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  1. Study protocol

    Health coaching to improve self-management and quality of life for low income patients with chronic obstructive pulmonary disease (COPD): protocol for a randomized controlled trial

    Chronic obstructive pulmonary disease (COPD) severely hinders quality of life for those affected and is costly to the health care system. Care gaps in areas such as pharmacotherapy, inhaler technique, and know...

    Beatrice Huang, Rachel Willard-Grace, Denise De Vore, Jessica Wolf, Chris Chirinos, Stephanie Tsao, Danielle Hessler, George Su and David H. Thom

    BMC Pulmonary Medicine 2017 17:90

    Published on: 9 June 2017

  2. Research article

    Evaluation of gene xpert for routine diagnosis of HIV-associated tuberculosis in Nigeria: A prospective cohort study

    Xpert MTB/Rif (Xpert) is described as a game changer in tuberculosis (TB) control. We evaluated the impact of Xpert on diagnosis, time to treatment, and treatment outcome among patients with HIV associated TB ...

    Maxwell Oluwole Akanbi, Chad Achenbach, Babafemi Taiwo, John Idoko, Agatha Ani, Yetunde Isa, Oche Agbaji, Christiana Ukoli, Patrick Akande, Mamoudou Maiga and Robert Leo Murphy

    BMC Pulmonary Medicine 2017 17:87

    Published on: 30 May 2017

  3. Case report

    Sarcoidosis as a rare cause for symmetrical giant bullous disease

    Sarcoidosis presents with typical clinic-radiological findings and shows histologically non-caseating granulomas. Pulmonary manifestations of sarcoidosis can be diverse, involving the intrathoracic lymph nodes...

    Wolfgang Jungraithmayr, Elisa Leggeri, Walter Weder and Bart Vrugt

    BMC Pulmonary Medicine 2017 17:88

    Published on: 30 May 2017

  4. Research article

    Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString technology

    ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for...

    Adriane F. Evangelista, Maicon F. Zanon, Adriana Cruvinel Carloni, Flávia E. de Paula, Mariana Andozia Morini, Maressa Ferreira-Neto, Iberê Cauduro Soares, Jose Elias Miziara, Pedro de Marchi, Cristovam Scapulatempo-Neto and Rui M. Reis

    BMC Pulmonary Medicine 2017 17:86

    Published on: 26 May 2017

  5. Research article

    Mechanical ventilation in idiopathic pulmonary fibrosis: a nationwide analysis of ventilator use, outcomes, and resource burden

    Idiopathic pulmonary fibrosis (IPF) is associated with increased risk of respiratory-related hospitalizations. Studies suggest mechanical ventilation (MV) use in IPF does not improve outcomes and guidelines re...

    Joshua J. Mooney, Karina Raimundo, Eunice Chang and Michael S. Broder

    BMC Pulmonary Medicine 2017 17:84

    Published on: 22 May 2017

  6. Research article

    Single use and conventional bronchoscopes for Broncho alveolar lavage (BAL) in research: a comparative study (NCT 02515591)

    Broncho alveolar lavage (BAL) is widely used for investigative research to study innate, cellular and humoral immune responses, and in early phase drug trials. Conventional (multiple use) flexible bronchoscope...

    Seher Raza Zaidi, Andrea M. Collins, Elena Mitsi, Jesús Reiné, Kayleigh Davies, Angela D Wright, Jessica Owugha, Richard Fitzgerald, Amitava Ganguli, Stephen B Gordon, Daniela Mulari Ferreira and Jamie Rylance

    BMC Pulmonary Medicine 2017 17:83

    Published on: 5 May 2017

  7. Research article

    Risk of incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drugs: a population-based study

    Mycobacterium tuberculosis (TB) is one of the world’s most devastating public health threats. Our goal is to evaluate whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) ...

    Chun-Wei Wu, Jiunn-Yih Wu, Meng-Tse Gabriel Lee, Chih-Cheng Lai, I-Lin Wu, Yi-Wen Tsai, Shy-Shin Chang and Chien-Chang Lee

    BMC Pulmonary Medicine 2017 17:82

    Published on: 4 May 2017

  8. Research article

    Chronic hypersensitivity pneumonitis: identification of key prognostic determinants using automated CT analysis

    Chronic hypersensitivity pneumonitis (CHP) has a variable disease course. Computer analysis of CT features was used to identify a subset of CHP patients with an outcome similar to patients with idiopathic pulm...

    Joseph Jacob, Brian J. Bartholmai, Ryoko Egashira, Anne Laure Brun, Srinivasan Rajagopalan, Ronald Karwoski, Maria Kokosi, David M. Hansell and Athol U. Wells

    BMC Pulmonary Medicine 2017 17:81

    Published on: 4 May 2017

  9. Research article

    Seasonal influenza vaccination in patients with COPD: a systematic literature review

    Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life,...

    Rafik Bekkat-Berkani, Tom Wilkinson, Philippe Buchy, Gael Dos Santos, Dimitris Stefanidis, Jeanne-Marie Devaster and Nadia Meyer

    BMC Pulmonary Medicine 2017 17:79

    Published on: 3 May 2017

  10. Research article

    Epithelial ciliated beating cells essential for ex vivo ALI culture growth

    Bronchial epithelium plays a key role in orchestrating innate and adaptive immunity. The fate of ex vivo airway epithelial cultures growing at the air liquid interface (ALI) derived from human endobronchial bi...

    Delphine Gras, Aurélie Petit, Jérémy Charriot, Lucie Knabe, Khuder Alagha, Anne Sophie Gamez, Céline Garulli, Arnaud Bourdin, Pascal Chanez, Nicolas Molinari and Isabelle Vachier

    BMC Pulmonary Medicine 2017 17:80

    Published on: 3 May 2017

  11. Research article

    Prognostic factors in hospitalized community-acquired pneumonia: a retrospective study of a prospective observational cohort

    To date, only few studies have examined the prognostic factors of community-acquired pneumonia (CAP) defined according to the latest criteria, which excludes healthcare-associated pneumonia (HCAP). Therefore, ...

    Akihiro Ito, Tadashi Ishida, Hironobu Tokumasu, Yasuyoshi Washio, Akio Yamazaki, Yuhei Ito and Hiromasa Tachibana

    BMC Pulmonary Medicine 2017 17:78

    Published on: 2 May 2017

  12. Research article

    Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care

    Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate ...

    Francisco Javier Álvarez Gutiérrez, Marta Ferrer Galván, Juan Francisco Medina Gallardo, Marta Barrera Mancera, Beatriz Romero Romero and Auxiliadora Romero Falcón

    BMC Pulmonary Medicine 2017 17:77

    Published on: 2 May 2017

  13. Research article

    Asthma control using fluticasone propionate/salmeterol in Asian and non-Asian populations: a post hoc analysis of the GOAL study

    To analyse the efficacy of fluticasone propionate (FP) alone and combined with salmeterol (SAL) in achieving guideline-defined asthma control in Asian patients.

    Jean Bousquet, Neil Barnes, Michael Gibbs, Nadeem Gul, Susan A Tomkins, Xin Zhou, Young-Joo Cho, Hae-Sim Park, William Busse and Nanshan Zhong

    BMC Pulmonary Medicine 2017 17:75

    Published on: 28 April 2017

  14. Case report

    Invasive pulmonary mucormycosis: rare presentation with pulmonary eosinophilia

    Fungi can cause a variety of infectious diseases, including invasive mycosis and non-invasive mycosis, as well as allergic diseases. The different forms of mycosis usually have been described as mutually exclu...

    Taizou Hirano, Mitsuhiro Yamada, Kei Sato, Koji Murakami, Tokiwa Tamai, Yoshiya Mitsuhashi, Tsutomu Tamada, Hisatoshi Sugiura, Naomi Sato, Ryoko Saito, Junya Tominaga, Akira Watanabe and Masakazu Ichinose

    BMC Pulmonary Medicine 2017 17:76

    Published on: 28 April 2017

  15. Research article

    Exploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension

    Chronic inflammation emerges as a feature of the pathogenesis of pulmonary arterial hypertension (PAH) in experimental models. Alterations of circulating cell subsets have been observed in patients with PAH. W...

    Lars Harbaum, Kaaja M. Baaske, Marcel Simon, Tim Oqueka, Christoph Sinning, Antonia Glatzel, Nicole Lüneburg, Karsten Sydow, Carsten Bokemeyer and Hans Klose

    BMC Pulmonary Medicine 2017 17:72

    Published on: 26 April 2017

  16. Research article

    Latin America validation of FACED score in patients with bronchiectasis: an analysis of six cohorts

    The FACED score is an easy-to-use multidimensional grading system that has demonstrated an excellent prognostic value for mortality in patients with bronchiectasis. A Spanish group developed the score but no m...

    Rodrigo Athanazio, Mônica Corso Pereira, Georgina Gramblicka, Fernando Cavalcanti-Lundgren, Mara Fernandes de Figueiredo, Francisco Arancibia, Samia Rached, David de la Rosa, Luis Máiz-Carro, Rosa Girón, Casilda Olveira, Concepción Prados and Miguel Angel Martinez-Garcia

    BMC Pulmonary Medicine 2017 17:73

    Published on: 26 April 2017

  17. Research article

    Co-colonisation with Aspergillus fumigatus and Pseudomonas aeruginosa is associated with poorer health in cystic fibrosis patients: an Irish registry analysis

    Pulmonary infection is the main cause of death in cystic fibrosis (CF). Aspergillus fumigatus (AF) and Pseudomonas aeruginosa (PA) are the most prevalent fungal and bacterial pathogens isolated from the CF airway...

    Emma Reece, Ricardo Segurado, Abaigeal Jackson, Siobhán McClean, Julie Renwick and Peter Greally

    BMC Pulmonary Medicine 2017 17:70

    Published on: 21 April 2017

  18. Research article

    Asthma–COPD overlap syndrome (ACOS) in primary care of four Latin America countries: the PUMA study

    Asthma–COPD overlap syndrome (ACOS) prevalence varies depending on the studied population and definition criteria. The prevalence and clinical characteristics of ACOS in an at-risk COPD primary care population...

    Maria Montes de Oca, Maria Victorina Lopez Varela, Maria E. Laucho-Contreras, Alejandro Casas, Eduardo Schiavi and Juan Carlos Mora

    BMC Pulmonary Medicine 2017 17:69

    Published on: 21 April 2017

  19. Research article

    Water-pipe smoke condensate increases the internalization of Mycobacterium Bovis of type II alveolar epithelial cells (A549)

    Tuberculosis (TB) is a major global health problem, and there is an association between tobacco smoke and TB. Water pipe smoking has become an increasing problem not only in Middle Eastern countries but also g...

    Esmaeil Mortaz, Shamila D. Alipoor, Masoud Movassaghi, Mohammad Varahram, Jahangir Ghorbani, Gert Folkerts, Johan Garssen and Ian M. Adcock

    BMC Pulmonary Medicine 2017 17:68

    Published on: 21 April 2017

  20. Research article

    The utility of electron microscopy in detecting asbestos fibers and particles in BALF in diffuse lung diseases

    In patients with diffuse lung diseases, differentiating occupational lung diseases from other diseases is clinically important. However, the value of assessing asbestos and particles in bronchoalveolar lavage ...

    Takashi Kido, Yasuo Morimoto, Kazuhiro Yatera, Hiroshi Ishimoto, Takaaki Ogoshi, Keishi Oda, Kei Yamasaki, Toshinori Kawanami, Shohei Shimajiri and Hiroshi Mukae

    BMC Pulmonary Medicine 2017 17:71

    Published on: 21 April 2017

  21. Research article

    Impact of lymphocyte differential count > 15% in BALF on the mortality of patients with acute exacerbation of chronic fibrosing idiopathic interstitial pneumonia

    Chronic fibrosing idiopathic interstitial pneumonia (CFIIP) has a potential risk of acute exacerbation (AE). However, the usefulness of cellular analysis of bronchoalveolar lavage fluid (BALF) has never been e...

    Reoto Takei, Machiko Arita, Shogo Kumagai, Yuhei Ito, Maki Noyama, Fumiaki Tokioka and Tadashi Ishida

    BMC Pulmonary Medicine 2017 17:67

    Published on: 20 April 2017

  22. Research article

    Efficacy of budesonide/formoterol maintenance and reliever therapy compared with higher-dose budesonide as step-up from low-dose inhaled corticosteroid treatment

    Asthma management may involve a step up in treatment when symptoms are not well controlled. We examined whether budesonide/formoterol maintenance and reliever therapy (MRT) is as effective as higher, fixed-dos...

    Christine R. Jenkins, Göran Eriksson, Eric D. Bateman, Helen K. Reddel, Malcolm R. Sears, Magnus Lindberg and Paul M. O’Byrne

    BMC Pulmonary Medicine 2017 17:65

    Published on: 20 April 2017

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