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  1. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) is one of the major public health problems worldwide. Despite an increasing burden of COPD in the world, it is often a neglected disease in low income countries and...

    Authors: Gashaw Garedew Woldeamanuel, Alemu Basazin Mingude and Teshome Gensa Geta

    Citation: BMC Pulmonary Medicine 2019 19:181

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  2. Content type: Research article

    E-cigarette use prevalence has grown rapidly in the US. Despite the popularity of these products, few acute exposure toxicity studies exist, and studies on long-term pulmonary health effects are limited. E-cig...

    Authors: Albert D. Osei, Mohammadhassan Mirbolouk, Olusola A. Orimoloye, Omar Dzaye, S. M. Iftekhar Uddin, Zeina A. Dardari, Andrew P. DeFilippis, Aruni Bhatnagar and Michael J. Blaha

    Citation: BMC Pulmonary Medicine 2019 19:180

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  3. Content type: Research article

    Most international guidelines recommend empirical therapy for community-acquired pneumonia (CAP) to be based on site of care. Some patients with severe CAP are managed in general wards because of limited inten...

    Authors: Phunsup Wongsurakiat and Napat Chitwarakorn

    Citation: BMC Pulmonary Medicine 2019 19:179

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  4. Content type: Case report

    Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder that is associated with oculocutaneous albinism, bleeding diathesis, granulomatous colitis, and highly penetrant pulmonary fibrosis in some su...

    Authors: Martina Doubková, Jakub Trizuljak, Zuzana Vrzalová, Anna Hrazdirová, Ivona Blaháková, Lenka Radová, Šárka Pospíšilová and Michael Doubek

    Citation: BMC Pulmonary Medicine 2019 19:178

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  5. Content type: Research article

    In non-small cell lung cancer (NSCLC) patients, concomitant idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) are independently related to poor survival. CPFE is a condition with features of both pulmon...

    Authors: Sung Woo Moon, Moo Suk Park, Young Sam Kim, Joon Jang, Jae Ho Lee, Choon-Taek Lee, Jin-Haeng Chung, Hyo Sup Shim, Kyung Won Lee, Seung-Seob Kim, Sang Hoon Lee and Ho Il Yoon

    Citation: BMC Pulmonary Medicine 2019 19:177

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  6. Content type: Research article

    Several major randomized control studies have demonstrated that mepolizumab, an anti-IL-5 monoclonal antibody, is effective for patients with severe eosinophilic asthma who show exacerbation or require systemi...

    Authors: Takanori Numata, Katsutoshi Nakayama, Hirofumi Utsumi, Kenji Kobayashi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Jun Araya and Kazuyoshi Kuwano

    Citation: BMC Pulmonary Medicine 2019 19:176

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  7. Content type: Research article

    Asthma is an extensive public health problem and inadequate disease control is not uncommon. Individuals’ self-perceived barriers to medical treatment for the entire treatment chain (from seeking care for symp...

    Authors: Tove Hedenrud, Annika Jakobsson, Hanan El Malla and Helle Håkonsen

    Citation: BMC Pulmonary Medicine 2019 19:175

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  8. Content type: Research article

    Chronic kidney disease (CKD) is a common comorbidity of chronic obstructive pulmonary disease (COPD). Although high hemoglobin (Hb) is detrimental to CKD patients, its relationship with poor outcomes in the CO...

    Authors: Libin Xu, Yuanhan Chen, Zhen Xie, Qiang He, Shixin Chen, Wenji Wang, Guohui Liu, Yuanjiang Liao, Chen Lu, Li Hao, Jin Sun, Wei Shi and Xinling Liang

    Citation: BMC Pulmonary Medicine 2019 19:174

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  9. Content type: Research article

    Wheezes and crackles are well-known signs of lung diseases, but can also be heard in apparently healthy adults. However, their prevalence in a general population has been sparsely described. The objective of t...

    Authors: J. C. Aviles-Solis, C. Jácome, A. Davidsen, R. Einarsen, S. Vanbelle, H. Pasterkamp and H. Melbye

    Citation: BMC Pulmonary Medicine 2019 19:173

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  10. Content type: Research article

    Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian r...

    Authors: Scichilone Nicola, Antonelli Incalzi Raffaele, Blasi Francesco, Schino Pietro, Cuttitta Giuseppina, Zullo Alessandro, Ori Alessandra and Canonica Giorgio Walter

    Citation: BMC Pulmonary Medicine 2019 19:171

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  11. Content type: Research article

    Idiopathic Pulmonary Fibrosis (IPF) is an aggressive interstitial lung disease with an unpredictable course. Occupational dust exposure may contribute to IPF onset, but its impact on antifibrotic treatment and...

    Authors: Valeria Casillo, Stefania Cerri, Andrea Ciervo, Mariarita Stendardo, Lamberto Manzoli, Maria Elena Flacco, Maurizio Manno, Marialuisa Bocchino, Fabrizio Luppi and Piera Boschetto

    Citation: BMC Pulmonary Medicine 2019 19:170

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  12. Content type: Research article

    Emphysema and chronic obstructive pulmonary disease (COPD) are well known independent risk factors for lung cancer. However, the developmental mechanisms between emphysema/COPD and lung cancer remain unknown. ...

    Authors: Ken Arimura, Yasuo Sekine, Kenzo Hiroshima, Satoru Shimizu, Noriyuki Shibata, Mitsuko Kondo, Kiyoshi Takeyama and Etsuko Tagaya

    Citation: BMC Pulmonary Medicine 2019 19:169

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  13. Content type: Case report

    The diagnosis of lung typical carcinoid tumors results challenging when limited size and unfavorable sampling location is associated. It has been reported that bronchoscopy with endobronchial ultrasound (EBUS)...

    Authors: Roberto Piro, Roberto Tonelli, Sofia Taddei, Alessandro Marchioni, Giovanni Musci, Enrico Clini and Nicola Facciolongo

    Citation: BMC Pulmonary Medicine 2019 19:168

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  14. Content type: Research article

    Pulmonary hypertension (PH) is traditionally defined as a resting mean pulmonary artery pressure (mPAP) of ≥25 mmHg, while mPAP in the range of 21 to 24 mmHg is recognized as “borderline PH.” Interstitial lung...

    Authors: Kenji Nemoto, Shuji Oh-ishi, Tatsuya Akiyama, Yuki Yabuuchi, Hitomi Goto, Mizu Nonaka, Yuika Sasatani, Hiroaki Tachi, Naoki Arai, Hiroaki Ishikawa, Kentaro Hyodo, Isano Hase, Yukiko Miura, Takio Takaku, Kenji Hayashihara and Takefumi Saito

    Citation: BMC Pulmonary Medicine 2019 19:167

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  15. Content type: Case report

    Myelolipoma is a rare benign tumor composed of mature adipose and hematopoietic tissues. Most myelolipomas are found in the adrenal glands, whereas intrathoracic myelolipoma is extremely rare. In particular, b...

    Authors: Hyun Sung Chung, Kyu Min Lee, Jung Seop Eom, Insu Kim, Seyeon Park, Jihyun Ahn, Ahrong Kim, Chang Hun Lee, Geewon Lee and Min Ki Lee

    Citation: BMC Pulmonary Medicine 2019 19:151

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  16. Content type: Research article

    Recent studies have highlighted the contribution of senescent mesenchymal and epithelial cells in Idiopathic Pulmonary Fibrosis (IPF), but little is known regarding the molecular mechanisms that regulate the a...

    Authors: David M. Habiel, Miriam S. Hohmann, Milena S. Espindola, Ana Lucia Coelho, Isabelle Jones, Heather Jones, Richard Carnibella, Isaac Pinar, Freda Werdiger and Cory M. Hogaboam

    Citation: BMC Pulmonary Medicine 2019 19:165

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  17. Content type: Case report

    Burkholderia contaminans is one of the 20 closely related bacterial of the Burkholderia cepacia complex, a group of bacteria that are ubiquitous in the environment and capable of infecting people with cystic fibr...

    Authors: Daniela Savi, Serena Quattrucci, Maria Trancassini, Claudia Dalmastri, Riccardo V. De Biase, Marta Maggisano, Paolo Palange and Annamaria Bevivino

    Citation: BMC Pulmonary Medicine 2019 19:164

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  18. Content type: Research article

    To compare the microbiological culture within endotracheal aspirate specimens (ETAs) and endotracheal tube specimens (ETTs) in patients undergoing mechanical ventilation (MV) by statistical tools.

    Authors: Lijuan Shen, Fei Wang, Junfeng Shi, Weixin Xu, Tingting Jiang, Huifang Tang, Xiuwen Yu, Hao Yin, Shanyou Hu, Xiao Wu, Siu Kit Chan, Jie Sun and Qing Chang

    Citation: BMC Pulmonary Medicine 2019 19:162

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  19. Content type: Research article

    CTD-related pleural effusions are rare and challenging to diagnose. Our lung inflammation service (with expertise in rheumatology, interstitial lung disease and respiratory failure) works closely with the pleu...

    Authors: Hugh Ip, Parthipan Sivakumar, Eugene Ace McDermott, Sangita Agarwal, Boris Lams, Alex West and Liju Ahmed

    Citation: BMC Pulmonary Medicine 2019 19:161

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  20. Content type: Research article

    Diaphragmatic assessment by ultrasound (US) is a non-invasive and useful method in the clinical management of patients with Amyotrophic Lateral Sclerosis (ALS). The aim of our observational study was to evalua...

    Authors: Riccardo Fantini, Roberto Tonelli, Ivana Castaniere, Luca Tabbì, Maria Rosaria Pellegrino, Stefania Cerri, Francesco Livrieri, Francesco Giaroni, Marco Monelli, Valentina Ruggieri, Nicola Fini, Jessica Mandrioli, Enrico Clini and Alessandro Marchioni

    Citation: BMC Pulmonary Medicine 2019 19:160

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  21. Content type: Correspondence

    Lung ultrasound (LUS) is nowadays a fast-growing field of study since the technique has been widely acknowledged as a cost-effective, radiation free, and ready available alternative to standard X-ray imaging. ...

    Authors: Danilo Buonsenso, Anna Maria Musolino, Antonio Gatto, Ilaria Lazzareschi, Antonietta Curatola and Piero Valentini

    Citation: BMC Pulmonary Medicine 2019 19:159

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  22. Content type: Research article

    Severe non-allergic eosinophilic asthma (SNEA) is a rare asthma phenotype associated with severe clinical course, frequent exacerbations, and resistance to therapy, including high steroid doses. The key featur...

    Authors: Virginija Kalinauskaite-Zukauske, Andrius Januskevicius, Ieva Janulaityte, Skaidrius Miliauskas and Kestutis Malakauskas

    Citation: BMC Pulmonary Medicine 2019 19:158

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  23. Content type: Research article

    Nintedanib is an inhibitor of receptor tyrosine kinases, including vascular endothelial growth factor receptor, but its effects on pulmonary hypertension (PH) in idiopathic pulmonary fibrosis (IPF) patients wi...

    Authors: Masahiro Tahara, Keishi Oda, Kei Yamasaki, Takako Kawaguchi, Konomi Sennari, Shingo Noguchi, Noriho Sakamoto, Toshinori Kawanami, Hiroshi Mukae and Kazuhiro Yatera

    Citation: BMC Pulmonary Medicine 2019 19:157

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  24. Content type: Case report

    Nintedanib is a tyrosine kinase inhibitor that efficiently slows the progression of idiopathic pulmonary fibrosis (IPF) and has an acceptable tolerability profile. In contrast, immune checkpoint inhibitors (IC...

    Authors: Hideaki Yamakawa, Tomohiro Oba, Hiroki Ohta, Yuta Tsukahara, Gen Kida, Emiri Tsumiyama, Tomotaka Nishizawa, Rie Kawabe, Shintaro Sato, Keiichi Akasaka, Masako Amano, Kazuyoshi Kuwano and Hidekazu Matsushima

    Citation: BMC Pulmonary Medicine 2019 19:156

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  25. Content type: Research article

    Endobronchial ultrasound-guided trans-bronchial needle aspiration (EBUS-TBNA) is minimally invasive technique used for diagnosis and/or staging of benign and malignant pulmonary and non-pulmonary disease. Prev...

    Authors: Nicola Bailey, Zoe Krisnadi, Raena Kaur, Siobhain Mulrennan, Martin Phillips and Neli Slavova-Azmanova

    Citation: BMC Pulmonary Medicine 2019 19:155

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  26. Content type: Case report

    Atypical manifestations, such as elevated serum immunoglobulin-G4 (IgG4) and extra-pulmonary IgG4 positive plasmacyte infiltration, have been described in patients with eosinophilic granulomatosis with polyang...

    Authors: Li Zhou, Fen Cao, Songqing Fan, Ping Chen, Shuizi Ding, Guiqian Liu and Ruoyun Ouyang

    Citation: BMC Pulmonary Medicine 2019 19:154

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  27. Content type: Research article

    Honeycombing on high-resolution computed tomography (HRCT) is a distinguishing feature of usual interstitial pneumonia and predictive of poor outcome in interstitial lung diseases (ILDs). Although fine crackle...

    Authors: Toshikazu Fukumitsu, Yasushi Obase, Yuji Ishimatsu, Shota Nakashima, Hiroshi Ishimoto, Noriho Sakamoto, Kosei Nishitsuji, Shunpei Shiwa, Tomoya Sakai, Sueharu Miyahara, Kazuto Ashizawa, Hiroshi Mukae and Ryo Kozu

    Citation: BMC Pulmonary Medicine 2019 19:153

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  28. Content type: Research article

    The phase III REMoxTB study prospectively enrolled HIV-positive (with CD4+ count > 250 cells, not on anti-retroviral therapy) and HIV-negative patients. We investigated the incidence of adverse events and cure...

    Authors: Conor D. Tweed, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Lerato Mohapi, Michael E. Murphy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman and Stephen H. Gillespie

    Citation: BMC Pulmonary Medicine 2019 19:152

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  29. Content type: Case report

    Histoplasmosis is a mycosis caused by soil-based fungus Histoplasma capsulatum endemic in the USA, Latin America, Africa and South-East Asia. The disease is usually self-resolving, but exposure to a large inoculu...

    Authors: Krzysztof Specjalski, Karolina Kita, Krzysztof Kuziemski, Beata Tokarska, Lucyna Górska, Jolanta Szade, Alicja Siemińska, Marta Chełmińska and Ewa Jassem

    Citation: BMC Pulmonary Medicine 2019 19:150

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  30. Content type: Research article

    Lung cancer is a common comorbidity of idiopathic pulmonary fibrosis (IPF) and has poor outcomes. The incidence and clinical factors related to development of lung cancer in idiopathic pulmonary fibrosis (IPF)...

    Authors: Hongseok Yoo, Byeong-Ho Jeong, Myung Jin Chung, Kyung Soo Lee, O. Jung Kwon and Man Pyo Chung

    Citation: BMC Pulmonary Medicine 2019 19:149

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  31. Content type: Research article

    Oxygen toxicity is one potential side effect of hyperbaric oxygen therapy (HBOT). Previous small studies showed mild reductions in pulmonary functions reflecting reductions in small airway conductance after re...

    Authors: Amir Hadanny, Tal Zubari, Liat Tamir-Adler, Yair Bechor, Gregory Fishlev, Erez Lang, Nir Polak, Jacob Bergan, Mony Friedman and Shai Efrati

    Citation: BMC Pulmonary Medicine 2019 19:148

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  32. Content type: Research article

    Pneumonia is a significant public health problem globally. The early identification and management of the determinants of pneumonia demands clear evidence. But, there is a limited data on this issue in the cur...

    Authors: Sefinew Getaneh, Girma Alem, Maru Meseret, Yihun Miskir, Tilahun Tewabe, Gebeyaw Molla and Yihalem Abebe Belay

    Citation: BMC Pulmonary Medicine 2019 19:147

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  33. Content type: Research article

    Clinical studies demonstrate that ivacaftor (IVA) improves health-related quality of life (HRQoL) in patients aged ≥6 years with cystic fibrosis (CF). The real-world impact of IVA and standard of care (SOC) in...

    Authors: Scott C. Bell, Jochen G. Mainz, Gordon MacGregor, Susan Madge, Julie Macey, Moshe Fridman, Ellison D. Suthoff, Siva Narayanan and Nils Kinnman

    Citation: BMC Pulmonary Medicine 2019 19:146

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  34. Content type: Research article

    Aerosol administration is increasingly being used as a therapeutic intervention for mechanically ventilated preterm infants. However, the effects of inhalation therapy on retinopathy of prematurity (ROP) have ...

    Authors: Mei-Chin Yang, Hsiu-Feng Hsiao, Hsiu-Li Tseng, Ya-Wen Chiu and Yi-Hao Weng

    Citation: BMC Pulmonary Medicine 2019 19:145

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  35. Content type: Research article

    Asthma is a heterogeneous disease and understanding this heterogeneity will enable the realisation of precision medicine. We sought to compare the sputum and serum inflammatory profiles in moderate-to-severe a...

    Authors: Michael A. Ghebre, Pee Hwee Pang, Dhananjay Desai, Beverley Hargadon, Chris Newby, Joanne Woods, Laura Rapley, Suzanne E. Cohen, Athula Herath, Erol A. Gaillard, Richard D. May and Chris E. Brightling

    Citation: BMC Pulmonary Medicine 2019 19:144

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  36. Content type: Study protocol

    A minority of patients presenting with lower respiratory tract infection (LRTI) to their general practitioner (GP) have community-acquired pneumonia (CAP) and require antibiotic therapy. Identifying them is ch...

    Authors: Loïc Lhopitallier, Andreas Kronenberg, Jean-Yves Meuwly, Isabella Locatelli, Julie Dubois, Joachim Marti, Yolanda Mueller, Nicolas Senn, Valérie D’Acremont and Noémie Boillat-Blanco

    Citation: BMC Pulmonary Medicine 2019 19:143

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  37. Content type: Research article

    This study aims to investigate the effects of CCAAT/enhancer binding protein alpha (C/EBPα) overexpression on cell proliferation, apoptosis and surfactant protein-C(SP-C) in alveolar epithelial type II (AEC II...

    Authors: Hongyan Lu, Xiaoqing Chen, Yanmin Lu, Haitao Zhu, Wei Tang and Qiuxia Wang

    Citation: BMC Pulmonary Medicine 2019 19:142

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  38. Content type: Research article

    Epidemiologic characteristics of nontuberculous mycobacterial (NTM) disease remain largely unknown. The objective of this study was to evaluate incidence, prevalence, and mortality of NTM infection in a large ...

    Authors: Seon Cheol Park, Min Jin Kang, Chang Hoon Han, Sun Min Lee, Cheong Ju Kim, Jung Mo Lee and Young Ae Kang

    Citation: BMC Pulmonary Medicine 2019 19:140

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  39. Content type: Research article

    Caffeine therapy for apnea of prematurity reduces the incidence of bronchopulmonary dysplasia (BPD) in premature neonates. Several mechanisms, including improvement in pulmonary mechanics underly beneficial ef...

    Authors: Vikramaditya Dumpa, Lori Nielsen, Huamei Wang and Vasantha H. S. Kumar

    Citation: BMC Pulmonary Medicine 2019 19:138

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  40. Content type: Research article

    Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental...

    Authors: Weihan Xu, Ruimin Li and Yongchang Sun

    Citation: BMC Pulmonary Medicine 2019 19:137

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  41. Content type: Research article

    Chest computed tomography (CT) scans have a recognised role in investigating adults with severe asthma to exclude alternative diagnoses, but its role in children is less clear. The objective of this study was ...

    Authors: David Lo, Amit Maniyar, Sumit Gupta and Erol Gaillard

    Citation: BMC Pulmonary Medicine 2019 19:136

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  42. Content type: Research article

    Primary ciliary dyskinesia (PCD) is a rare genetic disorder. Although the genetic tests and new diagnostic algorithms have recently been recommended, clinical signs and electron microscope (EM) findings have h...

    Authors: Atsushi Inaba, Masanori Furuhata, Kozo Morimoto, Mahbubur Rahman, Osamu Takahashi, Minako Hijikata, Michael R. Knowles and Naoto Keicho

    Citation: BMC Pulmonary Medicine 2019 19:135

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  43. Content type: Research article

    To investigate the effect of asthma rehabilitation at high altitude (3100 m, HA) compared to low altitude (760 m, LA).

    Authors: Stéphanie Saxer, Simon R. Schneider, Paula Appenzeller, Patrick R. Bader, Mona Lichtblau, Michael Furian, Ulan Sheraliev, Bermet Estebesova, Berik Emilov, Talant Sooronbaev, Konrad E. Bloch and Silvia Ulrich

    Citation: BMC Pulmonary Medicine 2019 19:134

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  44. Content type: Case report

    Pulmonary capillary hemangiomatosis (PCH) is a progressive and refractory vascular disease in the lung. Pulmonary hypertension is frequently combined with PCH when capillary proliferation invades to nearby pul...

    Authors: Chang Dong Yeo, Deokjae Han, Jongmin Lee, Woo-Baek Chung, Jung Im Jung, Kyo-Young Lee, Tae-Jung Kim, Woori Jang, Myungshin Kim and Ji Young Kang

    Citation: BMC Pulmonary Medicine 2019 19:133

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  45. Content type: Research article

    Noninvasive ventilation (NIV) reduces the rate of endotracheal intubation (ETI) and overall mortality in severe acute exacerbation of COPD (AECOPD) with acute respiratory failure and is increasingly applied in...

    Authors: Alexandru T. Steriade, Shirin Johari, Nicoleta Sargarovschi, Daniela Necula, Cornelia E. Tudose, Diana Ionita, Miron A. Bogdan and Dragos Bumbacea

    Citation: BMC Pulmonary Medicine 2019 19:131

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