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  1. Content type: Research article

    The breakdown of alveolar barrier dysfunction contributes to Lipopolysaccharide stimulated pulmonary edema and acute lung injury. Actin cytoskeleton has been implicated to be critical in regulation of epitheli...

    Authors: Weiju Wang, Jie Weng, Lei Yu, Qiaobing Huang, Yong Jiang and Xiaohua Guo

    Citation: BMC Pulmonary Medicine 2018 18:178

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  2. Content type: Research article

    Pirfenidone is an antifibrotic compound approved for the treatment of idiopathic pulmonary fibrosis (IPF). We present our real-world experience in terms of Pirfenidone’s effect on mortality and adverse events ...

    Authors: George A. Margaritopoulos, Athina Trachalaki, Athol U. Wells, Eirini Vasarmidi, Eleni Bibaki, George Papastratigakis, Stathis Detorakis, Nikos Tzanakis and Katerina M. Antoniou

    Citation: BMC Pulmonary Medicine 2018 18:177

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  3. Content type: Research article

    We aimed to determine the presepsin concentration in pleural fluid from patients with pleural effusions of different aetiologies and to compare its diagnostic value with that of pleural fluid C-reactive protei...

    Authors: Naoki Watanabe, Tomoya Ishii, Nobuyuki Kita, Nobuhiro Kanaji, Hiroyuki Nakamura, Nobuki Nanki, Yutaka Ueda, Yasunori Tojo, Norimitsu Kadowaki and Shuji Bandoh

    Citation: BMC Pulmonary Medicine 2018 18:176

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  4. Content type: Research article

    Diaphragmatic dysfunction remains the main cause of weaning difficulty or failure. Ultrasonographic measurement of diaphragmatic function can be used to predict the outcomes of weaning from mechanical ventilat...

    Authors: Pongdhep Theerawit, Dararat Eksombatchai, Yuda Sutherasan, Thitiporn Suwatanapongched, Charn Kiatboonsri and Sumalee Kiatboonsri

    Citation: BMC Pulmonary Medicine 2018 18:175

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  5. Content type: Research article

    The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficien...

    Authors: Eva Verjans, Stephanie Kanzler, Kim Ohl, Annette D. Rieg, Nadine Ruske, Angela Schippers, Norbert Wagner, Klaus Tenbrock, Stefan Uhlig and Christian Martin

    Citation: BMC Pulmonary Medicine 2018 18:174

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  6. Content type: Research article

    Untreated Obstructive Sleep Apnea Hypnopnea Syndrome (OSAHS) is a known factor contributing to resistant hypertension (HT). Continuous Positive Airways Pressure (CPAP) is effective to decrease blood pressure (...

    Authors: Florent Seguro, Vincent Bard, Kamila Sedkaoui, Maya Riche, Alain Didier and Béatrice Bouhanick

    Citation: BMC Pulmonary Medicine 2018 18:173

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  7. Content type: Research article

    Idiopathic pulmonary fibrosis (IPF) is a chronic disease with a high symptom burden and poor survival that influences patients’ health-related quality of life (HRQOL). We aimed to evaluate IPF patients’ sympto...

    Authors: K. Rajala, J. T. Lehto, E. Sutinen, H. Kautiainen, M. Myllärniemi and T. Saarto

    Citation: BMC Pulmonary Medicine 2018 18:172

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  8. Content type: Research article

    The purpose of this study was to compare clinical outcomes of Erlotinib versus Gefitinib in the treatment of Asian patients with exon 19 EGFR-mutant lung adenocarcinoma and newly diagnosed brain metastases.

    Authors: Ye Jiang, Jing Zhang, Juanjuan Huang, Bo Xu, Ning Li, Lei Cao and Mingdong Zhao

    Citation: BMC Pulmonary Medicine 2018 18:171

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  9. Content type: Case report

    Non-Tuberculous Mycobacterial–pulmonary disease (NTM-PD) is increasing in incidence and prevalence. Mycobacterium abscessus (M.abscessus) is a rapid growing multi-resistant NTM associated with severe NTM-PD requi...

    Authors: C. Addy, G. Doran, A. L. Jones, G. Wright, S. Caskey and D. G. Downey

    Citation: BMC Pulmonary Medicine 2018 18:170

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  10. Content type: Research article

    Pulmonary nontuberculous mycobacteria (NTM) disease is of increasing public health concern in China. Information is limited regarding risk factors associated with this disease in China. The objective of this s...

    Authors: Yaoju Tan, Biyi Su, Wei Shu, Xingshan Cai, Shaojia Kuang, Haobin Kuang, Jianxiong Liu and Yu Pang

    Citation: BMC Pulmonary Medicine 2018 18:168

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  11. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) is a major and increasing global health problem. Serotonin is a neurotransmitter that participates in several pulmonary functions and it has been involved in oxidat...

    Authors: Pietro Pirina, Elisabetta Zinellu, Panagiotis Paliogiannis, Alessandro G. Fois, Viviana Marras, Salvatore Sotgia, Ciriaco Carru and Angelo Zinellu

    Citation: BMC Pulmonary Medicine 2018 18:167

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  12. Content type: Research article

    The level of physical activity among individuals with chronic obstructive pulmonary disease (COPD) is associated with the disease severity and prognosis. The aim of this study was to describe the prevalence of...

    Authors: Pedro Barbolla Benito and Germán Peces-Barba Romero

    Citation: BMC Pulmonary Medicine 2018 18:166

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  13. Content type: Correction

    Following publication of the original article [1], the author flagged aspects of the article that affected readability of some of the article’s scientific content.

    Authors: Oliver Fuchs, Thomas Bahmer, Markus Weckmann, Anna-Maria Dittrich, Bianca Schaub, Barbara Rösler, Christine Happle, Folke Brinkmann, Isabell Ricklefs, Inke R. König, Henrik Watz, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen and Erika von Mutius

    Citation: BMC Pulmonary Medicine 2018 18:165

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    The original article was published in BMC Pulmonary Medicine 2018 18:140

  14. Content type: Research article

    Interleukin (IL)-3 amplifies inflammation. However, the effect of IL-3 in acute lung injury (ALI), an acute inflammatory disease, is unclear. The aim of this study was to test the hypothesis that IL-3 plays an...

    Authors: Zhijian Huang, Wei Zhang, Jian Yang, Feiyu Sun and Hongwei Zhou

    Citation: BMC Pulmonary Medicine 2018 18:164

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  15. Content type: Research article

    COPD is a treatable disease with increasing prevalence worldwide. Treatment aims to stop disease progression, to improve quality of life, and to reduce exacerbations. We aimed to evaluate the association of th...

    Authors: Magdalena Humenberger, Andreas Horner, Anna Labek, Bernhard Kaiser, Rupert Frechinger, Constanze Brock, Petra Lichtenberger and Bernd Lamprecht

    Citation: BMC Pulmonary Medicine 2018 18:163

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  16. Content type: Case report

    Until recently, lung transplantation was not considered in patients with human immunodeficiency virus (HIV). HIV seropositive patients with suppressed viral loads can now expect long-term survival with the adv...

    Authors: Shaun Ong, Robert D Levy, John Yee, Nilu Partovi, Andrew Churg, Philippe Roméo, Jean Chalaoui, Roland Nador, Alissa Wright, Hélène Manganas and Christopher J Ryerson

    Citation: BMC Pulmonary Medicine 2018 18:162

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  17. Content type: Research article

    Risk assessment of pulmonary arterial hypertension (PAH) contributes to its management. Unfortunately, the existing risk assessment approaches are defective for clinicians to practice in daily clinical setting...

    Authors: Wei Xiong, Yunfeng Zhao, Mei Xu, Bigyan Pudasaini, Xuejun Guo and Jinming Liu

    Citation: BMC Pulmonary Medicine 2018 18:161

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  18. Content type: Research article

    We explored the hypothesized importance of early knowledge of microbiological etiology in patients with pleural infection, including comorbidity and treatment factors in the outcome analyses.

    Authors: Christian Niels Meyer, Karin Armbruster, Michael Kemp, Trine Rolighed Thomsen and Ram Benny Dessau

    Citation: BMC Pulmonary Medicine 2018 18:160

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  19. Content type: Research article

    Pulmonary function tests (PFTs) are routinely performed in the upright position due to measurement devices and patient comfort. This systematic review investigated the influence of body position on lung functi...

    Authors: Shikma Katz, Nissim Arish, Ariel Rokach, Yacov Zaltzman and Esther-Lee Marcus

    Citation: BMC Pulmonary Medicine 2018 18:159

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  20. Content type: Research article

    Pulmonary hypertension (PH) is a rare disease characterized by proliferation and occlusion of small pulmonary arterioles, which has been associated with a high mortality rate. The pathogenesis of PH is complex...

    Authors: Caiyong Yin, Kai Li, Yanfang Yu, Huijie Huang, Youjia Yu, Zhongqun Wang, Jinchuan Yan, Yan Pu, Zheng Li, Ding Li, Peng Chen and Feng Chen

    Citation: BMC Pulmonary Medicine 2018 18:158

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  21. Content type: Research article

    In exacerbations of chronic obstructive pulmonary disease, administration of high concentrations of oxygen may cause hypercapnia and increase mortality compared with oxygen titrated, if required, to achieve an...

    Authors: George Bardsley, Janine Pilcher, Steven McKinstry, Philippa Shirtcliffe, James Berry, James Fingleton, Mark Weatherall and Richard Beasley

    Citation: BMC Pulmonary Medicine 2018 18:157

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  22. Content type: Research article

    Treatment of tuberculous-destroyed lung (TDL) with pleuropulmonary resection is challenging. Pulmonary hemorrhage is a frequent complication of this surgical procedure. Continuous efforts have been made to inv...

    Authors: Gang Chen, Fang-Ming Zhong, Xu-Dong Xu, Guo-Can Yu and Peng-Fei Zhu

    Citation: BMC Pulmonary Medicine 2018 18:156

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  23. Content type: Research article

    In randomized controlled trials, bronchial thermoplasty (BT) has been proven to reduce symptoms in severe asthma, but the mechanisms by which this is achieved are uncertain as most studies have shown no improv...

    Authors: David Langton, Alvin Ing, Kim Bennetts, Wei Wang, Claude Farah, Matthew Peters, Virginia Plummer and Francis Thien

    Citation: BMC Pulmonary Medicine 2018 18:155

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  24. Content type: Research article

    Pulmonary rehabilitation (PR), delivered as a supervised multidisciplinary program including exercise training, is one of the cornerstones in the chronic obstructive pulmonary disease (COPD) management. We per...

    Authors: Camilla Koch Ryrsø, Nina Skavlan Godtfredsen, Linette Marie Kofod, Marie Lavesen, Line Mogensen, Randi Tobberup, Ingeborg Farver-Vestergaard, Henriette Edemann Callesen, Britta Tendal, Peter Lange and Ulrik Winning Iepsen

    Citation: BMC Pulmonary Medicine 2018 18:154

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  25. Content type: Research article

    The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective wa...

    Authors: Carla Cristina Souza Gomez, Fernando Augusto Lima Marson, Maria Fátima Servidoni, Antônio Fernando Ribeiro, Maria Ângela Gonçalves Oliveira Ribeiro, Veruska Acioli Lopes Gama, Eduardo Tavares Costa, José Dirceu Ribeiro and Francisco Ubaldo Vieira Junior

    Citation: BMC Pulmonary Medicine 2018 18:153

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  26. Content type: Research article

    The aim of this investigation was to study change in adults over a 20 year period in the prevalence of respiratory symptoms and disorders and its association to year of birth, life style and sleep related vari...

    Authors: Christer Janson, Ane Johannessen, Karl Franklin, Cecilie Svanes, Linus Schiöler, Andrei Malinovschi, Thorarinn Gislason, Bryndis Benediktsdottir, Vivi Schlünssen, Rain Jõgi, Deborah Jarvis and Eva Lindberg

    Citation: BMC Pulmonary Medicine 2018 18:152

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  27. Content type: Research article

    Candidates for preoperative or intraoperative nodal assessment among patients with non-small cell lung cancer (NSCLC) manifesting as a subsolid tumor are not established. The present study was conducted to dem...

    Authors: Jun Yeun Cho, Cho Sun Leem, Youlim Kim, Eun Sun Kim, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Jae Ho Lee, Choon-Taek Lee and Ho Il Yoon

    Citation: BMC Pulmonary Medicine 2018 18:151

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  28. Content type: Research article

    Associations between ambient air pollution and child health outcomes have been well documented in developed countries such as the United States; however, only a limited number of studies have been conducted in...

    Authors: Jie Song, Mengxue Lu, Liheng Zheng, Yue Liu, Pengwei Xu, Yuchun Li, Dongqun Xu and Weidong Wu

    Citation: BMC Pulmonary Medicine 2018 18:150

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  29. Content type: Research article

    Despite the known occupational hazards, it is not yet clear whether long-term career firefighting leads to a greater rate of decline in lung function than would normally be expected, and how this rate of chang...

    Authors: Flynn Slattery, Kylie Johnston, Catherine Paquet, Hunter Bennett and Alan Crockett

    Citation: BMC Pulmonary Medicine 2018 18:149

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  30. Content type: Research article

    Cigarette smoke (CS) exposure causes an abnormal inflammatory response, which can result in chronic obstructive pulmonary disease (COPD). Previous studies show that this disorder predominantly occurs in periph...

    Authors: Hario Baskoro, Tadashi Sato, Keiko Karasutani, Yohei Suzuki, Aki Mitsui, Naoko Arano, Fariz Nurwidya, Motoyasu Kato, Fumiyuki Takahashi, Yuzo Kodama, Kuniaki Seyama and Kazuhisa Takahashi

    Citation: BMC Pulmonary Medicine 2018 18:148

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  31. Content type: Research article

    Mobile health applications are increasingly used in patients with Chronic Obstructive Pulmonary Disease (COPD) to improve their self-management, nonetheless, without firm evidence of their efficacy. This meta-...

    Authors: Fen Yang, Yuncui Wang, Chongming Yang, Hui Hu and Zhenfang Xiong

    Citation: BMC Pulmonary Medicine 2018 18:147

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  32. Content type: Research article

    Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., ...

    Authors: Chuan-Jiang Deng, Fu-Qiang Dai, Kai Qian, Qun-You Tan, Ru-Wen Wang, Bo Deng and Jing-Hai Zhou

    Citation: BMC Pulmonary Medicine 2018 18:146

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  33. Content type: Research article

    Nontuberculous mycobacterial (NTM) pulmonary disease has conventionally been classified on the basis of radiology into fibrocavitary and nodular-bronchiectatic disease. Whilst being of great clinical utility, ...

    Authors: Steven A. Cowman, Joseph Jacob, Sayed Obaidee, R. Andres Floto, Robert Wilson, Charles S. Haworth and Michael R. Loebinger

    Citation: BMC Pulmonary Medicine 2018 18:145

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  34. Content type: Research article

    The fractal dimension characterizing the cumulative size distribution of low attenuation area (LAA) clusters, identified with a fixed threshold such as − 950 Hounsfield Units (HU), on computed tomography (CT) ...

    Authors: Naoya Tanabe, Shigeo Muro, Susumu Sato, Tsuyoshi Oguma, Atsuyasu Sato and Toyohiro Hirai

    Citation: BMC Pulmonary Medicine 2018 18:144

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  35. Content type: Case report

    Pulmonary nocardiosis frequently develops as an opportunistic infection in cell-mediated immunosuppressive patients, and sometimes requires differentiation from pulmonary malignancy. Ectopic adrenocorticotropi...

    Authors: Keigo Kobayashi, Takanori Asakura, Makoto Ishii, Soichiro Ueda, Hidehiro Irie, Hiroyuki Ozawa, Kohei Saitoh, Isao Kurihara, Hiroshi Itoh and Tomoko Betsuyaku

    Citation: BMC Pulmonary Medicine 2018 18:142

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  36. Content type: Research article

    Pneumonia and septic pneumonic shock are the most common indications for long-term mechanical ventilation and prolonged weaning, independent of any comorbidities. Multidrug resistant (MDR) bacteria are emergin...

    Authors: Johannes Bickenbach, Daniel Schöneis, Gernot Marx, Nikolaus Marx, Sebastian Lemmen and Michael Dreher

    Citation: BMC Pulmonary Medicine 2018 18:141

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  37. Content type: Study protocol

    Asthma and wheezing disorders in childhood and adulthood are clinically heterogeneous regarding disease presentation, natural course, and response to treatment. Deciphering common disease mechanisms in distinc...

    Authors: Oliver Fuchs, Thomas Bahmer, Markus Weckmann, Anna-Maria Dittrich, Bianca Schaub, Barbara Rösler, Christine Happle, Folke Brinkmann, Isabell Ricklefs, Inke R. König, Henrik Watz, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen and Erika von Mutius

    Citation: BMC Pulmonary Medicine 2018 18:140

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    The Correction to this article has been published in BMC Pulmonary Medicine 2018 18:165

  38. Content type: Case report

    Approximately a quarter of patients with advanced sarcoidosis develop pulmonary hypertension (PH), which affects their prognosis. We report unusual case of confirmed chronic thromboembolic pulmonary hypertensi...

    Authors: Andrzej Labyk, Dominik Wretowski, Sabina Zybińska-Oksiutowicz, Aleksandra Furdyna, Katarzyna Ciesielska, Dorota Piotrowska-Kownacka, Olga Dzikowska –Diduch, Barbara Lichodziejewska, Andrzej Biederman, Piotr Pruszczyk and Marek Roik

    Citation: BMC Pulmonary Medicine 2018 18:139

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  39. Content type: Research article

    Yellow nail syndrome (YNS) is a rare disease characterized by the triad of thickened, slow-growing yellow nails, lymphedema, and chronic respiratory manifestations. The cause of YNS is not known; however, it i...

    Authors: Sachi Matsubayashi, Manabu Suzuki, Tomoyuki Suzuki, Ayako Shiozawa, Konomi Kobayashi, Satoru Ishii, Motoyasu Iikura, Shinyu Izumi, Koichiro Kudo and Haruhito Sugiyama

    Citation: BMC Pulmonary Medicine 2018 18:138

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  40. Content type: Research article

    The diagnostic yields and safety profiles of transbronchial lung biopsy have not been evaluated in inexperienced physicians using the combined modality of radial probe endobronchial ultrasound and a guide shea...

    Authors: Jung Seop Eom, Jeong Ha Mok, Insu Kim, Min Ki Lee, Geewon Lee, Hyemi Park, Ji Won Lee, Yeon Joo Jeong, Won-Young Kim, Eun Jung Jo, Mi Hyun Kim, Kwangha Lee, Ki Uk Kim and Hye-Kyung Park

    Citation: BMC Pulmonary Medicine 2018 18:137

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  41. Content type: Research article

    Lung ultrasound and echocardiography are mainly applied in critical care and emergency medicine. However, the diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress ...

    Authors: Daozheng Huang, Huan Ma, Zhiyuan Xiao, Michael Blaivas, Ying Chen, Jianyi Wen, Weixin Guo, Jun Liang, Xiaolong Liao, Zhonghua Wang, Hanbiao Li, Jie Li, Yangong Chao, Xiao ting Wang, Yan Wu, Tiehe Qin…

    Citation: BMC Pulmonary Medicine 2018 18:136

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  42. Content type: Research article

    As reported in Surveillance, Epidemiology, and End Results (SEER) data, US incidence and prevalence of neuroendocrine tumors (NET) has increased over recent years. The study objective was to update incidence a...

    Authors: Michael S. Broder, Beilei Cai, Eunice Chang and Maureen P. Neary

    Citation: BMC Pulmonary Medicine 2018 18:135

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  43. Content type: Research article

    Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this ...

    Authors: Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe and Masanori Tsuchida

    Citation: BMC Pulmonary Medicine 2018 18:134

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  44. Content type: Research article

    Pneumoconiosis patients receive community-based or home-based pulmonary rehabilitation (PR) for symptom management and enhancement of physical and mental well-being. This study aimed to review the clinical ben...

    Authors: Eric W. Tsang, Henry Kwok, Aidan K. Y. Chan, Kah Lin Choo, Kin Sang Chan, Kam Shing Lau and Chetwyn C. H. Chan

    Citation: BMC Pulmonary Medicine 2018 18:133

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  45. Content type: Research article

    Screening mutations in epidermal growth factor receptor (EGFR) to analyze non-small-cell lung cancer (NSCLC) profile is the criterion to choose the best therapeutic strategy.

    Authors: Zohra Mraihi, Jihen Ben Amar, Hend Bouacha, Soumaya Rammeh and Lamia Hila

    Citation: BMC Pulmonary Medicine 2018 18:132

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  46. Content type: Research article

    Adipose-derived mesenchymal stem cell (ASCs) exerts immunomodulatory roles in asthma. However, the underlying mechanism remains unclear. The present study aimed to explore the effects and mechanisms of ASCs on...

    Authors: Ranran Dai, Youchao Yu, Guofeng Yan, Xiaoxia Hou, Yingmeng Ni and Guochao Shi

    Citation: BMC Pulmonary Medicine 2018 18:131

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  47. Content type: Research article

    Src homology 2 containing protein tyrosine phosphatase (PTP) 2 (Shp2) is a typical tyrosine phosphatase interacting with receptor tyrosine kinase to regulate multiple signaling pathways in diverse pathological...

    Authors: Yusheng Cheng, Min Yu, Jian Xu, Mengyu He, Hong Wang, Hui Kong and Weiping Xie

    Citation: BMC Pulmonary Medicine 2018 18:130

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  48. Content type: Research article

    To determine the association of lymphatic vessel density (LVD) with the prognosis of Asian non-small cell lung cancer (NSCLC) patients via a meta-analysis.

    Authors: Shuanglan Xu, Jiao Yang, Shuangyan Xu, Yun Zhu, Chunfang Zhang, Liqiong Liu, Hao Liu, Yunlong Dong, Zhaowei Teng and Xiqian Xing

    Citation: BMC Pulmonary Medicine 2018 18:128

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