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  1. Taking into consideration a recent surge of a lung injury condition associated with electronic cigarette use, we devised an in vitro model of sub-chronic exposure of human bronchial epithelial cells (HBECs) in...

    Authors: Baishakhi Ghosh, Hermes Reyes-Caballero, Sevcan Gül Akgün-Ölmez, Kristine Nishida, Lakshmana Chandrala, Lena Smirnova, Shyam Biswal and Venkataramana K. Sidhaye

    Citation: BMC Pulmonary Medicine 2020 20:216

    Content type: Research article

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  2. Tumor necrosis factor-α (TNF-α) has been reported to play a part in the development of obstructive sleep apnea (OSA) and its complications. However, the relationship between TNF-α and OSA still remains inconcl...

    Authors: Yuan Cao, Yali Song, Pu Ning, Liyu Zhang, Shuang Wu, Juan Quan and Qiao Li

    Citation: BMC Pulmonary Medicine 2020 20:215

    Content type: Review

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  3. The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (...

    Authors: Hiroaki Nakagawa, Ryota Otoshi, Kohsuke Isomoto, Takuma Katano, Tomohisa Baba, Shigeru Komatsu, Eri Hagiwara, Yasutaka Nakano, Ichiro Kuwahira and Takashi Ogura

    Citation: BMC Pulmonary Medicine 2020 20:214

    Content type: Research article

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  4. Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors all over the world. In recent years, long non-coding RNAs (lncRNAs) have been proven to participate in the development of different...

    Authors: Lei Weng, Kejie Qiu, Weijing Gao, Chunbo Shi and Fen Shu

    Citation: BMC Pulmonary Medicine 2020 20:213

    Content type: Research article

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  5. Contradictory results regarding changes in serum club cell protein 16 (CC16) levels in patients with acute respiratory distress syndrome (ARDS) have been reported, challenging the value of CC16 as a diagnostic...

    Authors: Jinle Lin, Wuyuan Tao, Jian Wei, Jian Wu, Wenwu Zhang, Jianbing Ye, Xuan Fu, Shiyong Zeng, Qingli Dou, Lijun Wang and Fang Tian

    Citation: BMC Pulmonary Medicine 2020 20:212

    Content type: Research article

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  6. Benralizumab, an anti-interleukin-5 (IL-5) receptor α monoclonal antibody, significantly reduces the number of annual exacerbations and oral corticosteroid (OCS) maintenance doses for patients with severe eosi...

    Authors: Takanori Numata, Hanae Miyagawa, Saiko Nishioka, Keitaro Okuda, Hirofumi Utsumi, Mitsuo Hashimoto, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Jun Araya and Kazuyoshi Kuwano

    Citation: BMC Pulmonary Medicine 2020 20:207

    Content type: Research article

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  7. Acute respiratory distress syndrome (ARDS) in infants undergoing cardiac surgery is associated with significant mortality and prolonged ventilation; surfactant administration may be a useful therapy. The purpo...

    Authors: Rongyuan Zhang, Xu Wang, Shoujun Li and Jun Yan

    Citation: BMC Pulmonary Medicine 2020 20:210

    Content type: Research article

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  8. ALK-rearrangement is observed in < 5% non-small cell lung cancer (NSCLC) cases and prior to the advent of oral tyrosine kinase inhibitors, the natural history of oncogenic NSCLC was typically poor. Literature ...

    Authors: Maria Walls, Gerard M. Walls, Jacqueline A. James, Kyle T. Crawford, Hossam Abdulkhalek, Tom B. Lynch, Aaron J. Peace, Terry E. McManus and O. Rhun Evans

    Citation: BMC Pulmonary Medicine 2020 20:209

    Content type: Case report

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  9. Plasma levels of cell-free DNA (cf-DNA) are known to be elevated in sepsis and high levels are associated with a poor prognosis. Mechanical ventilation affects systemic inflammation in which lung-protective venti...

    Authors: Axel Nyberg, Alexander Larsson, Juulia Jylhävä, Mikko Hurme, Jesper Sperber, Miklós Lipcsey and Markus Castegren

    Citation: BMC Pulmonary Medicine 2020 20:206

    Content type: Research article

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  10. Common variable immunodeficiency (CVID) is a group of heterogeneous primary immunodeficiencies characterised by a dysregulated and impaired immune response. In addition to an increased susceptibility to infect...

    Authors: Jake E. Cowen, James Stevenson, Madhusudan Paravasthu, James Darroch, Anu Jacob, Salaheddin Tueger, John R. Gosney, Anneliese Simons, Lisa G. Spencer and Eoin P. Judge

    Citation: BMC Pulmonary Medicine 2020 20:205

    Content type: Case report

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  11. Adiponectin is a biomarker closely related to heart failure. However, its role in pulmonary hypertension remains unclear. In this study, we investigated the association between adiponectin and hemodynamic abno...

    Authors: Dongling Luo, Pengyuan Chen, Ziyang Yang, Yongheng Fu, Yigao Huang, Hezhi Li, Jimei Chen, Jian Zhuang and Caojin Zhang

    Citation: BMC Pulmonary Medicine 2020 20:204

    Content type: Research article

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  12. COVID-19 is an infectious disease caused by a novel coronavirus (SARS-CoV-2). The immunopathogenesis of the infection is currently unknown. Healthcare workers (HCWs) are at highest risk of infection and disease.

    Authors: Giovanni Sotgiu, Alessandra Barassi, Monica Miozzo, Laura Saderi, Andrea Piana, Nicola Orfeo, Claudio Colosio, Giovanni Felisati, Matteo Davì, Alberto Giovanni Gerli and Stefano Centanni

    Citation: BMC Pulmonary Medicine 2020 20:203

    Content type: Research article

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  13. The clinical landscape of pulmonary arterial hypertension (PAH) has evolved in terms of disease definition and classification, trial designs, available therapies and treatment strategies as well as clinical gu...

    Authors: Max Schlueter, Amélie Beaudet, Evan Davies, Binu Gurung and Andreas Karabis

    Citation: BMC Pulmonary Medicine 2020 20:202

    Content type: Research article

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  14. To investigate the use of do-not-resuscitate (DNR) orders in patients hospitalized with community-acquired pneumonia (CAP) and the association with mortality.

    Authors: Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Pelle Trier Petersen, Stine Bang Andersen, Bjarne Ørskov Lindhardt, Gernot Rohde, Pernille Ravn and Christian von Plessen

    Citation: BMC Pulmonary Medicine 2020 20:201

    Content type: Research article

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  15. Blood eosinophil counts (BEC) were recently included in the 2019 Global Initiative for Obstructive Lung Disease (GOLD) guideline as an easily accessible theragnostic biomarker for Chronic Obstructive Pulmonary...

    Authors: Inès Van Rossem, Jan Vandevoorde, Shane Hanon, Sander Deridder and Eef Vanderhelst

    Citation: BMC Pulmonary Medicine 2020 20:200

    Content type: Research article

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  16. Prednisone has been shown to reverse lung function declines in hypersensitivity pneumonitis patients without established fibrosis. Second line immunosuppressants like azathioprine and mycophenolate mofetil hav...

    Authors: Sungryong Noh, Ruchi Yadav, Manshi Li, Xiaofeng Wang, Debasis Sahoo, Daniel A. Culver and Aman Pande

    Citation: BMC Pulmonary Medicine 2020 20:199

    Content type: Research article

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  17. Tracheal bifurcation resection remains the greatest challenge in airway reconstruction, especially with extensive lesions. Additionally, lung cancer and pulmonary tuberculosis comorbidity complicate the chemor...

    Authors: Dmitry Giller, Boris Giller, Galina Scherbakova, Elizaveta V. Mikhaylenko, Liudmila M. Mikhaleva, Vladimir N. Nikolenko, Liliya V. Gavryushova, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev

    Citation: BMC Pulmonary Medicine 2020 20:197

    Content type: Case report

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  18. Dermatomyositis (DM) is a systemic autoimmune inflammatory disorder that affects primarily skin, muscle and lung, frequently associated with interstitial lung disease (ILD). The objective of this study is to i...

    Authors: Yueyan Lou, Yu Zheng, Bijun Fan, Liyan Zhang, Feng Zhu, Xiaodong Wang, Zhiwei Chen, Xiaoming Tan and Qing Wei

    Citation: BMC Pulmonary Medicine 2020 20:196

    Content type: Research article

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  19. Paraquat (PQ) is an herbicide widely used in the world. PQ can cause pulmonary toxicity and even acute lung injury. Treatment for PQ poisoning in a timely manner is still a challenge for clinicians. Mesenchymal s...

    Authors: Lichun Zhang, Yu Wang, Haitao Shen and Min Zhao

    Citation: BMC Pulmonary Medicine 2020 20:195

    Content type: Research article

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  20. Advanced lung disease in adult cystic fibrosis (CF) drives most clinical care requirements. The aim was to evaluate outcome (time to death while in the study) in a cohort of adult CF patients with severe lung ...

    Authors: Guilherme Figueiredo Silva, Nicholas J. Simmonds and Paulo de Tarso Roth Dalcin

    Citation: BMC Pulmonary Medicine 2020 20:194

    Content type: Research article

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  21. Chronic obstructive pulmonary disease (COPD) is a common lung disorder characterized by persistent and progressive airflow limitation as well as systemic changes. Metabolic changes in blood may help detect COP...

    Authors: Ivana Prokić, Lies Lahousse, Maaike de Vries, Jun Liu, Marita Kalaoja, Judith M. Vonk, Diana A. van der Plaat, Cleo C. van Diemen, Ashley van der Spek, Alexandra Zhernakova, Jingyuan Fu, Mohsen Ghanbari, Mika Ala-Korpela, Johannes Kettunen, Aki S. Havulinna, Markus Perola…

    Citation: BMC Pulmonary Medicine 2020 20:193

    Content type: Research article

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  22. Bronchiolar adenoma(BA) is a recently recognized, rare tumor of the bronchioles. It can be divided into proximal and distal types according to the proportion of mucinous and ciliated cells on the luminal surfa...

    Authors: Yajing Sun, Min Liu, Zhongmin Jiang and Baojiang Li

    Citation: BMC Pulmonary Medicine 2020 20:192

    Content type: Case report

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  23. In patients with idiopathic pulmonary fibrosis (IPF) treated with pirfenidone (Esbriet®, Genentech USA, Inc. South San Francisco, CA.), effectively managing treatment-related adverse events (AEs) may improve a...

    Authors: Franck F. Rahaghi, Zeenat Safdar, Anne Whitney Brown, Joao A. de Andrade, Kevin R. Flaherty, Robert J. Kaner, Christopher S. King, Maria L. Padilla, Imre Noth, Mary Beth Scholand, Adrian Shifren and Steven D. Nathan

    Citation: BMC Pulmonary Medicine 2020 20:191

    Content type: Research article

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  24. Asthma is one of the leading causes of disease burden when measured in terms of disability adjusted life years, despite low prevalence of self-reported cases among young women. This paper deals with the meso-s...

    Authors: Shri Kant Singh, Jitendra Gupta, Himani Sharma, Sarang P. Pedgaonkar and Nidhi Gupta

    Citation: BMC Pulmonary Medicine 2020 20:190

    Content type: Research article

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  25. Pirfenidone and nintedanib are antifibrotic therapies which slow disease progression in idiopathic pulmonary fibrosis (IPF), an irreversible, progressive lung disease with poor prognosis. We compared adherence...

    Authors: Mitra Corral, Kathryn DeYoung and Amanda M. Kong

    Citation: BMC Pulmonary Medicine 2020 20:188

    Content type: Research article

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  26. Conventional CTCS images the mid/lower chest for coronary artery disease (CAD). Because many CAD patients are also at risk for lung malignancy, CTCS often discovers incidental pulmonary nodules (IPN). CTCS exc...

    Authors: Boxiang Jiang, Philip A. Linden, Amit Gupta, Craig Jarrett, Stephanie G. Worrell, Vanessa P. Ho, Yaron Perry and Christopher W. Towe

    Citation: BMC Pulmonary Medicine 2020 20:187

    Content type: Research article

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  27. Pulmonary veno-occlusive disease (PVOD) and pulmonary arterial hypertension (PAH) share an overlapping disease phenotype. Hence it is necessary to distinguish them.

    Authors: Xiaofang Zeng, Fan Chen, Anandharajan Rathinasabapathy, Tangzhiming Li, Agila Adnan Ali Mohammed Mohammed and Zaixin Yu

    Citation: BMC Pulmonary Medicine 2020 20:186

    Content type: Case report

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  28. Long noncoding RNA POU class 3 homeobox 3 (POU3F3) is upregulated in esophageal squamous-cell carcinomas. The present study aimed to investigate the role of POU3F3 in non-small cell lung cancer (NSCLC).

    Authors: Qigang Zeng, Yong Dai, Chenxia Duan, Rong Zeng, Qingxiang Zeng and Chengong Wei

    Citation: BMC Pulmonary Medicine 2020 20:185

    Content type: Research article

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  29. Benralizumab is a monoclonal antibody that binds to the human interleukin-5 (IL-5) receptor (IL-5R), thereby preventing IL-5 from binding to its receptor and inhibiting differentiation and maturation of eosino...

    Authors: A. Padilla-Galo, RCh Levy-Abitbol, C. Olveira, B. Valencia Azcona, M. Pérez Morales, F. Rivas-Ruiz, B. Tortajada-Goitia, I. Moya-Carmona and A. Levy-Naon

    Citation: BMC Pulmonary Medicine 2020 20:184

    Content type: Research article

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  30. Identification of pathologic features is helpful for the management of nonresolving acute respiratory distress syndrome (ARDS). Transbronchial lung cryobiopsy (TBLC) is a novel biopsy technique that may have c...

    Authors: Guowu Zhou, Yingying Feng, Shiyao Wang, Yi Zhang, Ye Tian, Xiaojing Wu, Ling Zhao, Dan Wang, Ying Li, Zheng Tian and Qingyuan Zhan

    Citation: BMC Pulmonary Medicine 2020 20:183

    Content type: Research article

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  31. In recent years, many studies have discovered that cystatin C (Cys C) may play an important role in respiratory diseases, especially in chronic obstructive pulmonary disease (COPD). However, the findings of th...

    Authors: Limin Chai, Wei Feng, Cui Zhai, Wenhua Shi, Jian Wang, Xin Yan, Qingting Wang, Qianqian Zhang and Manxiang Li

    Citation: BMC Pulmonary Medicine 2020 20:182

    Content type: Research article

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  32. This retrospective study aimed to investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism (PAPE).

    Authors: Chuan Liu, Hui-lu Zhan, Zhang-Heng Huang, Chuan Hu, Yue-Xin Tong, Zhi-Yi Fan, Meng-Ying Zheng, Cheng-Liang Zhao and Gui-Yun Ma

    Citation: BMC Pulmonary Medicine 2020 20:180

    Content type: Research article

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  33. A surfactant protein-A-derived peptide, which we call SPA4 peptide (amino acids: GDFRYSDGTPVNYTNWYRGE), alleviates lung infection and inflammation. This study investigated the effects of intratracheally admini...

    Authors: Shanjana Awasthi, Negar Rahman, Bin Rui, Gaurav Kumar, Vibhudutta Awasthi, Melanie Breshears and Stanley Kosanke

    Citation: BMC Pulmonary Medicine 2020 20:179

    Content type: Research article

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  34. Accurately diagnosing pleural effusion is a frequent and significant problem in clinical practice. Combining pleural biomarkers with patients’ age may be a valuable method for diagnosing TPE. We sought to eval...

    Authors: Chun-Guo Jiang, Wen Wang, Qiong Zhou, Xiu-Zhi Wu, Xiao-Juan Wang, Zhen Wang, Kan Zhai and Huan-Zhong Shi

    Citation: BMC Pulmonary Medicine 2020 20:178

    Content type: Research article

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  35. The six-minute walking test (6MWT) is a tool that plays a key role in evaluating the functional exercise capacity, prognosis and evaluation of treatment response of patients with various cardiopulmonary diseas...

    Authors: He Zou, Jia Zhang, Yingying Zou, Xiaoshu Chen, Yi Wang, Hao Chen, Fanhao Ye and Haizhu Yu

    Citation: BMC Pulmonary Medicine 2020 20:177

    Content type: Research article

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  36. The cluster randomized controlled trial on (cost-)effectiveness of integrated chronic obstructive pulmonary disease (COPD) management in primary care (RECODE) showed that integrated disease management (IDM) in...

    Authors: Eline Meijer, Annelies E. van Eeden, Annemarije L. Kruis, Melinde R. S. Boland, Willem J. J. Assendelft, Apostolos Tsiachristas, Maureen P. M. H. Rutten-van Mölken, Marise J. Kasteleyn and Niels H. Chavannes

    Citation: BMC Pulmonary Medicine 2020 20:176

    Content type: Research article

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  37. Tumor necrosis factor (TNF) has been investigated to be correlated with the occurrence and progression of lung cancer. This investigation was to assess the efficacy and safety of recombinant mutant human tumor...

    Authors: Tian Fu, Yong Lin, Qingdi Zeng, Wei Yao and Liping Han

    Citation: BMC Pulmonary Medicine 2020 20:175

    Content type: Research article

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  38. Beginning at a young age, children with cystic fibrosis (CF) embark on demanding care regimens that pose challenges to parents. We examined the extent to which clinical, demographic and psychosocial features i...

    Authors: Rhonda D. Szczesniak, Teresa Pestian, Leo L. Duan, Dan Li, Sophia Stamper, Brycen Ferrara, Elizabeth Kramer, John P. Clancy and Daniel Grossoehme

    Citation: BMC Pulmonary Medicine 2020 20:174

    Content type: Research article

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  39. The prevalence of non-cystic fibrosis (CF) bronchiectasis is increasing in both developed and developing countries in recent years. Although the main features remain similar, etiologies seem to change. Our aim...

    Authors: Ela Erdem Eralp, Yasemin Gokdemir, Emine Atag, Nilay Bas Ikizoglu, Pinar Ergenekon, Cansu Yilmaz Yegit, Arif Kut, Refika Ersu, Fazilet Karakoc and Bulent Karadag

    Citation: BMC Pulmonary Medicine 2020 20:172

    Content type: Research article

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  40. Low lung function has been associated with increased body mass index (BMI). The aim of this study was to investigate whether the effect of BMI on lung function is mediated by DNA methylation.

    Authors: André F. S. Amaral, Medea Imboden, Matthias Wielscher, Faisal I. Rezwan, Cosetta Minelli, Judith Garcia-Aymerich, Gabriela P. Peralta, Juha Auvinen, Ayoung Jeong, Emmanuel Schaffner, Anna Beckmeyer-Borowko, John W. Holloway, Marjo-Riitta Jarvelin, Nicole M. Probst-Hensch and Deborah L. Jarvis

    Citation: BMC Pulmonary Medicine 2020 20:171

    Content type: Research article

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  41. COPD is a well-known risk factor for lung cancer, independent of smoking behavior. By investigating the retrospective National Health Insurance Service-National Sample Cohort (NHIS-NSC) in Korea, this study at...

    Authors: Song Vogue Ahn, Eunyoung Lee, Bumhee Park, Jin Hee Jung, Ji Eun Park, Seung Soo Sheen, Kwang Joo Park, Sung Chul Hwang, Jae Bum Park, Hae-Sim Park and Joo Hun Park

    Citation: BMC Pulmonary Medicine 2020 20:170

    Content type: Research article

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  42. Norwegian guideline recommendations on first-line empirical antibiotic prescribing in hospitalised patients with community-acquired pneumonia (CAP) are penicillin G/V in monotherapy, or penicillin G in combina...

    Authors: June Utnes Høgli, Beate Hennie Garcia, Kristian Svendsen, Vegard Skogen and Lars Småbrekke

    Citation: BMC Pulmonary Medicine 2020 20:169

    Content type: Research article

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  43. Asthma patients experience impairments in health-related quality of life (HRQL). Interventions are available to improve HRQL. EQ-5D-5L is a common generic tool used to evaluate health interventions. However, t...

    Authors: Boglárka L. Szentes, Konrad Schultz, Dennis Nowak, Michael Schuler and Larissa Schwarzkopf

    Citation: BMC Pulmonary Medicine 2020 20:168

    Content type: Research article

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  44. Forced expiratory volume in 1 second (FEV1) is the only parameter currently recognized as a surrogate endpoint in cystic fibrosis (CF) trials. However, FEV1 is relatively insensitive to changes in the small airwa...

    Authors: Sivagurunathan Sutharsan, Susanne Naehrig, Uwe Mellies, Christian Sieder and Jörg Ziegler

    Citation: BMC Pulmonary Medicine 2020 20:167

    Content type: Research article

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