Articles

Waiting time and mortality rate on lung transplant candidates in Japan: a single-center retrospective cohort study

As lung transplantation (LTX) is a valuable treatment procedure for end-stage pulmonary disease, delayed referral to a transplant center should be avoided. We aimed to conduct a single-center analysis of the s...

Authors: Takashi Hirama, Miki Akiba, Tatsuaki Watanabe, Yui Watanabe, Hirotsugu Notsuda, Hisashi Oishi, Hiromichi Niikawa and Yoshinori Okada

Prognostic characterization of immune molecular subtypes in non-small cell lung cancer to immunotherapy

Non-small cell lung cancer (NSCLC) was usually associated with poor prognosis and invalid therapeutical response to immunotherapy due to biological heterogeneity. It is urgent to screen reliable biomarkers, es...

Authors: Chenlu Li, Jingjing Pan, Jing Luo and Xupeng Chen

Patient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study

There is little evidence about the factors that predict persistence/adherence in treatment-naïve patients with COPD in clinical practice. The aim of this study was to evaluate persistence and adherence levels ...

Authors: López-Pintor Elsa, Grau Justo and Lumbreras Blanca

Usefulness of procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) levels in the differential diagnosis of acute bacterial, viral, and mycoplasmal respiratory tract infections in children

There is a lack of studies comparing PCT, CRP and WBC levels in the differential diagnosis of acute bacterial, viral, and mycoplasmal respiratory tract infections. It is necessary to explore the correlation be...

Authors: Yang Li, Lanfang Min and Xin Zhang

Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model

Allergic asthma is a chronic airway inflammatory disease with a number of cytokines participating in its pathogenesis and progress. Interleukin (IL)-22, which is derived from lymphocytes, acts on epithelial ce...

Authors: Jingru Wang, Shengnan Gao, Jingyuan Zhang, Chunxiao Li, Hongwen Li and Jiangtao Lin

Bevacizumab-induced esophageal pleural fistula during maintenance therapy without radiation in lung cancer

Esophageal pleural fistula (EPF) is a rare but fatal complication associated with bevacizumab use; however, cases reports of EPF caused by bevacizumab have not been previously published.

Authors: Ting Wang, Asmitananda Thakur and Baoqing Chen

Immune infiltration landscape and immune-marker molecular typing of pulmonary fibrosis with pulmonary hypertension

Pulmonary arterial hypertension (PH) secondary to pulmonary fibrosis (PF) is one of the most common complications in PF patients, it causes severe disease and usually have a poor prognosis. Whether the combina...

Authors: Haomin Cai and Hongcheng Liu

Longitudinal serological assessment of type VI collagen turnover is related to progression in a real-world cohort of idiopathic pulmonary fibrosis

Remodeling of the extracellular matrix (ECM) is a central mechanism in the progression of idiopathic pulmonary fibrosis (IPF), and remodeling of type VI collagen has been suggested to be associated with diseas...

Authors: Henrik Jessen, Nils Hoyer, Thomas S. Prior, Peder Frederiksen, Sarah R. Rønnow, Morten A. Karsdal, Diana J. Leeming, Elisabeth Bendstrup, Jannie M. B. Sand and Saher B. Shaker

Correction to: GPC3 affects the prognosis of lung adenocarcinoma and lung squamous cell carcinoma

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Authors: Jing Ning, Shenyi Jiang, Xiaoxi Li, Yang Wang, Xuhong Deng, Zhiqiang Zhang, Lijie He, Daqing Wang and Youhong Jiang

Chlamydia pneumoniae-associated pleuropericarditis: a case report and systematic review of the literature

Chlamydia pneumoniae is a common cause of atypical community acquired pneumonia (CAP). The diagnostic approach of chlamydial infections remains a challenge. Diagnosis of delayed chlamydial-associated complication...

Authors: Konstantinos G. Kyriakoulis, Anastasios Kollias, George E. Diakos, Ioannis P. Trontzas, Eleni Fyta, Nikolaos K. Syrigos and Garyphallia Poulakou

The function role of ubiquitin proteasome pathway in the ER stress-induced AECII apoptosis during hyperoxia exposure

Bronchopulmonary dysplasia (BPD) is a major cause of mortality and morbidity in premature infants, characterized by alveolar dysplasia and pulmonary microvascular remodeling. In the present study, we have inve...

Authors: Yue Zhu, Huimin Ju, Hongyan Lu, Wei Tang, Junying Lu and Qiuxia Wang

The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea

Obstructive sleep apnoea (OSA) is one cause of pulmonary hypertension (PH) and can also emerge along with PH. The clinical diagnosis and treatment of OSA in patients with PH are still controversial. The purpos...

Authors: Lu Yan, Zhihui Zhao, Qing Zhao, Qi Jin, Yi Zhang, Xin Li, Anqi Duan, Qin Luo and Zhihong Liu

Model difference in the effect of cilostazol on the development of experimental pulmonary hypertension in rats

Preventing pulmonary vascular remodeling is a key strategy for pulmonary hypertension (PH). Causes of PH include pulmonary vasoconstriction and inflammation. This study aimed to determine whether cilostazol (C...

Authors: Toshikazu Ito, Erquan Zhang, Ayaka Omori, Jane Kabwe, Masako Kawai, Junko Maruyama, Amphone Okada, Ayumu Yokochi, Hirofumi Sawada, Yoshihide Mitani and Kazuo Maruyama

C-EBPβ mediates in cigarette/IL-17A-induced bronchial epithelial–mesenchymal transition in COPD mice

Cigarettes smoking and IL-17A contribute to chronic obstructive pulmonary disease (COPD), and have synergistical effect on bronchial epithelial cell proliferation. CCAAT/enhancer-binding protein β (C-EBPβ) cou...

Authors: Shuyuan Chu, Libing Ma, Yashan Wu, Xiaoli Zhao, Bo Xiao and Qilu Pan

Trends in incidence and mortality of tuberculosis in India over past three decades: a joinpoint and age–period–cohort analysis

Tuberculosis, as a communicable disease, is an ongoing global epidemic that accounts for high burden of global mortality and morbidity. Globally, with an estimated 10 million new cases and around 1.4 million d...

Authors: Deepak Dhamnetiya, Priyanka Patel, Ravi Prakash Jha, Neha Shri, Mayank Singh and Krittika Bhattacharyya

Antibacterial prescription and the associated factors among outpatients diagnosed with respiratory tract infections in Mbarara Municipality, Uganda

Respiratory tract infections (RTI) are the second most frequent diagnosis after Malaria amongst Outpatients in Uganda. Majority are Non pneumonia cough and flu which are self-limiting and often do not require ...

Authors: Timothy Eria Muwanguzi, Tadele Mekuriya Yadesa and Amon Ganafa Agaba

Correlation between immune-related adverse events and therapeutic effects of nivolumab in patients with malignant pleural mesothelioma

Nivolumab is used for the treatment of malignant pleural mesothelioma (MPM). However, immune-related adverse events (irAEs) occur in patients treated with nivolumab. Several studies have reported the correlati...

Authors: Hiroto Yoneda, Hiroshi Nokihara, Atsushi Mitsuhashi, Ryohiko Ozaki, Yohei Yabuki, Hirokazu Ogino, Kenji Otsuka and Yasuhiko Nishioka

Understanding socio-economic inequalities in the prevalence of asthma in India: an evidence from national sample survey 2017–18

Today, over 300 million people reside with asthma worldwide and India alone is home for 6% of children and 2% of adults suffering from this chronic disease. A common notion of disparity persists in terms of he...

Authors: Rashmi Rashmi, Pradeep Kumar, Shobhit Srivastava and T. Muhammad

Magnesium isoglycyrrhizinate inhibits airway inflammation in rats with chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a kind of chronic lung diseases with the characteristics of airway remodeling and airflow obstruction. Magnesium isoglycyrrhizinate (MgIG) is an anti-inflammator...

Authors: Ye Yang, Lei Huang, Chongchong Tian and Bingjun Qian

Interstitial lung disease is a dominant feature in patients with circulating myositis-specific antibodies

Many patients with polymyositis (PM) or dermatomyositis (DM) have circulating myositis-specific antibodies (MSAs). Interstitial lung disease (ILD) is a common manifestation of PM/DM, and it can even precede th...

Authors: Abhinav K. Misra, Nathan L. Wong, Terrance T. Healey, Edward V. Lally and Barry S. Shea

Preliminary development of a questionnaire to measure the extra-pulmonary symptoms of severe asthma

Research into the effects of asthma treatments on the extra-pulmonary symptoms of severe asthma is limited by the absence of a suitable questionnaire. The aim was to create a questionnaire suitable for interve...

Authors: Giulio de Felice, Michael E. Hyland, Joseph W. Lanario, Yuri Antonacci, Rupert C. Jones and Matthew Masoli

Solitary multicystic lesion lung cancer: two case reports and review of the literature

Lung cancer associated with cystic airspaces, especially solitary multicystic lesion lung cancer, is a rare disease (a rare imaging performance of non-small cell lung cancer). It is difficult to diagnose owing...

Authors: Xi Tang, Gang Liu, Xianglan Tan, Chengjun Liu, Jin Xiang and Yu Jiang

Modified high-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients undergoing bronchoscopy: a randomized clinical trial

Hypoxemia frequently occurs during bronchoscopy. High-flow nasal cannula (HFNC) oxygen therapy may be a feasible alternative to prevent the deterioration of gas exchange during bronchoscopy. With the convenien...

Authors: Rui Wang, Hai-Chao Li, Xu-Yan Li, Xiao Tang, Hui-Wen Chu, Xue Yuan, Zhao-Hui Tong and Bing Sun

Effect of arterial blood bicarbonate (HCO₃⁻) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea

To evaluate the effect of arterial bicarbonate (HCO₃⁻) concentration on the accuracy of STOP-Bang questionnaire (SBQ) screening for obstructive sleep apnea (OSA).

Authors: Chong Pei and Shuyu Gui

Symptoms, impacts, and suitability of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT™) questionnaire in patients with sarcoidosis-associated pulmonary hypertension (SAPH): a qualitative interview study

Sarcoidosis-associated pulmonary hypertension (SAPH) is a prevalent and serious complication of sarcoidosis. No SAPH-specific self-report instruments for assessing SAPH symptoms and their impact on patients ar...

Authors: Brooke M. Currie, Evan W. Davies, Amélie Beaudet, Larissa Stassek, Leah Kleinman and Robert P. Baughman

Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study

The inflammatory phenotypes of asthma predict the treatment response and prognosis. The phenotype distributions differ depending on the geographical region. This study aimed to assess the distribution of diffe...

Authors: Bingqing Shi, Wei Li, Hongna Dong, Mengting Xu, Yuqiu Hao and Peng Gao

Influence of the timing of bronchoscopic alveolar lavage on children with adenovirus pneumonia: a comparative study

Adenovirus pneumonia is prone to severe clinical and imaging manifestations in children. Bronchoscopic alveolar lavage (BAL) is an important adjunctive therapy for patients with severe imaging findings. The st...

Authors: Xue-hua Xu, Hui-feng Fan, Ting-Ting Shi, Di-Yuan Yang, Li Huang, Wen-hui Jiang and Gen Lu

LncRNA GAS5 participates in childhood pneumonia by inhibiting cell apoptosis and promoting SHIP-1 expression via downregulating miR-155

LncRNA GAS5 and miR-155 are reported to play opposite roles in lung inflammatory responses. Lung inflammation participates in childhood pneumonia, indicating the involvement of GAS5 and miR-155 in pneumonia. T...

Authors: Xiaoping Wang, Ping Guo, Jiahui Tian, Jie Li, Na Yan, Xin Zhao and Yue Ma

High intensity interval training versus moderate intensity continuous training for people with interstitial lung disease: protocol for a randomised controlled trial

Interstitial lung disease is a debilitating condition associated with significant dyspnoea, fatigue, and poor exercise tolerance. Pulmonary rehabilitation is an effective and key intervention in people with in...

Authors: Leona M. Dowman, Anthony K. May, Catherine J. Hill, Janet Bondarenko, Lissa Spencer, Norman R. Morris, Jennifer A. Alison, James Walsh, Nicole S. L. Goh, Tamera Corte, Ian Glaspole, Daniel C. Chambers, Christine F. McDonald and Anne E. Holland

Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects

Drug-resistant tuberculosis (DR-TB) is the barrier for global TB elimination efforts with a lower treatment success rate. Loss to follow-up (LTFU) in DR-TB is a serious problem, causes mortality and morbidity ...

Authors: Soedarsono Soedarsono, Ni Made Mertaniasih, Tutik Kusmiati, Ariani Permatasari, Ni Njoman Juliasih, Cholichul Hadi and Ilham Nur Alfian

Clinical analysis of the “small plateau” sign on the flow-volume curve followed by deep learning automated recognition

Small plateau (SP) on the flow-volume curve was found in parts of patients with suspected asthma or upper airway abnormalities, but it lacks clear scientific proof. Therefore, we aimed to characterize its clin...

Authors: Yimin Wang, Wenya Chen, Yicong Li, Changzheng Zhang, Lijuan Liang, Ruibo Huang, Jianling Liang, Yi Gao and Jinping Zheng

One-session bilateral sequential whole lung lavage (OSBSWLL) for the management of pulmonary alveolar proteinosis

Whole Lung Lavage (WLL) has been an important part in the management of Pulmonary Alveolar Proteinosis (PAP) since it improves radiologic and clinical parameters. Bilateral WLL is usually performed in two sess...

Authors: Javier Diaz-Mendoza, Eduardo Celis Valdiviezo, Niral M. Patel and Michael J. Simoff

Electrical impedance tomography in pediatric patients with COVID-19, the first reports

Electrical impedance tomography (EIT) is a noninvasive, radiation-free, bedside tool to monitor ventilation distribution in real time.

Authors: Milena S. Nascimento, Glasiele C. Alcala, Ana I. A. Guzman, Leticia C. Corrêa, Diana M. Baggio, Felipe S. Rossi, Linus P. Fascina, Marcelo B. P. Amato and Cristiane do Prado

Hospital admission trends due to respiratory diseases in England and Wales between 1999 and 2019: an ecologic study

Identifying trends of hospital admissions for respiratory diseases is crucial for public health and research to guide future clinical improvements for better outcomes. This study aims to define the trends of r...

Authors: Abdallah Y. Naser, Munthir M. Mansour, Abeer F. R. Alanazi, Omar Sabha, Hassan Alwafi, Zahraa Jalal, Vibhu Paudyal, Mohammad S. Dairi, Emad M. Salawati, Jaber S. Alqahtan, Shalan Alaamri and Moaath K. Mustafa Ali

Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial

Supplemental oxygen delivered with standard oxygen therapy (SOT) improves exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Although high-flow nasal cannula oxygen therapy (HFNC) improves...

Authors: Diana Badenes-Bonet, Pilar Cejudo, Anna Rodó-Pin, Clara Martín-Ontiyuelo, Roberto Chalela, Jose Antonio Rodríguez-Portal, Rosa Vázquez-Sánchez, Joaquim Gea, Xavier Duran, Oswaldo Antonio Caguana, Diego Agustín Rodriguez-Chiaradia and Eva Balcells

Clinical outcomes of intravenous immunoglobulin therapy in COVID-19 related acute respiratory distress syndrome: a retrospective cohort study

Intravenous immunoglobulin (IVIG) has been used as an immunomodulatory therapy to counteract severe systemic inflammation in coronavirus disease 2019 (COVID-19). But its use in COVID-19 related acute respirato...

Authors: Husain S. Ali, Moustafa S. Elshafei, Mohamed O. Saad, Hassan A. Mitwally, Mohammad Al Wraidat, Asra Aroos, Nissar Shaikh, Dore C. Ananthegowda, Mohamed A. Abdelaty, Saibu George, Abdulqadir J. Nashwan, Ahmed S. Mohamed and Mohamad Y. Khatib

Lung ultrasound for the diagnosis of cystic fibrosis pulmonary exacerbation

High-resolution computed tomography (HRCT) is the gold standard for the evaluation of cystic fibrosis (CF) lung disease; however, lung ultrasound (LUS) is being increasingly used for the assessment of lung in ...

Authors: Maryam Hassanzad, Arda Kiani, Atefeh Abedini, Hoseinali Ghaffaripour, Habib Emami, Niloufar Alizadeh, Ghazal Zoghi, Saeed Hashemi and Ali Akbar Velayati

Early signs of pneumoconiosis in a dental technician in Italy: a case report

Dental technicians are at high risk of pneumoconiosis, usually driven by inhalation of mixed dusts, including metals. An etiological diagnosis is not easy to be performed, particularly in advanced stages.

Authors: Mara Maria Tiraboschi, Emma Sala, Matteo Ferroni, Andrea Tironi, Andrea Borghesi, Maria Enrica Gilberti, Paolo Ceruti, Emanuele Sansone and Giuseppe De Palma

Disturbances in branched-chain amino acid profile and poor daily functioning in mildly depressed chronic obstructive pulmonary disease patients

Depression is one of the most common and untreated comorbidities in chronic obstructive pulmonary disease (COPD), and is associated with poor health outcomes (e.g. increased hospitalization/exacerbation rates)...

Authors: Marisa R. Pinson, Nicolaas E. P. Deutz, Rajesh Harrykissoon, Anthony J. Zachria and Mariëlle P. K. J. Engelen

Drug-induced hypersensitivity syndrome caused by minodronic acid hydrate

Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an important adverse reaction caused by a few drugs. Reactivation of human herpesvirus 6 ...

Authors: Yutaka Muto, Naoyuki Kuse, Minoru Inomata, Nobuyasu Awano, Mari Tone, Kohei Takada, Kazushi Fujimoto, Yuan Bae, Toshio Kumasaka and Takehiro Izumo

Development of a nomogram for predicting the presence of combined pulmonary fibrosis and emphysema

In the clinical management of patients with combined pulmonary fibrosis and emphysema (CPFE), early recognition and appropriate treatment is essential. This study was designed to develop an accurate prognostic...

Authors: Xueting Yuan, Jin Jin and Xiaomao Xu

High-throughput next-generation sequencing for identifying pathogens during early-stage post-lung transplantation

High-throughput next-generation sequencing (HT-NGS) has the potential to detect a large variety of pathogens; however, the application of HT-NGS in lung transplant (LTx) recipients remains limited. We aimed to...

Authors: Qiao-yan Lian, Ao Chen, Jian-heng Zhang, Wei-jie Guan, Xin Xu, Bing Wei, Dan-xia Huang, Jian-xing He and Chun-rong Ju

HB-EGF-induced IL-8 secretion from airway epithelium leads to lung fibroblast proliferation and migration

We have reported that heparin-binding epidermal growth factor (HB-EGF) is increased in patients with chronic obstructive pulmonary disease (COPD) and associated with collagen deposition, but the mechanisms rem...

Authors: Yanyu Li, Guomei Su, Yu Zhong, Zhilin Xiong, Tong Huang, Jingyun Quan, Jiewen Huang, Xiaoxia Wen, Chaole Luo, Weilin Zheng, Jinfeng Chen, Junfen Cheng, Weimin Yao and Tianwen Lai

Prognostic value of radiological findings indeterminate for UIP pattern and anterior upper lobe honeycomb-like lesion in chronic fibrosing interstitial lung disease associated with MPO-ANCA

Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) is often positive in patients with interstitial lung disease (ILD), which is also often present in patients with microscopic polyangiitis (MPA). A...

Authors: Hideaki Yamakawa, Shintaro Sato, Tomohiko Nakamura, Tomotaka Nishizawa, Rie Kawabe, Tomohiro Oba, Masanobu Horikoshi, Keiichi Akasaka, Masako Amano, Kazuyoshi Kuwano, Hiroki Sasaki and Hidekazu Matsushima

In-hospital mortality associated with community-acquired pneumonia due to methicillin-resistant Staphylococcus aureus: a matched-pair cohort study

It remains unclear whether methicillin-resistant Staphylococcus aureus (MRSA) pneumonia is associated with higher mortality compared with non-MRSA pneumonia. This study’s objective was to compare outcomes includi...

Authors: Yukiyo Sakamoto, Yasuhiro Yamauchi, Taisuke Jo, Nobuaki Michihata, Wakae Hasegawa, Hideyuki Takeshima, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga and Takahide Nagase

Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method

Spirometric reference values are well known in several ethnic groups but the normative spirometric values of blacks living in Africa have been less studied. The purpose of this study is to establish normative ...

Authors: Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Virginie Poka-Mayap, Amadou Djenabou, Massongo Massongo, Nguetsa Arsene Ofimboudem, Catherine Fanny Mayoh-Nguemfo, Antoinette Ghislaine Tsala, Halidou Hadjara and Francine Amougou

Weighted gene co-expression network analysis to identify key modules and hub genes associated with paucigranulocytic asthma

Asthma is a heterogeneous disease that can be divided into four inflammatory phenotypes: eosinophilic asthma (EA), neutrophilic asthma (NA), mixed granulocytic asthma (MGA), and paucigranulocytic asthma (PGA)....

Authors: Min Li, Wenye Zhu, Chu Wang, Yuanyuan Zheng, Shibo Sun, Yan Fang and Zhuang Luo

Repeated bronchoscopy in health and obstructive lung disease: is the airway microbiome stable?

Little is known concerning the stability of the lower airway microbiome. We have compared the microbiota identified by repeated bronchoscopy in healthy subjects and patients with ostructive lung diseaseases (O...

Authors: Rune Nielsen, Yaxin Xue, Inge Jonassen, Ingvild Haaland, Øyvind Kommedal, Harald G. Wiker, Christine Drengenes, Per S. Bakke and Tomas M. L. Eagan

Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study

The prevalence of delirium, its associated factors, and its impact on long-term mortality among survivors of acute respiratory distress syndrome (ARDS) is unclear.

Authors: Tak Kyu Oh, Hye Youn Park and In-Ae Song

Correction to: Clinical, radiological and functional outcomes in patients with SARS-CoV-2 pneumonia: a prospective observational study

Authors: Pietro Gianella, Elia Rigamonti, Marco Marando, Adriana Tamburello, Lorenzo Grazioli Gauthier, Gianluca Argentieri, Carla Puligheddu, Alberto Pagnamenta, Marco Pons and Tanja Fusi-Schmidhauser