Articles

Exposure–safety analyses of nintedanib in patients with chronic fibrosing interstitial lung disease

Nintedanib reduces the rate of decline in forced vital capacity in patients with idiopathic pulmonary fibrosis (IPF), other chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype and ...

Authors: Ulrike Schmid, Benjamin Weber, Celine Sarr and Matthias Freiwald

Efficacy of treatment with corticosteroids for fibrotic hypersensitivity pneumonitis: a propensity score-matched cohort analysis

Fibrotic hypersensitivity pneumonitis (HP) is a chronic interstitial lung disease caused by allergic responses to repeated exposures to a causative antigen. Therapeutic evidence of the use of corticosteroids t...

Authors: Masaru Ejima, Tsukasa Okamoto, Takafumi Suzuki, Tatsuhiko Anzai, Kunihiko Takahashi and Yasunari Miyazaki

LINC01089 suppresses lung adenocarcinoma cell proliferation and migration via miR-301b-3p/STARD13 axis

Lung adenocarcinoma (LUAD) is one of the most common cancers with high morbidity and mortality worldwide. Long non-coding RNAs (lncRNAs) serve as tumor promoters or suppressors in the development of various hu...

Authors: Ye Qian, Yan Zhang, Haoming Ji, Yucheng Shen, Liangfeng Zheng, Shouliang Cheng and Xiaomin Lu

Residual respiratory impairment after COVID-19 pneumonia

The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing the potential...

Authors: Francesco Lombardi, Angelo Calabrese, Bruno Iovene, Chiara Pierandrei, Marialessia Lerede, Francesco Varone, Luca Richeldi and Giacomo Sgalla

Anesthesia considerations to reduce motion and atelectasis during advanced guided bronchoscopy

Partnership between anesthesia providers and proceduralists is essential to ensure patient safety and optimize outcomes. A renewed importance of this axiom has emerged in advanced bronchoscopy and intervention...

Authors: Michael A. Pritchett, Kelvin Lau, Scott Skibo, Karen A. Phillips and Krish Bhadra

Outcomes for hospitalized patients with idiopathic pulmonary fibrosis treated with antifibrotic medications

Idiopathic Pulmonary Fibrosis is a chronic, progressive interstitial lung disease for which there is no cure. However, lung function decline, hospitalizations, and mortality may be reduced with the use of the ...

Authors: Bryan T. Kelly, Viengneesee Thao, Timothy M. Dempsey, Lindsey R. Sangaralingham, Stephanie R. Payne, Taylor T. Teague, Teng Moua, Nilay D. Shah and Andrew H. Limper

Pain in Veterans with COPD: relationship with physical activity and exercise capacity

Pain is a common but underappreciated symptom experienced by people with Chronic Obstructive Pulmonary Disease (COPD). The relationships between pain and physical activity (PA) and exercise capacity are poorly...

Authors: Rebecca A. Raphaely, Maria A. Mongiardo, Rebekah L. Goldstein, Stephanie A. Robinson, Emily S. Wan and Marilyn L. Moy

Risk assessment in interstitial lung disease: the incremental prognostic value of cardiopulmonary ultrasound

The mortality risk of chronic interstitial lung disease (ILD) is currently assessed using the ILD-GAP score. The present study evaluates whether the addition of cardiopulmonary ultrasound parameters to the ILD...

Authors: Wei-wei Zhu, Hong Li, Yi-dan Li, Lanlan Sun, Lingyun Kong, Xiaoguang Ye, Qizhe Cai and Xiu-zhang Lv

Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis

Acute lung injury (ALI) is a pulmonary disorder that leads to acute respiration failure and thereby results in a high mortality worldwide. Increasing studies have indicated that toll-like receptor 4 (TLR4) is ...

Authors: Qingsong Sun, Man Luo, Zhiwei Gao, Xiang Han, Weiqin Wu and Hongmei Zhao

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors

Secondary polycythemia is associated with cigarette smoking and chronic obstructive pulmonary disease (COPD). However, the prevalence of polycythemia in COPD and the contributing risk factors for polycythemia ...

Authors: Jingzhou Zhang, Dawn L. DeMeo, Edwin K. Silverman, Barry J. Make, R. Chad Wade, J. Michael Wells, Michael H. Cho and Brian D. Hobbs

LncRNA PCGEM1 induces proliferation and migration in non-small cell lung cancer cells through modulating the miR-590-3p/SOX11 axis

Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers. As reported, long non-coding RNAs (lncRNAs) induce various biological behaviors in cancers. LncRNA PCGEM1 prostate-specific transcript (...

Authors: Huanshun Wen, Hongxiang Feng, Qianli Ma and Chaoyang Liang

Longitudinal trajectories of pneumonia lesions and lymphocyte counts associated with disease severity among convalescent COVID-19 patients: a group-based multi-trajectory analysis

To explore the long-term trajectories considering pneumonia volumes and lymphocyte counts with individual data in COVID-19.

Authors: Nannan Shi, Chao Huang, Qi Zhang, Chunzi Shi, Fengjun Liu, Fengxiang Song, Qinguo Hou, Jie Shen, Fei Shan, Xiaoming Su, Cheng Liu, Zhiyong Zhang, Lei Shi and Yuxin Shi

The need for race-specific reference equations for pulmonary diffusing capacity for nitric oxide

Few reference equations exist for healthy adults of various races for pulmonary diffusing capacity for nitric oxide (DLNO). The purpose of this study was to collect pilot data to demonstrate that race-specific...

Authors: Gerald Stanley Zavorsky, Ahmad Saleh Almamary, Mobarak Khalid Alqahtani, Shi Huh Samuel Shan and Douglas Shawn Gardenhire

Association between dual use of e-cigarette and cigarette and chronic obstructive pulmonary disease: an analysis of a nationwide representative sample from 2013 to 2018

The association between the dual use of electronic cigarette (e-cigarette) and conventional cigarettes (c-cigarette) and spirometry-defined chronic obstructive pulmonary disease (COPD) has not been studied tho...

Authors: Taeyun Kim and Jihun Kang

Massive haemorrhagic complications of ruptured pulmonary arteriovenous malformations: outcomes from a 12 years’ retrospective study

The life-threatening haemorrhagic complications of pulmonary arteriovenous malformations (PAVMs) are extremely rare, and only described in isolated cases. This study was designed to comprehensively investigate...

Authors: Xu Ma, Bing Jie, Dong Yu, Ling-Ling Li and Sen Jiang

A novel ferroptosis-related genes model for prognosis prediction of lung adenocarcinoma

Ferroptosis is a newly discovered form of cell death characterized by iron-dependent lipid peroxidation. This study aims to investigate the potential correlation between ferroptosis and the prognosis of lung a...

Authors: Fei Li, Dongcen Ge and Shu-lan Sun

Role of respiratory intermediate care units during the SARS-CoV-2 pandemic

The SARS-CoV2 pandemic increased exponentially the need for both Intensive (ICU) and Intermediate Care Units (RICU). The latter are of particular importance because they can play a dual role in critical and po...

Authors: Mónica Matute-Villacís, Jorge Moisés, Cristina Embid, Judith Armas, Isabel Fernández, Montserrat Medina, Miquel Ferrer, Oriol Sibila and Joan Ramón Badia

Internet search results correlate with seasonal variation of sarcoidosis

The etiology and pathophysiology of sarcoidosis remains unclear, with epidemiologic studies limited by its relatively low prevalence. The internet has prompted patients to seek information about medical diagno...

Authors: Amanda Stanton and Steven J. Katz

An update of the long-term outcome of patients with nonspecific pleurisy at medical thoracoscopy

Medical thoracoscopy (MT) is recommended in patients with undiagnosed exudative pleural effusion and offers a degree of diagnostic sensitivity for pleural malignancy. However, not all patients who undergo MT r...

Authors: Yan-Xia Yu, Yuan Yang, Yan-Bing Wu, Xiao-Juan Wang, Li-Li Xu, Zhen Wang, Feng Wang, Zhao-Hui Tong and Huan-Zhong Shi

Rheological effects of hypertonic saline and sodium bicarbonate solutions on cystic fibrosis sputum in vitro

Cystic fibrosis (CF) is a life-threatening multiorgan genetic disease, particularly affecting the lungs, where recurrent infections are the main cause of reduced life expectancy. In CF, mutations in the gene e...

Authors: Mária Budai-Szűcs, Szilvia Berkó, Anita Kovács, Pongsiri Jaikumpun, Rita Ambrus, Adrien Halász, Piroska Szabó-Révész, Erzsébet Csányi and Ákos Zsembery

Contrast-enhanced ultrasound guided pleural biopsy improves diagnostic confidence for pleural based lesions: a 3-year prospective study

To evaluate the accuracy and safety of contrast-enhanced ultrasound (CEUS) guided biopsy in the diagnosis of radiologically determined pleural based lesions.

Authors: Wenwen Sun, Yiming Zhou, Cong Yang, Zhengwei Dong, ZheMin Zhang, Yin Wang and Lin Fan

A rare case of ciliated muconodular papillary tumor accompanied with adenocarcinoma in situ

Ciliated muconodular papillary tumor (CMPT) is an incredibly rare pulmonary tumor. Currently, little is known about CMPT, and it has not yet been classified by the World Health Organization. The clinical manif...

Authors: Lei Zhao, Conner M. Willson, Nathan T. Givens, Ziwen Zhu, Mark R. Wakefield, Yongsheng Wang, Wanchun Yang and Yujiang Fang

Cerebral arterial air embolism after endobronchial electrocautery: a case report and review of the literature

Endobronchial electrocautery is a common and safe therapeutic endoscopic treatment for malignant airway obstruction. Cerebral arterial air embolism (CAAE) is a rare but potentially fatal complication of endobr...

Authors: Yu-Ping He, Yuan-Ling Liu, Xing-Lin Gao and Li-Hua Wang

Switching antifibrotics in patients with idiopathic pulmonary fibrosis: a multi-center retrospective cohort study

Currently, there are two antifibrotics used to treat idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. Antifibrotics slow disease progression by reducing the annual decline of forced vital capac...

Authors: Yuzo Suzuki, Kazutaka Mori, Yuya Aono, Masato Kono, Hirotsugu Hasegawa, Koshi Yokomura, Hyogo Naoi, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Hidenori Nakamura and Takafumi Suda

Multidisciplinary management of difficult-to-treat drug resistant tuberculosis: a review of cases presented to the national consilium in Uganda

Patients with drug resistant tuberculosis (DR-TB) with comorbidities and drug toxicities are difficult to treat. Guidelines recommend such patients to be managed in consultation with a multidisciplinary team o...

Authors: Joseph Baruch Baluku, Richard Katuramu, Joshua Naloka, Enock Kizito, Martin Nabwana and Felix Bongomin

IL-6 expression helps distinguish Castleman’s disease from IgG4-related disease in the lung

It is difficult to distinguish between multicentric Castleman’s disease (MCD) and IgG4-related lung disease (IgG4-LD), an IgG4-related disease (IgG4-RD) in the lung.

Authors: Yasuhiro Kinugawa, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Shota Kobayashi, Tomoyuki Nakajima, Masamichi Komatsu, Masanori Yasuo, Hiroshi Yamamoto and Hiroyoshi Ota

Efficacy of early antifibrotic treatment for idiopathic pulmonary fibrosis

Although antifibrotic drugs, including nintedanib and pirfenidone, slow the progression of idiopathic pulmonary fibrosis (IPF), there is little data about the timing of start of antifibrotic treatment in real-...

Authors: Keishi Sugino, Hirotaka Ono, Natsumi Watanabe, Masahiro Ando, Eiyasu Tsuboi, Sakae Homma and Kazuma Kishi

Application of bedside ultrasound in predicting the outcome of weaning from mechanical ventilation in elderly patients

With the increased ageing of society, more and more elderly people are admitted to the intensive care unit, How to accurately predict whether elderly patients can successfully wean from the ventilator is more ...

Authors: Shigang Li, Zhe Chen and Weifeng Yan

Classification of COPD patients and compliance to recommended treatment in Greece according to GOLD 2017 report: the RELICO study

Chronic obstructive pulmonary disease (COPD) is a multifactorial clinical condition, characterized by chronic progressive (or worsening) respiratory symptoms, structural pulmonary abnormalities, and impaired l...

Authors: Nikolaos Tzanakis, Nikolaos Koulouris, Katerina Dimakou, Konstantinos Gourgoulianis, Epameinondas Kosmas, Georgia Chasapidou, Athanasios Konstantinidis, Christos Kyriakopoulos, Theodoros Kontakiotis, Aggeliki Rapti, Mina Gaga, Konstantinos Kalafatakis and Konstantinos Kostikas

XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis

Chronic obstructive pulmonary disease (COPD) is a disease that causes obstructed airways and abnormal inflammatory responses in the lungs. Early growth response 3 (EGR3) has been revealed to play a vital role in ...

Authors: Panfeng Chen, Ping Jiang, Jianing Chen, Yang Yang and Xiumei Guo

Risk factors for severe adult-onset asthma: a multi-factor approach

The aim was to identify risk factors for severe adult-onset asthma.

Authors: Sanna Toppila-Salmi, Riikka Lemmetyinen, Sebastien Chanoine, Jussi Karjalainen, Juha Pekkanen, Jean Bousquet and Valérie Siroux

LINC01414/LINC00824 genetic polymorphisms in association with the susceptibility of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a complicated multi-factor, multi-gene disease. Here, we aimed to assess the association of genetic polymorphisms in LINC01414/ LINC00824 and interactions with COPD...

Authors: Xiaoman Zhou, Yunjun Zhang, Yutian Zhang, Quanni Li, Mei Lin, Yixiu Yang, Yufei Xie and Yipeng Ding

Pneumonia caused by Pseudomonas fluorescens: a case report

Pseudomonas fluorescens (P. fluorescens) has been detected in respiratory samples from patients. However, no previous reports have been published about these P. fluorescens cultures from lung tissues.

Authors: Xiao Liu, Lei Xiang, Yunhong Yin, Hao Li, Dedong Ma and Yiqing Qu

Prevalence and clinical implications of bronchiectasis in patients with overlapping asthma and chronic rhinosinusitis: a single-center prospective study

As a typical “united airway” disease, asthma-chronic rhinosinusitis (CRS) overlap has recently drawn more attention. Bronchiectasis is a heterogeneous disease related to a variety of diseases. Whether bronchie...

Authors: Haiyan Sheng, Xiujuan Yao, Xiangdong Wang, Yuhong Wang, Xiaofang Liu and Luo Zhang

Male adolescents with contralateral blebs undergoing surgery for primary spontaneous pneumothorax may benefit from simultaneous contralateral blebectomies

In adults with primary spontaneous pneumothorax (PSP), contralateral recurrence occurs in about 25–28% when there are asymptomatic blebs. How to treat contralateral recurrence of PSP in pediatric populations r...

Authors: Chieh-Ni Kao, Shah-Hwa Chou, Ming-Ju Tsai, Po-Chih Chang and Yu-Wei Liu

The optimal timing of FDG-PET/CT in non-small cell lung cancer diagnosis and staging in an Australian centre

Clinical practice guidelines and re-imbursement schedules vary in the recommended timing of FDG-PET/CT in the diagnostic evaluation of suspected or confirmed lung cancer. The aim was to estimate the probabilit...

Authors: Anne Johnson, Richard Norman, Francesco Piccolo and David Manners

Dual targeting of MEK and PI3K effectively controls the proliferation of human EGFR-TKI resistant non-small cell lung carcinoma cell lines with different genetic backgrounds

Molecular targeted therapy for non-small cell lung carcinoma (NSCLC) is restricted due to resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). This study evaluated the effec...

Authors: Ge-Ping Qu, Min Shi, Dan Wang, Jiong-He Wu, Peng Wang, Mei-Liang Gong and Zhi-Jian Zhang

Concurrent pulmonary tuberculosis and lepromatous leprosy in a newly diagnosed HIV positive patient: a case report

The leprosy-tuberculosis (TB) co-infection is rarely reported in recent times. However, this dual comorbidity is associated with high mortality and major morbidity. Unrecognised leprosy-TB co-infection may pre...

Authors: Josiah T. Masuka, Zamambo Mkhize, Somasundram Pillay and Anisa Mosam

Spatial clustering and genetic diversity of Mycobacterium tuberculosis isolate among pulmonary tuberculosis suspected patients, Arsi Zone, Ethiopia

Tuberculosis remains a serious public health concern globally. The enormous social, economic, and health impacts of the diseases are attributed to the lack of updated data on the prevalence, geospatial distrib...

Authors: Ketema Tafess, Teresa Kisi Beyen, Sisay Girma, Asnakech Girma and Gilman Siu

Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns

To assess mortality rate (MR) and standardized mortality rate (SMR) of rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients and to evaluate the role of radiographic patterns in mortality.

Authors: Maria A. Nieto, Maria J. Rodriguez-Nieto, Olga Sanchez-Pernaute, Fredeswinda Romero-Bueno, Leticia Leon, Cristina Vadillo, Dalifer D. Freites-Nuñez, Juan A. Jover, Jose L. Álvarez-Sala and Lydia Abasolo

Anti-TIF1 gamma-positive IPAF patient developed stage IVB lung squamous carcinoma in 1 year: a case report

Patients with connective tissue disease, such as dermatomyositis (DM), and positive anti-TIF1γ self-antibodies are commonly diagnosed with malignant tumors as a comorbidity. The relationship between anti-TIF1γ...

Authors: Jiao-jiao Xie, Bin Li, Rui Xu, Xian-zhi Du and Jin-zhi He

Sequential non-invasive following short-term invasive mechanical ventilation in the treatment of tuberculosis with respiratory failure: a randomized controlled study

Invasive and non-invasive mechanical ventilation (MV) have been combined as sequential MV in the treatment of respiratory failure. However, the effectiveness remains unclear. Here, we performed a randomized co...

Authors: Nai-Min Kang, Nan Zhang, Bao-Jian Luo, En-Dong Wu, Jian-Quan Shi, Liang Li and Li Jiang

Mechanical power normalized to lung-thorax compliance predicts prolonged ventilation weaning failure: a prospective study

Mechanical power (MP) of artificial ventilation, the energy transferred to the respiratory system, is a chief determinant of adequate oxygenation and decarboxylation. Calculated MP, the product of applied airw...

Authors: Alessandro Ghiani, Joanna Paderewska, Swenja Walcher and Claus Neurohr

Evaluation of blood and tooth element status in asthma cases: a preliminary case–control study

Asthma is a common respiratory disorder; some data were present on the correlation between increased levels of some elements and the risk of asthma development. It was aimed to evaluate the levels of 13 select...

Authors: S. Songül Yalçın, Nagehan Emiralioğlu and Suzan Yalçın

Long non-coding RNA CDKN2B-AS1 enhances LPS-induced apoptotic and inflammatory damages in human lung epithelial cells via regulating the miR-140-5p/TGFBR2/Smad3 signal network

Sepsis is a complicated disease with systemic inflammation or organ dysfunction, and it is the leading cause of acute lung injury (ALI). Long non-coding RNAs (lncRNAs) have played important roles in the pathog...

Authors: Bing Wang, Qi Sun, Wen Ye, Lianghai Li and Ping Jin

GPC3 affects the prognosis of lung adenocarcinoma and lung squamous cell carcinoma

Glypican 3 (GPC3) is a heparin sulphate proteoglycan whose expression is associated with several malignancies. However, its expression in non-small-cell lung carcinoma (NSCLC) is limited and ambiguous. This st...

Authors: Jing Ning, Shenyi Jiang, Xiaoxi Li, Yang Wang, Xuhong Deng, Zhiqiang Zhang, Lijie He, Daqing Wang and Youhong Jiang

Guidelines on analgosedation, monitoring, and recovery time for flexible bronchoscopy: a systematic review

Patients undergoing bronchoscopy in spontaneous breathing are prone to hypoxaemia and hypercapnia. Sedation, airway obstruction, and lung diseases impair respiration and gas exchange. The restitution of normal...

Authors: Daniel Strohleit, Thomas Galetin, Nils Kosse, Alberto Lopez-Pastorini and Erich Stoelben

NAPG mutation in family members with hereditary hemorrhagic telangiectasia in China

Hereditary hemorrhagic telangiectasia (HHT) is a disease characterized by arteriovenous malformations in the skin and mucous membranes. We enrolled a large pedigree comprising 32 living members, and screened f...

Authors: Yu Xu, Yong-Biao Zhang, Li-Jun Liang, Jia-Li Tian, Jin-Ming Lin, Pan-Pan Wang, Rong-Hui Li, Ming-Liang Gu and Zhan-Cheng Gao

Should Aspergillus screening before bronchial thermoplasty?

Authors: Shinji Sasada

Correction to: Efects of high-flow oxygen therapy on patients with hypoxemia after extubation and predictors of reintubation: a retrospective study based on the MIMIC-IV database

An amendment to this paper has been published and can be accessed via the original article.

Authors: Taotao Liu, Qinyu Zhao and Bin Du