Articles

Effect of urban air pollution on CRP and coagulation: a study on inpatients with acute exacerbation of chronic obstructive pulmonary disease

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an important event in the course of chronic obstructive pulmonary disease that negatively affects patients’ quality of life and leads to ...

Authors: Lingling Tang, Suofang Shi, Bohan Wang, Li Liu, Ying Yang, Xianhong Sun, Zhenhua Ni and Xiongbiao Wang

Development and validation of a set of patient reported outcome measures to assess effectiveness of asthma prophylaxis

In the local setting, asthma control is assessed by symptoms and signs elicited by clinicians because of the limited availability of spirometry. Hence, we intended to develop a patient reported outcome measure...

Authors: Yalini Guruparan, Thiyahiny S. Navaratinaraja, Gowry Selvaratnam, Nalika Gunawardena and Shalini Sri Ranganathan

¹⁸F-FDG PET/CT predicts acute exacerbation in idiopathic pulmonary fibrosis after thoracic surgery

Acute exacerbation (AE) is the most lethal postoperative complication in idiopathic pulmonary fibrosis (IPF); however, prediction before surgery is difficult. We investigated the role of ¹⁸F-fluorodeoxyglucose po...

Authors: Hee-Young Yoon, Suk Hyun Lee, Sejin Ha, Jin-Sook Ryu and Jin Woo Song

Re-expansion pulmonary edema following a pneumothorax drainage in a patient with COVID-19

Re-expansion pulmonary edema is an uncommon complication following drainage of a pneumothorax or pleural effusion. While pneumothorax is noted to complicate COVID-19 patients, no case of COVID-19 developing re...

Authors: Kosaku Komiya, Ryosuke Hamanaka, Hisayuki Shuto, Hiroki Yoshikawa, Atsushi Yokoyama, Kazufumi Hiramatsu and Jun-ichi Kadota

DNA methylation and gene expression profiles to identify childhood atopic asthma associated genes

Asthma is a chronic inflammatory disorder of the airways involving many different factors. This study aimed to screen for the critical genes using DNA methylation/CpGs and miRNAs involved in childhood atopic a...

Authors: Rui Chen, Li-Zhen Piao, Ling Liu and Xiao-Fei Zhang

A potential mechanism of the onset of immune-related pneumonitis triggered by anti-PD-1 treatment in a patient with advanced adenocarcinoma lung cancer: case report

In recent years, the application of immunotherapy combined with chemotherapy in the first-line lung cancer has showed significant benefit in improving long-term survival. Immunotherapy also has risks of immune...

Authors: Yu Feng, Cuncun Chen, Liming Zhao, Xuyou Zhu, Xiaoping Zhu and Qiang Li

Chronic cough caused by choledochoduodenal fistula: a case report

Chronic cough is characterized by cough as the only or main symptom, with a duration of more than 8 weeks and no obvious abnormality in chest X-ray examination. Its etiology is complex, including respiratory d...

Authors: Jiaofei Cao, Yue Hu, Shaojun Jin, Fei Chen, Li Li and Huaqiong Huang

Opioids in patients with COPD and refractory dyspnea: literature review and design of a multicenter double blind study of low dosed morphine and fentanyl (MoreFoRCOPD)

Refractory dyspnea or breathlessness is a common symptom in patients with advanced chronic obstructive pulmonary disease (COPD), with a high negative impact on quality of life (QoL). Low dosed opioids have bee...

Authors: Marlies van Dijk, Kris J. M. Mooren, Jan-Willem K. van den Berg, Wendy J. C. van Beurden-Moeskops, Roxane Heller-Baan, Sander M. de Hosson, Wai Yee Lam-Wong, Liesbeth Peters, Karin Pool and Huib A. M. Kerstjens

High neutrophils and low lymphocytes percentages in bronchoalveolar lavage fluid are prognostic factors of higher in-hospital mortality in diffuse alveolar hemorrhage

Diffuse alveolar hemorrhage (DAH) is a syndrome resulting from bleeding in the microcirculation of the lung, with a poor prognosis. The study aim was to identify prognostic factors of DAH, especially bronchoal...

Authors: Kensuke Kanaoka, Seigo Minami, Shoichi Ihara and Kiyoshi Komuta

LncRNA LINC00520 aggravates cell proliferation and migration in lung adenocarcinoma via a positive feedback loop

Lung adenocarcinoma (LUAD) is the most common histological subtype of primary lung cancer. To identify the biomarker of diagnosis for LUAD is of great significance. Long non-coding RNAs (lncRNAs) were previous...

Authors: Wen Huang, Xinxing Wang, Fubing Wu and Fanggui Xu

First case of lung cancer with pneumoconiosis and endobronchial leiomyoma complicating the diagnosis

In the treatment of lung cancer, the presence or absence of mediastinal lymph node involvement has a significant bearing on the indication for surgery. In addition, if a tumor is found in the trachea during pr...

Authors: Yutaka Takahara, Kouichi Yamamura, Nozomu Motono, Taku Oikawa, Hidetaka Uramoto and Shiro Mizuno

Hyperoxaemia and hypoxaemia are associated with harm in patients with ARDS

Oxygen therapy is routinely administered to mechanically ventilated patients. However, there remains uncertainty about the optimal oxygen titration target in patients with the acute respiratory distress syndro...

Authors: Andrew J. Boyle, David N. Holmes, Jonathan Hackett, Susanna Gilliland, Michael McCloskey, Cecilia M. O’Kane, Paul Young, Stefania Di Gangi and Daniel F. McAuley

Cough hypersensitivity in patients with metabolic syndrome: a clinical finding and its possible mechanisms

To investigate the changes of cough sensitivity in patients with metabolic syndrome and its possible mechanisms.

Authors: Jiafen Cheng, Zhuangli Xie, Shengyuan Wang, Siwan Wen, Shanshan Niu, Cuiqin Shi, Li Yu and Xianghuai Xu

A nomogram for predicting postoperative pulmonary infection in esophageal cancer patients

Although postoperative pulmonary infection (POI) commonly occurs in patients with esophageal cancer after curative surgery, a patient-specific predictive model is still lacking. The main aim of this study is t...

Authors: Shuang Li, Jingwen Su, Qiyu Sui and Gongchao Wang

Circulating activated immune cells as a potential blood biomarkers of non-small cell lung cancer occurrence and progression

Treatment for non-small cell lung cancer (NSCLC) has greatly improved in recent years. However, noninvasive early screening for carcinogenesis and progression unclear. The aim of this study was to explore the ...

Authors: Yingyi Wang, Na Zhou, Rui Zhu, Xiaoyuan Li, Zhao Sun, Yang Gao, Wei Liu, Changting Meng, Yuping Ge, Chunmei Bai, Taisheng Li and Hongsheng Liu

Clinical-radiological predictive model in differential diagnosis of small (≤ 20 mm) solitary pulmonary nodules

There is a lack of clinical-radiological predictive models for the small (≤ 20 mm) solitary pulmonary nodules (SPNs). We aim to establish a clinical-radiological predictive model for differentiating malignant ...

Authors: Hai-Cheng Zhao, Qing-Song Xu, Yi-Bing Shi and Xi-Juan Ma

Candidate gene prioritization for chronic obstructive pulmonary disease using expression information in protein–protein interaction networks

Identifying or prioritizing genes for chronic obstructive pulmonary disease (COPD), one type of complex disease, is particularly important for its prevention and treatment.

Authors: Wan Li, Yihua Zhang, Yahui Wang, Zherou Rong, Chenyu Liu, Hui Miao, Hongwei Chen, Yuehan He, Weiming He and Lina Chen

Pulmonary fibrosis in dyskeratosis congenita: a case report with a PRISMA-compliant systematic review

Dyskeratosis congenita (DC) is a rare genetic disorder of poor telomere maintenance. Pulmonary fibrosis (PF) related to DC is rarely reported.

Authors: Ping Wang and Zuojun Xu

Delayed positive COVID19 nasopharyngeal test, a case study with clinical and pathological correlation

There are various reasons for delayed positive nasopharyngeal PCR tests for coronavirus disease 2019 (COVID19) in not only asymptomatic but also severely diseased patients. The pathophysiological attributes ar...

Authors: Lei Zhang, Syam P. Vunnamadala, Shigeo Yagi, Riffat Meraj and Michele Carbone

LncRNA DLGAP1-AS2 regulates miR-503/cyclin D1 to promote cell proliferation in non-small cell lung cancer

LncRNA DLGAP1-AS2 plays an oncogenic role in glioma, while its role in other cancers is unknown. This study aimed to study the role of DLGAP1-AS2 in non-small cell lung cancer (NSCLC).

Authors: Lu Wang, Lei Tang, Tengfei Ge, Feng Zhu, Dan Liu, Hua Guo, Peng Qian and Ning Xu

Paradoxical effects of cigarette smoke and COPD on SARS-CoV-2 infection and disease

How cigarette smoke (CS) and chronic obstructive pulmonary disease (COPD) affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection and severity is controversial. We investigated the effects...

Authors: M. Tomchaney, M. Contoli, J. Mayo, S. Baraldo, S. Li, C. R. Cabel, D. A. Bull, S. Lick, J. Malo, S. Knoper, S. S. Kim, J. Tram, J. Rojas-Quintero, M. Kraft, J. G. Ledford, Y. Tesfaigzi…

Lung "holes" after cryobiopsy: a case report

Transbronchial lung cryobiopsy is a safe technique increasingly used in the study of lung diseases. Until now, only a case of pneumatocele was described but this interesting condition is probably underestimate...

Authors: Roberto Piro, Sofia Taddei, Matteo Fontana, Chiara Scelfo, Eleonora Casalini and Nicola Facciolongo

Incidence and risk factors of postoperative complications in patients with tuberculosis-destroyed lung

The purpose of this study was to determine risk factors of postoperative complications in tuberculosis-destroyed lung (TDL) patients.

Authors: Hongyun Ruan, Fangchao Liu, Ming Han and Changfan Gong

LncRNA MANCR positively affects the malignant progression of lung adenocarcinoma

LncRNA MANCR (mitosis-related lncRNA, LINC00704) is deemed as a pivotal regulator in various cancers, yet the biological function it performs in lung adenocarcinoma (LUAD) was rarely reported. We made an in-de...

Authors: Chang Liu, Haifeng Li, Xiaojing Li, Xuejing Zhao and Xia Zhang

Elevated levels of arginase activity are related to inflammation in patients with COPD exacerbation

Within the pathogenesis of the chronic obstructive pulmonary disease (COPD) there are interactions between different inflammatory mediators that are enhanced during an exacerbation. Arginase is present in bron...

Authors: Marcel Jose Rodríguez-Guzmán, Germán Peces-Barba Romero, Sandra Pérez Rial, Cristina Serrano del Castillo, Miguel Ángel Palomero Rodríguez, Ignacio Mahillo-Fernandez and Felipe Villar-Álvarez

Identifying specific needs in adult cystic fibrosis patients: a pilot study using a custom questionnaire

Adult patients with cystic fibrosis (CF) experience daily physical symptoms and disabilities that can be challenging to address for health care teams.

Authors: Sandra Dury, Jeanne-Marie Perotin, Bruno Ravoninjatovo, Catherine Llerena, Julien Ancel, Pauline Mulette, Muriel Griffon, Sophie Carré, Amélie Perrin, François Lebargy, Gaëtan Deslée and Claire Launois

Fundamental movement skill proficiency and objectively measured physical activity in children with bronchiectasis: a cross-sectional study

Bronchiectasis is a major contributor to respiratory morbidity and healthcare utilization in children. Children with bronchiectasis exhibit low levels of physical activity (PA) and poor fundamental movement sk...

Authors: Barbara Joschtel, Sjaan R. Gomersall, Sean Tweedy, Helen Petsky, Anne B. Chang and Stewart G. Trost

Randomized, placebo controlled, double blinded pilot superiority phase 2 trial to evaluate the effect of curcumin in moderate to severe asthmatics

Curcumin, a derivative of the spice turmeric, has been adopted by Eastern medicine for centuries as an adjunct to treat several medical conditions (e.g., anorexia and arthritis) because of its well-established...

Authors: Michele Quan, Abdullah Alismail, Noha Daher, Derrick Cleland, Sonia Chavan and Laren D. Tan

Prevalence and clinical consequences of atelectasis in SARS-CoV-2 pneumonia: a computed tomography retrospective cohort study

The aim of the study is to estimate the prevalence of atelectasis assessed with computer tomography (CT) in SARS-CoV-2 pneumonia and the relationship between the amount of atelectasis with oxygenation impairme...

Authors: Álvaro Mingote, Andrea Albajar, Paulino García Benedito, Jessica Garcia-Suarez, Paolo Pelosi, Lorenzo Ball and Javier García-Fernández

Effectiveness of one-on-one coaching in improving pressurized metered dose inhaler (pMDI) technique among COPD patients: a prospective clinical study

Incorrect use of inhalers among asthma and COPD patients is very prevalent. Yet, no single intervention is considered standard of care. We aimed to conduct a COPD-specific investigation of active one-on-one co...

Authors: Jin Sun Kim, Nader Hashweh, Hannah Li, Salik Choudhary, Sadashiv Santosh and Edward Charbek

A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center

The objective of the present study is to describe the clinical, diagnostic, radiological and therapeutic aspects of osteoarticular tuberculosis (OATB) in patients in a tertiary pediatric hospital, to know if t...

Authors: Napoleón González Saldaña, Mercedes Macías Parra, Luis Xochihua Díaz, Martin Palavicini Rueda, Ana Jocelyn Carmona Vargas, José Iván Castillo Bejarano, Quetzalli Veloz Corona, Hugo Juárez Olguín and Juan Luis Chavez Pacheco

Deep vein thrombosis in acute respiratory distress syndrome caused by bacterial pneumonia

Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by acute hypoxaemia, and few studies have reported the incidence of deep vein thrombosis (DVT) in direct ARDS caused by bacterial...

Authors: Na Cui, Song Mi, Chunguo Jiang, Wanlu Sun, Wenping Mao, Liming Zhang and Xiaokai Feng

Novel compound heterozygous mutations of DNAH5 identified in a pediatric patient with Kartagener syndrome: case report and literature review

Kartagener syndrome is a subtype of primary ciliary dyskinesia that may exhibit various symptoms including neonatal respiratory distress and frequent infections of the lung, sinus and middle ear because of the...

Authors: Lina Wang, Xin Zhao, Hang Liang, Li Zhang, Chunyan Li, Deli Li, Xiangfeng Meng, Fanzheng Meng and Mao Gao

The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients

We characterized the clinical features, radiographic characteristics, and response to treatment of immunocompetent and immunocompromised patients with pulmonary cryptococcosis (PC).

Authors: Yan Hu, Si-Ying Ren, Peng Xiao, Feng-Lei Yu and Wen-Liang Liu

Outcome and prognostic factors after lung transplantation for bronchiectasis other than cystic fibrosis

While lung transplant (LTX) can be an effective therapy to provide the survival benefit in selected populations, post-transplant outcome in LTX recipients with bronchiectasis other than cystic fibrosis (CF) ha...

Authors: Takashi Hirama, Fumiko Tomiyama, Hirotsugu Notsuda, Tatsuaki Watanabe, Yui Watanabe, Hisashi Oishi and Yoshinori Okada

Characteristics of patients meeting the new definition of pre-capillary pulmonary hypertension (Nice 2018) in a single Japanese pulmonary hypertension center

The 6th World Symposium on Pulmonary Hypertension (Nice 2018) proposed a new definition of pre-capillary pulmonary hypertension (PH) as a condition with mean pulmonary artery pressure (mPAP) > 20 mmHg, pulmona...

Authors: Keiko Yamamoto, Nobuhiro Tanabe, Yukiko Takahashi, Akira Naito, Ayumi Sekine, Rika Suda, Takayuki Jujo Sanada, Toshihiko Sugiura, Ayako Shigeta, Seiichiro Sakao and Koichiro Tatsumi

Diagnostic possibility of the combination of exhaled nitric oxide and blood eosinophil count for eosinophilic asthma

Tests to identify reversible airflow limitation are important in asthma diagnosis, but they are time-consuming and it may be difficult for patients to cooperate. We aimed to evaluate whether the combination of...

Authors: Jiang-Hua Li, Rui Han, Yu-Bo Wang, Min Cheng, Heng-Yi Chen, Wen-Hui Lei, Li Li, Chen Gao, Na-Na Zhao, Nai-Fu Nie, Zhong-Yan Li, Guo-Qing Yin, Shuai Huang and Yong He

Emergency admission parameters for predicting in-hospital mortality in patients with acute exacerbations of chronic obstructive pulmonary disease with hypercapnic respiratory failure

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common presentation in emergency departments (ED) that can be fatal. This study aimed to develop a mortality risk assessment model for ...

Authors: Lan Chen, Lijun Chen, Han Zheng, Sunying Wu and Saibin Wang

The role of clinical characteristics and pulmonary function testing in predicting risk of pneumothorax by CT-guided percutaneous core needle biopsy of the lung

We aim to analyze the risk factors for pneumothorax associated with computed tomography (CT)-guided percutaneous core needle biopsy (PCNB) of the lung. Whether the lung function characteristics are related to ...

Authors: Chunhai Li, Dexiang Wang, Fengxia Yang, Yang Song, Xuejuan Yu, Bo Liu, Haipeng Jia and Wei Zhou

Functional respiratory imaging in relation to classical outcome measures in cystic fibrosis: a cross-sectional study

Functional Respiratory Imaging (FRI) combines HRCT scans with computational fluid dynamics to provide objective and quantitative information about lung structure and function. FRI has proven its value in pulmo...

Authors: Eline Lauwers, Annemiek Snoeckx, Kris Ides, Kim Van Hoorenbeeck, Maarten Lanclus, Wilfried De Backer, Jan De Backer and Stijn Verhulst

Living conditions and autonomy levels in COPD patients receiving non-invasive ventilation: impact on health related quality of life

Research on health-related quality of life (HRQL) has become increasingly important in recent decades. However, the impact of both living conditions and the level of autonomy impairments on HRQL in COPD patien...

Authors: Sarah Bettina Schwarz, Tim Mathes, Daniel Sebastian Majorski, Maximilian Wollsching-Strobel, Doreen Kroppen, Friederike Sophie Magnet and Wolfram Windisch

An uncommon etiological factor for aspiration pneumonitis caused by spontaneous sphenoid sinus meningoencephalocele with cerebrospinal fluid rhinorrhea: a case report

Aspiration pneumonitis is an inflammatory disease of the lungs which is difficult to diagnose accurately. Large-volume aspiration of oropharyngeal or gastric contents is essential for the development of aspira...

Authors: Jiayu Cao, Wei Liu, Li Wang, Yujuan Yang, Yu Zhang and Xicheng Song

Time-to-first exacerbation, adherence, and medical costs among US patients receiving umeclidinium/vilanterol or tiotropium as initial maintenance therapy for chronic obstructive pulmonary disease: a retrospective cohort study

Adherence to chronic obstructive pulmonary disease (COPD) maintenance medication is important for managing symptoms and exacerbation risk, and is associated with reduced mortality, hospitalizations, and costs....

Authors: David Slade, Riju Ray, Chad Moretz, Guillaume Germain, François Laliberté, Qin Shen, Mei Sheng Duh, Malena Mahendran and Beth Hahn

Emodin inhibits viability, proliferation and promotes apoptosis of hypoxic human pulmonary artery smooth muscle cells via targeting miR-244-5p/DEGS1 axis

This study aimed to determine the effects of emodin on the viability, proliferation and apoptosis of human pulmonary artery smooth muscle cells (PASMCs) under hypoxia and to explore the underling molecular mec...

Authors: Li Yi, JunFang Liu, Ming Deng, Huihua Zuo and Mingyan Li

Pulmonary hypertension in systemic sclerosis: diagnosis by systematic screening and prognosis after three years follow-up

Systemic sclerosis (SSc) is a rare disease, and the presence of pulmonary hypertension can be a determining factor in prognosis. The aim of this study was to evaluate the diagnosis, profile, and prognosis of s...

Authors: Verônica Silva Vilela, Marcio Macri Dias, Ângelo Antunes Salgado, Bruno Rangel Antunes da Silva, Agnaldo José Lopes, Elizabeth Jauhar Cardoso Bessa, Leonardo Palermo Bruno, Cláudia Henrique da Costa, Roger Abramino Levy and Rogério Rufino

Rationale and design of REGULATE: an observational study protocol for relationship between plasma metabolome and the efficacy of systemic glucocorticoid in acute exacerbation of chronic obstructive pulmonary disease

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) significantly increases the mortality of patients with COPD. Guidelines have recommended systemic glucocorticoid as a regular treatment. Rec...

Authors: Qiu-Yu Li, Zhuo-Yu An, Zi-Han Pan and Rui-Ying Qi

Cyclophosphamide for interstitial lung disease-associated acute respiratory failure: mortality, clinical response and radiological characteristics

Treatment for interstitial lung disease (ILD) patients with acute respiratory failure (ARF) is challenging, and literature to guide such treatment is scarce. The reported in-hospital mortality rates of ILD pat...

Authors: Johanna P. van Gemert, Inge A. H. van den Berk, Esther J. Nossent, Leo M. A. Heunks, Rene E. Jonkers, Alexander P. Vlaar and Peter I. Bonta

Correction to: A multicenter randomized trial to assess the efficacy of CONvalescent plasma therapy in patients with Invasive COVID-19 and acute respiratory failure treated with mechanical ventilation: the CONFIDENT trial protocol

Authors: Benoît Misset, Eric Hoste, Anne Françoise Donneau, David Grimaldi, Geert Meyfroidt, Michel Moutschen, Veerle Compernolle, André Gothot, Daniel Desmecht, Mutien Garigliany, Tome Najdovski and Pierre François Laterre

Silencing of long non-coding RNA KCNQ1OT1 alleviates LPS-induced lung injury by regulating the miR-370-3p/FOXM1 axis in childhood pneumonia

Long non-coding RNAs (lncRNAs) play important roles in the development of pneumonia. We aimed to explore the role of the lncRNA KCNQ1OT1 in pneumonia and its underlying mechanisms.

Authors: Ping Wang, Haitao Zhang, Weiqing Zhao and Nini Dai

Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study

Observational studies show an association between reduced lung function and impaired cognition. Cognitive dysfunction influences important health outcomes and is a precursor to dementia, but treatments options...

Authors: Daniel H. Higbee, Raquel Granell, Gibran Hemani, George Davey Smith and James W. Dodd