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  1. Content type: Research article

    Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has previously been demonstrated to play a pro-inflammatory role in allergic airways disease and COPD through the upregulation of the E3 ubiquit...

    Authors: Adam M. Collison, Junyao Li, Ana Pereira de Siqueira, Xuejiao Lv, Hamish D. Toop, Jonathan C. Morris, Malcolm R. Starkey, Philip M. Hansbro, Jie Zhang and Joerg Mattes

    Citation: BMC Pulmonary Medicine 2019 19:31

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  2. Content type: Case report

    Double lumen intubation and one-lung ventilation should be applied without delay in cases of traumatic main bronchial rupture. In most cases, when the patients’ vital signs have been stabilized, the repair can...

    Authors: Feng Yun Wang, Bin Fang, Zhi Hui Yu, Jing Song Shao, Wei Biao Wen and Li Xin Zhou

    Citation: BMC Pulmonary Medicine 2019 19:30

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  3. Content type: Research article

    CD147 is expressed in many tissues and is involved in many inflammatory diseases. Emerging evidence suggests that the overproduction of mucus is a malignant factor in chronic obstructive pulmonary disease (COP...

    Authors: Qiao Yu, Danhui Yang, Xi Chen and Qiong Chen

    Citation: BMC Pulmonary Medicine 2019 19:29

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  4. Content type: Research article

    Osteoporosis is a common comorbidity in non-cystic fibrosis (non-CF) bronchiectasis patients. We determined whether desaturation during 6-min walk test (6MWT) can be a predictor for osteoporosis risk.

    Authors: Hung-Yu Huang, Te-Fang Sheng, Chang-Wei Lin, Ting-Wen Wang, Chun-Yu Lo, Fu-Tsai Chung, Lan-Yan Yang, Yu-Bin Pan and Chun-Hua Wang

    Citation: BMC Pulmonary Medicine 2019 19:28

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  5. Content type: Research article

    Chronic cough is a difficult-to-treat comorbidity of idiopathic pulmonary fibrosis (IPF), and significantly impacts on the quality of life of patients with IPF. Transient receptor potential (TRP) channel prote...

    Authors: Yali Guo, Sun Ying, Xuehui Zhao, Jian Liu and Yuguang Wang

    Citation: BMC Pulmonary Medicine 2019 19:27

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  6. Content type: Case report

    Immunoglobulin G4-related disease (IgG4-RD) encompasses a group of immune-mediated disorders that are gaining increasing recognition. Pulmonary presentations are common, with four types of patterns been descri...

    Authors: Junping Fan, Ruie Feng, Xiaomeng Hou, Ji Li, Xuefeng Sun, Jinglan Wang, Juhong Shi, Mengzhao Wang and Yan Xu

    Citation: BMC Pulmonary Medicine 2019 19:26

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  7. Content type: Case report

    Any immunological mechanisms induced by influenza virus could cause severe secondary bacterial superinfection such as those by Streptococcus pyogenes [group A streptococcus (GAS)], Streptococcus pneumoniae or Sta...

    Authors: Nobuhiro Asai, Hiroyuki Suematsu, Daisuke Sakanashi, Hideo Kato, Mao Hagihara, Hiroki Watanabe, Arufumi Shiota, Yusuke Koizumi, Yuka Yamagishi and Hiroshige Mikamo

    Citation: BMC Pulmonary Medicine 2019 19:25

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  9. Content type: Research article

    Bronchial provocation is often used to confirm asthma. Dyspnea sensation, however, associates poorly with the evoked drop in FEV1. Provocation tests only use the large airways parameter FEV1, although dyspnea is ...

    Authors: Claire A. Cox, Ilse M. Boudewijn, Sebastiaan J. Vroegop, Siebrig Schokker, Anne J. Lexmond, Henderik W. Frijlink, Paul Hagedoorn, Judith M. Vonk, Martijn P. Farenhorst, Nick H. T. ten Hacken, Huib A. M. Kerstjens and Maarten van den Berge

    Citation: BMC Pulmonary Medicine 2019 19:23

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  10. Content type: Study protocol

    Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality all over the world. Acute exacerbation of COPD (AECOPD) not only accelerates the progression of disease, but also causes...

    Authors: Tianyu Zhou, Yijue Zhong, Jiping Liao, Guangfa Wang, Xueying Li, Xiaosen Qian, Pingchao Xiang, Xinsheng Chen, Zhenyang Xu, Fengzhen Zhang, Xiaoguang Wang, Senlin Wang, Xiangxin Li, Chunxiao Yu, Yongxiang Zhang, Guoguang Xia…

    Citation: BMC Pulmonary Medicine 2019 19:22

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  11. Content type: Study protocol

    Telehealth and telemonitoring is an emerging area of study in people with cystic fibrosis (CF), with the potential of increasing access to care, and minimising infection control risks to patients without compr...

    Authors: Ray Lei Lang, Christine Wilson, Kellie Stockton, Trevor Russell and Leanne Marie Johnston

    Citation: BMC Pulmonary Medicine 2019 19:21

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  12. Content type: Research article

    By comparing diagnoses made by pre-transplant surgical lung biopsy (SLB) and the final pathologic diagnosis of the explanted pathology (EP), we aimed to study the factors that could impact pathologic diagnoses...

    Authors: Tanmay S. Panchabhai, Andrea Valeria Arrossi, Kristin B. Highland, Debabrata Bandyopadhyay, Daniel A. Culver, Marie M. Budev and Carol F. Farver

    Citation: BMC Pulmonary Medicine 2019 19:20

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  13. Content type: Research article

    RGM medium is an agar-based, selective culture medium designed for the isolation of nontuberculous mycobacteria (NTM) from the sputum of patients with cystic fibrosis (CF). We evaluated RGM medium for the dete...

    Authors: D. Stephenson, A. Perry, M. R. Appleby, D. Lee, J. Davison, A. Johnston, A. L. Jones, A. Nelson, S. J. Bourke, M. F. Thomas, A. De Soyza, J. L. Lordan, J. Lumb, A. E. Robb, J. R. Samuel, K. E. Walton…

    Citation: BMC Pulmonary Medicine 2019 19:19

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  14. Content type: Research article

    The high cost and low availability of polysomnography (PSG) limits the timely diagnosis of OSA. Herein, we developed and validated a simple-to-use nomogram for predicting OSA.

    Authors: Huajun Xu, Xiaolong Zhao, Yue Shi, Xinyi Li, Yingjun Qian, Jianyin Zou, Hongliang Yi, Hengye Huang, Jian Guan and Shankai Yin

    Citation: BMC Pulmonary Medicine 2019 19:18

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  15. Content type: Research article

    Extra-pulmonary tuberculosis (EPTB) is defined as any bacteriologically confirmed or clinically diagnosed case of TB involving organs other than the lungs. It is frequently a diagnostic and therapeutic challen...

    Authors: Teyim Pride Mbuh, Irene Ane-Anyangwe, Wandji Adeline, Benjamin D. Thumamo Pokam, Henry Dilonga Meriki and Wilfred Fon Mbacham

    Citation: BMC Pulmonary Medicine 2019 19:17

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  16. Content type: Research article

    Standardization of trans-bronchial lung cryobiopsy in diffuse parenchymal lung diseases is imminent; however, the majority of published series on cryobiopsy include a limited number of patients and are charact...

    Authors: Claudia Ravaglia, Athol U. Wells, Sara Tomassetti, Carlo Gurioli, Christian Gurioli, Alessandra Dubini, Alberto Cavazza, Thomas V. Colby, Sara Piciucchi, Silvia Puglisi, Marcello Bosi and Venerino Poletti

    Citation: BMC Pulmonary Medicine 2019 19:16

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  17. Content type: Case report

    Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe condition with limited treatment strategies. Although respiratory infection is a major cause of AE-IPF, no reports have indicated pertus...

    Authors: Kuniaki Hirai, Tetsuya Homma, Fumihiro Yamaguchi, Munehiro Yamaguchi, Shintaro Suzuki, Akihiko Tanaka, Tsukasa Ohnishi and Hironori Sagara

    Citation: BMC Pulmonary Medicine 2019 19:15

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  18. Content type: Research article

    Endosonography with needle aspiration (EBUS/EUS-NA) is recommended as the first choice for mediastinal nodal assessment in non-small cell lung cancer (NSCLC). It is important to maintain adequate negative pred...

    Authors: Sukyeon Kim, Beomsu Shin, Hyun Lee, Jick Hwan Ha, Kyungjong Lee, Sang-Won Um, Hojoong Kim and Byeong-Ho Jeong

    Citation: BMC Pulmonary Medicine 2019 19:14

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    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:69

  19. Content type: Research article

    The Severe Respiratory Insufficiency (SRI) questionnaire is a specific measure of health-related quality of life (HRQoL) in patients treated with long-term mechanical ventilation (LTMV). The aim of the present...

    Authors: Heidi Markussen, Sverre Lehmann, Roy M. Nilsen and Gerd K. Natvig

    Citation: BMC Pulmonary Medicine 2019 19:13

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  20. Content type: Case report

    Sporadic lymphangioleiomyomatosis (LAM) is a rare form of diffuse parenchymal lung disease. PD-1 blocking antibodies constitute an essential treatment option for advanced non-small-cell lung cancer (NSCLC). Th...

    Authors: Johan Pluvy, Solenn Brosseau, Sandrine Stelianides, Claire Danel, Marina Nguenang, Antoine Khalil, Bruno Crestani, Gérard Zalcman and Valérie Gounant

    Citation: BMC Pulmonary Medicine 2019 19:12

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  21. Content type: Research article

    Idiopathic pulmonary fibrosis (IPF) is a rare life-threating interstitial lung disease (ILD). This study characterizes demographics, health care utilization, and comorbidities among elderly IPF patients and es...

    Authors: Kathleen Mortimer, Nadine Hartmann, Christine Chan, Heather Norman, Laura Wallace and Cheryl Enger

    Citation: BMC Pulmonary Medicine 2019 19:11

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  22. Content type: Research article

    Relapse of cryptogenic organizing pneumonia (COP) may lead to poor long-term prognosis and necessitates multiple rounds of steroid treatment with potential adverse effects. The objective of this study is to id...

    Authors: Zenya Saito, Yugo Kaneko, Tsukasa Hasegawa, Masahiro Yoshida, Kyuto Odashima, Tsugumi Horikiri, Akira Kinoshita, Keisuke Saitoh and Kazuyoshi Kuwano

    Citation: BMC Pulmonary Medicine 2019 19:10

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  23. Content type: Research article

    Surfactant is usually deficiency in adult acute respiratory distress syndrome(ARDS) patients and surfactant administration may be a useful therapy. The aim of this study was to perform a meta-analysis of the effe...

    Authors: Shan-Shan Meng, Wei Chang, Zhong-Hua Lu, Jian-Feng Xie, Hai-Bo Qiu, Yi Yang and Feng-Mei Guo

    Citation: BMC Pulmonary Medicine 2019 19:9

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  24. Content type: Case report

    Cystic lung lesions involving both lungs include a variety of diseases, such as pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis and pulmonary metastasis. Primary pulmonary meningioma accompan...

    Authors: Xin Wang, Pengfei Li, Ping Zhou, Yiyun Fu, Yutian Lai and Guowei Che

    Citation: BMC Pulmonary Medicine 2019 19:8

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  25. Content type: Research article

    Bronchiectasis is a major contributor to respiratory morbidity and health care utilization in children and youth. Current treatment guidelines for bronchiectasis recommend participation in regular physical act...

    Authors: Barbara Joschtel, Sjaan R. Gomersall, Sean Tweedy, Helen Petsky, Anne B. Chang and Stewart G. Trost

    Citation: BMC Pulmonary Medicine 2019 19:7

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  26. Content type: Case report

    Although the prevalence of pneumoconiosis has been decreasing due to improvements in working conditions and regular health examinations, occupational hygiene measures are still being established. Plasterers en...

    Authors: Fumio Kurosaki, Tamiko Takemura, Masashi Bando, Tomonori Kuroki, Toshio Numao, Hiroshi Moriyama and Koichi Hagiwara

    Citation: BMC Pulmonary Medicine 2019 19:6

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  27. Content type: Research article

    Inhibition of interleukin (IL)-13, a Type 2 inflammatory mediator in asthma, improves lung function and reduces exacerbations; however, more effective therapies are needed. A subset of asthma patients also exh...

    Authors: Tracy L. Staton, Kun Peng, Ryan Owen, David F. Choy, Christopher R. Cabanski, Alice Fong, Flavia Brunstein, Kathila R. Alatsis and Hubert Chen

    Citation: BMC Pulmonary Medicine 2019 19:5

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  28. Content type: Study protocol

    Up to fifty percent of microbiologically cured tuberculosis (TB) patients may be left with permanent, moderate or severe pulmonary function impairment. Very few studies have systematically examined pulmonary o...

    Authors: Andrea Rachow, Olena Ivanova, Robert Wallis, Salome Charalambous, Ilesh Jani, Nilesh Bhatt, Beate Kampmann, Jayne Sutherland, Nyanda E. Ntinginya, Denise Evans, Knut Lönnroth, Stefan Niemann, Ulrich E. Schaible, Christof Geldmacher, Ian Sanne, Michael Hoelscher…

    Citation: BMC Pulmonary Medicine 2019 19:4

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  29. Content type: Research article

    EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib based theranostic agent for the molecular imaging of ...

    Authors: Maxime Patout, Florian Guisier, Xavier Brune, Pierre Bohn, Anthony Romieu, Nasrin Sarafan-Vasseur, Richard Sesboüé, Pierre-Yves Renard, Luc Thiberville and Mathieu Salaün

    Citation: BMC Pulmonary Medicine 2019 19:3

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  30. Content type: Research article

    Although dynamic lung volume is not considered a limiting factor of peak oxygen uptake (VO2peak) in healthy subjects, an association between forced expiratory lung volume in one second (FEV1) and VO2peak has been...

    Authors: Øystein Rasch-Halvorsen, Erlend Hassel, Arnulf Langhammer, Ben M. Brumpton and Sigurd Steinshamn

    Citation: BMC Pulmonary Medicine 2019 19:2

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  31. Content type: Research article

    The lung ultrasound score has been regarded as a decent semiquantitative score to measure the lung aeration loss. The score has been proven to be valuable in diagnosing and monitoring lung pathology, but no st...

    Authors: Wanhong Yin, Tongjuan Zou, Yao Qin, Jing Yang, Yi Li, Xueying Zeng and Yan Kang

    Citation: BMC Pulmonary Medicine 2019 19:1

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  32. Content type: Research article

    Impaired angiogenesis is assumed to be an important factor in the development of chronic thromboembolic pulmonary hypertension (CTEPH). However, the role of endothelial cells (ECs) in CTEPH remains unclear. Th...

    Authors: Akira Naito, Seiichiro Sakao, Irene M. Lang, Norbert F. Voelkel, Takayuki Jujo, Keiichi Ishida, Toshihiko Sugiura, Goro Matsumiya, Ichiro Yoshino, Nobuhiro Tanabe and Koichiro Tatsumi

    Citation: BMC Pulmonary Medicine 2018 18:197

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  33. Content type: Research article

    A clinical heterogeneity was reported in patients with Cystic Fibrosis (CF) with the same CFTR genotype and between siblings with CF.

    Authors: Vito Terlizzi, Marco Lucarelli, Donatello Salvatore, Adriano Angioni, Arianna Bisogno, Cesare Braggion, Roberto Buzzetti, Vincenzo Carnovale, Rosaria Casciaro, Giuseppe Castaldo, Natalia Cirilli, Mirella Collura, Carla Colombo, Antonella Miriam Di Lullo, Ausilia Elce, Vincenzina Lucidi…

    Citation: BMC Pulmonary Medicine 2018 18:196

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  34. Content type: Research article

    Evidence from several studies show poor guideline adherence to COPD treatment, but no such study has been undertaken in Norway. The objectives of this study, was to estimate and compare the guideline adherence...

    Authors: Bahareh Jouleh, Marta Erdal, Tomas Mikal Eagan, Per Bakke, Amund Gulsvik and Rune Nielsen

    Citation: BMC Pulmonary Medicine 2018 18:195

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  35. Content type: Research article

    The present study aimed to develop an automated computed tomography (CT) score based on the CT quantification of high-attenuating lung structures, in order to provide a quantitative assessment of lung structur...

    Authors: Trieu-Nghi Hoang-Thi, Marie-Pierre Revel, Pierre-Régis Burgel, Laurence Bassinet, Isabelle Honoré, Thong Hua-Huy, Charlotte Martin, Bernard Maitre and Guillaume Chassagnon

    Citation: BMC Pulmonary Medicine 2018 18:194

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  36. Content type: Case report

    Pulmonary carcinosarcoma (PCS) is a rare primary lung malignancy and has a poor prognosis among lung tumor histological subtypes. However, an appropriate treatment strategy has not been developed for unresecta...

    Authors: Azusa Tanimoto, Shinji Takeuchi, Hiroshi Kotani, Kaname Yamashita, Tadaaki Yamada, Koushiro Ohtsubo, Hiromichi Ebi, Hiroko Ikeda and Seiji Yano

    Citation: BMC Pulmonary Medicine 2018 18:193

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  37. Content type: Research article

    The optimal procedure for maximizing the diagnostic yield and minimizing the procedural complexity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is controversial. We conducted...

    Authors: Xiaoxiao Lin, Min Ye, Yuping Li, Jing Ren, Qiyan Lou, Yangyang Li, Xiaohui Jin, Ko-Pen Wang and Chengshui Chen

    Citation: BMC Pulmonary Medicine 2018 18:192

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  38. Content type: Research article

    Guidelines currently do not recommend the routine use of chest x-ray (CXR) in bronchiolitis. However, CXR is still performed in a high percentage of cases, mainly to diagnose or rule out pneumonia. The inappro...

    Authors: Carlotta Biagi, Luca Pierantoni, Michelangelo Baldazzi, Laura Greco, Ada Dormi, Arianna Dondi, Giacomo Faldella and Marcello Lanari

    Citation: BMC Pulmonary Medicine 2018 18:191

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  39. Content type: Research article

    Home mechanical ventilation is an established treatment for chronic respiratory failure resulting in improved survival and quality of life. Technological advancement, evolving health care reimbursement systems...

    Authors: Luca Valko, Szabolcs Baglyas, Janos Gal and Andras Lorx

    Citation: BMC Pulmonary Medicine 2018 18:190

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  40. Content type: Research article

    Hepatic ischemia-reperfusion injury (IRI) is a common pathological phenomenon, which causes hepatic injury as well as remote organ injuries such as the lung. Several mediators, such as oxidative stress, Ca2+ over...

    Authors: Yao Tong, Zhuang Yu, Renlingzi Zhang, Xibing Ding, Zhixia Chen and Quan Li

    Citation: BMC Pulmonary Medicine 2018 18:189

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  41. Content type: Research article

    Hsp90-beta has been investigated to be correlated with the occurrence and development of tumor. The intention of this research was to test the level of Hsp90-beta in malignant pleural effusion (MPE) of patient...

    Authors: Rong Biaoxue, Li Min, Fu Tian, Gao Wenlong and Liu Hua

    Citation: BMC Pulmonary Medicine 2018 18:188

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  42. Content type: Research article

    Lung hyperinflation contributes to dyspnea, morbidity and mortality in chronic obstructive pulmonary disease (COPD). The inspiratory-to-total lung capacity (IC/TLC) ratio is a measure of lung hyperinflation an...

    Authors: Linn T. Aalstad, Jon A. Hardie, Birgitte Espehaug, Einar Thorsen, Per S. Bakke, Tomas M. L. Eagan and Bente Frisk

    Citation: BMC Pulmonary Medicine 2018 18:187

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  43. Content type: Research article

    There is a lack of robust data about factors predicting continuation (or termination) of positive airway pressure therapy (PAP) for sleep apnea. This analysis of big data from a German homecare provider descri...

    Authors: Holger Woehrle, Michael Arzt, Andrea Graml, Ingo Fietze, Peter Young, Helmut Teschler and Joachim H. Ficker

    Citation: BMC Pulmonary Medicine 2018 18:186

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  44. Content type: Case report

    Coexistence of aspergilloma and allergic bronchopulmonary aspergillosis (ABPA) has rarely been reported. Although the treatment for ABPA includes administration of corticosteroids and antifungal agents, little...

    Authors: Kohei Horiuchi, Takanori Asakura, Naoki Hasegawa and Fumitake Saito

    Citation: BMC Pulmonary Medicine 2018 18:185

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  45. Content type: Research article

    This study was conducted in order to determine the prevalence of asthma and associated risk factors in the adult population of Karachi, Pakistan.

    Authors: Shama Razzaq, Asaad Ahmed Nafees, Unaib Rabbani, Muhammad Irfan, Shahla Naeem, Muhammad Arslan Khan, Zafar Fatmi and Peter Burney

    Citation: BMC Pulmonary Medicine 2018 18:184

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  46. Content type: Research article

    Disease control is an important objective of COPD management. The SINCON study evaluated the level of control in terms of respiratory symptoms and exacerbations in Spanish patients with COPD for ≥2 years.

    Authors: Adolfo Baloira, José Miguel Rodriguez Gonzalez-Moro, Estefanía Sanjuán, Juan Antonio Trigueros and Ricard Casamor

    Citation: BMC Pulmonary Medicine 2018 18:183

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  48. Content type: Case report

    Granulomatosis with polyangiitis (GPA) is a systemic ANCA-associated vasculitis characterized by necrotizing granulomatous inflammation and a predilection for the upper and lower respiratory tract. Eosinophili...

    Authors: Michele V. Quan, Stephen K. Frankel, Mehrnaz Maleki-Fischbach and Laren D. Tan

    Citation: BMC Pulmonary Medicine 2018 18:181

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  49. Content type: Research article

    2′-5′-Oligoadenylate synthetase 1 (OAS1) plays an important role in inflammatory immune reactions. OAS1 polymorphisms have been associated with increased susceptibility to various diseases. We investigated the as...

    Authors: Shouquan Wu, Yu Wang, Guo Chen, Miaomiao Zhang, Minggui Wang and Jian-Qing He

    Citation: BMC Pulmonary Medicine 2018 18:180

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