thoracic radiology for diffuse lung diseases (T.W. and T.M. with 5 and 10 years’ experience of image diagnosis of pulmonary fibrosis, respectively) and one respiratory medicine specialist (K.I.) independently evaluated the TSCT or HRCT images of each patient within 3 months after the first visit to the hospital. The three observers selected one of the four categories of CT patterns: UIP or probable UIP pattern (defined as UIP pattern in this study), indeterminate for UIP pattern, alternative diagnosis pattern, and no abnormal change [13]. When three observers’ conclusions did not coincide, the final decision was made by group discussion. The kappa coefficient was calculated for evaluation of interobserver agreement. Representative UIP patterns in CT images from patients with ANCA-nephritis and IPF at two time points are shown in Figs. 1 and 2, respectively.

Fig. 1
figure 1

Representative thin-slice CT images of the lung from a patient with ANCA nephritis with a UIP pattern. (a–c) CT images at initial examination. (d–f) CT images 48 months after the initial CT examination. CT, computed tomography; ANCA, anti-neutrophil cytoplasmic antibody; UIP, usual interstitial pneumonia

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Fig. 2
figure 2

Representative thin-slice CT images of the lung from a patient with IPF. (a–c) CT images at initial examination. (d–f) CT images 36 months after the initial CT examination. CT, computed tomography; IPF, idiopathic pulmonary fibrosis

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Evaluation of lung volume by three-dimensional CT

Eighteen patients were selected from both groups of patients (those with MPO-ANCA nephritis with a UIP pattern and those with IPF) who had undergone TSCT (Aquilion ONE ViSION; Toshiba Medical Systems, Tokyo, Japan) at least twice, including the first time when physicians recognized pulmonary fibrosis and a second or later time point at least 6 months after the first TSCT. We reconstructed three-dimensional (3D) images of the whole lung from these TSCT data and calculated the lung volume using 3D reconstruction software (AZE Virtual Place; AZE Ltd., Tokyo, Japan) (Fig. 3). In brief, a 3D image of the lung was generated by extracting lung and bronchial images from the TSCT data followed by subtraction of the bronchial fraction. The software automatically calculated the volume of the created lungs. Next, we analyzed the difference (decline) in the 3D image lung volume between the first and latest TSCT. The annual change was calculated assuming that the lung volume declined at a regular pace. We evaluated the net and percent lung volume decline from baseline. We did not use the CT data just before death (within 1 month) because the lung volume might have been affected by various serious end-stage conditions such as pneumothorax, diffuse alveolar damage, or infection. In addition, nine patients with IPF who had undergone video-assisted thoracoscopic surgical biopsy were excluded because the surgical procedure could have affected expansion of the lung.

Fig. 3
figure 3

Representative data of three-dimensional reconstruction images of the lung from the CT data at the initial and following examinations. (a, b) ANCA nephritis with a UIP pattern. (c, d) IPF. (a, c) Whole-lung images reconstructed from the data of the initial CT examination. (b) CT image 48 months after the initial CT examination. (d) CT image 36 months after the initial CT examination. CT, computed tomography; ANCA, anti-neutrophil cytoplasmic antibody; UIP, usual interstitial pneumonia; IPF, idiopathic pulmonary fibrosis

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Statistical analysis

We used the nonparametric Wilcoxon signed-rank test for comparative analyses between the two groups. The kappa coefficient was used to assess interobserver agreement in the CT evaluation. Survival curves were evaluated by the Kaplan–Meier method, and the median survival time was analyzed by the log-rank test. All statistical analyses were performed using JMP version 13 (SAS Institute, Tokyo, Japan).

Results

CT patterns in patients with MPO-ANCA nephritis

The chest CT patterns in patients with MPO-ANCA nephritis are shown in Table 1. Among 126 patients with MPO-ANCA nephritis, 31 (24.6%) had a UIP or probable UIP pattern, 8 (6.3%) had findings indeterminate for a UIP pattern, and 27 (21.4%) had pulmonary infiltrations suggestive of a diagnosis other than UIP (alternative diagnosis). Sixty patients (47.6%) had no pulmonary infiltration. The Interobserver agreement as evaluated by the kappa coefficient was good or excellent (range, 0.79–0.97).

Table 1 Chest CT findings in patients with ANCA nephritis (n = 126) and concordance among three observers
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Patient characteristics

The clinical features of the 31 patients with MPO-ANCA nephritis with a UIP pattern and the 32 patients with IPF retrospectively recruited in this study are summarized in Table 2. The clinical backgrounds, respiratory symptoms, lactate dehydrogenase level, and Krebs von den Lungen-6 glycoprotein level were equivalent in both groups. Significantly more male patients and smokers (current and ex-smokers) were present among the patients with IPF (p = 0.0021 and p = 0.0062, respectively). Table 3 shows the details of renal dysfunction in the patients with MPO-ANCA nephritis with a UIP pattern. All but one patient had microscopic polyangiitis. The mean estimated glomerular filtration rate and serum creatinine level in the patients with MPO-ANCA nephritis with a UIP pattern were 34.1 mL/min/1.73 m2 and 2.66 mg/dL, respectively. Eight patients with MPO-ANCA nephritis with a UIP pattern had undergone hemodialysis, whereas no patients with IPF had started dialysis. Most patients with MPO-ANCA nephritis with a UIP pattern had been treated with immunosuppressive agents (n = 28, 90.0%), although two patients (6.4%) had received no treatment. Among the 28 patients with ANCA-nephritis who had received immunosuppressive therapy, seven (22.5%) experienced relapses after transient improvements of nephritis. Most recurrences occurred during tapering of the corticosteroid dose, and all relapsed patients subsequently recovered after re-increasing the steroid dose. All patients with IPF had been treated with antifibrotic agents (nintedanib n = 14 (300 mg/day n = 4, 200 mg/day n = 10) or pirfenidone n = 18 (1800 mg/day n = 3, 1200 mg/day n = 11, 600 mg/day n = 4)), whereas only one patient with MPO-ANCA nephritis had received antifibrotic therapy (nintedanib 300 mg/day) (Table 2).

Table 2 Clinical characteristics of patients with MPO-ANCA nephritis with a UIP pattern and patients with IPF
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Table 3 Renal findings in patients with MPO-ANCA nephritis with a UIP pattern
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Prognostic analysis of patients with MPO-ANCA nephritis with a UIP pattern

The results of the survival analysis between the patients with MPO-ANCA nephritis with a UIP pattern and those with IPF are shown in Fig. 4. The median survival time of the patients with MPO-ANCA nephritis and IPF was 50.8 and 55.8 months, respectively, with no significant difference (p = 0.65). We also analyzed the annual decline in lung volume calculated by 3D images of the lung reconstructed from TSCT data. The net annual decline in lung volume was − 221.7 mL/year in the patients with MPO-ANCA nephritis with a UIP pattern and − 191.4 mL/year in those with IPF (Fig. 5a); the difference was not statistically significant (p = 0.457). Similarly, the annual percent change from the baseline lung volume was − 6.36% per year in the patients with MPO-ANCA nephritis with a UIP pattern and − 5.48% in those with IPF (Fig. 5b), again with no significant difference (p = 0.189).

Fig. 4
figure 4

Kaplan–Meier distribution of survival rates in patients with MPO-ANCA nephritis with a UIP pattern versus those with IPF. MPO-ANCA, myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis; UIP, usual interstitial pneumonia; N.S., no significant difference

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Fig. 5
figure 5

Comparison of annual decline rate of lung volume from baseline calculated from three-dimensional computed tomography data between patients with MPO-ANCA nephritis with a UIP pattern and IPF. (a) Net lung volume decline and (b) percent lung volume decline. MPO-ANCA, myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis; UIP, usual interstitial pneumonia; IPF, idiopathic pulmonary fibrosis

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Causes of death

In total, 17 patients with MPO-ANCA nephritis with a UIP pattern and 13 patients with IPF died during the follow-up period. Causes of death in both groups are summarized in Table 4. There was an obvious difference in the causes of death between the two groups. Among the patients with MPO-ANCA nephritis with a UIP pattern, about half of the deceased patients (n = 8) had died of non-respiratory causes. In contrast, among the patients with IPF, 92% of the deceased patients (n = 12) had died of respiratory causes. Acute exacerbation (38%) and respiratory failure (38%) were the two major causes of death in patients with IPF. Notably, four patients with MPO-ANCA nephritis with a UIP pattern but none with IPF had died of alveolar hemorrhage.

Table 4 Causes of death in patients with MPO-ANCA nephritis with a UIP pattern and patients with IPF
Full size table

Discussion

Some excellent studies have addressed the clinical features, including the prognosis of pulmonary fibrosis, in patients with serum MPO-ANCA positivity [10, 14]. These studies showed that the prognosis of MPO-ANCA-positive pulmonary fibrosis was worse than that of ANCA-negative pulmonary fibrosis associated with other collagen vascular diseases. However, few studies have focused on the development of pulmonary fibrosis in patients with MPO-ANCA nephritis. A previous review showed that pulmonary fibrosis in patients with MPA and GPA exhibits various HRCT patterns, including the typical UIP pattern with honeycombing in the basal lung (most common, 47%), a combined pulmonary fibrosis and emphysema pattern, and a fibrotic nonspecific interstitial pneumonia pattern [15, 16]. Hosoda et al. [17] reported that the clinical features of MPO-ANCA-positive UIP without any overt collagen diseases were distinguishable from the clinical features of IPF. Thus, the present study, which is the first study to elucidate the prognosis of a UIP pattern of pulmonary fibrosis in patients with MPO-ANCA nephritis, may have clinical relevance.

Tzelepis et al. [18] reported that the overall survival of patients with MPO-ANCA nephritis with pulmonary fibrosis was 72 months, which is more favorable than in the present study. However, their study included pulmonary fibrosis with various chest CT patterns, not only a UIP pattern. In addition, they included younger patients than in our study. Conversely, the median survival time of patients with IPF in the present study was 55.8 months, which is more favorable than previously reported in Japan [19] and Western countries [20,21,22,23]. Notably, our patients with IPF had been treated with antifibrotic agents (nintedanib or pirfenidone). These previous articles were published before these antifibrotic agents had been introduced to daily clinical practice. Although there is no clear evidence that antifibrotic agents improve the survival of patients with IPF, some research has shown that pirfenidone might reduce mortality and improve life expectancy compared with best supportive care [24, 25]. We speculate that our patients with IPF might have had a more favorable prognosis because they had all received either pirfenidone or nintedanib. Our study showed that MPO-ANCA nephritis with a UIP pattern might have a poor prognosis similar to that of IPF under the appropriate therapy for each type of disease (anti-inflammatory therapy for MPO-ANCA nephritis and antifibrotic therapy for IPF).

Although our study showed no significant difference in prognosis, we found a striking difference in the causes of death between MPO-ANCA nephritis with a UIP pattern and IPF. Among patients with IPF, 92% of deaths were respiratory-related. These results are consistent with those of an epidemiologic study of Japanese patients with IPF [19]. In contrast, in patients with MPO-ANCA nephritis with a UIP pattern, deaths were more frequently related to anti-immune therapy (infectious complication) or vasculitis itself (alveolar hemorrhage and perhaps cardiovascular disease). Intriguingly, though the decline in lung volume and median survival time were similar between the two groups in this study, the causes of death were different. This might indicate that the respiratory impairment in patients with IPF may not be caused only by low vital capacity; other factors (impairment of diffusion capacity or acute exacerbation) may also have a significant prognostic influence.

In this study, we used 3D CT reconstruction data of the whole lung to evaluate the annual decline in lung volume. Because this study was a retrospective analysis of data from patients with nephritis (most patients were followed up mainly in the nephrology department), spirometry data obtained through regular follow-up were not available. Iwano et al. [26] reported that lung volume calculated using 3D CT volumetry was well correlated with lung volume measured using spirometry. Because the decline of vital capacity in spirometry is an important prognostic factor in patients with IPF, we substituted the decline in lung volume calculated from 3D CT for the spirometric decline in vital capacity. Although further studies are needed to confirm the reliability, we believe that lung volume data calculated from CT images could be useful for evaluation of pulmonary restrictive impairment.

This study has some limitations. First, this was a single-center retrospective study involving a small number of patients. Second, we were unable to analyze pulmonary function test data. Thus, the decline in the true vital capacity and diffusion capacity could not be evaluated in this study. In addition, we cannot rule out the possibility that the decline in vital capacity calculated from reconstructed 3D lung images might have been influenced by timing or the time interval in which chest CT was performed. Finally, we selected patients with MPO-ANCA nephritis with a UIP pattern only by HRCT findings, not pathological findings. In addition, we did not include patients in whom pulmonary fibrosis preceded the onset of nephritis. The time interval between the nephritis diagnosis and initial consultation with the pulmonologist depended on the individual nephrologist, but the mean interval between diagnosis of nephritis and diagnosis of UIP (lung fibrosis) was 18 months. The patients with ANCA-nephritis UIP in our study might thus have had relatively advanced disease and we might have excluded more patients with mild or early-stage fibrosis with a UIP pattern from the patients with ANCA nephritis. Further multicenter prospective studies with large numbers of patients are needed to fully elucidate the clinical characteristics of MPO-ANCA nephritis with a UIP pattern.

Conclusions

The prognosis of MPO-ANCA nephritis with a UIP pattern is poor and equivalent to that of IPF treated with antifibrotic agents. The lung volume reduction rate might be equivalent in both diseases. However, according to the present study, non-respiratory events are the cause of death in nearly half of patients with MPO-ANCA nephritis with a UIP pattern, whereas respiratory events are the cause of death in most patients with IPF.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

3D:

Three-dimensional

AAV:

Anti-neutrophil cytoplasmic antibody-associated vasculitis

ANCA:

Anti-neutrophil cytoplasmic antibody

CT:

Computed tomography

GPA:

Granulomatous polyangiitis

HRCT:

High-resolution computed tomography

IPF:

Idiopathic pulmonary fibrosis

MPA:

Microscopic polyangiitis

MPO:

Myeloperoxidase

TSCT:

Thin-section computed tomography

UIP:

Usual interstitial pneumonia

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Acknowledgments

The authors thank Mr. Yoshifumi Kuwayama (Department of Medical Information System, Fujita Health University) for technical advice and support with reconstruction of whole-lung 3D images from TSCT data, Mrs. Naomi Maeda for her excellent secretarial work and Mrs. Chiemi Oka for her technical assistance. The corresponding author has full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The authors also thank Angela Morben, DVM, ELS, from Edanz Group (www.edanzediting.com/ac), for editing a draft of this manuscript.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan

    Toshikazu Watanabe, Tomoyuki Minezawa, Yasuhiro Goto, Takuya Okamura, Yosuke Sakakibara, Yoshikazu Niwa, Atsushi Kato, Masamichi Hayashi, Sumito Isogai, Masashi Kondo & Kazuyoshi Imaizumi

  2. Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan

    Midori Hasegawa

  3. Center for Joint Research Facilities Support , Research Promotion and Support Headquarters, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan

    Naoki Yamamoto

  4. Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Naozumi Hashimoto

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Study conception and design: TW, TM, MH1, KI. Data acquisition: TW, MH1, YG, TO, YS, YN, AK. Data analysis and interpretation: TW, TM, MH1, MH2, SI, MK, KI. Drafting of the manuscript: TW, TM, NY. Critical revision of the manuscript: NH, KI. All authors have read and approved the manuscript in its current state.

Corresponding author

Correspondence to Kazuyoshi Imaizumi.

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Ethics approval and consent to participate

The study was conducted in accordance with the Declaration of Helsinki. The clinical data were retrieved from the electronic medical records with the endorsement of the Institutional Review Board of Fujita Health University (approval number HM-18-108).

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Not applicable; no personal information is presented in this article.

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The authors report no relationships that could be construed as a conflict of interest.

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Watanabe, T., Minezawa, T., Hasegawa, M. et al. Prognosis of pulmonary fibrosis presenting with a usual interstitial pneumonia pattern on computed tomography in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis: a retrospective single-center study. BMC Pulm Med 19, 194 (2019). https://doi.org/10.1186/s12890-019-0969-5

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Keywords

BMC Pulmonary Medicine

ISSN: 1471-2466

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