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  1. In children, chronic wet cough may be a sign of underlying lung disease, including protracted bacterial bronchitis (PBB) and bronchiectasis. Chronic (> 4 weeks in duration) wet cough (without indicators pointi...

    Authors: Pamela J. Laird, Roz Walker, Gabrielle McCallum, Maree Toombs, Melanie Barwick, Peter Morris, Robyn Aitken, Matthew Cooper, Richard Norman, Bhavini Patel, Gloria Lau, Anne B. Chang and André Schultz
    Citation: BMC Pulmonary Medicine 2022 22:492
  2. Patient-reported interstitial lung disease (ILD) questionnaires are commonly used for the evaluation of ILD patients. However, research to test their performance is scarce.

    Authors: Tal Moshe Perluk, Inbal Friedman Regev, Ophir Freund, Eyal Kleinhendler, Tzlil Hershko, Sharona Ben-Ami, Amir Bar-Shai and Avraham Unterman
    Citation: BMC Pulmonary Medicine 2022 22:489
  3. Chronic intermittent hypoxia (CIH) causes lung injury but the mechanism is unclear. Ferroptosis is a novel form of programmed cell death. In this research, we attempted to explore the role of ferroptosis in CI...

    Authors: Jia Chen, Huixin Zhu, Qin Chen, Yisong Yang, Mengxue Chen, Jiefeng Huang, Menglan Chen and Ningfang Lian
    Citation: BMC Pulmonary Medicine 2022 22:488
  4. As the detection of non-alcoholic fatty liver disease (NAFLD) is imperative for the prevention of its complications, we aimed to explore the predictive value of platelet to lymphocyte count ratio (PLR) and whi...

    Authors: Menglan Chen, Biying Wang, Jiefeng Huang, Jianming Zhao, Jia Chen and Gongping Chen
    Citation: BMC Pulmonary Medicine 2022 22:487
  5. Lung adenocarcinoma (LUAD) is a common cancer with a bad prognosis. Numerous investigations have indicated that the metabolism of fatty acids plays an important role in the occurrence, progression, and treatme...

    Authors: Guichuan Huang, Jing Zhang, Ling Gong, Xiaowen Wang, Bangyan Zhang and Daishun Liu
    Citation: BMC Pulmonary Medicine 2022 22:486
  6. Cardiopulmonary exercise testing (CPET), and its primary outcome of peak oxygen uptake (VO2peak), are acknowledged as biomarkers in the diagnostic and prognostic management of interstitial lung disease (ILD). How...

    Authors: Owen W. Tomlinson, Laura Markham, Rebecca L. Wollerton, Bridget A. Knight, Anna Duckworth, Michael A. Gibbons, Chris J. Scotton and Craig A. Williams
    Citation: BMC Pulmonary Medicine 2022 22:485
  7. Tracheostomy tube capping is a commonly used test to determine if the tracheostomy tube can be removed. The success of the capping trial depends on the patient’s ability to maintain sufficient spontaneous brea...

    Authors: Andreas Nowak, Sten Martin, Maik Höhne, Winfried Heller, Taras I. Usichenko and Eckart Klemm
    Citation: BMC Pulmonary Medicine 2022 22:484
  8. Immune checkpoint inhibitors (ICIs) have been shown to significantly improve the survival of patients with advanced lung adenocarcinoma (LUAD). However, only limited proportion of patients could benefit from I...

    Authors: Wengang Zhang, Xiaoling Shang, Ni Liu, Xinchun Ma, Rui Yang, Handai Xia, Yuqing Zhang, Qi Zheng, Xiuwen Wang and Yanguo Liu
    Citation: BMC Pulmonary Medicine 2022 22:483
  9. Airway complications are frequent after lung transplantation (LT), as they affect up to 23% of recipients. The implication of perioperative extracorporeal membrane oxygenation (ECMO) support and haemodynamic i...

    Authors: Enora Atchade, Mélissa Ren, Sylvain Jean-Baptiste, Alexy Tran Dinh, Sébastien Tanaka, Parvine Tashk, Brice Lortat-Jacob, Maksud Assadi, Gaelle Weisenburger, Hervé Mal, Jean Nicolas Sénémaud, Yves Castier, Christian de Tymowski and Philippe Montravers
    Citation: BMC Pulmonary Medicine 2022 22:482
  10. Respiratory diseases are the leading cause of morbidity and mortality in the survivors exposed to Sulfur Mustard (SM). The late abnormalities can be present as chronic bronchitis, tracheobronchial stenosis, as...

    Authors: Shahin Kavousi, Hossein Akbarialiabad, Davood Mehrabani, Alireza Mohamadian, Aria Ghahramani, Ali Shirkhoda and Reza Jalli
    Citation: BMC Pulmonary Medicine 2022 22:481
  11. Acute lung injury and the acute respiratory distress syndrome are characterized by pulmonary inflammation, reduced endothelial barrier integrity and filling of the alveolar space with protein rich edema fluid ...

    Authors: Alexander L. Politowicz, Andrew T. Burks, Yushen Dong, Yu Maw Htwe, Steven M. Dudek, G. Elisabeta Marai and Patrick Belvitch
    Citation: BMC Pulmonary Medicine 2022 22:480
  12. Lung cancer is one of the most common solid tumors worldwide and the leading cause of cancer-associated death. Non-small cell lung cancer (NSCLC) is accounts for approximately 85% of all the lung cancers and l...

    Authors: Xintong Zhang, Jinjing Tan, Yan Chen, Shang Ma, Wanqiu Bai, Yanjing Peng and Guangli Shi
    Citation: BMC Pulmonary Medicine 2022 22:479
  13. Optimising smoking cessation services within a low radiation-dose computed tomography (LDCT) lung cancer screening programme has the potential to improve cost-effectiveness and overall efficacy of the programm...

    Authors: Harriet D. Quinn-Scoggins, Rachael L. Murray, Samantha L. Quaife, Pamela Smith, Kate E. Brain, Matthew E. J. Callister, David R. Baldwin, John Britton, Philip A. J. Crosbie, Rebecca Thorley and Grace M. McCutchan
    Citation: BMC Pulmonary Medicine 2022 22:478
  14. Gravity, and thus body position, can affect the regional distribution of lung ventilation and blood flow. Therefore, body positioning is a potential tool to improve regional ventilation, thereby possibly enhan...

    Authors: Kris M. Ides, Wilfried A. De Backer, Maarten Lanclus, Glenn Leemans, Wendel Dierckx, Eline Lauwers, Dirk Vissers, Jan Steckel and Jan W. De Backer
    Citation: BMC Pulmonary Medicine 2022 22:477
  15. Previous studies on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) have found that those who died in hospital had higher blood urea nitrogen levels and a worse nutritional status compared...

    Authors: Zixiong Zeng, Xiaocui Ke, Shan Gong, Xin Huang, Qin Liu, Xiaoying Huang, Juan Cheng, Yuqun Li and Liping Wei
    Citation: BMC Pulmonary Medicine 2022 22:476
  16. Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with few treatment options. N-acetylcysteine (NAC) is a well-tolerated, inexpensive treatment with antioxidant and anti-fibrotic properties. The N...

    Authors: Anna J. Podolanczuk, John S. Kim, Christopher B. Cooper, Joseph A. Lasky, Susan Murray, Justin M. Oldham, Ganesh Raghu, Kevin R. Flaherty, Cathie Spino, Imre Noth and Fernando J. Martinez
    Citation: BMC Pulmonary Medicine 2022 22:475
  17. Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, with complex etiology, difficult treatment and poor prognosis....

    Authors: Weibin Wu, Ai Chen, Siming Lin, Qiuran Wang, Guili Lian, Li Luo and Liangdi Xie
    Citation: BMC Pulmonary Medicine 2022 22:474
  18. Pulmonary chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a devastating complication and often diagnosed at a late stage when lung dysfunction ...

    Authors: Lingyi Yang, Jia Cheng, Fei Li, Ruiqi Qian, Xiuqin Zhang, Song Jin, Xuefeng He, Ting Xu, Xiaohui Hu, Xiao Ma, Jia Chen, Yehan Zhu and Feng Chen
    Citation: BMC Pulmonary Medicine 2022 22:473
  19. This study aimed to establish normative spirometric equations in a healthy population of Iranian children and adults, and compare these equations with those developed by the Caucasian Global Lung Initiative (G...

    Authors: Leyla Sahebi, Besharat Rahimi, Mamak Shariat, Seyyed Hosein Mousavy and Mohsen Hosseini
    Citation: BMC Pulmonary Medicine 2022 22:472
  20. This study aimed to investigate the association between exposure to diverse indoor microbial aerosols and lower respiratory tract infections (LRTI) among children aged 1 to 59 months in Ibadan, Nigeria.

    Authors: Adekunle Gregory Fakunle, Nkosana Jafta, Lidwien A. M. Smit and Rajen N. Naidoo
    Citation: BMC Pulmonary Medicine 2022 22:471
  21. Endobronchial ultrasound-guided transbronchial needle aspiration is a minimally invasive and effective sampling approach for patients with mediastinal or hilar lymphadenopathy. Increased recognition of the ult...

    Authors: Yan Yan, Zhilong Wang, Wanpu Yan, Shijie Li and Qi Wu
    Citation: BMC Pulmonary Medicine 2022 22:470
  22. miR-125b-5p plays an important role in the development of cancer and drug resistance. However, in cisplatin resistance of non-small cell lung cancer (NSCLC), the function and potential mechanism of miR-125b-5p...

    Authors: Qiuyu Tan, Jinzhu Ma, Hao Zhang, Xu Wu, Qiang Li, Xiaoxuan Zuo, Yuxin Jiang, Haijun Liu and Liang Yan
    Citation: BMC Pulmonary Medicine 2022 22:469
  23. Extra-pulmonary multi-organ failure in patients with severe acute respiratory distress syndrome (ARDS) is a major cause of high mortality. Our purpose is to assess whether airway pressure release ventilation (...

    Authors: Aijia Ma, Bo Wang, Jiangli Cheng, Meiling Dong, Yang Li, Canzheng Wei, Yongfang Zhou, Yang Xue, Hui Gao, Lican Zhao, Siyu Li, Yiwei Qin, Mengni Zhang, Qin Wu, Jing Yang and Yan Kang
    Citation: BMC Pulmonary Medicine 2022 22:468
  24. Tripartite motif (TRIM) family genes get involved in the pathogenesis and development of various biological processes; however, the prognostic value of TRIM genes for idiopathic pulmonary fibrosis (IPF) needs ...

    Authors: Mi Zhou, Jie Ouyang, Guoqing Zhang and Xin Zhu
    Citation: BMC Pulmonary Medicine 2022 22:467
  25. ICU-acquired weakness, comprising Critical Illness Polyneuropathy (CIP) and Myopathy (CIM) is associated with immobilization and prolonged mechanical ventilation. This study aims to assess feasibility of early de...

    Authors: Caroline Attwell, Laurent Sauterel, Jane Jöhr, Lise Piquilloud, Thierry Kuntzer and Karin Diserens
    Citation: BMC Pulmonary Medicine 2022 22:466
  26. Despite the growing evidence on efficacy, little is known regarding the cost-utility of Vaxom/Imocur (OM-85 BV) supplementation to decrease the probability of recurrent respiratory tract infections in OM-85 BV...

    Authors: Jefferson Antonio Buendía, Diana Guerrero Patiño and Erika Fernanda Lindarte
    Citation: BMC Pulmonary Medicine 2022 22:465
  27. Fibrinolytic therapy can be effective for management of complex pleural effusions. Tissue plasminogen activator (tPA, 10 mg) and deoxyribonuclease (DNAse) every 12 h with a dwell time of one hour is a common s...

    Authors: Alexandra Townsend, Harsha Raju, Krystina A. Serpa, Rachel Pruett, Syed S. Razi, Francisco A. Tarrazzi, Catherine M. Tami and Mark I. Block
    Citation: BMC Pulmonary Medicine 2022 22:464
  28. This study evaluated the effects of less invasive surfactant administration (LISA) and intubation-surfactant-extubation (InSurE) on bronchopulmonary dysplasia (BPD) in preterm infants with respiratory distress...

    Authors: Chun-cai Xu, Ying-ying Bao, Jing-xin Zhao, Ke Cheng, Ling Sun, Jing-yuan Wu, Ming-yuan Wu and Jia-jun Zhu
    Citation: BMC Pulmonary Medicine 2022 22:462
  29. Mycobacterium avium complex lung disease (MAC-LD) is an infection that is increasing in frequency, associated with substantial disease burden, and often refractory to treatment. Amikacin liposome inhalation suspe...

    Authors: Timothy Aksamit, Jasmanda Wu, Mariam Hassan, Emily Achter and Anjan Chatterjee
    Citation: BMC Pulmonary Medicine 2022 22:461
  30. Pneumonic-type invasive mucinous adenocarcinoma (IMA) was often misdiagnosed as pneumonia in clinic. However, the treatment of these two diseases is different.

    Authors: Shuai Zhang, Xinxin Yu, Yong Huang, Pei Nie, Yan Deng, Ning Mao, Sha Li, Baosen Zhu, Li Wang, Bo Wang and Ximing Wang
    Citation: BMC Pulmonary Medicine 2022 22:460
  31. Diaphragmatic ultrasound has been increasingly used to evaluate diaphragm function. However, current diaphragmatic ultrasound parameters provide indirect estimates of diaphragmatic contractile function, and th...

    Authors: Qiancheng Xu, Xiao Yang, Yan Qian, Chang Hu, Weihua Lu, Shuhan Cai, Bo Hu and Jianguo Li
    Citation: BMC Pulmonary Medicine 2022 22:459
  32. Chronic obstructive pulmonary disease (COPD) is the most common co-morbidity associated with non-small cell lung cancer (NSCLC) patients. Immune checkpoint inhibitors related pneumonitis (CIP) is a common immu...

    Authors: Zhu Zeng, Jingjing Qu, Yake Yao, Fei Xu, Shan Lu, Pei Zhang, Yinan Yao, Ning Li, Jianying Zhou and Yuehong Wang
    Citation: BMC Pulmonary Medicine 2022 22:458
  33. Asthma education programs (AEPs) have been shown to increase quality of life and reduce emergency treatments and hospital admissions. Despite the proven benefits, only a minority of asthma patients attend such...

    Authors: Stefanie Eck, Alexander Hapfelmeier, Klaus Linde, Konrad Schultz, Jochen Gensichen, Linda Sanftenberg, Thomas Kühlein, Stefanie Stark, Ildikó Gágyor, Christian Kretzschmann and Antonius Schneider
    Citation: BMC Pulmonary Medicine 2022 22:457
  34. Expectations can enhance the intensity and the neural processing of breathlessness. Previous breathlessness episodes may influence the perception of subsequent episodes because of psycho-traumatic consequences...

    Authors: Kris Mooren, Kirsten Smit, Yvonne Engels, Daisy Janssen and Judith Godschalx
    Citation: BMC Pulmonary Medicine 2022 22:456
  35. Gefitinib is recommended as a first-line treatment option for elderly patients with non-small cell lung cancer (NSCLC). Because no pharmacokinetics of gefitinib have been examined, we prospectively assessed th...

    Authors: Yuta Nio, Hiroo Ishida, Natsumi Matsumoto, Sojiro Kusumoto, Yutaro Kubota, Takuya Tsunoda, Yasutsuna Sasaki and Ken-ichi Fujita
    Citation: BMC Pulmonary Medicine 2022 22:454
  36. Pulmonary sarcomatoid carcinoma (PSC) is a heterogeneous disease with poor prognosis. It is essential to understand the molecular basis of its progression in order to devise novel therapeutic strategies. The a...

    Authors: Yingying Yu, Xiumei Duan, Shuai Wang, Hua He, Shijie Lan, Zhen Guo and Di Wu
    Citation: BMC Pulmonary Medicine 2022 22:453
  37. Nontuberculous mycobacteria (NTM) usually invades vulnerable hosts. Disseminated NTM (dNTM) infection can affect nearly all organs and be easily misdiagnosed as metastatic carcinoma or other systemic diseases,...

    Authors: Xiaochuan Sun, Ting Zhang, Hongli Sun and Xuefeng Sun
    Citation: BMC Pulmonary Medicine 2022 22:452
  38. Authors: Wen Zhang, Jiang-Ling Wang, Shuang Fu, Jia-Ming Zhou, Ye-Jing Zhu, Shu-Nv Cai, Jun Fang, Xinzhong Chen and Kangjie Xie
    Citation: BMC Pulmonary Medicine 2022 22:451

    The original article was published in BMC Pulmonary Medicine 2022 22:389

  39. Endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB) facilitates the diagnosis of various respiratory diseases. The safety of performing EBUS-guided TBB in patients with a finding of pulmonary hy...

    Authors: Yuta Takashima, Naofumi Shinagawa, Daisuke Morinaga, Junichi Nakamura, Megumi Furuta, Tetsuaki Shoji, Hajime Asahina, Eiki Kikuchi, Junko Kikuchi, Jun Sakakibara-Konishi, Ichizo Tsujino and Satoshi Konno
    Citation: BMC Pulmonary Medicine 2022 22:449
  40. Pulmonary rehabilitation (PR) is recommended in the treatment of people with idiopathic pulmonary fibrosis (IPF). Little is known about the experiences of people with IPF of PR. Due to Covid-19 there has been ...

    Authors: Orlagh O’Shea, Grainne Murphy, Luke Forde and Katherine M. A. O’Reilly
    Citation: BMC Pulmonary Medicine 2022 22:448
  41. The allergic phenotype is responsible for more than 50% of severe asthma cases. In a stepwise approach, add-on treatments such as anti-IgE are used for severe allergic asthma (SAA). This study was aimed to des...

    Authors: Carlos A. Torres-Duque, Jaime Ocampo-Gómez, Mauricio Morales Castillo, Diana Cano-Rosales, Ángela Giraldo-Montoya, Freddy Rodríguez, Isabel Palacios-Ortega, Mauricio Durán-Silva, Humberto Reynales and Elizabeth García
    Citation: BMC Pulmonary Medicine 2022 22:447
  42. Obstructive sleep apnea (OSA), nocturnal hypoxemia and excessive daytime sleepiness (EDS) are common comorbidities in people with cystic fibrosis (pwCF). Most of the data showing this originates from children ...

    Authors: Matthias Welsner, Sarah Dietz-Terjung, Florian Stehling, Tim Schulte, Ute Niehammer, Fatma-Ezzahra Gahbiche, Christian Taube, Svenja Strassburg, Christoph Schoebel, Gerhard Weinreich and Sivagurunathan Sutharsan
    Citation: BMC Pulmonary Medicine 2022 22:446
  43. There is limited information on the patient’s perspective of how biologic treatments impact their lives. We conducted a qualitative study to explore the patient’s experience of being considered a super-respond...

    Authors: Joseph W. Lanario, Lucy Cartwright, Rupert C. Jones, Ross Sayers, Michael E. Hyland and Matthew Masoli
    Citation: BMC Pulmonary Medicine 2022 22:445
  44. At present, chronic respiratory diseases are a major burden in terms of morbidity and mortality and are of increasing public health concern in China. Meanwhile, the prevalence of diabetes has increased by more...

    Authors: Wei Li, Yi Ning, Yuan Ma, Xinshan Lin, Sailimai Man, Bo Wang, Chen Wang and Ting Yang
    Citation: BMC Pulmonary Medicine 2022 22:444
  45. Accumulating evidence highlights the critical roles of circular RNAs (circRNAs) in the malignant progression of cancers. In this study, we investigated the expression pattern of a newly identified circRNA (hsa...

    Authors: Bo Yang, Bin Zhang, Qi Qi and Changli Wang
    Citation: BMC Pulmonary Medicine 2022 22:443
  46. Bronchoscopy is commonly utilized for non-surgical sampling of indeterminant pulmonary lesions, but nondiagnostic procedures are common. Accurate assessment of the risk of malignancy is essential for decision ...

    Authors: Diana H. Yu, Majid Shafiq, Hitesh Batra, Marla Johnson, Bailey Griscom, Janna Chamberlin, Lori R. Lofaro, Jing Huang, William A. Bulman, Giulia C. Kennedy, Lonny B. Yarmus, Hans J. Lee and David Feller-Kopman
    Citation: BMC Pulmonary Medicine 2022 22:442
  47. Impaired respiratory function caused by respiratory muscle dysfunction is one of the common consequences of chronic obstructive pulmonary disease (COPD). In this study, two-dimensional shear wave elastography ...

    Authors: Yongjian Chen, Jingyun Li, Bingtian Dong, Zhixing Zhu and Guorong Lyu
    Citation: BMC Pulmonary Medicine 2022 22:441

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