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A feasibility study evaluating a reservoir storage system for continuous oxygen delivery for children with hypoxemia in Kenya

Abstract

Background

Supplemental oxygen is an essential treatment for childhood pneumonia but is often unavailable in low-resource settings or unreliable due to frequent and long-lasting power outages. We present a novel medium pressure reservoir (MPR) which delivers continuous oxygen to pediatric patients through power outages.

Methods

An observational case series pilot study assessing the capacity, efficacy and user appraisal of a novel MPR device for use in low-resource pediatric wards. We designed and tested a MPR in a controlled preclinical setting, established feasibility of the device in two rural Kenyan hospitals, and sought user feedback and satisfaction using a standardized questionnaire.

Results

Preclinical data showed that the MPR was capable of bridging power outages and delivering a continuous flow of oxygen to a simulated patient. The MPR was then deployed for clinical testing in nine pediatric patients at Ahero and Suba Hospitals. Power was unavailable for 2% of the total time observed due to 11 power outages (median 4.6 min, IQR 3.6–13.0 min) that occurred during treatment with the MPR. Oxygen flowrates remained constant across all 11 power outages. Feedback on the MPR was uniformly positive; all respondents indicated that the MPR was easy to use and provided clinically significant help to their patients.

Conclusion

We present a MPR oxygen delivery device that has the potential to mitigate power insecurity and improve the standard of care for hypoxemic pediatric patients in resource-limited settings.

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Background

Pneumonia accounts for more fatalities in children globally than any other infectious disease [1]. In 2010, 120 million cases of pneumonia were recorded in children under 5 years of age. Treatment includes supplemental oxygen [2]; however, the availability of medical oxygen is unreliable in many low- to middle-income countries (LMICs) [3]. Our study took place in Kenya, a high burden country for pediatric pneumonia, with widespread oxygen insecurity. The under-five mortality rate in Kenya is approximately 4.6%, with 68,882 deaths annually [1]. Pneumonia accounts for 16% of child mortality, the second leading cause of death in children [2].

Hypoxemia, a blood oxygen saturation (SpO2) < 90%, increases the risk of mortality in children with pneumonia fivefold [4, 5]. Therefore, timely diagnosis and treatment of hypoxemia are essential to optimize patient outcomes [6]. Oxygen cylinders and oxygen concentrators are standard oxygen delivery methods employed in LMICs [6, 7]. However, cylinders are costly to transport, require regular replenishment [8], and are only feasible as a method of oxygen delivery where there is a reliable supply chain [9]. Oxygen concentrators [10] are less costly and more convenient than cylinders; however, they depend on a reliable source of electricity [9].

Power insecurity in healthcare facilities in LMICs remains a critical barrier to providing reliable oxygen delivery [11]. Power interruptions in many areas are frequent and long-lasting [3]. One solution may be to store oxygen in a reservoir while power is available, for use during power outages. Currently, there are a limited number of devices capable of bridging power outages to deliver continuous oxygen [6, 7, 12]. High-pressure oxygen storage systems are associated with safety hazards and may be vulnerable to leakage from fittings. On the other hand, low pressure reservoirs (LPRs) occupy a large volume and have restricted mobility [12]. LPRs are often housed outside of the ward and may not be feasibly installed in all facilities [13]. A medium-pressure reservoir (MPR) may have the benefits of safety, ruggedness, and compact size.

The objectives of our study were: (1) to design and test an MPR in a controlled pre-clinical environment; (2) to establish the feasibility of using the MPR device in two low-resource hospitals; (3) to determine whether the MPR was capable of delivering an uninterrupted oxygen supply during power outages; and (4) to assess end-user (health worker) feedback on the MPR oxygen delivery system.

Methods

Pre-clinical design

The design of the MPR sought to balance the need for continuous supply of oxygen with the cost, complexity, and ease of use of the storage device. An ideal MPR solution would maximize stored oxygen volume while minimizing the system’s physical footprint and operational complexity while being compatible with all commercial oxygen concentrators. Considerations included in the design were: (1) preference for off-the-shelf commercial products to capitalize on economies of scale costing and manufacturer component durability testing; (2) appropriate boost compressor size so it was not choked by output specifications of the oxygen concentrator and would reliably operate up to our maximum pressure without stalling; (3) safety of operation with respect to ignition risk due to storing high concentration oxygen at elevated pressure. A more complete description of the design considerations is included in the online supporting materials.

Clinical pilot study design and setting

This was an observational case series piloting the MPR on a small number of children with hypoxemia. Two rural hospitals in Kenya were chosen based on their high volumes of pediatric inpatients and unreliable electricity for deployment of the MPR oxygen delivery system: Ahero Hospital (Kisumu County), and Suba Hospital (Homa Bay County). We have previously reported on the availability and reliability of medical oxygen and electrical power at these and other facilities in the area [3].

Clinical definitions

Tachypnea and tachycardia were defined as respiratory rate or heart rate above the 99th percentile for age, respectively [14]. The Signs of Inflammation in Children that Kill (SICK) score is a composite severity-of-illness instrument used to predict the risk of subsequent mortality [15]. Non-invasive clinical assessment of patients’ respiratory rate, heart rate, capillary refill time, SpO2, systolic blood pressure and temperature are used to calculate the SICK score [16]. Patients with SICK scores exceeding 2.3 are at high risk of mortality [17].

Inclusion, exclusion and early discontinuation criteria

Patients were enrolled in the study if they met the following inclusion criteria: (1) age > 1 year and < 16 years; (2) hypoxemia (SpO2 < 90%); (3) admission to hospital warranted by the attending physician; and (4) provided written informed consent from the child’s legal guardian, and assent from children > 7 years of age. Exclusion or early discontinuation from the MPR occurred if: (1) patient SICK scores exceeded 2.3; (2) they required an oxygen flowrate > 2 L/min; or (3) an alarm indicated that reservoir was nearly depleted or oxygen concentration was < 82%.

Equipment and patient monitoring

The MPR instrument was monitored using near-continuous measurements of the flowrate (Honeywell Zephyr, Charlotte, NC), tank pressure (Honeywell PX3, Charlotte, NC), and oxygen quality (Compass Controls Manufacturing, 120-G, Lenexa, KS). Grid power reliability was assessed using a customized enVision 23,010 IC power monitor (Ametek®, Knightdale, NC). Measurements were logged every 0.1 min and stored for future analysis at the end of the trial. Nurses monitored patient vital signs as well as oxygen saturation every four hours (Rad-5® oximeter, Masimo Corp., Irvine, CA).

Satisfaction questionnaire

A 10-item satisfaction questionnaire was designed to systematically evaluate the user feedback on the device. The questionnaire was administered to a convenience sample of users of the device at the end of the clinical trial and included information on ease of use, perceived strengths and limitations, and overall appraisal of the MPR.

Results

Design and pre-clinical testing of medium pressure reservoir

We designed a novel MPR that integrates with a commercial oxygen concentrator (Airsep Newlife Intensity 10, Chart Industries, Ball Ground, GA) to provide a continuous stream of oxygen during power interruptions (Fig. 1a, Additional file 1: Figure S1, Table S1). This device capitalized on power when it is available, providing oxygen to up to two patients at a time while simultaneously diverting excess oxygen to a reservoir (Fill state, Fig. 1b). In the event of a power interruption, the device automatically began delivering stored oxygen to the patients (Drain state, Fig. 1b). Alternatively, the device could be operated in Bypass state (Fig. 1b), when the reservoir is full or patient demand is high. In pre-clinical testing, the fully pressurized MPR delivered a continuous stream of oxygen at a clinically relevant flowrate of 5 L/min for approximately 3 h under conditions of simulated power outages (Fig. 2). The MPR stored oxygen up to 790 kPa and could provide continuous oxygen flow for 891, 445, and 178 min at 1, 2, and 5 LPM flowrates, respectively. The MPR was designed and manufactured to comply with relevant safety standards to meet the objectives of this study [18,19,20,21,22].

Fig. 1
figure1

Medium pressure reservoir (MPR) to bridge gaps in oxygen delivery. a Picture of the MPR. b Functional states of the MPR. Drain state represents the power outage scenario where oxygen is drawn from the oxygen reservoir to patients. Fill state represents the normal operating condition (power available) where input from the oxygen concentrator is used to fill the reservoir and/or directed to patients. Bypass state is used when filling the reservoir is not a priority (reservoir is full or patient demand is high). In this state, oxygen is drawn directly from the oxygen concentrator to patient

Fig. 2
figure2

Pre-clinical testing of medium pressure reservoir (MPR). Benchtop performance of the MPR with simulated power outages (shaded region) and a constant patient flowrate of 5 L/min

Pilot clinical trial

Between May 20, 2019 and July 10, 2019, 88 pediatric patients hospitalized at Ahero and Suba Hospitals were screened. Nine met inclusion criteria and were enrolled in a pilot study of the MPR (Additional file 1: Figure S2). Patient characteristics are shown in Table 1.

Table 1 Characteristics of trial participants

Patients required oxygen therapy for a median duration of 9.2 h (range 1.1–43), representing a total time of oxygen delivery of 162 patient-hours. A total of 11 power interruptions lasting more than one minute (median duration 8.2 min, IQR 4.8–13) were observed, representing 1.4% of the total time of oxygen delivery (Table 2). The two longest power outages (34.7 min and 31.2 min) are depicted in Fig. 3. Oxygen flowrates did not change when power outages occurred.

Table 2 Power failures during study period
Fig. 3
figure3

The MPR bridges power failures in Kenyan children receiving oxygen therapy. a, c In two representative patients, oxygen flowrate (black line) and peripheral oxygen saturation (spot check, green circles) were maintained through several power cuts, including cuts lasting > 30 min. b, d MPR output flowrate (black line) and tank pressure (blue line) through the longest power cuts. Flow was maintained during the power cut. The MPR pressure dropped as expected during power cut and rose again with tank filling when power returned

Four patients (44%) were removed from the MPR device early and transferred to a standard oxygen cylinder (Table 1, Additional file 1: Figure S2) for the following reasons: they required a higher oxygen flowrate than mandated by the study protocol (> 2 L/min); an alarm signaled that oxygen purity had fallen below an acceptable standard; they needed to be transferred to another facility; or they were uncooperative. One patient in our study presented with hypoxemia, malaria, and stridor at rest, and subsequently died (11%). Careful review of the case concluded that death was unrelated to the MPR device for the following reasons: (1) the patient was transferred to a standard oxygen cylinder one hour prior to death, per protocol, because the required flowrate was greater than the protocol-mandated maximum of 2 L/min; (2). no significant power outages (> 1 min) were recorded, therefore the reservoir tank was never utilized; and (3) oxygen purity from the concentrator remained at > 82% throughout treatment.

End user satisfaction questionnaire

Seven users (nurses and clinicians) from Suba Hospital provided feedback on the MPR at the end of the trial, using a standardized satisfaction questionnaire (Table 3).

Table 3 End user satisfaction questionnaire

Discussion

Here we demonstrate the potential utility of a novel MPR that can bridge power outages to deliver a continuous oxygen supply. After pre-clinical development and testing, the MPR was deployed in two rural hospitals in Kenya, demonstrating feasibility for use on resource-limited pediatrics wards. Real-world power outages lasting > 30 min were seamlessly and automatically bridged by the MPR. User feedback was uniformly positive. Our study supports further development of the MPR device and encourages larger non-inferiority trials.

Hypoxemia is a severe and life-threatening complication of pneumonia. The median prevalence of hypoxemia in children with pneumonia requiring hospitalisation is 13% [23]. The case-fatality rate of pneumonia ranges from 3 to 15%, with a fivefold higher odds of death in children with hypoxemia [24]. In our study, 9/88 (10%) of screened patients were hypoxemic, and 1/9 (11%) of hypoxemic patients died, consistent with these data.

More than half of the patients in our study experienced one or more power outages, all of which were successfully bridged by the MPR (Table 2). Most power outages occurred at a critical time of oxygen dependency, such that clinical consequences may have been severe without backup flow from the MPR. Two power interruptions lasted > 30 min and were potentially life-threatening. A previous study on power insecurity in 12 sub-Saharan African countries found that electricity was fully available in only 35% of the 231 healthcare facilities assessed [25]. We previously showed that power was unavailable for a median of 7% of the time in Kenyan facilities [3]. In light of these findings, tenuous electrical supply in our study and previous studies highlights the need for interventions like the MPR.

Previous studies have assessed the use of high-pressure and low-pressure oxygen storage reservoirs in pre-clinical studies [12, 13, 26]. In hospitals where there is a reliable supply chain from an oxygen plant, high-pressure oxygen cylinders are the standard. However, a previous study in Uganda found that only 10% of nurses showed adequate skills in operating a high-pressure oxygen cylinder [26] and tightening of high-pressure mechanical fittings requires considerable manual strength [27]. Our MPR was user-friendly and did not require manual intervention from the ward nurses. Problems with low-pressure oxygen cylinders are associated with the size of the reservoir. Space requirements are considerable, and often lead to the relocation of the low-pressure reservoir outside the hospital ward [13]. In contrast, the MPR was maneuverable and integrated well in the clinical workflow. Thus, medium-pressure oxygen storage methods have the potential to overcome many of the limitations associated with high- and low-pressure oxygen cylinders.

There are several limitations to our study. The design was a pilot study that did not have a control group and was not statistically powered to demonstrate efficacy of the MPR. Our conclusions are therefore limited to feasibility of the MPR and its ability to bridge power outages on resource-limited pediatrics wards. We included two health facilities; however, a wider sampling of hospitals and health centres, across a range of available grid electricity, would be desirable to assess the ideal use case for the MPR. The cut off for the SICK score excluded the sickest patients and limited our ability to know how this intervention could impact outcomes in that cohort. Our study was limited to public facilities whereas non-state providers are increasingly present in low-income settings; our conclusions should therefore be extrapolated with caution to private health care facilities. The device described in this study is an engineering sample designed to test the feasibility of providing continuous oxygen through power outages. A commercial product is being developed with cost appropriate to LMICs being a consideration. The return on investment over the lifetime of the device should be comparable to the cost of oxygen cylinders and the logistics to deliver them. A formal cost-effectiveness analysis would be of interest, but is beyond the scope of the current manuscript.

Conclusion

Our MPR mitigates the risks of power insecurity and may improve the standard of care for hypoxemic pediatric patients in resource-limited settings. This device is likely to have the highest impact in high-volume health centers with frequent power interruptions, and it may not be suitable for large district hospitals. Further studies into where the MPR proves most effective are warranted.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. The data are available at the following clinical data repository: Association for Health Innovation in Africa (AFHIA, https://sites.google.com/view/afhia-drc-uganda/clinical-data-repository. Accession number 2020.001).

Abbreviations

LMICs:

Low-to middle-income countries

SpO2 :

Blood oxygen saturation

LPRs:

Low-pressure reservoirs

MPR:

Medium-pressure reservoir

SICK:

Signs of inflammation in children that kill

References

  1. 1.

    Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, et al. Global burden of childhood pneumonia and diarrhoea. The Lancet. 2013;381(9875):1405–16.

    Article  Google Scholar 

  2. 2.

    Mantero M, Tarsia P, Gramegna A, Henchi S, Vanoni N, Pasquale MD. Antibiotic therapy, supportive treatment and management of immunomodulation-inflammation response in community acquired pneumonia: review of recommendations. Multidiscip Respir Med. 2017;12:1–19.

    Article  Google Scholar 

  3. 3.

    Otiangala D, Agai NO, Olayo B, Adudans S, Ng CH, Calderon R, et al. Oxygen insecurity and mortality in resource-constrained healthcare facilities in rural Kenya. Pediatr Pulmonol. 2020;55:1043–9.

    Article  Google Scholar 

  4. 4.

    Onyango F, Steinhoff M, Wafula E, Wariua S, Musia J, Kitonyi J. Hypoxaemia in young Kenyan children with acute lower respiratory infection. BMJ. 1993;306(6878):612–5.

    CAS  Article  Google Scholar 

  5. 5.

    Usen S, Weber M, Mulholland K, Jaffar S, Oparaugo A, Omosigho C, et al. Clinical predictors of hypoxaemia in Gambian children with acute lower respiratory tract infection: prospective cohort study. BMJ. 1999;318(7176):86–91.

    CAS  Article  Google Scholar 

  6. 6.

    Basnet S, Adhikari R, Gurung C. Hypoxemia in children with pneumonia and its clinical predictors. Indian J Pediatr. 2006;73(9):777–81.

    Article  Google Scholar 

  7. 7.

    Ginsburg A, Cleve V, Thompson M, English M. Oxygen and pulse oximetry in childhood pneumonia: a survey of healthcare providers in resource-limited settings. J Trop Pediatr. 2012;58(5):389–93.

    Article  Google Scholar 

  8. 8.

    Duke T, Graham S, Cherian M, Ginsburg A, English M, Howie S, et al. Oxygen is an essential medicine: a call for international action. Int J Tuberc Lung Dis. 2010;14(11):1362–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. 9.

    Howie S, Hill S, Ebonyi A, Krishnan G, Njie O, Sanneh M, et al. Meeting oxygen needs in Africa: an options analysis from the Gambia. Bull World Health Organ. 2009;87:763–71.

    Article  Google Scholar 

  10. 10.

    WHO. Oxygen therapy for children: a manual for health workers. 2016.

  11. 11.

    Belle J, Cohen H, Shindo N, Lim M, Velazquez-Berumen A, Ndihokubwayo J, et al. Influenza preparedness in low resource settings: a look at oxygen delivery in 12 African countries. J Infect Dev Ctries. 2010a;4(7):419–24.

    Article  Google Scholar 

  12. 12.

    Calderon R, Morgan M, Kuiper M, Nambuya H, Wangwe N, Somoskovi A, et al. Assessment of a storage system to deliver uninterrupted therapeutic oxygen during power outages in resource-limited settings. PLoS ONE. 2019;14(2):e0211027.

    CAS  Article  Google Scholar 

  13. 13.

    Rassool R, Sobott B, Peake D, Mutetire B, Moschovis P, Black J. A low-pressure oxygen storage system for oxygen supply in low-resource settings. Respir Care. 2017;62(12):1582–7.

    Article  Google Scholar 

  14. 14.

    Fleming S, Thompson M, Stevens R, Heneghan C, Pluddemann A, Maconochie I, et al. Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies. Lancet. 2011;377(9770):1011–8.

    Article  Google Scholar 

  15. 15.

    Bhal S, Tygai V, Kumar N, Sreenivas V, Puliyel JM. Signs of inflammation in children that can kill (SICK score): preliminary prospective validation of a new non-invasive measure of severity-of-illness. J Postgrad Med. 2006;52(2):102–5.

    CAS  PubMed  Google Scholar 

  16. 16.

    Kumar N, Thomas N, Singhal D, Puliyel JM, Sreenivas V. Triage score for severity of illness. Indian Pediatr. 2003;40(3):204–10.

    CAS  PubMed  Google Scholar 

  17. 17.

    Conroy AL, Hawkes M, Hayford K, Namasopo S, Opoka RO, John CC, et al. Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness. Crit Care. 2015;19(1):1–11.

    Article  Google Scholar 

  18. 18.

    International A. ASTM G93/G93M—19, Standard guide for cleanliness levels and cleaning methods for materials and equipment used in oxygen-enriched environments. West Conshosocken, PA. 2019.

  19. 19.

    ISO. ISO 15001:2010, Anaesthetic and respiratory equipment—Compatibility with oxygen. 2016.

  20. 20.

    ISO. ISO 80601-2-69:2014, Medical electrical equipment—Part 2-69: Particular requirements for basic safety and essential performance of oxygen concentrator equipment. 2014.

  21. 21.

    IEC. IEC 60601-1-2:2014, Medical electrical equipment—Part 1–2: General requirements for basic safety and essential performance—Collateral Standard: Electromagnetic disturbances—Requirements and tests. 2014.

  22. 22.

    IEC. IEC 60601-1:2005+AMD1:2012 CSV, Consolidated version, Medical electrical equipment—Part 1: General requirements for basic safety and essential performance. 2012.

  23. 23.

    Subhi R, Adamson M, Campbell H, Weber M, Smith K, Duke T, et al. The prevalence of hypoxaemia among ill children in developing countries: a systematic review. Lancet Infect Dis. 2009;9(4):219–27.

    Article  Google Scholar 

  24. 24.

    Lazzerini M, Sonego M, Pellegrin MC. Hypoxaemia as a mortality risk factor in acute lower respiratory infections in children in low and middle-income countries: systematic review and meta-analysis. PLoS ONE. 2015;10(9):e0136166.

    Article  Google Scholar 

  25. 25.

    Belle J, Cohen H, Shindo N, Lim M, Velazquez-Berumen A, Ndihokubwayo J, et al. Influenza preparedness in low-resource settings: a look at oxygen delivery in 12 African countries. J Infect Dev Ctries. 2010b;4(7):419–24.

    Article  Google Scholar 

  26. 26.

    Nabwire J, Namasopo S, Hawkes M. Oxygen availability and nursing capacity for oxygen therapy in Ugandan paediatric wards. J Trop Pediatr. 2018;64(2):97–103.

    Article  Google Scholar 

  27. 27.

    Hawkes M, Conroy A, Namasopo S, Bhargava R, Kain K, Mian Q, et al. Solar-powered oxygen delivery in low-resource settings: a randomized clinical noninferiority trial. JAMA Pediatr. 2018;172(7):694–6.

    Article  Google Scholar 

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Acknowledgements

We thank all the patients and their families, and the nurses that cared for the patients and collected study data.

Funding

This study was supported by Global Good Fund I, LLC (www.globalgood.com).

Author information

Affiliations

Authors

Contributions

AS, DB and DL conceived and designed the study, designed the MPR, performed data analysis and critically reviewed the manuscript. EF performed data analysis and wrote and critically reviewed the manuscript. BO designed the study, supervised and conducted the data collection in the field, and critically reviewed the manuscript. DO, NA and SA supervised and conducted the data collection in the field, and critically reviewed the manuscript. CB designed the study, oversaw regulatory procedures, and critically reviewed the manuscript. CHN and RC designed the MPR and performed data analysis. MH designed the study, supervised data analysis, wrote and critically reviewed the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Michael Hawkes.

Ethics declarations

Ethics approval and consent to participate

The study was approved by the Maseno University Ethics Review Committee (Maseno, Kenya; ref: MSU/DRPI/MUERC/00433/17), the Western Institutional Review Board-Copernicus Group (Seattle, USA; tracking number: 20171427), and the University of Alberta Research Ethics Board Biomedical Panel (Edmonton, Canada; ref: Pro00086635). Accompanying parents or legal guardians provided written informed consent and patients > 7 years of age provided assent at the time of enrolment. All study procedures were carried out in accordance with the guidelines and regulations of the Kenyan authorities and Maseno University Ethics Review Committee.

Consent for publication

Not applicable.

Competing interests

DL, CB, CHN, and RC are employed by Global Good to design and manufacture an oxygen storage system. DO, NOA, BO, SA, EF, DB, MH, and AS have no competing interests to declare.

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Supplementary Information

Additional file 1.

Materials provided in the online additional file include: (1) Engineering design of medium pressure reservoir (MPR); (2) Figure S1, Detailed schematic of MPR; (3) Table S1, Description of components of MPR; and (4) Figure S2, Pilot clinical trial profile.

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Otiangala, D., Agai, N.O., Olayo, B. et al. A feasibility study evaluating a reservoir storage system for continuous oxygen delivery for children with hypoxemia in Kenya. BMC Pulm Med 21, 78 (2021). https://doi.org/10.1186/s12890-021-01433-6

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Keywords

  • Pneumonia
  • Hypoxemia
  • Electricity
  • Global health
  • Africa