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  1. Content type: Research article

    Interstitial lung disease (ILD) is a prognostic indicator of poor outcome in myositis. Although the pathogenesis of myositis-associated ILD is not well understood, neutrophils are thought to play a pivotal rol...

    Authors: Noriho Sakamoto, Hiroshi Ishimoto, Tomoyuki Kakugawa, Minoru Satoh, Tomoko Hasegawa, Shin Tanaka, Atsuko Hara, Shota Nakashima, Hirokazu Yura, Takuto Miyamura, Hanako Koyama, Towako Morita, Seiko Nakamichi, Yasushi Obase, Yuji Ishimatsu and Hiroshi Mukae

    Citation: BMC Pulmonary Medicine 2018 18:44

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  2. Content type: Research article

    Bacterial respiratory infections (BRI) are major complications contributing to increased morbidity and mortality after lung transplantation (LT). This study analyzed epidemiology and outcome of 175 consecutive...

    Authors: Sebastien Tanaka, Claire Geneve, Gianpiero Tebano, Nathalie Grall, Pascal Piednoir, Régis Bronchard, Mathieu Godement, Enora Atchade, Pascal Augustin, Herve Mal, Yves Castier, Philippe Montravers and Mathieu Desmard

    Citation: BMC Pulmonary Medicine 2018 18:43

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  3. Content type: Research article

    There is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enrich...

    Authors: Jiyoun Yeo, Diego A. Morales, Tian Chen, Erin L. Crawford, Xiaolu Zhang, Thomas M. Blomquist, Albert M. Levin, Pierre P. Massion, Douglas A. Arenberg, David E. Midthun, Peter J. Mazzone, Steven D. Nathan, Ronald J. Wainz, Patrick Nana-Sinkam, Paige F. S. Willey, Taylor J. Arend…

    Citation: BMC Pulmonary Medicine 2018 18:42

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  4. Content type: Research article

    Aldosterone is a mineralocorticoid hormone critically involved in arterial blood pressure regulation. Although pharmacological aldosterone antagonism reduces mortality and morbidity among patients with severe ...

    Authors: Mario Boehm, Nadine Arnold, Adam Braithwaite, Josephine Pickworth, Changwu Lu, Tatyana Novoyatleva, David G. Kiely, Friedrich Grimminger, Hossein A. Ghofrani, Norbert Weissmann, Werner Seeger, Allan Lawrie, Ralph T. Schermuly and Baktybek Kojonazarov

    Citation: BMC Pulmonary Medicine 2018 18:41

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  5. Content type: Study protocol

    Exercise training is an integral component of evidence-based management programs for many chronic cardiac and respiratory conditions. Despite this, there are limited high-quality studies available on the signi...

    Authors: Norman R. Morris, Menaka Louis, Wendy Strugnell, Julie Harris, Aaron Lin, John Feenstra and Helen Seale

    Citation: BMC Pulmonary Medicine 2018 18:40

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  6. Content type: Case report

    Actinomycosis is a rare bacterial infection caused by Actinomyces. The symptom of actinomycosis is nonspecific and radiological images present as a slow-progressive mass lesion similarly to malignancies. Thus, it...

    Authors: Munemasa Nagao, Akihisa Fukuda, Takeshi Matsumura, Toshiyuki Kimura and Hiroshi Seno

    Citation: BMC Pulmonary Medicine 2018 18:39

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  7. Content type: Research article

    An adequate threshold for the Clinical Chronic Obstructive Pulmonary Disease (COPD) Questionnaire (CCQ) defining more symptomatic COPD patients has not been determined. We aimed to determine the efficacy of th...

    Authors: Yong Suk Jo, Sangshin Park, Deog Kyeom Kim, Chul-Gyu Yoo and Chang-Hoon Lee

    Citation: BMC Pulmonary Medicine 2018 18:38

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  8. Content type: Research article

    The prison situations are notorious for causing interruptions of tuberculosis (TB) treatment and occurrence of unfavorable outcomes. In Ethiopian prisons, though TB treatment programs exist, treatment outcome ...

    Authors: Kelemework Adane, Mark Spigt and Geert-Jan Dinant

    Citation: BMC Pulmonary Medicine 2018 18:37

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  9. Content type: Research article

    Although the impact of therapeutic thoracentesis on lung function and blood gases has been evaluated in several studies, some physiological aspects of pleural fluid withdrawal remain unknown. The aim of the st...

    Authors: Monika Zielinska-Krawczyk, Elzbieta M. Grabczak, Marcin Michnikowski, Krzysztof Zielinski, Piotr Korczynski, Anna Stecka, Tomasz Golczewski and Rafal Krenke

    Citation: BMC Pulmonary Medicine 2018 18:36

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  10. Content type: Research article

    Infection with Burkholderia cepacia complex (Bcc) results in a heterogeneous clinical course ranging from asymptomatic colonization of the airways to fulminant respiratory failure in patients with cystic fibrosis...

    Authors: Bryan A. Garcia, Jacque L. Carden, Dana L. Goodwin, Tim A. Smith, Amit Gaggar, Kevin Leon, Veena B. Antony, Steven M. Rowe and George M. Solomon

    Citation: BMC Pulmonary Medicine 2018 18:35

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  11. Content type: Research article

    Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and valid...

    Authors: Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A. Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A. Castro-Rodriguez, Gretchen A. Voge, Hongfang Liu and Young J. Juhn

    Citation: BMC Pulmonary Medicine 2018 18:34

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  12. Content type: Research article

    Questionnaires can be used to assess perceived indoor air quality and symptoms in schools. Questionnaires for primary school aged children have traditionally been parent-administered, but self-administered que...

    Authors: Jussi Lampi, Sari Ung-Lanki, Päivi Santalahti and Juha Pekkanen

    Citation: BMC Pulmonary Medicine 2018 18:32

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  13. Content type: Study protocol

    Physical activity (PA) and exercise have become an accepted and valued component of cystic fibrosis (CF) care. Regular PA and exercise can positively impact pulmonary function, improve physical fitness, and en...

    Authors: Helge Hebestreit, Larry C. Lands, Nancy Alarie, Jonathan Schaeff, Chantal Karila, David M. Orenstein, Don S. Urquhart, Erik H. J. Hulzebos, Lothar Stein, Christian Schindler, Susi Kriemler and Thomas Radtke

    Citation: BMC Pulmonary Medicine 2018 18:31

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  14. Content type: Research article

    Bronchial thermoplasty (BT) is a non-pharmacological intervention for severe asthma whose mechanism of action is not completely explained by a reduction of airway smooth muscle (ASM). In this study we analyzed...

    Authors: N. Facciolongo, A. Di Stefano, V. Pietrini, C. Galeone, F. Bellanova, F. Menzella, N. Scichilone, R. Piro, G. L. Bajocchi, B. Balbi, L. Agostini, P. P. Salsi, D. Formisano and M. Lusuardi

    Citation: BMC Pulmonary Medicine 2018 18:29

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  15. Content type: Research article

    Mortality is similarly high among individuals with usual interstitial pneumonia (UIP) due to idiopathic pulmonary fibrosis (IPF) and interstitial pneumonia with autoimmune features (IPAF). Circulating anti-nuc...

    Authors: Justin M. Oldham, Leah J. Witt, Ayodeji Adegunsoye, Jonathan H. Chung, Cathryn Lee, Scully Hsu, Lena W. Chen, Aliya Husain, Steven Montner, Rekha Vij, Mary E. Strek and Imre Noth

    Citation: BMC Pulmonary Medicine 2018 18:30

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  16. Content type: Research article

    In the 1980s, randomized-controlled trials showed that high-dose corticosteroid treatment did not improve the mortality of acute respiratory distress syndrome (ARDS). However, while the diagnostic criteria for...

    Authors: Takashi Kido, Keiji Muramatsu, Takeshi Asakawa, Hiroki Otsubo, Takaaki Ogoshi, Keishi Oda, Tatsuhiko Kubo, Yoshihisa Fujino, Shinya Matsuda, Toshihiko Mayumi, Hiroshi Mukae and Kazuhiro Yatera

    Citation: BMC Pulmonary Medicine 2018 18:28

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  17. Content type: Research article

    The relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied. We assessed this relationship in elderly subjects with either good or poor spirometric...

    Authors: Stefan Karrasch, Jürgen Behr, Rudolf M. Huber, Dennis Nowak, Annette Peters, Stefan Peters, Rolf Holle, Rudolf A. Jörres and Holger Schulz

    Citation: BMC Pulmonary Medicine 2018 18:27

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  18. Content type: Research article

    In the Commonwealth of Independent States (CIS) countries the epidemiology of chronic obstructive pulmonary disease (COPD) is poorly characterized. The objective of this analysis is to present the prevalence, ...

    Authors: Damilya Nugmanova, Yuriy Feshchenko, Liudmyla Iashyna, Olga Gyrina, Kateryna Malynovska, Eljan Mammadbayov, Irada Akhundova, Nadezhda Nurkina, Luqman Tariq, Janina Makarova and Averyan Vasylyev

    Citation: BMC Pulmonary Medicine 2018 18:26

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  19. Content type: Research article

    Pulmonary emphysema combined with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) occurs more often in smokers but also in never-smokers. This study aimed to describe a new finding characte...

    Authors: Hideaki Yamakawa, Tamiko Takemura, Tae Iwasawa, Yumie Yamanaka, Satoshi Ikeda, Akimasa Sekine, Hideya Kitamura, Tomohisa Baba, Shinichiro Iso, Koji Okudela, Kazuyoshi Kuwano and Takashi Ogura

    Citation: BMC Pulmonary Medicine 2018 18:25

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  20. Content type: Case report

    Nivolumab, an anti-programmed cell death-1 (PD-1) monoclonal antibody used as an immune checkpoint inhibitor, is commonly employed for its anti-tumor effects against various types of malignant tumors. However,...

    Authors: N. Koyama, O. Iwase, E. Nakashima, K. Kishida, T. Kondo, Y. Watanabe, H. Takahashi, Y. Umebayashi, Y. Ogawa and H. Miura

    Citation: BMC Pulmonary Medicine 2018 18:23

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  21. Content type: Research article

    Pneumococcal pneumonia causes high morbidity and mortality among adults. This study aimed to identify risk factors for bacteremic pneumococcal pneumonia, and to construct a prediction model for the development...

    Authors: Yasuyoshi Washio, Akihiro Ito, Shogo Kumagai, Tadashi Ishida and Akio Yamazaki

    Citation: BMC Pulmonary Medicine 2018 18:24

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  22. Content type: Research article

    Pneumoconiosis may play an important role in the development of chronic obstructive pulmonary disease (COPD), and the complication of COPD may impose a heavy burden of illness.

    Authors: Yating Peng, Xin Li, Shan Cai, Yan Chen, Weirong Dai, Wenfeng Liu, Zijing Zhou, Jiaxi Duan and Ping Chen

    Citation: BMC Pulmonary Medicine 2018 18:22

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  23. Content type: Research article

    Exacerbations of chronic obstructive pulmonary disease (COPD) are an important measure of disease severity in terms of impaired disease progression, increased recovery time, healthcare resource utilization, ov...

    Authors: Gunnar Johansson, Vasili Mushnikov, Tobias Bäckström, Andreas Engström, Javaria Mona Khalid, Jennifer Wall and Fabian Hoti

    Citation: BMC Pulmonary Medicine 2018 18:17

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  24. Content type: Research article

    Patients with symptoms of both asthma and chronic obstructive pulmonary disease (COPD) may be classified with the term asthma-COPD overlap (ACO). ACO is of considerable interest as it is currently poorly chara...

    Authors: Sumitra Shantakumar, Raoh-Fang Pwu, Liesel D’Silva, Keele Wurst, Yao-Wen Kuo, Yen-Yun Yang, Yi-Chen Juan and K. Arnold Chan

    Citation: BMC Pulmonary Medicine 2018 18:16

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  25. Content type: Research article

    Hospitalization for a severe exacerbation of COPD (eCOPD) is an important event in the natural history of COPD. Identifying factors related to mortality 1 year after hospitalization could help determine interv...

    Authors: Cristóbal Esteban, Ady Castro-Acosta, Carlos Jose Alvarez-Martínez, Alberto Capelastegui, José Luis López-Campos and Francisco Pozo-Rodriguez

    Citation: BMC Pulmonary Medicine 2018 18:18

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  26. Content type: Research article

    Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal fibrosing lung disease of unknown cause. The advent of anti-fibrotic medications known to slow disease progression has revolutionised IPF manageme...

    Authors: Helen E. Jo, Ian Glaspole, Yuben Moodley, Sally Chapman, Samantha Ellis, Nicole Goh, Peter Hopkins, Greg Keir, Annabelle Mahar, Wendy Cooper, Paul Reynolds, E. Haydn Walters, Christopher Zappala, Christopher Grainge, Heather Allan, Sacha Macansh…

    Citation: BMC Pulmonary Medicine 2018 18:19

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  27. Content type: Research article

    In individuals with cystic fibrosis (CF), colonization with methicillin-resistant Staphylococcus aureus (MRSA) was reported to be associated with a deterioration of pulmonary disease as reflected by an accelerate...

    Authors: Alexander Kiefer, Christian Bogdan and Volker O. Melichar

    Citation: BMC Pulmonary Medicine 2018 18:20

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  28. Content type: Research article

    Nasal Highflow (NHF) delivers a humidified and heated airflow via nasal prongs. Current data provide evidence for efficacy of NHF in patients with hypoxemic respiratory failure. Preliminary data suggest that N...

    Authors: Jens Bräunlich, Friederike Mauersberger and Hubert Wirtz

    Citation: BMC Pulmonary Medicine 2018 18:14

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  29. Content type: Case report

    Crizotinib is recommended as first-line therapy in ROS1-driven lung adenocarcinoma. However, the optimal first-line therapy for this subgroup of lung cancer is controversial according to the available clinical...

    Authors: Liang Dong, Jingwen Xia, Jing Zhang, Yuanyuan Zhang, Ning Zhu, Peng Zhang, Youzhi Zhang, Xiujuan Zhang and Shengqing Li

    Citation: BMC Pulmonary Medicine 2018 18:13

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  30. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) is one of the most common comorbidities in community acquired pneumonia (CAP) patients. We aimed to investigate the characteristics and mortality risk factors of CO...

    Authors: Ruo-Xuan Dai, Qing-Hua Kong, Bei Mao, Wen Xu, Ru-Jia Tao, Xiao-Ru Wang, Qing-Yao Kong and Jin-Fu Xu

    Citation: BMC Pulmonary Medicine 2018 18:12

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  31. Content type: Research article

    An association between body weight in childhood and subsequent lung function and asthma has been suggested, but few longitudinal studies exist. Our aim was to explore whether weight-related anthropometric meas...

    Authors: Kristine Kjer Byberg, Ingvild Bruun Mikalsen, Geir Egil Eide, Michele R. Forman, Pétur Benedikt Júlíusson and Knut Øymar

    Citation: BMC Pulmonary Medicine 2018 18:10

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  32. Content type: Research article

    Chronic obstructive pulmonary disease is a global problem and available data from sub-Saharan Africa is very limited.

    Authors: Thomas Zoller, Elirehema H. Mfinanga, Tresphory B. Zumba, Peter J. Asilia, Edwin M. Mutabazi, David Wimmersberger, Florian Kurth, Francis Mhimbira, Frederick Haraka and Klaus Reither

    Citation: BMC Pulmonary Medicine 2018 18:11

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  33. Content type: Research article

    The diagnosis of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILD) presents significant clinical challenges. To gain insights regarding the diagnostic experience of patients with I...

    Authors: Gregory P. Cosgrove, Pauline Bianchi, Sherry Danese and David J. Lederer

    Citation: BMC Pulmonary Medicine 2018 18:9

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  34. Content type: Research article

    Recurrent airway infections are common in patients with Down’s syndrome (DS). Hence, ruling out Cystic Fibrosis (CF) in these patients is often required. In the past, the value of sweat testing – the gold stan...

    Authors: Katharina Ruf, Antonia Demerath, Helge Hebestreit and Steffen Kunzmann

    Citation: BMC Pulmonary Medicine 2018 18:8

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  35. Content type: Research article

    Acute respiratory infections (ARI) are a leading cause of morbidity and mortality in under-five children worldwide. About 6.6 million children less than 5 years of age die every year in the world; 95% of them ...

    Authors: Alexis A. Tazinya, Gregory E. Halle-Ekane, Lawrence T. Mbuagbaw, Martin Abanda, Julius Atashili and Marie Therese Obama

    Citation: BMC Pulmonary Medicine 2018 18:7

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  36. Content type: Case report

    Tuberculosis and cryptococcosis co-infection usually occurs in immunosuppressed patients with impaired cell-mediated immunity. However, there are few reports about such co-infection in non-HIV patients without...

    Authors: Toyomitsu Sawai, Takumi Nakao, Satoru Koga, Shotaro Ide, Sumako Yoshioka, Nobuko Matsuo and Hiroshi Mukae

    Citation: BMC Pulmonary Medicine 2018 18:6

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  37. Content type: Research article

    The aim of our study was to assess current practice patterns and attitudes towards diagnosis and management of idiopathic pulmonary fibrosis (IPF) patients in Latin America.

    Authors: Iván Cherrez-Ojeda, Vincent Cottin, Juan Carlos Calderón, César Delgado, Erick Calero, Daniel Simanca-Racines, Silvia Quadrelli and Annia Cherrez

    Citation: BMC Pulmonary Medicine 2018 18:5

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  38. Content type: Research article

    Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has been established more than 10 years ago. Therefore...

    Authors: Takanori Numata, Katsutoshi Nakayama, Satoko Fujii, Yoko Yumino, Nayuta Saito, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara…

    Citation: BMC Pulmonary Medicine 2018 18:4

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  39. Content type: Research article

    Inhalation of nebulised medications is performed in upright sitting to maximise lung volumes. The pattern of deposition is poor for inhaled medications in people with Cystic Fibrosis. The pattern tends to be n...

    Authors: Ruth L. Dentice, Mark R. Elkins, Genevieve M. Dwyer and Peter T. P. Bye

    Citation: BMC Pulmonary Medicine 2018 18:3

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  40. Content type: Research article

    There is only limited information on the impact of thin-section computed tomography (TSCT)-determined usual interstitial pneumonia (UIP) pattern in the decision-making for resection in newly diagnosed lung can...

    Authors: Naozumi Hashimoto, Akira Ando, Shingo Iwano, Koji Sakamoto, Shotaro Okachi, Asuka Matsuzaki, Yu Okada, Kenji Wakai, Kohei Yokoi and Yoshinori Hasegawa

    Citation: BMC Pulmonary Medicine 2018 18:2

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  41. Content type: Research article

    Annexin-A1 (ANXA1) is a glucocorticoid-induced protein with multiple actions in the regulation of inflammatory cell activation. The anti-inflammatory protein ANXA1 and its N-formyl peptide receptor 2 (FPR2) ha...

    Authors: Sun-Hye Lee, Pureun-Haneul Lee, Byeong-Gon Kim, Hyun-Jeong Seo, Ae-Rin Baek, Jong-Sook Park, June-Hyuk Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park and An-Soo Jang

    Citation: BMC Pulmonary Medicine 2018 18:1

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  42. Content type: Research article

    There is conflicting evidence regarding the benefit of adjunctive corticosteroid therapy in patients with Mycoplasma pneumoniae pneumonia. We hypothesised that corticosteroid therapy could reduce mortality and le...

    Authors: Masato Tashiro, Kiyohide Fushimi, Kei Kawano, Takahiro Takazono, Tomomi Saijo, Kazuko Yamamoto, Shintaro Kurihara, Yoshifumi Imamura, Taiga Miyazaki, Katsunori Yanagihara, Hiroshi Mukae and Koichi Izumikawa

    Citation: BMC Pulmonary Medicine 2017 17:219

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  43. Content type: Research article

    Following positive results from the Phase III CHEST-1 study in patients with inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH), the Phase IIIb CTEPH early access study (E...

    Authors: Vallerie V. McLaughlin, Pavel Jansa, Jens E. Nielsen-Kudsk, Michael Halank, Gérald Simonneau, Ekkehard Grünig, Silvia Ulrich, Stephan Rosenkranz, Miguel A. Gómez Sánchez, Tomás Pulido, Joanna Pepke-Zaba, Joan Albert Barberá, Marius M. Hoeper, Jean-Luc Vachiéry, Irene Lang, Francine Carvalho…

    Citation: BMC Pulmonary Medicine 2017 17:216

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  44. Content type: Research article

    Early onset of lung injury is considerable common after cardiac surgery and is associated with increasing in morbidity and mortality, but current clinical predictors for the occurrence of this complication alw...

    Authors: XiWang Liu, QiXing Chen, YuJia Luo, YaoQin Hu, DengMing Lai, XiaoLe Zhang, XiangHong Zhang, JianGen Yu, XiangMing Fang and Qiang Shu

    Citation: BMC Pulmonary Medicine 2017 17:218

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  45. Content type: Research article

    In lung disease, physical activity (PA) yields beneficial health effects, but its association with the function of healthy lungs has rarely been studied. We investigated the association of accelerometer-based ...

    Authors: Agnes Luzak, Stefan Karrasch, Barbara Thorand, Dennis Nowak, Rolf Holle, Annette Peters and Holger Schulz

    Citation: BMC Pulmonary Medicine 2017 17:215

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  46. Content type: Research article

    Previous studies show that overexpression of EMMPRIN involved in the malignant biological behavior of tumors. This investigation was to disclose the expression status of EMMPRIN in non-small cell lung cancer (...

    Authors: Bing Liu, Zhaohui Wan, Baowei Sheng, Yong Lin, Tian Fu, Qingdi Zeng and Congcong Qi

    Citation: BMC Pulmonary Medicine 2017 17:214

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  47. Content type: Case report

    Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and sk...

    Authors: Olivia Wilcox, Mohamed Hassanein, John Armstrong and Nader Kassis

    Citation: BMC Pulmonary Medicine 2017 17:217

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