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  1. Endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB) facilitates the diagnosis of various respiratory diseases. The safety of performing EBUS-guided TBB in patients with a finding of pulmonary hy...

    Authors: Yuta Takashima, Naofumi Shinagawa, Daisuke Morinaga, Junichi Nakamura, Megumi Furuta, Tetsuaki Shoji, Hajime Asahina, Eiki Kikuchi, Junko Kikuchi, Jun Sakakibara-Konishi, Ichizo Tsujino and Satoshi Konno
    Citation: BMC Pulmonary Medicine 2022 22:449
  2. Pulmonary rehabilitation (PR) is recommended in the treatment of people with idiopathic pulmonary fibrosis (IPF). Little is known about the experiences of people with IPF of PR. Due to Covid-19 there has been ...

    Authors: Orlagh O’Shea, Grainne Murphy, Luke Forde and Katherine M. A. O’Reilly
    Citation: BMC Pulmonary Medicine 2022 22:448
  3. The allergic phenotype is responsible for more than 50% of severe asthma cases. In a stepwise approach, add-on treatments such as anti-IgE are used for severe allergic asthma (SAA). This study was aimed to des...

    Authors: Carlos A. Torres-Duque, Jaime Ocampo-Gómez, Mauricio Morales Castillo, Diana Cano-Rosales, Ángela Giraldo-Montoya, Freddy Rodríguez, Isabel Palacios-Ortega, Mauricio Durán-Silva, Humberto Reynales and Elizabeth García
    Citation: BMC Pulmonary Medicine 2022 22:447
  4. Obstructive sleep apnea (OSA), nocturnal hypoxemia and excessive daytime sleepiness (EDS) are common comorbidities in people with cystic fibrosis (pwCF). Most of the data showing this originates from children ...

    Authors: Matthias Welsner, Sarah Dietz-Terjung, Florian Stehling, Tim Schulte, Ute Niehammer, Fatma-Ezzahra Gahbiche, Christian Taube, Svenja Strassburg, Christoph Schoebel, Gerhard Weinreich and Sivagurunathan Sutharsan
    Citation: BMC Pulmonary Medicine 2022 22:446
  5. There is limited information on the patient’s perspective of how biologic treatments impact their lives. We conducted a qualitative study to explore the patient’s experience of being considered a super-respond...

    Authors: Joseph W. Lanario, Lucy Cartwright, Rupert C. Jones, Ross Sayers, Michael E. Hyland and Matthew Masoli
    Citation: BMC Pulmonary Medicine 2022 22:445
  6. At present, chronic respiratory diseases are a major burden in terms of morbidity and mortality and are of increasing public health concern in China. Meanwhile, the prevalence of diabetes has increased by more...

    Authors: Wei Li, Yi Ning, Yuan Ma, Xinshan Lin, Sailimai Man, Bo Wang, Chen Wang and Ting Yang
    Citation: BMC Pulmonary Medicine 2022 22:444
  7. Accumulating evidence highlights the critical roles of circular RNAs (circRNAs) in the malignant progression of cancers. In this study, we investigated the expression pattern of a newly identified circRNA (hsa...

    Authors: Bo Yang, Bin Zhang, Qi Qi and Changli Wang
    Citation: BMC Pulmonary Medicine 2022 22:443
  8. Bronchoscopy is commonly utilized for non-surgical sampling of indeterminant pulmonary lesions, but nondiagnostic procedures are common. Accurate assessment of the risk of malignancy is essential for decision ...

    Authors: Diana H. Yu, Majid Shafiq, Hitesh Batra, Marla Johnson, Bailey Griscom, Janna Chamberlin, Lori R. Lofaro, Jing Huang, William A. Bulman, Giulia C. Kennedy, Lonny B. Yarmus, Hans J. Lee and David Feller-Kopman
    Citation: BMC Pulmonary Medicine 2022 22:442
  9. Impaired respiratory function caused by respiratory muscle dysfunction is one of the common consequences of chronic obstructive pulmonary disease (COPD). In this study, two-dimensional shear wave elastography ...

    Authors: Yongjian Chen, Jingyun Li, Bingtian Dong, Zhixing Zhu and Guorong Lyu
    Citation: BMC Pulmonary Medicine 2022 22:441
  10. Authors: Xiong Khee Cheong, Andrea Yu-Lin Ban, Boon Hau Ng, Nik Nuratiqah Nik Abeed, Nik Azuan Nik Ismail, Nik Farhan Nik Fuad, Syed Zulkifli Syed Zakaria, Sheah Lin Ghan and Mohamed Faisal Abdul Hamid
    Citation: BMC Pulmonary Medicine 2022 22:440

    The original article was published in BMC Pulmonary Medicine 2022 22:199

  11. Intrapleural fibrinolytic therapy (IPFT) is one of the treatment options for complex pleural effusion. In this study, the IPFT agent used was alteplase, a tissue plasminogen activator (t-PA). This study aims t...

    Authors: Mohamed Faisal Abdul Hamid, Ahmad Hadyan Husainy Hasbullah, Mas Fazlin Mohamad Jailaini, Nik Nuratiqah Nik Abeed, Boon Hau Ng, Hairulfaizi Haron, Nur Ayub Md Ali, Muhammad Ishamuddin Ismail, Nik Azuan Nik Ismail, Mohd Ramzisham Abdul Rahman and Andrea Yu-Lin Ban
    Citation: BMC Pulmonary Medicine 2022 22:439
  12. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have considerably high mortality and re-hospitalisation rate. Diaphragmatic dysfunction (DD) is common in COPD patients. However, whether d...

    Authors: Shuoshuo Wei, Rong Lu, Zhengping Zhang, Faxuan Wang, Hai Tan, Xiaohong Wang, Jinlan Ma, Yating Zhang, Ning Deng and Juan Chen
    Citation: BMC Pulmonary Medicine 2022 22:438
  13. During Iraq-Iran conflict, chemical weapons, particularly SM gas, were used numerous times, whose aftereffects are still present. This study aimed to compare serum proteome in the chronic ML (n = 10) and HC (n...

    Authors: Shahram Parvin, Masoud Arabfard, Ali Ghazvini, Mostafa Ghanei and Ali Najafi
    Citation: BMC Pulmonary Medicine 2022 22:437
  14. Lung cancer surgery is reported as a risk factor for chronic pulmonary aspergillosis (CPA). However, limited data are available on its clinical impact. We aimed to determine the effect of developed CPA after l...

    Authors: Bo-Guen Kim, Yong Soo Choi, Sun Hye Shin, Kyungjong Lee, Sang-Won Um, Hojoong Kim, Yeong Jeong Jeon, Junghee Lee, Jong Ho Cho, Hong Kwan Kim, Jhingook Kim, Young Mog Shim and Byeong-Ho Jeong
    Citation: BMC Pulmonary Medicine 2022 22:436
  15. Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease. COPD is associated with accelerated lung aging. Circadian clock is believed to play important roles in COPD. Although the circ...

    Authors: Lingling Li, Min Zhang, Chunyang Zhao, Yusheng Cheng, Chuanmei Liu and Minhua Shi
    Citation: BMC Pulmonary Medicine 2022 22:435
  16. Effective-component compatibility of Bufei Yishen formula III (ECC-BYF III) demonstrates positive effects on stable chronic obstructive pulmonary disease (COPD).

    Authors: Min-yan Li, Yan-qin Qin, Yan-ge Tian, Kang-chen Li, Brian G. Oliver, Xue-fang Liu, Peng Zhao and Jian-sheng Li
    Citation: BMC Pulmonary Medicine 2022 22:434
  17. It is fundamental to optimize and retain health-related quality of life (HRQoL) in the long term in patients with home mechanical ventilation (HMV). Therefore, this study aimed to evaluate the evolution of the...

    Authors: Carla Ribeiro, Cristina Jácome, Luísa Castro, Sara Conde, Wolfram Windisch and Rui Nunes
    Citation: BMC Pulmonary Medicine 2022 22:433
  18. Pulmonary embolism (PE) is a common and potentially life-threatening condition. Since it is considered a ‘do not miss’ diagnosis, PE tends to be over-investigated beyond the evidence-based clinical decision su...

    Authors: Koshiar Medson, Jimmy Yu, Lovisa Liwenborg, Peter Lindholm and Eli Westerlund
    Citation: BMC Pulmonary Medicine 2022 22:432
  19. Ground glass opacity (GGO) is the main HRCT feature representing alveolitis in systemic sclerosis-associated interstitial lung disease (SSc-ILD), but may also represent other conditions such as atelectasis or ...

    Authors: Össur Ingi Emilsson, Angelica Dessle, Henrik Johansson, Shamisa Adeli, Andrei Malinovschi, Maija-Leena Eloranta and Tomas Hansen
    Citation: BMC Pulmonary Medicine 2022 22:430
  20. Although unmet medical needs for better care of patients with chronic cough exist in Japan, epidemiological information about these patients and their treatments is very limited.

    Authors: Yoko Arai, Kotoba Okuyama, Yoshie Onishi, Jonathan Schelfhout, Shigeru Tokita and Takekazu Kubo
    Citation: BMC Pulmonary Medicine 2022 22:429
  21. This study aimed to evaluate the diagnostic accuracy of pleural fluid (PF) lactate dehydrogenase (LDH) to adenosine deaminase (ADA) (LDH/ADA) ratio for tuberculous pleural effusion (TPE). Especially to explore...

    Authors: Zhi Yan, Jian-Xun Wen, Hua Wang, Ting-Wang Jiang, Jin-Hong Huang, Hong Chen, Li Yan, Zhi-De Hu and Wen-Qi Zheng
    Citation: BMC Pulmonary Medicine 2022 22:428
  22. Currently, the microbial etiology of community-acquired pneumonia in children remains challenging. While Gram stain and sputum culture are commonly used to detect bacterial pathogens, it is unclear whether the...

    Authors: Ruimu Zhang, Yue Wu, Guangcheng Deng and Jikui Deng
    Citation: BMC Pulmonary Medicine 2022 22:427
  23. Chronic cough, more than 8 weeks, can either be without co-morbidity called unexplained chronic cough (UCC) or with co-morbidity called refractory chronic cough (RCC). Using datasets from the Danish National P...

    Authors: Vibeke Backer, Andreas Porsborg, Victor Hansen, Tina Skjold, Johannes Martin Schmid, Mette Kehlet, Christian Torp-Pedersen and Kristian Aasbjerg
    Citation: BMC Pulmonary Medicine 2022 22:426
  24. This national study aimed to investigate the lung ultrasound (LUS) training and practice of respiratory therapists (RTs) in mainland China.

    Authors: Kai Liu, Yu-long Yao, Yu-xian Wang, Bi-lin Wei, Liu-cun Li, Qi-xing Wang, Hui-qing Ge, Er-shan Wang, Li-min Yang, Huan Chen, Yun-qing Yang, Hao Qin, Wen-jun Zhai, Shen-ji Yu, Xiao-ting Wang, Zhe Luo…
    Citation: BMC Pulmonary Medicine 2022 22:425
  25. Massive hemoptysis is a rare but potentially life-threatening condition of patients with cystic fibrosis (CF) and advanced pulmonary disease. Hypertrophied bronchial arteries are understood to cause massive he...

    Authors: Martha Dohna, Hilmar Kühl, Sivagurunathan Sutharsan, Christian Dohna-Schwake, Van Dai Vo Chieu, Susanne Hellms, Norman Kornemann, Diane M. Renz and Michael J. Montag
    Citation: BMC Pulmonary Medicine 2022 22:424
  26. Tracheobronchopathia osteochondroplastica (TO) is a rare condition of unknown etiology. TO is characterized by submucosal nodules, with or without calcifications, protruding in the anterolateral walls of the t...

    Authors: Antoine Dumazet, Claire Launois, Francois Lebargy, Romain Kessler, Hervé Vallerand, Pierre Schmitt, Christophe Hermant, Sandra Dury, Maxime Dewolf, Julien Dutilh, Maher Abouda, Marion Ferreira, Ihab Atallah, Samy Lachkar, Jérémy Charriot, Stéphane Jouneau…
    Citation: BMC Pulmonary Medicine 2022 22:423
  27. Dysphagia occurs in multiple respiratory pathophysiologies, increasing the risk of pulmonary complications secondary to aspiration. Reflux associated aspiration and a dysregulated lung microbiome is implicated...

    Authors: Amal Alamer, Rhys Jones, Michael Drinnan, A. John Simpson, Mike Griffin, Joanne M. Patterson, Abdullah Althuwaybi, Chris Ward and Ian A. Forrest
    Citation: BMC Pulmonary Medicine 2022 22:422
  28. Mechanical ventilation is a lifesaving treatment used to treat critical neonatal patients. It facilitates gas exchange, oxygenation, and CO2 removal. Despite advances in non-invasive ventilatory support method...

    Authors: Razieh Sangsari, Maryam Saeedi, Marzieh Maddah, Kayvan Mirnia and Jay P. Goldsmith
    Citation: BMC Pulmonary Medicine 2022 22:421
  29. Chronic cough is an extremely common clinical symptom of various diseases. However, the relationship between obstructive sleep apnea (OSA) and chronic cough in the general population has not been sufficiently ...

    Authors: Tae Hoon Kim, I Re Heo and Ho Cheol Kim
    Citation: BMC Pulmonary Medicine 2022 22:419
  30. Although asthma does not appear to be a risk factor for severe coronavirus disease 2019 (COVID-19), outcomes could vary for patients with different asthma subtypes. The objective of this analysis was to compar...

    Authors: Thomas R. Murphy, William Busse, Cecile T. J. Holweg, Yamina Rajput, Karina Raimundo, Craig S. Meyer, Arpamas Seetasith, Sachin Gupta, Ahmar Iqbal and Robert J. Kaner
    Citation: BMC Pulmonary Medicine 2022 22:418
  31. Tuberculosis (TB) is a highly heterogeneous disease that can affect any organ. Extrapulmonary TB (EPTB) is more difficult to diagnose due to various clinical presentations. Depending on the characteristics of ...

    Authors: Yun-Jeong Jeong, Ji Young Kang, Hyung Woo Kim, Jinsoo Min, Yousang Ko, Jee Youn Oh, Hyeon Hui Kang, Sung Chul Lim, Hun-Gyu Hwang, Kyeong-Cheol Shin, Heung Bum Lee, Ju Sang Kim, Jae Seuk Park, Sung Soon Lee and Hyeon-Kyoung Koo
    Citation: BMC Pulmonary Medicine 2022 22:417
  32. Previous studies have confirmed that exposure to fine particulate matter (PM2.5) is associated with respiratory disease mortality. However, due to the differences in PM2.5 concentration, composition and populatio...

    Authors: Qi Feng, Yan Chen, Sha Su, Xixing Zhang and Xijian Lin
    Citation: BMC Pulmonary Medicine 2022 22:416
  33. The purpose of our study was to perform a meta-analysis and systematic review to compare differences in clinical manifestations and chest computed tomography (CT) findings between immunocompetent and immunocom...

    Authors: Chunlin Xiong, Jianguo Lu, Ting Chen and Rui Xu
    Citation: BMC Pulmonary Medicine 2022 22:415
  34. Acute liver injury (ALI) induced by sepsis seriously endangers the health of human beings every year. Mesenchymal stem cells (MSCs) lysate containing various regulators had a positive effect on anti-inflammati...

    Authors: Zhe Wang, XingXing Zhang, Liuyao Qi, Wenjing Feng, Yahan Gu and Yuting Ding
    Citation: BMC Pulmonary Medicine 2022 22:414
  35. To compare overall survival (OS) and cancer-specific survival (CSS) outcomes of surgery with radiotherapy in octogenarians with stage Ia non-small cell lung cancer (NSCLC).

    Authors: Lianfang Ni, Gang Lin, Zhigang Zhang, Dan Sun, Zhonghui Liu and Xinmin Liu
    Citation: BMC Pulmonary Medicine 2022 22:411
  36. In the current study, we undertook a more detailed exploration of the reasons why patients undergoing HMV were screened out of a recently published study in order to better understand how applicable home initi...

    Authors: Ries J.M. van den Biggelaar, A. Hazenberg, N. A.M. Cobben, M. A. Gaytant, D. A.M.P.J. Gommers and P. J. Wijkstra
    Citation: BMC Pulmonary Medicine 2022 22:410
  37. In precapillary pulmonary hypertension (PH), the incidence of different tricuspid regurgitation (TR) degree is poorly defined. The impact of TR severity on pulmonary artery pressure (PAP) assessment and clinic...

    Authors: Jiahui Li, Aili Li, Yanan Zhai, Lei Li, Yu Zhang, Aihong Chen, Xincao Tao, Qian Gao, Wanmu Xie and Zhenguo Zhai
    Citation: BMC Pulmonary Medicine 2022 22:409
  38. Dyspnea is common after COVID-19 pneumonia and can be characterized by a defective CO2 diffusion (DLCO) despite normal pulmonary function tests (PFT). Nevertheless, DLCO impairment tends to normalize at 1 year, w...

    Authors: Gaetano Scaramuzzo, Luca Ronzoni, Gianluca Campo, Paolo Priani, Chiara Arena, Riccardo La Rosa, Cecilia Turrini, Carlo Alberto Volta, Alberto Papi, Savino Spadaro and Marco Contoli
    Citation: BMC Pulmonary Medicine 2022 22:408
  39. Uncontrolled severe asthma constitutes a major economic burden to society. Add-ons to standard inhaled treatments include inexpensive oral corticosteroids and expensive biologics. Nocturnal treatment with Temp...

    Authors: A. J. Chauhan, G. Eriksson, W. Storrar, T. Brown, S. Peterson, F. Radner, L. G. D’Cruz, P. Miller and L. Bjermer
    Citation: BMC Pulmonary Medicine 2022 22:407
  40. Chronic rhinosinusitis (CRS) is associated with generalised airway inflammation. Few studies have addressed the relationship between CRS and chronic bronchitis (CB).

    Authors: Joel Bergqvist, Mogens Bove, Anders Andersson, Linus Schiöler, Geir Klepaker, Regine Abrahamsen, Anne Kristin M. Fell and Johan Hellgren
    Citation: BMC Pulmonary Medicine 2022 22:406
  41. There is no universally accepted criterion for assessing exercise-induced desaturation (EID). The purpose of this study is to compare the two methods regularly used for determining EID in COPD patients, as wel...

    Authors: Lulu Yang, Minghui Shi, Xuanming Situ, Jiaze He, Shiwei Qumu and Ting Yang
    Citation: BMC Pulmonary Medicine 2022 22:405
  42. Surgical resection is usually recommended for the treatment of pulmonary sclerosing pneumocytoma (PSP). However, no comparative study has demonstrated that surgical resection leads to improved outcomes. We aim...

    Authors: So Jeong Kim, Hye-Rin Kang, Choon Geun Lee, Seung Ho Choi, Yeon Wook Kim, Hyun Woo Lee and Chang-Hoon Lee
    Citation: BMC Pulmonary Medicine 2022 22:404
  43. Diabetic patients with community-acquired pneumonia (CAP) have an increased risk of progressing to severe CAP. It is essential to develop predictive tools at the onset of the disease for early identification a...

    Authors: Ruoming Tan, Bing Liu, Chunliu Zhao, Junhai Yan, Tingting Pan, Min Zhou and Hongping Qu
    Citation: BMC Pulmonary Medicine 2022 22:403
  44. Radiotherapy is an important treatment for patients with stage III/IV non-small cell lung cancer (NSCLC), and due to its high incidence of radiation pneumonitis, it is essential to identify high-risk people as...

    Authors: Songhua Yang, Shixiong Huang, Xu Ye, Kun Xiong, Biao Zeng and Yingrui Shi
    Citation: BMC Pulmonary Medicine 2022 22:402
  45. N-acetylcysteine (NAC), which is specifically involved in airway mucus clearance and antioxidation, is recommended by the treatment guideline for non-cystic fibrosis bronchiectasis (NCFB). However, there is li...

    Authors: Yue Liao, Yanqiu Wu, Kai Zi, Yongchun Shen, Tao Wang, Jiangyue Qin, Lei Chen, Mei Chen, Lin Liu, Weiming Li, Hui Zhou, Shuguan Xiong, Fuqiang Wen and Jun Chen
    Citation: BMC Pulmonary Medicine 2022 22:401

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